{"id":9126,"date":"2024-08-15T18:54:50","date_gmt":"2024-08-15T18:54:50","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=9126"},"modified":"2024-08-15T18:54:50","modified_gmt":"2024-08-15T18:54:50","slug":"the-n-butanol-extract-of-polygonatum-sibiricum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/polygonatum-sibiricumun-butanol-ozutu\/","title":{"rendered":"Polygonatum sibiricum'un n-butanol ekstresinden elde edilen anti-enflamatuar etken maddeler \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"<p>Polygonatum sibiricum'un n-butanol ekstresinden elde edilen anti-enflamatuar etken maddeler \u00fczerine \u00e7al\u0131\u015fma<br \/>\nAcanthopanax henryi (Oliv.) Harms, Araliaceae familyas\u0131ndan 1000~3200 metre y\u00fckseklikte ormanlar\u0131n veya \u00e7al\u0131l\u0131klar\u0131n kenar\u0131nda yeti\u015fen yaprak d\u00f6ken bir \u00e7al\u0131 veya a\u011fa\u00e7t\u0131r. \u00c7in'in \u00f6zel bir bitkisi olarak Hunan, Sichuan, Anhui, Zhejiang ve di\u011fer yerlerde yayg\u0131n olarak bulunur. Aralia cinsinin bitkileri \u00c7in, G\u00fcney Kore ve Japonya gibi \u00fclkelerde geleneksel t\u0131pta \u00f6nemli bir rol oynamaktad\u0131r. Kuru k\u00f6k kabu\u011fu ve g\u00f6vde kabu\u011fu, halk t\u0131bb\u0131nda romatizma, artrit, fel\u00e7, kas ve kemik a\u011fr\u0131s\u0131 vb. tedavisinde yayg\u0131n olarak kullan\u0131lan \u00fcnl\u00fc geleneksel ila\u00e7lard\u0131r; Yapraklar\u0131 genellikle \u00e7ay i\u00e7eceklerinde veya halk t\u0131bb\u0131nda \u00e7ok i\u015flevli bir sebze \u00e7orbas\u0131 bile\u015feni olarak t\u00fcketilir. Kaba yaprakl\u0131 Wujia k\u00f6k kabu\u011fu (Wujia kabu\u011fu olarak da bilinir), Hunan Eyaletindeki geleneksel \u00c7in t\u0131bb\u0131n\u0131n yerel standartlar\u0131na dahildir. R\u00fczgar ve rutubeti giderme, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve tendonlar\u0131 rahatlatma, qi'yi d\u00fczenleme ve a\u011fr\u0131y\u0131 hafifletme etkilerine sahiptir. Esas olarak romatizma, uyu\u015fukluk, kas ve kemik zay\u0131fl\u0131\u011f\u0131, \u00f6dem, travmatik yaralanmalar, f\u0131t\u0131k ve kar\u0131n a\u011fr\u0131s\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131r. \u00d6n ara\u015ft\u0131rmam\u0131zda, monoterpenler, triterpenoid saponinler, flavonoidler, kafeoilkinik asit t\u00fcrevleri, lignanlar, steroidler, fenilpropanoidler, diterpenler, ya\u011f asitleri ve di\u011fer bile\u015fikler Acanthopanax senticosus'un meyvelerinden, yapraklar\u0131ndan, k\u00f6klerinden, k\u00f6k kabu\u011fundan, saplar\u0131ndan ve \u00e7i\u00e7eklerinden izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r. Ayn\u0131 zamanda, geleneksel \u00c7in t\u0131bb\u0131 kaba yaprak wujia'dan elde edilen bu monomerik bile\u015fiklerle ilgili anti n\u00f6roinflamasyon, anti-inflamatuar, anti ya\u011f \u00fcretimi, antibakteriyel, antioksidan ve anti asetilkolinesteraz aktiviteleri \u00fczerine art arda \u00e7al\u0131\u015fmalar yapt\u0131k ve raporlar haz\u0131rlad\u0131k. Bununla birlikte, \u015fimdiye kadar Acanthopanax senticosus meyvesi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar \u00e7o\u011funlukla etil asetat fraksiyonuna odaklanm\u0131\u015ft\u0131r ve n-b\u00fctanol ekstraksiyon fraksiyonunun maddi temeli hakk\u0131nda \u00e7ok az rapor vard\u0131r. Acanthopanax senticosus meyvesindeki y\u00fcksek oranda polar kimyasal bile\u015fenlerin incelenmesi ve ke\u015ffedilmesi i\u00e7in daha fazla dikkat gerekmektedir.<\/p>\n<p>Lipopolisakkarit (LPS), Gram negatif bakteri h\u00fccrelerinin d\u0131\u015f duvar\u0131n\u0131n lipid ve polisakkaritlerden (glikolipidler) olu\u015fan bir bile\u015fenidir. LPS, RAW264.7 makrofajlar\u0131nda ifade edilen Toll benzeri resept\u00f6rlere etki etti\u011finde, \u00e7e\u015fitli enflamatuar sinyal yollar\u0131n\u0131 aktive eder. Bu aktive makrofajlar genellikle nitrik oksit (NO), prostaglandin E2 (PGE2), t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc - \u03b1 (TNF - \u03b1), interl\u00f6kinler (ILs) gibi b\u00fcy\u00fck miktarlarda pro-inflamatuar arac\u0131lar ve sitokinler \u00fcretir ve salg\u0131lar. \u00d6nceki ara\u015ft\u0131rmalara dayanarak, geleneksel \u00c7in t\u0131bb\u0131 Wujia meyvesinin anti-enflamatuar madde temelini daha da netle\u015ftirmek ve bu bitki kayna\u011f\u0131n\u0131n t\u0131bbi k\u0131s\u0131mlar\u0131n\u0131 geni\u015fletmek i\u00e7in y\u00fcksek polar bile\u015fenlerinin potansiyelini ke\u015ffetmek amac\u0131yla, LPS ile ind\u00fcklenen RAW264.7 makrofaj modeline dayal\u0131 olarak Wujia meyvesinin n-b\u00fctanol ekstresinin anti-enflamatuar aktif bile\u015fenleri \u00fczerine ilk \u00e7al\u0131\u015fmay\u0131 ger\u00e7ekle\u015ftirdik.