Veri madencili\u011fi ve a\u011f farmakolojisine dayal\u0131 olarak \u00c7in Farmakopesi'nde \u00e7arp\u0131nt\u0131 tedavisinde kullan\u0131lan ila\u00e7lar\u0131n uyumlulu\u011funun ve etki mekanizmas\u0131n\u0131n analizi
\n\u00c7arp\u0131nt\u0131, geleneksel \u00c7in t\u0131bb\u0131nda bir hastal\u0131k ad\u0131d\u0131r ve So\u011fuk Hasar\u0131 ve \u00c7e\u015fitli Hastal\u0131klar Risalesi'nde \"\u00e7arp\u0131nt\u0131\", \"kalbin alt\u0131nda \u00e7arp\u0131nt\u0131\", \"kalpte \u00e7arp\u0131nt\u0131\" ve \"\u00e7arp\u0131nt\u0131\" olarak ge\u00e7mektedir. Hasta \u00e7arp\u0131nt\u0131, huzursuzluk, \u00e7arp\u0131nt\u0131 ve hatta kendini d\u00fczenleyememe hisseder. Nefes darl\u0131\u011f\u0131, kulak \u00e7\u0131nlamas\u0131, ba\u015f d\u00f6nmesi, g\u00f6\u011f\u00fcste s\u0131k\u0131\u015fma hissi ve nefes darl\u0131\u011f\u0131 gibi belirtilerin duygusal s\u0131k\u0131nt\u0131 veya a\u015f\u0131r\u0131 yorgunluk oldu\u011funda ortaya \u00e7\u0131kma olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir. Belirtilere g\u00f6re, \u00e7arp\u0131nt\u0131 Bat\u0131 t\u0131bb\u0131nda aritmi kategorisine girmektedir ve \u00c7in'de y\u00fcksek insidans ve \u00f6l\u00fcm oranlar\u0131yla en yayg\u0131n kardiyovask\u00fcler hastal\u0131k t\u00fcr\u00fcd\u00fcr. Ta\u015fikardi, bradikardi, atriyal fibrilasyon, iletim anormallikleri vb. dahil olmak \u00fczere bir\u00e7ok klinik hastal\u0131k t\u00fcr\u00fc vard\u0131r. Kontrol alt\u0131na al\u0131nmazsa, sadece miyokard h\u00fccrelerinde geri d\u00f6n\u00fc\u015f\u00fc olmayan hasara neden olmakla kalmaz, ayn\u0131 zamanda hastan\u0131n ya\u015fam\u0131 \u00fczerinde iyile\u015ftirilmesi zor bir etkiye sahip olan miyokard enfarkt\u00fcs\u00fc gibi ciddi komplikasyonlara da yol a\u00e7ar. Hastan\u0131n ya\u015fam kalitesini d\u00fc\u015f\u00fcr\u00fcrken, hastan\u0131n hayat\u0131n\u0131 da tehlikeye atacakt\u0131r. \u015eu anda, Bat\u0131 t\u0131bb\u0131 tedavisinde \u00e7o\u011funlukla antiaritmik ila\u00e7lar kullan\u0131lmaktad\u0131r, ancak kapsaml\u0131 uygulamalar baz\u0131 hastalar\u0131n hala Bat\u0131 t\u0131bb\u0131 tedavisine kar\u015f\u0131 n\u00fcks veya ila\u00e7 intolerans\u0131 gibi olumsuz sonu\u00e7lar ya\u015fad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Son y\u0131llarda, \u00c7in t\u0131bb\u0131 klinik tedavide yayg\u0131n olarak kullan\u0131lmaktad\u0131r, bu nedenle baz\u0131 bilim adamlar\u0131 aritmiyi \u00c7in t\u0131bb\u0131 ile tedavi etmeyi \u00f6nermi\u015f ve \u00e7arp\u0131nt\u0131 ilk olarak Zhang Zhongjing taraf\u0131ndan \u00f6nerilmi\u015ftir. Bu nedenle, eski \u00c7in t\u0131bb\u0131 ara\u015ft\u0131rmalar\u0131 yoluyla, \u00e7arp\u0131nt\u0131 nas\u0131l daha iyi tedavi edilir ve spesifik