Natural product research and development – breast cancer
The latest global cancer epidemiological data shows that more than 2.3 million new deaths will occur in the world in 2020, including 685000 deaths from breast cancer, accounting for 24.5% of newly diagnosed cases and 15.5% of female deaths. What’s more, the incidence rate of breast cancer is still rising, and its age of onset is also tending to be younger. Although breast cancer has made significant progress in early screening, surgery, chemoradiotherapy and other technologies, the lack of safe and effective drugs for the systemic metastasis of advanced breast cancer is the difficulty of clinical treatment at present. Therefore, it is imperative to find new effective, low toxic and low-cost treatment methods for breast cancer and improve the survival rate of breast cancer patients.
More and more evidence suggests that natural medicines can effectively improve the survival rate of cancer patients and reduce the risk of death. Natural medicines have reliable anti-tumor efficacy and low toxicity, and have been regarded as important reservoirs for the discovery of anti-cancer drugs. They have been widely developed and applied in the treatment of various cancers. At present, experimental studies have shown that baicalein, magnolol, delphinidin and other monomer components extracted from plants have the effect of anti breast cancer, and can inhibit the proliferation and migration of breast cancer cells and promote apoptosis by inhibiting Rho ROCK-MLC, Wnt/β – catenin, Bcl-2/Bax, Akt and other signal pathways. Therefore, this topic focuses on the latest research results of natural products in the prevention and treatment of breast cancer, providing reference for the treatment of breast cancer and new drug research.