{"id":8931,"date":"2024-08-15T10:39:02","date_gmt":"2024-08-15T10:39:02","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8931"},"modified":"2024-08-15T10:39:02","modified_gmt":"2024-08-15T10:39:02","slug":"vashancone","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/vashancone\/","title":{"rendered":"Vashancone'un Kimyasal Bile\u015fimi ve Tirozinaz \u0130nhibisyon Aktivitesi \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

Vashancone'un Kimyasal Bile\u015fimi ve Tirozinaz \u0130nhibisyon Aktivitesi \u00dczerine \u00c7al\u0131\u015fma
\nCastanopsis fargesii ve Castanopsis Huangshan Da\u011f\u0131 olarak da bilinen Castanopsis ceratacantha, \u00e7o\u011funlukla Yunnan, Guizhou ve g\u00fcneybat\u0131 Sichuan'da da\u011f\u0131t\u0131l\u0131r. Halk t\u0131bb\u0131nda kanama, susuzluk, ishal (f\u0131nd\u0131k), kronik \u00fclser ve di\u011fer hastal\u0131klar\u0131 durdurmak i\u00e7in yayg\u0131n olarak kullan\u0131l\u0131r. \u015eu anda, Aconitum carmichaelii'nin kimyasal bile\u015fimi ve biyolojik aktivite ara\u015ft\u0131rmas\u0131 hakk\u0131nda yurti\u00e7i ve yurtd\u0131\u015f\u0131nda ilgili literat\u00fcr bulunmamaktad\u0131r. Ara\u015ft\u0131rma grubumuz Aconitum carmichaelii yapraklar\u0131n\u0131n etanol ekstresi \u00fczerinde bir \u00f6n kimyasal bile\u015fim \u00e7al\u0131\u015fmas\u0131 y\u00fcr\u00fctm\u00fc\u015f ve yapraklar\u0131n yeni triterpenoid tannik bile\u015fikler i\u00e7erdi\u011fini tespit etmi\u015ftir. Bu bile\u015fikler, pentasiklik triterpenoidlerin ve benzersiz polifenollerin esterle\u015fme reaksiyonu ile \u00fcretilen ve \u015fimdiye kadar ke\u015ffedilen birka\u00e7 bile\u015fikten biridir. \u015eu anda sadece Aconitum bitkilerinden izole edilmi\u015flerdir. \u0130yi antioksidan, antikanser ve lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc aktivitelere sahiptir. Aconitum carmichaelii'nin maddi temelini ayd\u0131nlatmak ve yeni triterpenoid tannik bile\u015fikler ke\u015ffetmek i\u00e7in bu deneyde Aconitum carmichaelii'nin 80% etanol ekstresi sistematik olarak izole edilmi\u015f ve safla\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Tirozinaz (polifenol oksidaz olarak da bilinir) v\u00fccuttaki pigmentlerin senteziyle ilgilidir ve melanin sentezini do\u011frudan etkiler. Melanin sentezi i\u00e7in h\u0131z s\u0131n\u0131rlay\u0131c\u0131 enzimdir ve v\u00fccutta \u00f6zellikle cilt beyazlatma, antioksidan etkiler vb. gibi \u00e7e\u015fitli \u00f6nemli fizyolojik i\u015flevlere sahiptir. Ayr\u0131ca pigment bozukluklar\u0131 ve malign melanomun olu\u015fumu ve tedavisi ile de ilgilidir. Melanin olu\u015fumu s\u00fcrecinde tirozinaz\u0131n ana etki alan\u0131 hidroksildir ve Aconitum carmichaelii'nin etanol \u00f6z\u00fct\u00fc esas olarak tanenler i\u00e7erir, bunlar aras\u0131nda \u00e7oklu benzersiz polifenolik yap\u0131lar i\u00e7eren bile\u015fikler iyi antioksidan ve antikanser aktivitelere sahip olan ana bile\u015fiklerdir. Tirozinaz inhibit\u00f6r aktiviteye sahip olup olmad\u0131klar\u0131 hen\u00fcz rapor edilmemi\u015ftir. Bu deneyde, daha iyi aktiviteye sahip do\u011fal bile\u015fikler bulmak amac\u0131yla izole edilen \u00e7ok say\u0131da karakteristik tanen bile\u015fi\u011finin tirozinaz inhibit\u00f6r aktivitesi taranm\u0131\u015ft\u0131r.<\/p>\n

Aconitum carmichaelii yapraklar\u0131n\u0131n 80% etanol ekstresinden, \u00e7o\u011funlukla \u00e7oklu benzersiz polifenolik yap\u0131lar i\u00e7eren tanenler olmak \u00fczere on yedi bile\u015fik izole edilmi\u015ftir. Mevcut literat\u00fcre g\u00f6re, bunlar \u00e7o\u011funlukla Aconitum bitkilerinde bulunur. \u00c7o\u011fu koni bitkisinde triterpenoid tannik bile\u015fiklerin varl\u0131\u011f\u0131, habitatlar\u0131 ve ikincil metabolik yollar\u0131yla ili\u015fkili olabilir. Huashan kozala\u011f\u0131 yapraklar\u0131n\u0131n 80% etanol ekstrakt\u0131n\u0131n s\u0131v\u0131 kromatografi tespiti, yeni triterpenoid tannik bile\u015fiklerin varl\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir, ancak bunlar sistematik ay\u0131rma ve safla\u015ft\u0131rma i\u015flemi s\u0131ras\u0131nda elde edilmemi\u015ftir. Bu bile\u015fiklerin ay\u0131rma i\u015flemi s\u0131ras\u0131nda etkili bir \u015fekilde zenginle\u015ftirilmemi\u015f olmas\u0131 m\u00fcmk\u00fcnd\u00fcr ve ay\u0131rma ve safla\u015ft\u0131rma ara\u00e7lar\u0131n\u0131n daha da iyile\u015ftirilmesi gerekmektedir. \u015eu anda, yeni triterpenoid tannik bile\u015fiklerin biyolojik aktivitesi hakk\u0131nda \u00e7ok az rapor bulunmaktad\u0131r ve sadece anti-kanser, antioksidan ve lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc