{"id":8954,"date":"2024-08-15T10:49:05","date_gmt":"2024-08-15T10:49:05","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8954"},"modified":"2024-08-15T10:49:05","modified_gmt":"2024-08-15T10:49:05","slug":"silk-ear-golden-corn-orchid","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/ipek-kulak-altin-misir-orkidesi\/","title":{"rendered":"\u0130pek Kulak Alt\u0131n M\u0131s\u0131r Orkidesinin Kimyasal Bile\u015fenleri ve N\u00f6roprotektif Aktivitesi \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

\u0130pek Kulak Alt\u0131n M\u0131s\u0131r Orkidesinin Kimyasal Bile\u015fenleri ve N\u00f6roprotektif Aktivitesi \u00dczerine \u00c7al\u0131\u015fma
\nChloranthus ailesinde 13 t\u00fcr ve 5 \u00e7e\u015fit Chloranthus Swartz bitkisi bulunmaktad\u0131r ve bunlar \u00e7o\u011funlukla Yangtze Nehri'nin g\u00fcneyindeki illerde da\u011f\u0131l\u0131m g\u00f6stermektedir. Jin Su Lan cinsi bitkiler, uzun bir halk hekimli\u011fi ge\u00e7mi\u015fine ve bol miktarda yabani t\u0131bbi kayna\u011fa sahip olan Jiangxi Eyaletinde yayg\u0131n olarak kullan\u0131lan \u00c7in bitkisel ila\u00e7lar\u0131d\u0131r. \u015eu anda, Cymbidium cinsi bitkilerden izole edilen bile\u015fikler esas olarak seskiterpenler, seskiterpen dimerler, diterpenler vb. i\u00e7erir. Modern farmakolojik \u00e7al\u0131\u015fmalar, Cymbidium bitkilerinin iyi n\u00f6roprotektif, anti-inflamatuar, anti-t\u00fcm\u00f6r ve di\u011fer aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir. D\u00f6rt Bloklu Kiremit olarak da bilinen Chloranthus fortunei (A. Gray) Solms Laub, Chloranthus cinsinin bir bitkisidir ve r\u00fczgar\u0131, rutubeti giderme, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve kan staz\u0131n\u0131 giderme etkilerine sahiptir.<\/p>\n

\u015eu anda, ipek kulak alt\u0131n m\u0131s\u0131r orkidesinin farmakolojik madde temeli yeterince a\u00e7\u0131k de\u011fildir, bu da Jiangxi'deki karakteristik t\u0131bbi bitki kaynaklar\u0131n\u0131n geli\u015fimini ve kullan\u0131m\u0131n\u0131 ciddi \u015fekilde k\u0131s\u0131tlamaktad\u0131r. Kimyasal temelini daha iyi a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak ve biyolojik aktivitesinin ara\u015ft\u0131rma i\u00e7eri\u011fini geli\u015ftirmek amac\u0131yla, bu deneyde Lonicera japonica'n\u0131n 95% etanol \u00f6z\u00fct\u00fcn\u00fcn kimyasal bile\u015fimini incelemek i\u00e7in \u00e7e\u015fitli kromatografik ay\u0131rma y\u00f6ntemleri ve spektroskopik y\u00f6ntemler kullan\u0131lm\u0131\u015ft\u0131r. Monomer bile\u015fi\u011finin n\u00f6ronal koruyucu etkisi, Lonicera japonica'n\u0131n ila\u00e7 geli\u015fimi i\u00e7in referans sa\u011flamas\u0131 umuduyla H2O2 taraf\u0131ndan hasar g\u00f6ren bir PC12 h\u00fccre modeli kullan\u0131larak de\u011ferlendirilmi\u015ftir.<\/p>\n

Bu \u00e7al\u0131\u015fmada, Cymbidium sibiricum'un t\u00fcm bitkisinin 95% etanol fraksiyonundan 7 seskiterpen (1-6, 8), 1 diterpen (7), 1 monoterpen (9), 4 flavonoid (10-13) ve 1 fenolik asit (14) olmak \u00fczere 14 bile\u015fik izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r. Ayn\u0131 zamanda, baz\u0131 bile\u015fiklerin H2O2 taraf\u0131ndan hasar g\u00f6ren PC12 h\u00fccrelerinin b\u00fcy\u00fcmesi \u00fczerindeki etkileri ara\u015ft\u0131r\u0131lm\u0131\u015f ve seskiterpenler 1-6 orta derecede n\u00f6roprotektif etkiler g\u00f6stermi\u015ftir. Ayn\u0131 cinse ait bitkilerin aktif bile\u015fenleri \u00fczerine yap\u0131lan \u00f6nceki \u00e7al\u0131\u015fmalara dayanarak, seskiterpenlerin ipek kulak alt\u0131n m\u0131s\u0131r orkidesinde n\u00f6roprotektif aktif bile\u015fenler olabilece\u011fi tahmin edilmektedir. \u015eu anda, Cymbidium cinsi bitkilerden izole edilen bile\u015fikler esas olarak seskiterpenler, seskiterpen dimerleri, diterpenler, vb. \u00f6zellikle de bu bitki cinsinin karakteristik bile\u015fenleri olan wuyao tipi seskiterpenler ve dimerlerini i\u00e7ermektedir. Bununla birlikte, ipek kulak Cymbidium'da bu t\u00fcrden nispeten az say\u0131da bile\u015fik bulunmaktad\u0131r.<\/p>\n

