{"id":9202,"date":"2024-08-15T19:46:23","date_gmt":"2024-08-15T19:46:23","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9202"},"modified":"2024-08-15T19:46:23","modified_gmt":"2024-08-15T19:46:23","slug":"three-active-components-of-solidago","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/solidagonun-uc-aktif-bileseni\/","title":{"rendered":"Solidago esculenta'n\u0131n \u00fc\u00e7 aktif bile\u015feninin yeni koronavir\u00fcse kar\u015f\u0131 molek\u00fcler yerle\u015ftirme tahmini"},"content":{"rendered":"

Solidago esculenta'n\u0131n \u00fc\u00e7 aktif bile\u015feninin yeni koronavir\u00fcse kar\u015f\u0131 molek\u00fcler yerle\u015ftirme tahmini
\nAral\u0131k 2019'da, yeni koronavir\u00fcs SARS CoV-2, Hubei Eyaleti, Wuhan'da h\u0131zla patlak verdi. 22 Haziran 2020 itibariyle, \u00c7in'de 4646 \u00f6l\u00fcm dahil olmak \u00fczere 85018 do\u011frulanm\u0131\u015f yeni koronavir\u00fcs hastal\u0131\u011f\u0131 2019 (COVID-19) vakas\u0131 bulunmaktad\u0131r. Daha sonra, Amerika Birle\u015fik Devletleri, \u0130talya, \u0130spanya, Birle\u015fik Krall\u0131k, Fransa, Almanya, \u0130ran, \u0130svi\u00e7re, G\u00fcney Kore ve Japonya dahil olmak \u00fczere d\u00fcnya \u00e7ap\u0131nda 200'den fazla \u00fclkede 8,97 milyondan fazla enfeksiyon vakas\u0131 bildirilmi\u015ftir. SARS-CoV-2 ile enfekte olan hastalar\u0131n ortak semptomlar\u0131 ate\u015f, \u00f6ks\u00fcr\u00fck ve kas a\u011fr\u0131s\u0131 veya yorgunluktur. SARS-CoV-2'nin S proteini yap\u0131sal olarak SARS-CoV'unkine benzer ve her ikisi de insan h\u00fccrelerinin y\u00fczeyinde anjiyotensin d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc enzim 2 (ACE2) i\u00e7in \u00f6nemli bir ba\u011flanma afinitesine sahiptir ve ACE2 arac\u0131l\u0131\u011f\u0131 ile insan v\u00fccuduna girer. ACE2, akci\u011ferler, sindirim sistemi ve b\u00f6brekler gibi doku ve h\u00fccrelerde yayg\u0131n olarak ifade edilir ve \u015fu anda SARS-CoV-2'nin konak h\u00fccrelere girmesi i\u00e7in anahtar oldu\u011funa inan\u0131lmaktad\u0131r. Klinik tedavi, Bat\u0131 t\u0131bb\u0131 ile birlikte geleneksel \u00c7in t\u0131bb\u0131n\u0131n COVID-19 \u00fczerinde \u00f6nemli terap\u00f6tik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. \u015eimdiye kadar, COVID-19 tedavisi i\u00e7in hala spesifik ila\u00e7 eksikli\u011fi bulunmaktad\u0131r. Bu nedenle, bu hastal\u0131\u011f\u0131 engellemek i\u00e7in etkili antiviral ila\u00e7lar\u0131n bulunmas\u0131na acil ihtiya\u00e7 vard\u0131r.
