Bismuth subsalicylate is a pharmaceutical compound widely used for treating gastrointestinal discomfort. With the CAS number 14882-18-9 and molecular formula C7H5BiO4, this compound has become a staple in both over-the-counter and prescription medications.
What is Bismuth Subsalicylate?
Bismuth subsalicylate, also known as bismuth(III) subsalicylate or bismuth oxysalicylate, is a colloidal substance obtained through hydrolysis of bismuth salicylate. It appears as a white or off-white powder with a molecular weight of 362.09 g/mol. This compound is commonly found in popular antidiarrheal medications such as Pepto-Bismol and Kaopectate.
In the gut, bismuth subsalicylate hydrolyzes to form bismuth oxychloride and salicylic acid, which then exert their therapeutic effects. This unique mechanism of action makes it effective against various gastrointestinal issues.
What Are the Benefits?
Bismuth subsalicylate offers several therapeutic benefits:
Antibacterial Action
The compound exhibits bactericidal properties through an oligodynamic effect, where small amounts of heavy metals like bismuth damage bacterial cell membranes. This helps eliminate bacteria that cause stomach problems, including Helicobacter pylori, which is associated with stomach ulcers.
Anti-inflammatory Properties
The salicylic acid component inhibits cyclooxygenase enzymes, limiting the formation of prostaglandins – pro-inflammatory mediators. This provides relief from inflammation in the gastrointestinal tract.
Cytoprotective and Demulcent Activity
Bismuth subsalicylate forms a protective coating on the stomach lining, helping to protect against irritation and promoting healing of damaged tissues.
Antisecretory Effects
The compound helps reduce fluid secretion in the intestines, which is particularly beneficial in managing diarrhea.
Toxin-Adsorptive Properties
Bismuth subsalicylate can bind to and neutralize certain toxins in the digestive tract, providing relief from food poisoning and bacterial toxins.
What Are the Uses?
Bismuth subsalicylate is primarily used for:
- Treating Traveler’s Diarrhea: One of the most common uses of this compound is managing diarrhea associated with traveling to foreign countries.
- Relieving Heartburn and Indigestion: It provides relief from acid reflux and general stomach discomfort.
- Treating Stomach Ulcers: When used in combination with antibiotics, bismuth subsalicylate helps treat H. pylori infections that cause stomach ulcers.
- Managing Microscopic Colitis: The compound has shown effectiveness in treating this inflammatory bowel condition.
- Relieving Nausea: It helps reduce feelings of nausea and stomach upset.
Safety and Side Effects
When taken as directed, bismuth subsalicylate is generally safe for short-term use. However, some individuals may experience side effects:
Common Side Effects
- Black discoloration of tongue and stools (harmless and temporary)
- Constipation
- Nausea
- Tinnitus (ringing in the ears)
Important Precautions
- Should not be used by children or teenagers recovering from viral infections due to the risk of Reye’s syndrome
- Avoid use if you have allergies to salicylates or aspirin
- Consult a healthcare provider before use if pregnant or breastfeeding
- May interact with other medications – consult a doctor if taking blood thinners or other drugs
Chemical Specifications
| Property | Valeur |
|---|---|
| Numéro CAS | 14882-18-9 |
| Formule moléculaire | C7H5BiO4 |
| Poids moléculaire | 362.09 g/mol |
| Alternate Names | Bismuth(III) subsalicylate, Bismuth oxysalicylate, Bismuth salicylate basic |
| Apparence | Poudre blanche à blanc cassé |
| Formule linéaire | HOC6H4COOBiO |
Frequently Asked Questions
Is Bismuth Subsalicylate the same as Pepto-Bismol?
Yes, Pepto-Bismol is one of the most well-known brand names for medications containing bismuth subsalicylate as the active ingredient.
How long does it take for bismuth subsalicylate to work?
Most people experience relief within 30 minutes to 1 hour after taking the medication. The effects typically last 4-6 hours.
Can I take bismuth subsalicylate every day?
This medication is intended for short-term use only. Do not take it for more than 2 weeks continuously without consulting a healthcare professional.
Why does bismuth subsalicylate turn my tongue and stools black?
This harmless side effect occurs when bismuth combines with trace amounts of sulfur in your saliva and digestive system, forming bismuth sulfide, which is black in color. This is temporary and resolves after stopping the medication.
Why Choose Our Bismuth Subsalicylate?
We provide high-quality bismuth subsalicylate that meets pharmaceutical standards. Our product is:
- Produced under strict quality control conditions
- Available in various purity grades to meet different application needs
- Competitively priced for both research and commercial use
- Supported by technical documentation and certificate of analysis
- Available for bulk orders with reliable shipping
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Contact us today to learn more about our bismuth subsalicylate and other pharmaceutical intermediates.
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