molek\u00fcler hedefleri nelerdir? Bu \u00e7al\u0131\u015fma 2015 \u00c7in Farmakopesi (B\u00f6l\u00fcm I) (bundan b\u00f6yle \"\u00c7in Farmakopesi\" olarak an\u0131lacakt\u0131r) ile ba\u015flayacak, \u00e7arp\u0131nt\u0131 tedavisi i\u00e7in \"\u00c7in Farmakopesi \"ndeki geleneksel \u00c7in patentli ila\u00e7lar\u0131n ve basit preparatlar\u0131n form\u00fcl kurallar\u0131n\u0131 kazacak ve y\u00fcksek frekansl\u0131 ila\u00e7lar\u0131 analiz edecektir.<\/p>\n
\u00c7in Farmakopesi, uygulay\u0131c\u0131lar\u0131n ila\u00e7lar\u0131n geli\u015ftirilmesi, \u00fcretimi, i\u015fletilmesi ve y\u00f6netiminde uymas\u0131 gereken yasal bir dayanakt\u0131r ve \u00c7in'de ila\u00e7 kalitesini sa\u011flamaya y\u00f6nelik bir koddur. \u00d6n literat\u00fcr ara\u015ft\u0131rmas\u0131nda, akademisyenlerin farmakopede yer alan geleneksel \u00c7in t\u0131bb\u0131 kaynatma par\u00e7alar\u0131n\u0131n veya toksik bitkilerin s\u0131n\u0131fland\u0131r\u0131lmas\u0131 ve uyumluluk kurallar\u0131 hakk\u0131nda ara\u015ft\u0131rma yapt\u0131klar\u0131; toplanan re\u00e7ete preparatlar\u0131n\u0131n ana hastal\u0131klar\u0131 ve sendromlar\u0131 i\u00e7in geleneksel \u00c7in patentli ila\u00e7lar\u0131n ve basit preparatlar\u0131n re\u00e7ete kural\u0131 \u00fczerinde analiz yapt\u0131klar\u0131; \u00c7in Farmakopesinde yer alan form\u00fcle edilmi\u015f ve tek preparat i\u00e7in sistematik veri madencili\u011fi yap\u0131ld\u0131\u011f\u0131, ancak ilgili bir hastal\u0131\u011f\u0131, \u00f6zellikle kardiyovask\u00fcler hastal\u0131\u011f\u0131 tedavi etmek i\u00e7in kullan\u0131lan geleneksel \u00c7in patentli ila\u00e7lar ve basit preparatlar i\u00e7in veri madencili\u011fi ve analiz kurallar\u0131 bulunmad\u0131\u011f\u0131 tespit edilmi\u015ftir. Bu nedenle, bu \u00e7al\u0131\u015fma, \u00c7in Farmakopesi'nin 2015 bask\u0131s\u0131nda \u00e7arp\u0131nt\u0131 tedavisinde kullan\u0131lan geleneksel \u00c7in patentli ila\u00e7lar\u0131n ve basit preparatlar\u0131n ad\u0131n\u0131, i\u00e7eri\u011fini, dozaj\u0131n\u0131, i\u015flevini ve ana endikasyonlar\u0131n\u0131 ara\u015ft\u0131rma nesnesi olarak alm\u0131\u015f ve V2'yi kullanm\u0131\u015ft\u0131r.\u00c7in Geleneksel \u00c7in T\u0131bb\u0131 Bilimleri Akademisi \u00c7in T\u0131bb\u0131 Enstit\u00fcs\u00fc taraf\u0131ndan ila\u00e7 kullan\u0131m yasas\u0131n\u0131 analiz etmek i\u00e7in geli\u015ftirilen geleneksel \u00c7in t\u0131bb\u0131 kal\u0131t\u0131m yard\u0131mc\u0131 platformunun 5 versiyonu kullan\u0131lm\u0131\u015f ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n kullan\u0131m s\u0131kl\u0131\u011f\u0131 ve geleneksel \u00c7in ila\u00e7lar\u0131 aras\u0131ndaki ili\u015fki kurallar\u0131, ana i\u015flevi olan ili\u015fki kurallar\u0131 Apriori algoritmas\u0131, karma\u015f\u0131k sistem entropi k\u00fcmeleme ve di\u011fer denetimsiz veri madencili\u011fi y\u00f6ntemleri arac\u0131l\u0131\u011f\u0131yla analiz edilmi\u015ftir. Re\u00e7ete kurallar\u0131 ve yeni re\u00e7etelerin tahmini.<\/p>\n