\nLiliaceae familyas\u0131nda yer alan ve pire resti, \u00e7im nehir arabas\u0131 ve beyaz tatl\u0131 zambak olarak da bilinen Paris polyphylla bitkisi, Paris polyphylla ad\u0131 verilen bir k\u00f6k ve g\u00f6vdeye sahiptir. Uzun bir t\u0131bbi kullan\u0131m ge\u00e7mi\u015fine sahip geleneksel bir \u00c7in ilac\u0131 olan Chonglou, anti-enflamatuar, hemostatik, bakterisidal, yat\u0131\u015ft\u0131r\u0131c\u0131, analjezik, anti astmatik ve \u00f6ks\u00fcr\u00fck giderici etkilere sahiptir. Ayr\u0131ca halk t\u0131bb\u0131nda \u00e7e\u015fitli yara t\u00fcrlerini, karbonk\u00fclleri, zehirli y\u0131lan \u0131s\u0131r\u0131klar\u0131n\u0131 vb. tedavi etmek i\u00e7in kullan\u0131l\u0131r. 1970'lerden bu yana, a\u011f\u0131r binalardaki aktif bile\u015fenler \u00fczerine ara\u015ft\u0131rmalar devam etmektedir. \u015eu anda, a\u011f\u0131r binalarda y\u00fczden fazla kimyasal bile\u015fen ke\u015ffedilmi\u015ftir ve bunlar\u0131n aras\u0131nda 70'ten fazlas\u0131 steroidal saponindir. Chonglou'da daha y\u00fcksek i\u00e7eri\u011fe sahip steroidal saponinler aras\u0131nda dioscin ve spirostanol saponinleri bulunmaktad\u0131r. Polyphyllin I, Polyphyllin VI ve Polyphyllin VII, Polygonatum sibiricum'da bol miktarda bulunan ve anti-t\u00fcm\u00f6r, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme, antibakteriyel etkiler vb. dahil olmak \u00fczere \u00e7e\u015fitli hastal\u0131klar\u0131n tedavisinde yayg\u0131n olarak kullan\u0131lan dioscin kategorisine aittir (\u015eekil 1). Zhonglou saponinleri spiral steroid saponinlerdir; Saponinler aglikonlar ve \u015fekerler, glukuronik asitler veya di\u011fer organik asitlerden olu\u015fur. Yap\u0131s\u0131nda alt\u0131 halkadan ve 27 karbon atomundan olu\u015fan ortak bir ana \u00e7ekirdek i\u00e7erir (\u015eekil 1), A, B, C ve D steroid ana \u00e7ekirdekleridir (siklopentan dihidrofenantren). Steroid \u00e7ekirde\u011fi bir furan halkas\u0131 E ve bir piran halkas\u0131 F'ye ba\u011fl\u0131d\u0131r ve genellikle spiroketid \u015feklinde ba\u011flan\u0131r. Bu makalede, yeni koronavir\u00fcs SARS-CoV-2'nin tedavisi i\u00e7in \u00c7in bitkisel ilac\u0131 Yizhihua Aesculus'un aktif bile\u015fiklerini ke\u015ffetmek i\u00e7in molek\u00fcler yerle\u015ftirme y\u00f6ntemi kullan\u0131lm\u0131\u015ft\u0131r. SARS-CoV-2 esas olarak S proteini arac\u0131l\u0131\u011f\u0131yla insan h\u00fccrelerinin y\u00fczeyindeki anjiyotensin d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc enzim 2 (ACE2) resept\u00f6r\u00fcne ba\u011flan\u0131r. Bu \u00e7al\u0131\u015fma, Polygonatum sibiricum'da zengin \u00fc\u00e7 tip saponinin (I, VI, VII) ACE2 ile ba\u011flanma afinitesini molek\u00fcler yerle\u015ftirme sim\u00fclasyonu yoluyla tahmin etmi\u015ftir.<\/p>\n

SARS-CoV-2'nin yeni ke\u015ffedilen bir vir\u00fcs olmas\u0131 nedeniyle, \u015fu anda do\u011frulanm\u0131\u015f veya mevcut spesifik bir ila\u00e7 bulunmamaktad\u0131r. Ekonomik a\u00e7\u0131dan etkili tedavi stratejisi mevcut ila\u00e7lardan yararlanmakt\u0131r. Klinik tedavi, geleneksel \u00c7in t\u0131bb\u0131 ve Bat\u0131 t\u0131bb\u0131 kombinasyonunun COVID-19 \u00fczerinde \u00f6nemli terap\u00f6tik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Bu nedenle, geleneksel \u00c7in t\u0131bb\u0131ndan elde edilen mevcut ila\u00e7lar\u0131n taranmas\u0131 etkili bir stratejidir. \u00d6nceki \u00e7al\u0131\u015fmalar, klorokinin SARS-CoV-2 enfeksiyonunu in vitro olarak kontrol etmede olduk\u00e7a etkili oldu\u011funu bulmu\u015ftur. Klorokin, \u00f6ncelikle antimalaryal bir ila\u00e7 olarak kullan\u0131lmas\u0131n\u0131n yan\u0131 s\u0131ra, ACE2 resept\u00f6rlerinin terminal glikozilasyonunu azaltarak ve SARS-CoV-2'nin ACE2 resept\u00f6rlerine ba\u011flanmas\u0131na m\u00fcdahale ederek viral