{"id":8918,"date":"2024-08-15T10:33:03","date_gmt":"2024-08-15T10:33:03","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8918"},"modified":"2024-08-15T10:33:03","modified_gmt":"2024-08-15T10:33:03","slug":"the-stem-of-niujiaogua","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/niujiaoguanin-govdesi\/","title":{"rendered":"Niujiaogua K\u00f6k\u00fcn\u00fcn Kimyasal Bile\u015fimi ve Sitotoksik Aktivitesi \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

Niujiaogua K\u00f6k\u00fcn\u00fcn Kimyasal Bile\u015fimi ve Sitotoksik Aktivitesi \u00dczerine \u00c7al\u0131\u015fma
\nK\u0131r\u0131k Ba\u011f\u0131rsak Otu veya Be\u015f K\u00f6pek Yatan \u00c7i\u00e7ek Kalbi olarak da bilinen Calotropis gigantea (L.) Dry. ex Ait f. Asclepiadaceae familyas\u0131ndaki Calotropis cinsinden bir bitkidir. Esas olarak \u00c7in, Hindistan, Vietnam, Sri Lanka ve Myanmar'\u0131n yan\u0131 s\u0131ra \u00c7in'in Yunnan, Hainan, Guangdong ve Sichuan eyaletlerinde da\u011f\u0131l\u0131m g\u00f6sterir. D\u00fc\u015f\u00fck rak\u0131ml\u0131 g\u00fcne\u015fli yama\u00e7larda, a\u00e7\u0131k alanlarda ve sahillerde yeti\u015fir. Niujiaogua balgam s\u00f6kt\u00fcr\u00fcc\u00fc, ast\u0131m\u0131 hafifletici, antibakteriyel, antioksidan, antienflamatuar ve detoksifiye edici etkilere sahiptir. Bo\u011fa boynuzu kavun \u00e7i\u00e7eklerinin analjezik etkileri vard\u0131r; Sap\u0131n hepatoprotektif etkisi vard\u0131r; Yapraklar\u0131n ishal \u00f6nleyici etkileri vard\u0131r; S\u00fct\u00fcn yara iyile\u015fmesini te\u015fvik edici etkileri ve antibakteriyel \u00f6zellikleri vard\u0131r. Modern ara\u015ft\u0131rmalar, kruvasanlar\u0131n kardiyak glikozitler, steroidler, triterpenoidler ve flavonoidler dahil olmak \u00fczere \u00e7e\u015fitli kimyasal bile\u015fenler i\u00e7erdi\u011fini g\u00f6stermi\u015ftir. \u00d6nemli anti-t\u00fcm\u00f6r aktivitesi nedeniyle, bir\u00e7ok bilim insan\u0131 b\u00f6r\u00fclcenin kimyasal bile\u015fenlerini izole etmi\u015f, safla\u015ft\u0131rm\u0131\u015f ve yap\u0131sal olarak tan\u0131mlam\u0131\u015ft\u0131r. Niujiaogua bitkisinin kimyasal temelini daha iyi incelemek ve biyolojik aktivitesini daha da geli\u015ftirmek amac\u0131yla, bu \u00e7al\u0131\u015fmada Niujiaogua sap\u0131n\u0131n kimyasal bile\u015fimi ve sitotoksik aktivitesi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Niujiaogua sap\u0131n\u0131n etanol ekstrakt\u0131n\u0131n etil asetat fraksiyonunu ay\u0131rmak i\u00e7in silika jel ve Sephadex LH-20 gibi \u00e7e\u015fitli kromatografik ay\u0131rma teknikleri kullan\u0131lm\u0131\u015f ve bile\u015fi\u011fin d\u00f6rt tip t\u00fcm\u00f6r h\u00fccresine kar\u015f\u0131 in vitro sitotoksik aktivitesi MTT testi ile belirlenmi\u015ftir.<\/p>\n

Boynuzlu kaba\u011f\u0131n g\u00f6vdesinden on bile\u015fik izole edilmi\u015f olup, 1, 3, 4 ve 6-8 numaral\u0131 bile\u015fikler bu bitkiden izole edilen ilk bile\u015fiklerdir. Bunlar aras\u0131nda 1-4 numaral\u0131 bile\u015fikler lignanlar ve 8-10 numaral\u0131 bile\u015fikler fenolik bile\u015fiklerdir. Bile\u015fik 1-10'un d\u00f6rt tip t\u00fcm\u00f6re kar\u015f\u0131 sitotoksik aktivitesi test edilmi\u015f ve sonu\u00e7lar bile\u015fik 4 ve 5'in d\u00f6rt tip t\u00fcm\u00f6r h\u00fccresine kar\u015f\u0131 s\u0131ras\u0131yla 12.37 ila 49.29 ve 0.29 ila 0.98 \u03bc M aras\u0131nda de\u011fi\u015fen IC50 de\u011ferleri ile de\u011fi\u015fen derecelerde sitotoksik aktiviteye sahip oldu\u011funu g\u00f6stermi\u015ftir. Di\u011fer bile\u015fikler \u00f6nemli bir aktivite g\u00f6stermemi\u015ftir. Literat\u00fcr raporlar\u0131na g\u00f6re, bile\u015fik 4 insan yumurtal\u0131k kanseri h\u00fccre hatt\u0131 SK-OV-3'e kar\u015f\u0131 zay\u0131f sitotoksik aktiviteye sahiptir. Bile\u015fik 5, Fruktozid, boynuzlu kabaktaki ana kardiyak glikozit bile\u015fenidir, ekstrakt i\u00e7eri\u011finin 2.8%'sinden fazlas\u0131n\u0131 olu\u015fturur ve \u00e7e\u015fitli t\u00fcm\u00f6r h\u00fccrelerine kar\u015f\u0131 g\u00fc\u00e7l\u00fc sitotoksik aktiviteye sahiptir. Son \u00e7al\u0131\u015fmalar Fruktozid'in melanom h\u00fccrelerinde mitokondriyal arac\u0131l\u0131 apoptozu ind\u00fckleyebildi\u011fini ve bunun da melanomu \u00f6nlemeye yard\u0131mc\u0131 olabilece\u011fini g\u00f6stermi\u015ftir. Bu, bile\u015fi\u011fin hen\u00fcz geli\u015ftirilmemi\u015f ve daha fazla ara\u015ft\u0131rma i\u00e7in de\u011feri olan bir\u00e7ok potansiyel aktiviteye sahip olabilece\u011fini g\u00f6stermektedir.<\/p>","protected":false},"excerpt":{"rendered":"

Niujiaogua Calotropis gigantea (L.) Dry. ex Ait f. K\u00f6k\u00fcn\u00fcn Kimyasal Bile\u015fimi ve Sitotoksik Aktivitesi \u00dczerine \u00c7al\u0131\u015fma K\u0131r\u0131k Ba\u011f\u0131rsak Otu veya Be\u015f K\u00f6pek Yatan \u00c7i\u00e7ek Kalbi olarak da bilinen, Asclepiadaceae familyas\u0131ndaki Calotropis cinsinden bir bitkidir. Esas olarak \u00c7in, Hindistan, [...] b\u00f6lgelerinde da\u011f\u0131l\u0131m g\u00f6sterir.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/niujiaoguanin-govdesi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Chemical Composition and Cytotoxic Activity of the Stem of Niujiaogua Calotropis gigantea (L.) 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Dry. ex Ait f. Also known as the Broken Intestine Grass or the Five Dog Lying Flower Heart, it is a plant of the Calotropis genus in the Asclepiadaceae family. 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