{"id":9176,"date":"2024-08-15T19:34:32","date_gmt":"2024-08-15T19:34:32","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9176"},"modified":"2024-08-15T19:34:32","modified_gmt":"2024-08-15T19:34:32","slug":"principal-component-analysis-of-flavonoids","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/flavonoidlerin-temel-bilesen-analizi\/","title":{"rendered":"Epimedium'un farkl\u0131 \u00e7e\u015fitlerinden elde edilen flavonoidlerin temel bile\u015fen analizi ve b\u00f6brek yang eksikli\u011fi olan s\u0131\u00e7anlar \u00fczerindeki koruyucu etkileri"},"content":{"rendered":"

Epimedium'un farkl\u0131 \u00e7e\u015fitlerinden elde edilen flavonoidlerin temel bile\u015fen analizi ve b\u00f6brek yang eksikli\u011fi olan s\u0131\u00e7anlar \u00fczerindeki koruyucu etkileri
\nEpimedium, Epimedium wushanense T.S.Ying ve Epimedium sagittatum (Sieb. et Zucc.) Maxim dahil olmak \u00fczere Berberidaceae familyas\u0131ndan bir bitkidir Epimedium pubescens Maxim. veya Kore'den Epimedium koreanum Nakai'nin kurutulmu\u015f yapraklar\u0131, d\u00f6rt t\u00fcr, \u00c7in Halk Cumhuriyeti Farmakopesi'nin 2015 bask\u0131s\u0131nda yer almaktad\u0131r. Bu ila\u00e7 ilk olarak \"Shennong Bencao Jing \"de kaydedilmi\u015ftir ve bir\u00e7ok takma ad\u0131 olan birinci s\u0131n\u0131f bir ila\u00e7 olarak s\u0131n\u0131fland\u0131r\u0131lm\u0131\u015ft\u0131r. \"Ben Jing \"de \"Gangqian\", \"Lei Gong Pao Zhi Lun \"da \"Xianling Pi\" ve \"Rihuazi Bencao \"da \"Fang Tiao Cao\", \"Fei Tiao Cao\", \"Qian Liang Jin\", \"Gan Ji Jin\" ve \"Huang Lianzu\" olarak an\u0131lmaktad\u0131r. \"Bielu\", \"Treatise on Medicinal Properties\", \"Shu Bencao\" ve \"Dian Nan Bencao\" kitaplar\u0131n\u0131n hepsi do\u011fas\u0131n\u0131n keskin, tatl\u0131 ve s\u0131cak oldu\u011funu ve karaci\u011fer ve b\u00f6brek meridyenlerine ait oldu\u011funu kaydeder. B\u00f6brek yang\u0131n\u0131 tonifiye etme, tendonlar\u0131 ve kemikleri g\u00fc\u00e7lendirme, r\u00fczgar\u0131 ve rutubeti giderme etkilerine sahiptir. Modern farmakolojik ara\u015ft\u0131rmalar, Epimedium'un cinsel i\u015flevi uyarabildi\u011fini, insan ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131 art\u0131rabildi\u011fini, kalbe kan ve oksijen tedarik dengesini d\u00fczenleyebildi\u011fini, kalp ve beyin iskemisini ve hipoksiyi iyile\u015ftirebildi\u011fini, hematopoetik i\u015flevi te\u015fvik edebildi\u011fini, osteoporozu \u00f6nleyip tedavi edebildi\u011fini ve ayr\u0131ca ya\u015flanma kar\u015f\u0131t\u0131, antiviral, anti-t\u00fcm\u00f6r, antidepresan, anti-enflamatuar ve di\u011fer etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Epimedium'un kimyasal bile\u015fenleri aras\u0131nda flavonoidler, lignanlar, fenolik glikozitler, alkaloidler, polisakkaritler, u\u00e7ucu ya\u011flar, eser elementler, kromojenler, fenantren, antrakinon, tanenler, seskiterpenler, steroller vb. bulunmaktad\u0131r. Bunlar aras\u0131nda icariin, Asahuoding A, Asahuoding B ve Asahuoding C gibi flavonoidler ana aktif bile\u015fenleridir. Temel bile\u015fen analizi, numune bilgilerinin kapsaml\u0131 bir \u015fekilde de\u011ferlendirilmesi i\u00e7in yayg\u0131n olarak kullan\u0131lan y\u00f6ntemlerden biridir. Geleneksel \u00c7in t\u0131bb\u0131 alan\u0131nda uygulanmas\u0131, \u00e7e\u015fitli g\u00f6stergelerin a\u011f\u0131rl\u0131klar\u0131n\u0131n belirsizli\u011fini ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite de\u011ferlendirmesinde belirli g\u00f6stergeler aras\u0131ndaki korelasyonun neden oldu\u011fu rahats\u0131zl\u0131\u011f\u0131 telafi ederek geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite de\u011ferlendirme y\u00f6ntemini daha da geli\u015ftirmi\u015ftir. Literat\u00fcr taramas\u0131na g\u00f6re, Epimedium esas olarak ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi, anti-enflamatuar, ya\u015flanma kar\u015f\u0131t\u0131, anti-t\u00fcm\u00f6r ve di\u011fer aktivitelerin ara\u015ft\u0131r\u0131lmas\u0131na odaklanmaktad\u0131r. Epimedium'un b\u00f6brek tonland\u0131r\u0131c\u0131 ve yang besleyici etkileri \u00fczerine \u00e7ok az ara\u015ft\u0131rma vard\u0131r, bu nedenle b\u00f6brek tonland\u0131r\u0131c\u0131 ve yang besleyici etkileri \u00fczerine \u00f6n ara\u015ft\u0131rma yapt\u0131k. Epimedium'un klinik uygulamas\u0131 i\u00e7in bilimsel teorik temel ve t\u0131bbi temel sa\u011flay\u0131n.<\/p>\n