replikasyonu da inhibe edebilen bir 4-aminoquinoline'dir. Cheng ve arkada\u015flar\u0131, klorokin ve ACE2 aras\u0131ndaki ba\u011flanma enerjisini hesaplamak i\u00e7in molek\u00fcler yerle\u015ftirme kullanm\u0131\u015ft\u0131r. Sonu\u00e7lar, klorokin'in ACE2 ile -5,70 kcal\/mol ba\u011flanma serbest enerjisi ve Leu-95, Gln-58 ve Gln-102 ba\u011flanma b\u00f6lgeleri ile potansiyel ba\u011flanma kabiliyetine sahip oldu\u011funu g\u00f6stermi\u015ftir. Klorokin ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, \u00fc\u00e7 saponinin ACE2 ile docking ba\u011flanma serbest enerjileri daha d\u00fc\u015f\u00fckt\u00fcr. Son zamanlarda, SARS-CoV-2 enfeksiyonunun k\u00fcresel olarak yay\u0131lmas\u0131yla birlikte, giderek daha fazla ara\u015ft\u0131rmac\u0131 anti SARS-CoV-2 ila\u00e7lar\u0131n\u0131n taranmas\u0131na dahil olmu\u015ftur. Yan ve arkada\u015flar\u0131, ACE (PDB: 1R4L) ve vir\u00fcs\u00fcn ana M proteaz\u0131 (PDB: 6LU7) i\u00e7in 38 \u00c7in patentli ilac\u0131 molek\u00fcler yerle\u015ftirme yoluyla taram\u0131\u015f ve artemisinin, rutin, glisirizin, puerarin, andrographolide ve matrine dahil olmak \u00fczere 10 potansiyel anti SARS-CoV-2 ilac\u0131 ke\u015ffetmi\u015ftir. Liu ve arkada\u015flar\u0131, a\u011f farmakolojisi ve molek\u00fcler kenetlenme \u00e7al\u0131\u015fmalar\u0131 yoluyla luteolin (-26,78 kJ\/mol), kuersetin (-26,36 kJ\/mol) ve demetillenmi\u015f icariinin (-25,94 kJ\/mol) SARS-CoV-2 3CL hidrolaza ba\u011fland\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Baz\u0131 ila\u00e7lar ACE2 ile daha d\u00fc\u015f\u00fck kenetlenme aktivitesine sahip olabilir, ancak bu COVID-19 tedavisi i\u00e7in uygun olmad\u0131klar\u0131 anlam\u0131na gelmez, \u00e7\u00fcnk\u00fc kenetlenme sim\u00fclasyonlar\u0131 yaln\u0131zca \u00f6n ara\u015ft\u0131rma i\u00e7in bir referans sa\u011flar. Buna ek olarak, geleneksel \u00c7in t\u0131bb\u0131 re\u00e7etelerinin form\u00fcle edilme ilkeleri aras\u0131nda patojenik istilan\u0131n ortadan kald\u0131r\u0131lmas\u0131 ve v\u00fccudun direncinin art\u0131r\u0131lmas\u0131 yer almaktad\u0131r. Bu nedenle, baz\u0131 ila\u00e7lar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemini d\u00fczenleyerek COVID-19 \u00fczerinde bir etkiye sahip olabilece\u011fi olas\u0131l\u0131\u011f\u0131n\u0131 g\u00f6z ard\u0131 edemeyiz. Bu steroidal saponinlerin ACE2'yi hedef al\u0131p alamayaca\u011f\u0131n\u0131 ve h\u00fccre k\u00fclt\u00fcr\u00fc modellerinde ve deney hayvanlar\u0131nda SARS-CoV-2 enfeksiyonunu \u00f6nleyip \u00f6nleyemeyece\u011fini do\u011frulamak i\u00e7in daha fazla deney yap\u0131lmas\u0131 gerekmektedir.<\/p>","protected":false},"excerpt":{"rendered":"

Molecular docking prediction of three active components of Solidago esculenta against novel coronavirus In December 2019, novel coronavirus SARS CoV-2 broke out rapidly in Wuhan, Hubei Province. As of June 22, 2020, there are 85018 confirmed cases of novel coronavirus disease 2019 (COVID-19) in China, including 4646 deaths. Subsequently, over 8.97 million cases of infection […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMolecular docking prediction of three active components of Solidago esculenta against novel coronavirus - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/solidagonun-uc-aktif-bileseni\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular docking prediction of three active components of Solidago esculenta against novel coronavirus - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Molecular docking prediction of three active components of Solidago esculenta against novel coronavirus In December 2019, novel coronavirus SARS CoV-2 broke out rapidly in Wuhan, Hubei Province. 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