{"id":8807,"date":"2024-08-14T20:14:03","date_gmt":"2024-08-14T20:14:03","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8807"},"modified":"2024-08-14T20:14:03","modified_gmt":"2024-08-14T20:14:03","slug":"endophytic-fungus-phomopsis-prunorum-in-camellia-sinensis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/camellia-sinensiste-endofi\u0307ti\u0307k-fungus-phomopsis-prunorum\/","title":{"rendered":"Camellia sinensis'te endofitik fungus Phomopsis prunorum'un sekonder metabolitleri ve \u03b1-glukozidaz inhibit\u00f6r aktivitesi \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Camellia sinensis'te endofitik fungus Phomopsis prunorum'un sekonder metabolitleri ve \u03b1-glukozidaz inhibit\u00f6r aktivitesi \u00fczerine \u00e7al\u0131\u015fma
\nPhomopsis mantarlar\u0131, \u00e7e\u015fitli \u00fcr\u00fcnlerde ciddi hastal\u0131klara neden olabilen yayg\u0131n bir bitki patojeni t\u00fcr\u00fcd\u00fcr; Bu arada, bu cins i\u00e7indeki baz\u0131 t\u00fcrler de do\u011fadaki \u00e7o\u011fu bitkide yayg\u0131n olarak bulunan \u00f6nemli endofitik mantarlard\u0131r. Bitkilerde endofitik mantarlar olarak Phomopsis mantarlar\u0131, \u03b1-piranon, terpenler, alkaloidler ve h\u00fccre gev\u015feticiler de dahil olmak \u00fczere \u00e7ok \u00e7e\u015fitli aktif ikincil metabolitler \u00fcretebilir. Bu bile\u015fikler sadece antifungal, anti-t\u00fcm\u00f6r, n\u00f6roprotektif ve \u03b1-glukozidaz inhibisyonu gibi farmakolojik aktiviteler sergilemekle kalmaz, ayn\u0131 zamanda h\u00fccre b\u00fcy\u00fcme d\u00fczenleyicileri olarak da kullan\u0131labilir. T\u0131p ve tar\u0131m alanlar\u0131nda geni\u015f uygulama olanaklar\u0131na sahiptirler.
\nHypericum ascyron L., Primulaceae familyas\u0131ndan Hypericum cinsine ait bir bitkidir. \u015eifal\u0131 bir bitki olarak kullan\u0131l\u0131r ve kanamay\u0131 durdurma, a\u011fr\u0131y\u0131 hafifletme, antibakteriyel ve anti-inflamatuar \u00f6zelliklere sahiptir. Camellia sinensis'in kimyasal bile\u015fimi hakk\u0131nda, \u00e7o\u011funlukla flavonoidler, terpenler ve polisiklik poliizopren s\u00fcbstit\u00fce trifenilfenolleri i\u00e7eren raporlar bulunmaktad\u0131r. Bununla birlikte, Camellia sinensis'teki endofitik mantarlar\u0131n ikincil metabolitleri hakk\u0131nda \u00e7ok az rapor bulunmaktad\u0131r. Ara\u015ft\u0131rma grubumuz, Shennongjia b\u00f6lgesindeki Camellia sinensis bitkilerinin yapraklar\u0131ndan erken evrede bir endofitik mantar Phomopsis prunorum (F4-3) elde etmi\u015ftir. K\u00fc\u00e7\u00fck \u00f6l\u00e7ekli fermantasyon ve yeti\u015ftirmeden sonra, pirin\u00e7 fermantasyon \u00fcr\u00fcnlerinin zengin \u00e7e\u015fitlilikte yap\u0131sal tiplere sahip oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Bu mantar \u00fczerinde yap\u0131lan \u00f6nceki ara\u015ft\u0131rmalar P Prunorum'da (F4-3) yeni m\u00fcr seskiterpenler ve izokumarinler ke\u015ffedilmi\u015f ve tar\u0131msal patojenik bakterilere kar\u015f\u0131 iyi aktivite g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fma, P Prunorum (F4-3) mantar\u0131n\u0131n pirin\u00e7 fermantasyon \u00fcr\u00fcnleri \u00fczerinde ara\u015ft\u0131rma yap\u0131lm\u0131\u015f ve izole edilen ikincil metabolitlerin biyolojik aktivitesi, yeni yap\u0131sal tiplere ve \u00f6nemli farmakolojik aktivitelere sahip bile\u015fiklerin ke\u015ffedilmesi amac\u0131yla de\u011ferlendirilmi\u015ftir.<\/p>\n

