Camostat mesilate (also known as Camostat mesylate) is a synthetic serine protease inhibitor with the CAS number 59721-29-8. First described in scientific literature in 1981, this compound was initially researched for its potential in inhibiting skin tumors in mice. The compound is also known by its development code FOY-305 and has garnered significant attention in recent years due to its diverse pharmacological properties.
Camostat mesilate works by inhibiting various serine proteases, including trypsin, plasmin, kallikrein, and thrombin. It also suppresses cholecystokinin (CCK) and pro-inflammatory cytokines, making it a compound of interest for multiple therapeutic applications.
Chemische Eigenschaften
- Molekulare Formel: C₂₀H₂₂N₄O₅·CH₃SO₃H (or C₂₁H₂₆N₄O₈S)
- Molekulargewicht: 494.52 g/mol
- CAS-Nummer: 59721-29-8
- Synonyme: Camostat mesylate, FOY-305, 4-Guanidino-2-phenylbutyrylglycine ester mesylate
- Erscheinungsbild: Typically available as a white to off-white powder
Was sind die Vorteile?
Camostat mesilate offers several notable benefits that make it valuable in both clinical and research settings:
1. Pancreatitis Treatment
Camostat mesilate has been used for the treatment of acute pancreatitis and chronic pancreatitis. Its ability to inhibit trypsin and other pancreatic proteases helps reduce pancreatic inflammation and damage.
2. Anti-Inflammatory Properties
The compound exhibits potent anti-inflammatory effects by inhibiting pro-inflammatory cytokines. This mechanism makes it useful in managing various inflammatory conditions.
3. COVID-19 Research
Camostat mesilate gained significant attention during the COVID-19 pandemic as a potential treatment for SARS-CoV-2 infection. Research showed it could inhibit the virus’s entry into cells by targeting host cell proteases.
4. Liver Fibrosis Prevention
Studies have demonstrated that camostat mesilate can significantly attenuate liver fibrosis by reducing plasmin and TGF-beta levels, inhibiting hepatic stellate cell activation without causing significant systemic side effects.
5. Anticancer Potential
Originally researched for skin tumor inhibition, camostat mesilate continues to be investigated for its potential anticancer properties due to its ability to inhibit various proteases involved in tumor progression and metastasis.
6. Digestive Disorder Management
Clinical trials have shown that camostat mesilate is effective in managing dyspepsia associated with nonalcoholic mild pancreatic disease, with patients tolerating the treatment well.
Wozu dient es?
Camostat mesilate is utilized in various applications:
Anwendungen in der Pharmazie
- Acute and Chronic Pancreatitis: Primary therapeutic use
- COVID-19 Treatment: Investigational use
- Liver Disorders: Research for fibrosis treatment
- Digestive Health: Management of pancreatic insufficiency
Research Applications
- Biochemical Research: As a serine protease inhibitor
- Drug Development: Template for developing new protease inhibitors
- Virology Research: Studies on viral entry mechanisms
Industrielle Anwendungen
- Pharmaceutical Manufacturing: Active pharmaceutical ingredient production
- Laboratory Reagents: Biochemical studies
Sicherheit und Nebenwirkungen
Camostat mesilate has been generally well-tolerated in clinical studies:
- Common Side Effects: Mild gastrointestinal discomfort may occur
- Severity: Most adverse effects reported are mild in nature
- Clinical Trial Data: In studies with 200mg doses three times daily for two weeks, patients showed only mild side effects with no severe adverse reactions
- Tolerability: The compound demonstrates a favorable safety profile for long-term use
As with any pharmaceutical compound, proper handling and storage are essential. Camostat mesilate should be stored according to manufacturer specifications and handled by trained professionals.
Chemische Spezifikationen
| Eigenschaft | Wert |
| CAS-Nummer | 59721-29-8 |
| Molekulargewicht | 494.52 g/mol |
| Molekulare Formel | C₂₀H₂₂N₄O₅·CH₃SO₃H |
| Erscheinungsbild | Weißes bis cremefarbenes Pulver |
| Reinheit | Typically ≥98% |
| Löslichkeit | Wasserlöslich |
Häufig gestellte Fragen
What is Camostat Mesilate used for?
Camostat mesilate is primarily used for treating acute and chronic pancreatitis. It has also been investigated for COVID-19 treatment, liver fibrosis, and various inflammatory conditions.
Is Camostat Mesilate safe?
Clinical studies have shown camostat mesilate to be well-tolerated with mild side effects. However, it should only be used under medical supervision.
How does Camostat Mesilate work?
Camostat mesilate works by inhibiting serine proteases such as trypsin, plasmin, kallikrein, and thrombin. It also suppresses pro-inflammatory cytokines, providing its therapeutic effects.
Where can I purchase Camostat Mesilate?
Camostat mesilate is available from chemical suppliers and pharmaceutical distributors. Ensure you source from reputable suppliers that provide quality documentation and SDS.
Why Choose Our Camostat Mesilate?
When sourcing Camostat Mesilate (CAS 59721-29-8), partner with a trusted supplier committed to quality:
- High Purity: Our Camostat Mesilate meets rigorous quality standards (≥98% purity)
- Technischer Support: Our team provides comprehensive technical documentation and support
- Zuverlässige Versorgung: Consistent availability for research and manufacturing needs
- Wettbewerbsfähige Preise: Cost-effective solutions for bulk orders
- Quality Assurance: Full SDS and certificate of analysis available
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This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare professional before using any pharmaceutical compound.
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