Alzheimer hastal\u0131\u011f\u0131 (AH), d\u00fcnya \u00e7ap\u0131nda ya\u015fl\u0131larda \u00f6l\u00fcme neden olan ba\u015fl\u0131ca n\u00f6rolojik hastal\u0131klardan biridir. Klinik uygulamada, AD hastalar\u0131 genellikle kan staz\u0131n\u0131n e\u015flik etti\u011fi beyin fonksiyonlar\u0131nda kademeli bir d\u00fc\u015f\u00fc\u015f ya\u015farlar. Bu nedenle, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131n\u0131n kullan\u0131lmas\u0131 genellikle sonu\u00e7 verir. Kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131ndan yenilik\u00e7i anti AD ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesi geni\u015f beklentilere sahiptir. Jiangxi Eyaletindeki \u00e7e\u015fitli geleneksel \u00c7in t\u0131bb\u0131 preparatlar\u0131 i\u00e7in bir hammadde olan Jin Su Lan cinsinin \u015fifal\u0131 bitkileri, r\u00fczgar ve rutubeti giderme, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve kan staz\u0131n\u0131 da\u011f\u0131tma etkilerine sahiptir. Bu bitkiden izole edilen seskiterpenler iyi n\u00f6roprotektif aktivite sergilemektedir. Gelecekte, Cymbidium cinsindeki seskiterpenlerin n\u00f6roprotektif etkilerini daha fazla ara\u015ft\u0131raca\u011f\u0131z ve yap\u0131sal olarak yeni bile\u015fikler elde etmek amac\u0131yla hedeflenen izolasyon i\u00e7in \u015fu anda izole edilmi\u015f seskiterpenleri kullanaca\u011f\u0131z. Ard\u0131ndan, molek\u00fcler yerle\u015ftirme ve yap\u0131-aktivite ili\u015fkisi analizi rehberli\u011finde, bile\u015fiklerin PC12 h\u00fccreleri \u00fczerindeki koruyucu etkileri taranm\u0131\u015ft\u0131r. ROS i\u00e7eri\u011fi ve p-AMPK, Sirt 1, p-Sirt 1 ve Sirt 3 gibi proteinlerin ekspresyon seviyeleri tespit edilerek, Cymbidium cinsindeki bitkilerin AD tedavisindeki etki mekanizmas\u0131 oksidatif stres hasar\u0131n\u0131 hafifletme perspektifinden ara\u015ft\u0131r\u0131lm\u0131\u015f ve bu cinsteki n\u00f6roprotektif aktif maddelerin temeli ayd\u0131nlat\u0131lm\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

\u0130pek Kulak Alt\u0131n M\u0131s\u0131r Orkidesinin Kimyasal Bile\u015fenleri ve N\u00f6roprotektif Aktivitesi \u00dczerine \u00c7al\u0131\u015fma Chloranthus ailesinde, \u00e7o\u011funlukla Yangtze Nehri'nin g\u00fcneyindeki illerde da\u011f\u0131lm\u0131\u015f 13 t\u00fcr ve 5 \u00e7e\u015fit Chloranthus Swartz bitkisi vard\u0131r. Jin Su Lan cinsinin bitkileri, Jiangxi Eyaletinde yayg\u0131n olarak kullan\u0131lan \u00c7in bitkisel ila\u00e7lar\u0131d\u0131r ve [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on Chemical Components and Neuroprotective Activity of Silk Ear Golden Corn Orchid - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/ipek-kulak-altin-misir-orkidesi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on Chemical Components and Neuroprotective Activity of Silk Ear Golden Corn Orchid - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on Chemical Components and Neuroprotective Activity of Silk Ear Golden Corn Orchid There are 13 species and 5 varieties of Chloranthus Swartz plants in the Chloranthus family, mainly distributed in provinces south of the Yangtze River. 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