y\u00f6nlerde \u00f6n \u00e7al\u0131\u015fmalar yap\u0131lm\u0131\u015ft\u0131r. Bu makalede Aconitum carmichaelii yapraklar\u0131n\u0131n 80% etanol ekstrakt\u0131ndan yeni triterpenoid tannik bile\u015fikler izole edilmemi\u015f, ancak benzersiz polifenolik yap\u0131lar i\u00e7eren \u00e7ok say\u0131da bile\u015fik elde edilmi\u015ftir. Yap\u0131-aktivite ili\u015fkisine dayanarak, birden fazla benzersiz polifenolik yap\u0131 i\u00e7eren 9 karakteristik bile\u015fik, tirozinaz inhibit\u00f6r aktiviteleri a\u00e7\u0131s\u0131ndan taranm\u0131\u015ft\u0131r. Sonu\u00e7lar, bile\u015fik 14'\u00fcn pozitif ila\u00e7tan daha g\u00fc\u00e7l\u00fc enzim inhibit\u00f6r aktivitesine sahip oldu\u011funu g\u00f6sterdi; bu da bile\u015fikte daha fazla fenolik hidroksil grubunun varl\u0131\u011f\u0131yla ilgili olabilir. Tanen bile\u015fikleri zengin biyolojik aktiviteye sahiptir ve bu \u00f6zel tanen bile\u015fi\u011finin biyolojik aktivitesi ve etki mekanizmas\u0131 daha fazla ke\u015fif ve ara\u015ft\u0131rmaya ihtiya\u00e7 duymaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone Castanopsis ceratacantha, also known as Castanopsis fargesii and Castanopsis Mount Huangshan, is mainly distributed in Yunnan, Guizhou and southwest Sichuan. It is widely used in folk medicine to stop bleeding, thirst, diarrhea (nuts), chronic ulcers and other diseases. At present, there is no relevant […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/vashancone\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone Castanopsis ceratacantha, also known as Castanopsis fargesii and Castanopsis Mount Huangshan, is mainly distributed in Yunnan, Guizhou and southwest Sichuan. It is widely used in folk medicine to stop bleeding, thirst, diarrhea (nuts), chronic ulcers and other diseases. At present, there is no relevant […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/vashancone\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-15T10:39:02+00:00\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/vashancone\/\",\"url\":\"https:\/\/longchangextracts.com\/vashancone\/\",\"name\":\"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"datePublished\":\"2024-08-15T10:39:02+00:00\",\"dateModified\":\"2024-08-15T10:39:02+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/vashancone\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/vashancone\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/vashancone\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Vashancone'un Kimyasal Bile\u015fimi ve Tirozinaz \u0130nhibisyon Aktivitesi \u00dczerine \u00c7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/vashancone\/","og_locale":"tr_TR","og_type":"article","og_title":"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone - China Chemical Manufacturer","og_description":"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone Castanopsis ceratacantha, also known as Castanopsis fargesii and Castanopsis Mount Huangshan, is mainly distributed in Yunnan, Guizhou and southwest Sichuan. It is widely used in folk medicine to stop bleeding, thirst, diarrhea (nuts), chronic ulcers and other diseases. At present, there is no relevant […]","og_url":"https:\/\/longchangextracts.com\/tr\/vashancone\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-15T10:39:02+00:00","author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"3 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/vashancone\/","url":"https:\/\/longchangextracts.com\/vashancone\/","name":"Vashancone'un Kimyasal Bile\u015fimi ve Tirozinaz \u0130nhibisyon Aktivitesi \u00dczerine \u00c7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"datePublished":"2024-08-15T10:39:02+00:00","dateModified":"2024-08-15T10:39:02+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/vashancone\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/vashancone\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/vashancone\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the Chemical Composition and Tyrosinase Inhibition Activity of Vashancone"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/8931"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=8931"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/8931\/revisions"}],"predecessor-version":[{"id":8932,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/8931\/revisions\/8932"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=8931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=8931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=8931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}