Epimedium'un farkl\u0131 \u00e7e\u015fitlerinde icariin, icariin A, icariin B ve icariin C olmak \u00fczere d\u00f6rt etkili bile\u015fenin i\u00e7eri\u011fini belirlemek i\u00e7in HPLC kullan\u0131lm\u0131\u015ft\u0131r (Tablo 1). Farkl\u0131 Epimedium \u00e7e\u015fitlerinin kalitesini analiz etmek ve de\u011ferlendirmek i\u00e7in temel bile\u015fen analizi kullan\u0131lm\u0131\u015f ve Epimedium'un s\u0131\u00e7anlarda b\u00f6brek yang eksikli\u011fi \u00fczerindeki koruyucu etkisi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Deney hayvanlar\u0131 rastgele Yang eksikli\u011fi modeli kontrol grubu (model grup), Jin Kui Shen Qi Wan m\u00fcdahale grubu (pozitif grup) ve Epimedium'un d\u00fc\u015f\u00fck (125 mg\/kg, YYH-LG), orta (250 mg\/kg, YYH-MG) ve y\u00fcksek (500 mg\/kg, YYH-HG) doz gruplar\u0131na ayr\u0131lm\u0131\u015ft\u0131r. D\u00f6rt hafta sonra, b\u00f6brek yang\u0131s\u0131n\u0131n serumunda \u00fcrik asit (UA), kreatinin (CRE) ve \u00fcre azotu (BUN) \u00f6l\u00e7\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n

Bu \u00e7al\u0131\u015fmadaki temel bile\u015fen analizi sonu\u00e7lar\u0131, d\u00f6rt bile\u015fenden iki temel bile\u015fenin \u00e7\u0131kar\u0131ld\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir; birinci temel bile\u015fen icariin ve chaohuoding C ve ikinci temel bile\u015fen chaohuoding B'dir. Temel bile\u015fenlerin a\u011f\u0131rl\u0131k ortalamas\u0131na katk\u0131 oran\u0131 kullan\u0131larak ve 12 parti Epimedium bitkisinin puanlar\u0131 kar\u015f\u0131la\u015ft\u0131r\u0131larak, 5 parti numunenin daha d\u00fc\u015f\u00fck puanlara sahip oldu\u011fu bulunmu\u015ftur, bu da 12 parti numunenin kalitesindeki farkl\u0131l\u0131klar\u0131 g\u00f6stermektedir. Bu \u00e7al\u0131\u015fma, b\u00f6brek yang\u0131 eksikli\u011finin koruyucu etkisi \u00fczerine bir sonraki ara\u015ft\u0131rma i\u00e7in y\u00fcksek puanl\u0131 Epimedium pilosum'u se\u00e7mi\u015ftir.
\nKlinik uygulamada, b\u00f6brek fonksiyonu bozuldu\u011funda, UA, CRE ve BUN seviyeleri de\u011fi\u015fecektir. Bu \u00e7al\u0131\u015fmada, hidrokortizon ile ind\u00fcklenen s\u0131\u00e7an b\u00f6brek yang eksikli\u011fi deneysel nesne olarak kullan\u0131lm\u0131\u015f ve UA, CRE ve BUN tespit g\u00f6stergeleri olarak kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, YYH-LG grubu, YYH-MG grubu ve YYH-HG grubunun hepsinin UA, CRE ve BUN seviyelerini azaltabildi\u011fini g\u00f6stermi\u015ftir. Genel olarak, YYH-LG grubu \u00e7e\u015fitli g\u00f6stergelerde ve b\u00f6brek hasar\u0131nda iyi bir iyile\u015fme g\u00f6stermi\u015ftir. Bu nedenle, Epimedium b\u00f6brek yang eksikli\u011finin tedavisinde bir ila\u00e7 olarak b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Farkl\u0131 Epimedium \u00e7e\u015fitlerinden elde edilen flavonoidlerin temel bile\u015fen analizi ve b\u00f6brek yang eksikli\u011fi olan s\u0131\u00e7anlar \u00fczerindeki koruyucu etkileri Epimedium, Epimedium wushanense T.S.Ying ve Epimedium sagittatum (Sieb. et Zucc.) Maxim dahil olmak \u00fczere Berberidaceae familyas\u0131ndan bir bitkidir Kore'den Epimedium pubescens Maxim. veya Epimedium koreanum Nakai'nin kurutulmu\u015f yapraklar\u0131, d\u00f6rt t\u00fcr, [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nPrincipal component analysis of flavonoids from different varieties of Epimedium and their protective effects on rats with kidney yang deficiency - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/flavonoidlerin-temel-bilesen-analizi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Principal component analysis of flavonoids from different varieties of Epimedium and their protective effects on rats with kidney yang deficiency - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Principal component analysis of flavonoids from different varieties of Epimedium and their protective effects on rats with kidney yang deficiency Epimedium is a plant of the Berberidaceae family, including Epimedium wushanense T.S.Ying and Epimedium sagittatum (Sieb. et Zucc.) 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