Apigenin (CAS 520-36-5): Comprehensive Guide to This Potent Natural Flavonoid

Apigenin is a naturally occurring flavonoid compound found in various fruits, vegetables, and medicinal herbs. With the CAS number 520-36-5, this bioactive compound has garnered significant attention in pharmaceutical research, nutritional science, and cosmetic formulations due to its remarkable biological activities.

What is Apigenin?

Apigenin belongs to the flavone subclass of flavonoids and is widely distributed in the plant kingdom. It is particularly abundant in:

• Chamomile flowers (Matricaria chamomilla)
• Parsley (Petroselinum crispum)
• Celery (Apium graveolens)
• Citrus fruits
• Tea leaves

This natural compound appears as a yellow crystalline powder with the molecular formula C15H10O5 and a molecular weight of 254.24 g/mol. Its chemical structure features multiple hydroxyl groups that contribute to its potent antioxidant properties.

What Are the Benefits of Apigenin?

Apigenin exhibits a wide range of health-promoting effects that have been extensively studied in scientific research:

1. Powerful Antioxidant Activity

Apigenin demonstrates strong free radical scavenging capabilities, helping to protect cells from oxidative stress and damage caused by reactive oxygen species (ROS). This antioxidant activity plays a crucial role in preventing chronic diseases and supporting overall cellular health.

2. Anti-Inflammatory Properties

Research has shown that apigenin can modulate inflammatory pathways in the body. It inhibits the production of pro-inflammatory cytokines and enzymes, making it a promising natural compound for managing inflammatory conditions.

3. Anxiolytic and Sedative Effects

One of the most well-known benefits of apigenin is its calming effect on the nervous system. It binds to GABA-A receptors in the brain, promoting relaxation and reducing anxiety without causing significant sedation. This mechanism is similar to some pharmaceutical anxiolytics but with a more favorable safety profile.

4. Sleep Promotion

Apigenin has been studied for its potential to improve sleep quality. Its interaction with GABA receptors helps to reduce sleep latency and increase total sleep time, making it a natural alternative for those seeking better sleep.

5. Anticancer Potential

Preliminary research indicates that apigenin may possess anticancer properties. Studies have shown it can:

• Induce apoptosis (programmed cell death) in cancer cells
• Inhibit cancer cell proliferation
• Suppress tumor growth and metastasis
• Enhance the effects of chemotherapy agents

6. Neuroprotective Effects

Apigenin shows promise in protecting neurons from damage and may help in managing neurodegenerative diseases. It has been studied for its potential to:

• Reduce oxidative stress in brain cells
• Inhibit amyloid-beta plaque formation
• Support cognitive function

7. Cardiovascular Protection

The flavonoid supports heart health by:

• Improving endothelial function
• Reducing blood pressure
• Inhibiting platelet aggregation
• Protecting against atherosclerosis

What Are the Uses of Apigenin?

Apigenin is utilized in various industries and applications:

İlaç Alanındaki Uygulamalar

• Anxiety and sleep supplements: Natural calming agents
• Anti-inflammatory medications: Topical and oral formulations
• Neuroprotective drugs: Research for Alzheimer’s and Parkinson’s disease
• Chemopreventive agents: Cancer prevention formulations

Besin Takviyeleri

• Dietary supplements: Available in capsule, tablet, and powder forms
• Herbal extracts: Chamomile and parsley extracts standardized for apigenin content
• Functional foods: Added to beverages and food products for health benefits

Cosmetic and Skincare Products

• Anti-aging formulations: Due to its antioxidant properties
• Güneşten korunma ürünleri: Helps protect skin from UV-induced damage
• Skin calming treatments: For sensitive or irritated skin

Research and Development

• Laboratory reagent: Used in biochemical research
• Cell culture studies: Investigating mechanisms of action
• Drug development: As a lead compound for new therapeutics

Güvenlik ve Yan Etkiler

Apigenin is generally considered safe when consumed at recommended doses. However, some considerations should be noted:

Genel Güvenlik Profili

• Well-tolerated by most individuals
• Low toxicity even at higher doses
• Natural occurrence in foods makes it suitable for dietary use

Possible Side Effects

• Mild drowsiness when taken in large amounts
• Gastrointestinal discomfort in some users
• Potential interactions with certain medications

Kontrendikasyonlar ve Önlemler

• Hamilelik ve emzirme: Consultation with healthcare provider recommended
• Sedative medications: May enhance sedative effects
• Blood thinners: Potential interaction with anticoagulant drugs
• Surgery: Discontinue use at least 2 weeks before scheduled surgery

Önerilen Dozaj

Typical supplemental doses range from 50-500 mg daily, though optimal dosing varies based on the intended use and individual factors. It is advisable to start with lower doses and adjust as needed.

Kimyasal Özellikler

Mülk	Değer
CAS Numarası	520-36-5
Moleküler Formül	C15H10O5
Moleküler Ağırlık	254.24 g/mol
IUPAC Adı	5,7-Dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
Görünüş	Sarı kristal toz
Çözünürlük	Poorly soluble in water; soluble in organic solvents
Erime Noktası	345-350°C
PubChem CID	5280443

Sık Sorulan Sorular

What is the CAS number for Apigenin?

The CAS number for Apigenin is 520-36-5.

What are the main food sources of Apigenin?

Apigenin is found in chamomile tea, parsley, celery, citrus fruits, and various herbs.

Is Apigenin safe for daily consumption?

Yes, Apigenin is generally considered safe for daily consumption at recommended doses. However, consult a healthcare provider before starting any new supplement regimen.

Can Apigenin help with sleep?

Yes, Apigenin has been shown to promote relaxation and improve sleep quality due to its interaction with GABA receptors in the brain.

Does Apigenin have anticancer properties?

Research suggests that Apigenin exhibits anticancer potential in laboratory studies, but more clinical research is needed to confirm these effects in humans.

Is Apigenin better than other flavonoids?

Each flavonoid has unique properties. Apigenin is particularly notable for its anxiolytic and sleep-promoting effects, while other flavonoids like quercetin or kaempferol have different benefit profiles.

Where can I purchase Apigenin?

Apigenin is available from chemical suppliers, nutritional supplement retailers, and specialty chemical companies. Contact reputable suppliers for current pricing and availability.

Why Choose Our Apigenin?

• Yüksek Saflık: Our Apigenin meets strict quality standards for pharmaceutical and research applications
• Rekabetçi Fiyatlandırma: We offer attractive rates for bulk orders
• Güvenilir Tedarik: Consistent availability to meet your manufacturing needs
• Teknik Destek: Our team provides comprehensive product information and technical assistance
• Global Shipping: We deliver to customers worldwide

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