Yukar\u0131daki yaz\u0131l\u0131mdan elde edilen ila\u00e7 kal\u0131plar\u0131 analiz edildikten sonra, \u00e7arp\u0131nt\u0131 tedavisi i\u00e7in y\u00fcksek frekansl\u0131 ila\u00e7lar belirlenmi\u015ftir. Hopkins ve arkada\u015flar\u0131 taraf\u0131ndan geleneksel \u00c7in t\u0131bb\u0131 ve hastal\u0131klar aras\u0131ndaki do\u011frudan ili\u015fkiyi ke\u015ffetmek i\u00e7in \u00f6nerilen bilimsel ara\u015ft\u0131rma y\u00f6ntemi arac\u0131l\u0131\u011f\u0131yla - a\u011f farmakolojisi, sistematik analiz ve madencilik, geleneksel \u00c7in t\u0131bb\u0131n\u0131n mekanizma analizi ve ila\u00e7 geli\u015ftirme i\u00e7in yeni fikirler ve y\u00f6ntemler sa\u011flayabilecek \"geleneksel \u00c7in t\u0131bb\u0131 aktif bile\u015fenleri hastal\u0131k hedefleri hastal\u0131\u011f\u0131\" aras\u0131ndaki ili\u015fkiyi olu\u015fturmak i\u00e7in ger\u00e7ekle\u015ftirilmi\u015ftir. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n \u00e7ok bile\u015fenli ve \u00e7ok hedefli do\u011fas\u0131 nedeniyle, a\u011f farmakolojisi geleneksel \u00c7in t\u0131bb\u0131n\u0131n \u00e7arp\u0131nt\u0131 \u00fczerindeki etki mekanizmas\u0131n\u0131 daha iyi ayd\u0131nlatabilir.<\/p>\n
Bu makale, \u00c7in Farmakopesi'nin veri madencili\u011fi yoluyla, \u00e7arp\u0131nt\u0131 tedavisi i\u00e7in geleneksel \u00c7in patentli ila\u00e7lar\u0131n ve basit preparatlar\u0131n sistematik bir analizini yapm\u0131\u015f ve sonu\u00e7lar\u0131n farmakolojik analizi yoluyla \u00e7arp\u0131nt\u0131 tedavisi i\u00e7in salvia miltiorrhiza'n\u0131n spesifik molek\u00fcler hedef mekanizmas\u0131n\u0131 elde ederek sonraki klinik ila\u00e7 se\u00e7imi ve bilimsel ara\u015ft\u0131rmalar i\u00e7in bir referans sa\u011flam\u0131\u015ft\u0131r. Bununla birlikte, s\u0131n\u0131rl\u0131 alan nedeniyle, klinik uygulamaya daha fazla kan\u0131t sa\u011flamak i\u00e7in ginseng ve Ophiopogon japonicus gibi y\u00fcksek frekansl\u0131 ila\u00e7lar \u00fczerinde daha fazla ara\u015ft\u0131rma yap\u0131labilir.<\/p>","protected":false},"excerpt":{"rendered":"
Analysis of the compatibility and mechanism of action of drugs for treating palpitations in the Chinese Pharmacopoeia based on data mining and network pharmacology Palpitation is a traditional Chinese medicine disease name, which is referred to as “palpitations”, “palpitations below the heart”, “palpitations in the heart”, and “palpitations” in the Treatise on Cold Damage and […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n