Bu \u00e7al\u0131\u015fmada, P Prunorum'dan (F4-3) iki yeni \u03b1-piranon bile\u015fi\u011fi ve bilinen iki dibenzo \u03b1-piranon bile\u015fi\u011fi, bir izokumarin bile\u015fi\u011fi ve bir alkaloid bile\u015fi\u011fi dahil olmak \u00fczere alt\u0131 ikincil metabolit izole edilmi\u015ftir. \u03b1-piranon bile\u015fikleri 1 ve 2'nin yan zincir yap\u0131lar\u0131n\u0131n her ikisi de biti\u015fik dihidroksi par\u00e7alar\u0131 i\u00e7erir ve bile\u015fikler 4-6 ilk kez bu mantar cinsinden izole edilmi\u015ftir. Farmakolojik aktivite de\u011ferlendirmesi, sadece bile\u015fik 3'\u00fcn orta derecede alfa glukozidaz inhibit\u00f6r aktivitesine sahip oldu\u011funu, bile\u015fik 1-6'n\u0131n ise \u00f6nemli bir antibakteriyel aktivite g\u00f6stermedi\u011fini g\u00f6stermi\u015ftir. Literat\u00fcr raporlar\u0131na g\u00f6re, bile\u015fik 3 ayr\u0131ca belirli sitotoksik aktivite ve DPPH radikal s\u00fcp\u00fcrme aktivitesi (IC50 46.5 \u03bc M) sergilemekte ve \u00e7e\u015fitli bitki patojenlerine kar\u015f\u0131 zay\u0131f antibakteriyel aktiviteye sahiptir. Bu \u00e7al\u0131\u015fmada Camellia sinensis'inkilere benzer kimyasal bile\u015fim yap\u0131lar\u0131na sahip bile\u015fikler izole edilmemi\u015ftir. Bunun nedeni, ikincil metabolit sentez yollar\u0131yla ilgili bir\u00e7ok gen k\u00fcmesinin normal laboratuvar k\u00fclt\u00fcr\u00fc ko\u015fullar\u0131 alt\u0131nda susturulmu\u015f olmas\u0131 olabilir. Gelecekte, ikincil metabolit yap\u0131lar\u0131n\u0131n \u00e7e\u015fitlili\u011fini art\u0131rmak ve yeni ve aktif bile\u015fiklerin ke\u015ffedilme olas\u0131l\u0131\u011f\u0131n\u0131 geli\u015ftirmek i\u00e7in k\u00fclt\u00fcr ortam\u0131n\u0131n t\u00fcr\u00fcn\u00fc de\u011fi\u015ftirerek veya k\u00fclt\u00fcr ortam\u0131na kimyasal epigenetik de\u011fi\u015ftiriciler ekleyerek bakteri su\u015flar\u0131nda susturulmu\u015f genlerin ifadesini ind\u00fcklemeye \u00e7al\u0131\u015f\u0131lacakt\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Study on secondary metabolites and \u03b1 – glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis Phomopsis fungi are a common type of plant pathogen that can cause serious diseases in various crops; Meanwhile, some species within this genus are also important endophytic fungi, widely present in most plants in nature. Phomopsis fungi, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on secondary metabolites and \u03b1 - glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/camellia-sinensiste-endofi\u0307ti\u0307k-fungus-phomopsis-prunorum\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on secondary metabolites and \u03b1 - glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on secondary metabolites and \u03b1 – glucosidase inhibitory activity of endophytic fungus Phomopsis prunorum in Camellia sinensis Phomopsis fungi are a common type of plant pathogen that can cause serious diseases in various crops; Meanwhile, some species within this genus are also important endophytic fungi, widely present in most plants in nature. 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