What is Calcifediol Monohydrate?

Calcifediol Monohydrate, also known as 25-Hydroxyvitamin D3 Monohydrate ou 25-Hydroxycholecalciferol Monohydrate, is the major circulating metabolite of vitamin D3 in the human body. This compound serves as a crucial prehormone and is produced in the liver through the hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase.

Calcifediol represents a vital intermediate in the vitamin D metabolic pathway. Unlike its precursor vitamin D3 or its active form calcitriol (1,25-dihydroxyvitamin D3), calcifediol has a longer half-life in the bloodstream and is considered the best indicator of a patient’s vitamin D status. This makes it clinically significant for diagnosing and monitoring vitamin D deficiency.

Chemical Properties of Calcifediol Monohydrate

Numéro CAS	63283-36-3
Formule moléculaire	C₂₇H₄₄O₂ · H₂O
Poids moléculaire	418.65 g/mol
Synonymes	25-Hydroxyvitamin D3, 25-Hydroxycholecalciferol, Calcidiol
Apparence	White to light yellow powder or crystal
La pureté	≥98% (HPLC)
Solubilité	Soluble in organic solvents
Classification	API (Active Pharmaceutical Ingredient)

Benefits and Therapeutic Applications

Vitamin D Status Indicator

Calcifediol is considered the best biomarker for assessing vitamin D status in patients. Unlike other vitamin D metabolites, it has a circulating half-life of approximately 2-3 weeks, making it more stable for laboratory measurements. Healthcare providers worldwide measure calcifediol concentrations to determine whether a patient has sufficient vitamin D levels.

Treatment of Vitamin D Deficiency

Calcifediol monohydrate is used as a supplement for treating vitamin D deficiency. It offers advantages over other forms of vitamin D because:

• Better intestinal absorption – more readily absorbed compared to other vitamin D forms
• Direct utilization – already in the form that the body stores
• Effective for patients with liver dysfunction – bypasses the need for hepatic conversion

Chronic Kidney Disease (CKD) Management

One of the most important therapeutic applications of calcifediol is in treating secondary hyperparathyroidism associated with chronic kidney disease. Patients with CKD often have impaired kidney function that affects vitamin D activation. Extended-release calcifediol formulations have been shown to:

• Effectively raise serum 25-hydroxyvitamin D levels
• Suppress parathyroid hormone (iPTH) levels
• Improve calcium and phosphorus metabolism
• Manage vitamin D insufficiency in stage 3-4 CKD patients

Skin Health Benefits

Research has shown that calcifediol monohydrate may provide benefits for skin health:

• Reduces inflammatory cell infiltration
• Inhibits STAT3 phosphorylation
• Restores skin barrier function
• Downregulates AQP3 protein expression
• Inhibits abnormal cell proliferation

Immunomodulatory Effects

Calcifediol plays a role in immune system modulation and may:

• Support immune function
• Modulate inflammatory responses
• Stimulate production of both anti-inflammatory and pro-inflammatory cytokines

Utilisations et applications

Pharmaceutical Applications

• Vitamin D supplement – treatment and prevention of vitamin D deficiency
• Chronic kidney disease therapy – management of secondary hyperparathyroidism
• Osteoporosis treatment – as part of calcium and vitamin D therapy
• Dialysis patients – for patients undergoing renal dialysis

Research Applications

• Endocrinology research – study of vitamin D metabolism
• Hormone research – VDR (Vitamin D receptor) ligand studies
• Clinical diagnostics – reference standard for vitamin D testing
• Pharmaceutical manufacturing – intermediate for vitamin D formulations

Nutritional Supplements

Calcifediol is used in various dietary supplement formulations for:

• General vitamin D supplementation
• Bone health support
• Immune system support
• Age-related health maintenance

Safety and Side Effects

General Safety

Calcifediol monohydrate is safe under recommended conditions and levels of use. Research indicates:

• Safe for adults including pregnant and lactating women
• Safe for children over 11 years of age
• Recommended daily intake up to 10 μg/day is considered safe

Potential Side Effects

When taken in excessive amounts, calcifediol may cause:

• Hypercalcemia (elevated blood calcium levels)
• Nausea and vomiting
• Weakness and fatigue
• Kidney problems
• Calcification of soft tissues

Contraindications and Precautions

• Should not be used by patients with hypercalcemia
• Caution in patients with kidney stones
• Monitor serum calcium levels during treatment
• Consult healthcare provider before use

Why Choose Our Calcifediol Monohydrate?

When sourcing Calcifediol Monohydrate (CAS 63283-36-3) for your pharmaceutical, research, or supplement applications, our company offers:

• High purity – ≥98% HPLC guaranteed
• Quality assurance – Full Certificate of Analysis (CoA) available
• Consistent supply – Reliable production capacity for bulk orders
• Competitive pricing – Factory-direct pricing for quantity orders
• Technical support – Documentation and customization options
• Global shipping – Efficient logistics to customers worldwide

We supply Calcifediol Monohydrate to pharmaceutical companies, research institutions, and supplement manufacturers globally. Contact us for quotes on bulk orders, custom specifications, and packaging options tailored to your needs.

Frequently Asked Questions

Q: What is the difference between calcifediol and calcitriol?

A: Calcifediol (25-hydroxyvitamin D3) is the major circulating form of vitamin D and requires further activation in the kidneys to become calcitriol (1,25-dihydroxyvitamin D3), the biologically active form.

Q: How is calcifediol used in diagnosing vitamin D deficiency?

A: Serum calcifediol concentration is measured to assess vitamin D status because it has a longer half-life and reflects the body’s vitamin D stores more accurately than other forms.

Q: Is calcifediol safe for kidney disease patients?

A: Yes, extended-release calcifediol is specifically approved for treating secondary hyperparathyroidism in patients with stage 3-4 chronic kidney disease.

Q: What is the CAS number for calcifediol?

A: The CAS number for Calcifediol Monohydrate is 63283-36-3.

Q: Can calcifediol be used during pregnancy?

A: Research indicates calcifediol is safe for pregnant and lactating women when used at recommended levels. However, consult a healthcare provider before use.

Conclusion

Calcifediol Monohydrate (CAS 63283-36-3) is a crucial metabolite in the vitamin D pathway with significant clinical and therapeutic applications. Its role as the best indicator of vitamin D status, combined with its effectiveness in treating vitamin D deficiency and chronic kidney disease-related conditions, makes it an important compound in both clinical and research settings.

For pharmaceutical companies, research institutions, and supplement manufacturers seeking high-quality Calcifediol Monohydrate, our product offers reliability, purity, and comprehensive technical support.

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This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before using any supplement or medication.