<\/p>\n<p>Bu deney, Acanthopanax senticosus meyvesinden elde edilen n-butanol ekstrakt\u0131n\u0131n anti-enflamatuar ve farmakolojik madde temelini incelemek i\u00e7in biyolojik aktivite tarama modeli olarak lipopolisakkarit (LPS) ile ind\u00fcklenmi\u015f makrofaj RAW264.7'yi kullanan ilk deneydir. 3 flavonoid glikozit, 7 kafeoilkinik asit ve 7 monoterpenoid glikozit dahil olmak \u00fczere 17 bile\u015fik izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r (bkz. \u015eekil 1). Acanthopanax senticosus'un k\u00f6kleri ve k\u00f6k kabu\u011fu \u00fczerinde ilgili ara\u015ft\u0131rmalar yapt\u0131k ve 9 lignan, 4 kafeoilkinik asit, 3 fenolik asit, 2 steroid, 1 diterpenoid, 1 kumarin, 1 uzun zincirli ya\u011f asidi ve 1 alkaloid dahil olmak \u00fczere 22 bile\u015fik rapor ettik. Ana bile\u015fenler lignanlar, kafeoilkinik asitler, fenolik asitler ve steroidlerdir. Polygonatum sibiricum kaynaklar\u0131n\u0131n t\u0131bbi k\u0131s\u0131mlar\u0131n\u0131 daha da geni\u015fletmek ve meyve k\u0131s\u0131mlar\u0131n\u0131n t\u0131pta geleneksel t\u0131bbi k\u0131s\u0131mlar\u0131n\u0131n (k\u00f6kler) yerini al\u0131p alamayaca\u011f\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in, \u00f6nceki ara\u015ft\u0131rma temelimize dayanarak, Polygonatum sibiricum meyvesinin etil asetat ekstraksiyon k\u0131s\u0131mlar\u0131ndan 5 lignan, 4 monoterpen, 2 flavonoid glikozit, 1 fenolik asit, 1 kumarin, 1 fenilpropanoid glikozit, 1 furfural, 1 maltol, 1 fenilpropanoid glikozit ve 1 triterpenoid glikozit olmak \u00fczere 18 monomerik bile\u015fik izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r. Ana bile\u015fen t\u00fcrleri lignanlar ve monoterpenlerdir; Acanthopanax senticosus meyvesinin ana farmakolojik maddelerinin flavonoidler, kafeoilkinik asitler, monoterpenler ve lignanlar oldu\u011funu bulduk. Meyvelerin ve k\u00f6klerin kimyasal bile\u015fimi kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ba\u015flang\u0131\u00e7ta her bir par\u00e7an\u0131n farkl\u0131 kullan\u0131mlara sahip oldu\u011funu g\u00f6steren maddi temellerinde belirli farkl\u0131l\u0131klar oldu\u011fu bulunmu\u015ftur. Bu nedenle kullan\u0131mlar\u0131nda farkl\u0131la\u015ft\u0131rma yap\u0131lmal\u0131d\u0131r. Bu makale, \u00c7in'in \u00f6zel bitkisi Acanthopanax senticosus'un kimyasal \u00e7a\u011fr\u0131\u015f\u0131m\u0131n\u0131 daha da zenginle\u015ftirerek, gelecekte bu bitki \u00fczerinde yap\u0131lacak daha ileri ara\u015ft\u0131rmalar i\u00e7in bilimsel bir temel ve teorik referans sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Polygonatum sibiricum'un n-butanol ekstresinden elde edilen anti-enflamatuar aktif bile\u015fenler \u00fczerine \u00e7al\u0131\u015fma Acanthopanax henryi (Oliv.) Harms, Araliaceae familyas\u0131nda 1000 ~ 3200 metre y\u00fckseklikte ormanlar\u0131n veya \u00e7al\u0131l\u0131klar\u0131n kenar\u0131nda yeti\u015fen yaprak d\u00f6ken bir \u00e7al\u0131 veya a\u011fa\u00e7t\u0131r. \u00c7in'in \u00f6zel bir bitkisi olarak Hunan, [...]'da yayg\u0131n olarak da\u011f\u0131lm\u0131\u015ft\u0131r.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/polygonatum-sibiricumun-butanol-ozutu\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the anti-inflammatory active ingredients extracted from the n-butanol extract of Polygonatum sibiricum Acanthopanax henryi (Oliv.) 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Harms is a deciduous shrub or tree that grows on the edge of forests or shrubs at an altitude of 1000~3200 meters in the family Araliaceae. 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