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Milbemycin Oxime CAS 129496-10-2

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CAS number
129496-10-2
Chemical name
Milbemycin Oxime
Molecular formula
2C32H45NO7.2C31H43NO7
Molecular weight
2194.78

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Item Specifications Results
Appearance White orlight yellow amorphous powder White amorphous powder
Identification IR spectrum of sample corresponds to that of reference substance Comply
The retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the assay Comply
Water ≤3.0 % 1.0 %
Residue on ignition ≤0.5 % 0.1 %
Assay ( Sum of Milbemycin A4 oxime and Milbemycin A3 oxime) : 95.0%-102.0 on the anhydrous basis . 98.1 %
Ratio of Milbemycin A4 oxime ≥ 0.75 0.94
Ratio of Milbemycin A3 oxime ≥ 0.25 0.06
Organic impuritis Impurity a: 11’DesmethylMilbemycin A4 oxime ≤0.7 % 0.06 %
Impurity b: (20’R)-Hydroxymilbemycin A4keto form ≤0.5% 0.1 %
Impurity c: Milbemycin A4 keto form ≤0.7 % 0.4 %
Impurity d: Milbemycin D oxime ≤3.0% 0.2 %
Any other individual impurity ≤0.5 % 0.2 %
Total impurities ( excluding impurity d ) ≤3.5 % 1.3 %
Reporting threshold: 0.10 % 0.2 %
Solvent residue Trichloromethane ≤60 ppm Not detected
N-Heptane ≤5000 ppm 2 ppm
Ethanol ≤5000 ppm 24 ppm
Conclusion The product complies with the specification ( USP )
Storage Preserve in tight containers, and store at room temperature , protected from light .

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