Clopidogrel (CAS 113665-84-2)

What is Clopidogrel?

Clopidogrel is a potent antiplatelet agent belonging to the thienopyridine class of drugs. Known commercially as Plavix, it is widely used to prevent blood clots in patients with cardiovascular conditions. As a prodrug, clopidogrel requires metabolic activation in the liver to exert its platelet-inhibiting effects. The compound is synthesized through a multi-step process including an optical resolution to obtain the active S-enantiomer.

¿Cuáles son las ventajas?

Prevention of Cardiovascular Events

Clopidogrel significantly reduces the risk of heart attack, stroke, and other cardiovascular events in high-risk patients. It is particularly effective in patients with acute coronary syndrome (ACS), those who have previously experienced a heart attack, and individuals with peripheral vascular disease.

Superior Safety Profile

Compared to other antiplatelet drugs like ticlopidine, clopidogrel demonstrates fewer side effects, particularly a lower incidence of bone marrow suppression at standard dosages. This makes it a preferred choice for long-term antiplatelet therapy.

Proven Efficacy

Extensive clinical studies have established clopidogrel’s effectiveness in reducing thrombotic events. It works by irreversibly inhibiting the P2Y12 ADP receptor on platelets, preventing platelet aggregation and clot formation.

¿Para qué sirve?

Clopidogrel is indicated for the following medical conditions:

• Acute Coronary Syndrome (ACS): Used in patients with non-ST-elevated ACS and ST-elevated myocardial infarction
• Secondary Prevention: Prevents recurrent heart attack and stroke in patients with a history of cardiovascular events
• Peripheral Vascular Disease: Reduces thrombotic events in patients with peripheral arterial disease
• Coronary Artery Disease: Used in patients undergoing percutaneous coronary intervention (PCI) with stent placement
• Cerebrovascular Disease: Helps prevent ischemic stroke in at-risk patients

Safety / Side Effects

While clopidogrel is generally well-tolerated, patients should be aware of potential side effects:

• Common Side Effects: Easy bruising, bleeding more easily, nosebleeds, headache
• Serious Side Effects: Severe bleeding, thrombocytopenia, liver function abnormalities
• Interacciones farmacológicas: May interact with NSAIDs, warfarin, and other anticoagulants
• CYP2C19 Genetic Variation: Patients with variant alleles of CYP2C19 may have reduced efficacy

Importante: Patients should not discontinue clopidogrel without consulting their healthcare provider, as this may increase the risk of cardiovascular events.

Especificaciones químicas

Propiedad	Valor
Número CAS	113665-84-2
Fórmula molecular	C16H16ClNO2S
Peso molecular	321.8 g/mol (free base)
Apariencia	Polvo blanco a blanquecino
Drug Class	Thienopyridine antiplatelet agent
Product Form	Clopidogrel bisulfate

Preguntas frecuentes

How does clopidogrel work?

Clopidogrel is a prodrug that requires metabolic activation in the liver. Its active metabolite irreversibly binds to the P2Y12 ADP receptor on platelets, preventing platelet aggregation and reducing the risk of blood clot formation.

How long does clopidogrel take to work?

The antiplatelet effect begins within 2 hours of ingestion, with maximum platelet inhibition achieved within 3-7 days of regular dosing.

Can clopidogrel be used with aspirin?

Yes, dual antiplatelet therapy (DAPT) with both clopidogrel and aspirin is commonly prescribed after certain cardiovascular events or procedures, particularly after stent placement. However, this combination increases bleeding risk and should only be used under medical supervision.

What should I do if I miss a dose?

If you miss a dose of clopidogrel, take it as soon as you remember. However, if it is close to your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Why Choose Our Clopidogrel?

We supply high-quality Clopidogrel (CAS 113665-84-2) meeting international pharmacopeial standards. Our product undergoes rigorous quality control testing to ensure purity, potency, and consistency. We offer competitive pricing and reliable supply for pharmaceutical manufacturers and research institutions.

Our Advantages:

• High purity (≥99.0%)
• Consistent quality with COA
• Bulk supply capabilities
• Technical support and documentation
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