What is the 6 ‘-salivary lactose sodium salt of HMOs family members?

On June 6, 2023, the National Health Commission issued the delay notice of new varieties of 6 ‘-salivary lactose sodium salt food additives. As a kind of HMOs, 6’ -salivary lactose sodium salt is a functional raw material of widespread concern in the industry. The basic information and application situation of 6 ‘-salivary lactose sodium salt are summarized here.
What is 6 ‘-salivary lactose sodium salt
6 ‘-Sialyllactose sodium salt English name 6’ -Sialyllactose sodium salt, referred to as 6 ‘-SL, molecular weight is 655.53, CAS number is 157574-76-0, chemical formula is C23H38NO19Na, molecular structure is shown in the following figure.

6 ‘-SL is a rich human milk oligosaccharide (HMOs) composed of galactose, glucose and sialic acid, mostly obtained by microbial fermentation.
6 ‘-SL features
2.1 Promoting Intestinal health 6 ‘-SL can promote the growth of beneficial intestinal flora, such as bifidobacterium and Enterococcus infantiles, and inhibit the growth of harmful bacteria. By maintaining intestinal microecological balance, it can prevent intestinal diseases such as diarrhea and gastroenteritis in infants and children.
2.2 Enhance immunity 6 ‘-SL helps to promote the development of the intestinal immune system and enhance the immunity of the baby. At the same time, it can also protect the health of the digestive system by adhering to the intestinal mucosa to prevent the invasion of harmful bacteria and viruses.
2.3 Anti-inflammatory effects 6 ‘-SL can regulate the intestinal mucosal barrier, exert anti-inflammatory effects through various ways such as inhibiting inflammatory factors, and reduce intestinal inflammatory response. Studies have shown that infant formula supplemented with 6’ -SL can reduce the expression of interleukin-8 and achieve anti-inflammatory effects.
2.4 Promoting neural development 6 ‘-SL can affect the occurrence of neural signal transduction in the brain through direct or indirect means, and may have a positive promoting effect on the brain neural development of babies. It can be used as a neuronutrient to provide energy and material basis for the brain, regulate the shape and function of neurons, and may be helpful to improve the intellectual development and cognitive ability of infants and young children.
6 ‘-SL approval and application status
3.1 As a new food additive in China, the National Health Commission issued 6 ‘-salivate lactose sodium salt extension notice information on June 6, 2023, and delivered as follows:

The National Health Commission issued a notice of acceptance on May 4, 2023.

3.2 Since February 2020 in the United States, as a food additive, a total of 5 GRAS announcements involving 6 ‘-SL in the United States have been approved, and the relevant announcement information is as follows:

3.3 EU Since January 2021, the EU has issued two authorization announcements for 6 ‘-SL as a new resource food, which are as follows:

Brief summary
As an HMOs component, 6 ‘-SL has broad application prospects in infant formula powder and other fields due to its significant raw material characteristics. Food Partners will continue to pay attention to the approval progress of this substance in China, the United States and the European Union and other countries and organizations.