Adenine, also known as 6-aminopurine or vitamin B4, is a fundamental purine nucleobase with the chemical formula C5H5N5 and CAS number 73-24-5. This naturally occurring compound serves as one of the four primary nucleobases in both DNA and RNA, making it indispensable for life sciences research, pharmaceutical development, and various industrial applications.

What is Adenine?

Adenine is a purine derivative that belongs to the family of nitrogenous bases. It is characterized by its double-ring structure consisting of a six-membered pyrimidine ring fused to a five-membered imidazole ring. As a key component of nucleic acids, adenine plays a central role in storing and transmitting genetic information.

In the body, adenine combines with ribose to form adenosine, which can then be phosphorylated to create adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP). These adenine derivatives are essential for cellular energy metabolism and various biochemical processes.

What Are the Benefits?

Cellular Energy Production

Adenine is a critical component of ATP (adenosine triphosphate), often called the “energy currency” of cells. ATP provides energy for numerous cellular processes, including muscle contraction, nerve impulse transmission, and chemical synthesis. By supporting ATP production, adenine helps maintain optimal energy levels at the cellular level.

DNA and RNA Synthesis

As a fundamental building block of nucleic acids, adenine is essential for DNA replication and RNA transcription. In DNA, adenine pairs with thymine through two hydrogen bonds, while in RNA, it pairs with uracil. This base-pairing mechanism is crucial for accurate genetic information transfer.

Coenzyme Functions

Adenine is a component of several important coenzymes, including NAD+ (nicotinamide adenine dinucleotide) and NADP+ (nicotinamide adenine dinucleotide phosphate). These coenzymes are involved in oxidation-reduction reactions and play vital roles in metabolism.

Support for Cell Culture Research

In laboratory settings, adenine serves as a supplement in cell culture media to support cell growth and proliferation. It is particularly valuable for tissue engineering and regenerative medicine applications where robust cell proliferation is essential.

What Are the Uses?

Pharmaceutical Applications

Adenine is used in pharmaceutical formulations and drug development. It serves as an active ingredient in certain medications and is a precursor for synthesizing various adenine derivatives with therapeutic properties. Research has explored adenine’s potential in treating conditions related to energy metabolism dysfunction.

Cell Culture and Biotechnology

In biotechnology and life sciences research, adenine is widely used as a supplement in cell culture media. It supports the growth of various cell lines, including those used in cancer research, vaccine production, and regenerative medicine studies.

Nutritional Supplements

Sometimes referred to as vitamin B4, adenine has been used in dietary supplement formulations. While the body can synthesize adenine internally, supplemental forms are sometimes explored for their potential to support energy metabolism and overall cellular health.

Microbiological Media

Adenine is used in preparing microbiological culture media, particularly for growing certain yeast and bacterial strains that require adenine for optimal growth. It is also used in studies examining the role of boron in biological systems.

Antiviral Research

Adenine-based derivatives have shown antiviral activity against DNA viruses, making them valuable in antiviral drug development and research.

Safety and Side Effects

Adenine is generally recognized as safe when used appropriately in research and pharmaceutical applications. However, as with any bioactive compound, proper handling and dosing guidelines should be followed. In research settings, adenine should be used according to established safety protocols, including appropriate personal protective equipment (PPE).

When used in cell culture applications, adenine concentrations should be optimized for specific cell types to avoid potential cytotoxicity. Consult relevant safety data sheets (SDS) and follow institutional guidelines for handling.

Chemical Specifications

• CAS Number: 73-24-5
• Formule moléculaire : C5H5N5
• Molecular Weight: 135.13 g/mol
• Apparence : Poudre cristalline blanche à blanc cassé
• Alternative Names: 6-Aminopurine, Vitamin B4, Adenine
• Grade: Available in various grades including Research Grade, Cell Culture Grade, and Pharmaceutical Grade

Frequently Asked Questions

Q: What is the difference between adenine and adenosine?
A: Adenine is the nucleobase (the nitrogenous base), while adenosine is adenine attached to a ribose sugar. When phosphorylated, adenosine becomes AMP, ADP, or ATP.

Q: Is adenine the same as vitamin B4?
A: Yes, adenine has historically been referred to as vitamin B4, though it is not classified as a true vitamin since the body can synthesize it.

Q: What foods contain adenine?
A: Adenine is found in various foods, particularly in nucleic acid-rich sources such as organ meats, sardines, and certain legumes.

Q: How should adenine be stored?
A: Adenine should be stored in a cool, dry place away from light and moisture. Follow specific storage requirements based on the grade and application.

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