Analysis of the compatibility and mechanism of action of drugs for treating palpitations in the Chinese Pharmacopoeia based on data mining and network pharmacology
Palpitation is a traditional Chinese medicine disease name, which is referred to as “palpitations”, “palpitations below the heart”, “palpitations in the heart”, and “palpitations” in the Treatise on Cold Damage and Miscellaneous Diseases. The patient feels palpitations, restlessness, palpitations, and even inability to self regulate. Symptoms such as shortness of breath, tinnitus, dizziness, chest tightness, and shortness of breath are more likely to occur when there is emotional distress or excessive fatigue. According to symptoms, palpitations belong to the category of arrhythmia in Western medicine and are the most common type of cardiovascular disease in China, with high incidence and mortality rates. There are many clinical types of diseases, including tachycardia, bradycardia, atrial fibrillation, conduction abnormalities, etc. If not controlled, it will not only cause irreversible damage to myocardial cells, but also lead to serious complications such as myocardial infarction, which has a difficult to improve impact on the patient’s life. While reducing the patient’s quality of life, it will also endanger the patient’s life. At present, Western medicine treatment mostly uses antiarrhythmic drugs, but extensive practice has shown that some patients still experience adverse consequences such as recurrence or drug intolerance to Western medicine treatment. In recent years, Chinese medicine has been widely used in clinical treatment, so some scholars proposed to treat arrhythmia with Chinese medicine, and palpitation was first proposed by Zhang Zhongjing. Therefore, through ancient Chinese medicine research, how to better treat palpitation, and what are its specific molecular targets? This study will start with the 2015 Chinese Pharmacopoeia (Part I) (hereinafter referred to as the “Chinese Pharmacopoeia”), excavate the formula rules of traditional Chinese patent medicines and simple preparations in the “Chinese Pharmacopoeia” for the treatment of palpitation, and analyze high-frequency drugs.

The Chinese Pharmacopoeia is a legal basis that practitioners must abide by in the development, production, operation, and management of drugs, and is a code for ensuring drug quality in China. In the preliminary literature research, it was found that scholars have conducted research on the classification and compatibility rules of traditional Chinese medicine decoction pieces or toxic herbs included in the pharmacopoeia; Carry out analysis on the prescription rule of traditional Chinese patent medicines and simple preparations for the main diseases and syndromes of the collected prescription preparations; Systematic data mining was carried out for the formulated and single preparation contained in the Chinese Pharmacopoeia, but no data mining and analysis rules were found for the traditional Chinese patent medicines and simple preparations used to treat a related disease, especially cardiovascular disease. Therefore, this study took the name, ingredients, dosage, function and main indications of traditional Chinese patent medicines and simple preparations used to treat palpitations in the 2015 edition of the Chinese Pharmacopoeia as the research object, used the V2.5 version of the traditional Chinese medicine inheritance auxiliary platform developed by the Institute of Chinese Medicine of the Chinese Academy of Traditional Chinese Medicine Sciences to analyze the law of drug use, and analyzed the frequency of use of traditional Chinese medicine and the association rules between traditional Chinese medicines through its main function association rules Apriori algorithm, complex system entropy clustering and other unsupervised data mining methods. Prescription rules and prediction of new prescriptions.

After analyzing the medication patterns obtained from the above software, high-frequency drugs for treating palpitations were identified. Through the scientific research method proposed by Hopkins et al. to explore the direct relationship between traditional Chinese medicine and diseases – network pharmacology, systematic analysis and mining were carried out to construct the relationship between “traditional Chinese medicine active ingredients disease targets disease”, which can provide new ideas and methods for mechanism analysis and drug development of traditional Chinese medicine. Due to the multi-component and multi-target nature of traditional Chinese medicine, network pharmacology can better elucidate the mechanism of action of traditional Chinese medicine on palpitations.

Through data mining of the Chinese Pharmacopoeia, this paper has made a systematic analysis of traditional Chinese patent medicines and simple preparations for the treatment of palpitations, and obtained the specific molecular target mechanism of salvia miltiorrhiza for the treatment of palpitations through pharmacological analysis of the results, providing a reference for the subsequent clinical drug selection and scientific research. However, due to limited space, further research on high-frequency drugs such as ginseng and Ophiopogon japonicus can also be conducted to provide more evidence for clinical practice.