{"id":8803,"date":"2024-08-14T20:12:26","date_gmt":"2024-08-14T20:12:26","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8803"},"modified":"2024-08-14T20:12:26","modified_gmt":"2024-08-14T20:12:26","slug":"the-intestinal-fungus-alternaria-tenuissima","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/bagirsak-mantari-alternaria-tenuissima\/","title":{"rendered":"Tilapia'n\u0131n ba\u011f\u0131rsak mantar\u0131 Alternaria tenuissima SCSIO41701'deki antibakteriyel bile\u015fikler"},"content":{"rendered":"<p>Tilapia'n\u0131n ba\u011f\u0131rsak mantar\u0131 Alternaria tenuissima SCSIO41701'deki antibakteriyel bile\u015fikler<br \/>\nStreptococcus agalatae ve Streptococcus iniae'nin neden oldu\u011fu tilapia streptokok hastal\u0131\u011f\u0131, tilapia yeti\u015ftiricili\u011fi end\u00fcstrisinde ciddi ekonomik kay\u0131plara neden olmu\u015ftur. \u015eu anda tilapia yeti\u015ftiricili\u011finde streptokok hastal\u0131\u011f\u0131n\u0131 \u00f6nlemek ve tedavi etmek i\u00e7in \u00e7o\u011funlukla antibiyotikler ve di\u011fer kimyasal ila\u00e7lar kullan\u0131lmaktad\u0131r, ancak geni\u015f spektrumlu antibiyotiklerin uzun s\u00fcreli kullan\u0131m\u0131 ilaca diren\u00e7li su\u015flar\u0131 ind\u00fckleyebilir.<br \/>\nAlternaria mantarlar\u0131, 300'den fazla tan\u0131mlanm\u0131\u015f saprofitik, endofitik ve patojenik mantar t\u00fcr\u00fc ile do\u011fada yayg\u0131n olarak bulunur. Alternaria cinsi mantarlarda, \u00f6zellikle piranon, terpenler, steroller, aromatik poliketonlar, antrakinonlar, alkaloidler, peptitler vb. dahil olmak \u00fczere yap\u0131sal olarak yeni bir\u00e7ok aktif bile\u015fik ke\u015ffedilmi\u015ftir. Baz\u0131 bile\u015fikler enzim inhibisyonu, sitotoksisite, antifungal, antioksidan ve monokotiledon ve dikotiledon bitkilerde k\u00f6k b\u00fcy\u00fcmesinin te\u015fvik edilmesi gibi biyolojik aktivitelere sahiptir. Bunlar aras\u0131nda Alternariol, Alternariol metil eter ve tentoksin gibi Alternarian toksinleri \u00f6nemli toksisiteye sahiptir. Alternaria tenuissima, A ile ili\u015fkili yayg\u0131n bir \u00e7evresel mantard\u0131r. Tenuissima'n\u0131n ikincil metabolitleri hakk\u0131nda nispeten az ara\u015ft\u0131rma vard\u0131r. \u00c7al\u0131\u015fmam\u0131zda, Pan ve arkada\u015flar\u0131 derin deniz sediment kaynaklar\u0131ndan A. tenuissima DEFSCOS013'ten yeni spirosiklik hidrojenlenmi\u015f antrakinon ve azot i\u00e7eren antrakinon bile\u015fikleri izole edilmi\u015ftir.<br \/>\nYeni antibiyotikler aramak amac\u0131yla, tilapia ba\u011f\u0131rsak kanal\u0131ndan izole edilen ve tan\u0131mlanan bir grup mantar\u0131 antibakteriyel aktivite a\u00e7\u0131s\u0131ndan taramak i\u00e7in Streptococcus agalactiae ve Streptococcus iniae'yi indikat\u00f6r bakteriler olarak kulland\u0131k. Bunlar aras\u0131nda, Streptococcus agalactiae ve Streptococcus iniae'nin b\u00fcy\u00fcmesi \u00fczerinde \u00f6nemli inhibit\u00f6r aktiviteye sahip olan bir A. tenuissima SCSIO41701 su\u015fu tarand\u0131. Bu \u00e7al\u0131\u015fmada, tilapyada Streptococcus agalactiae ve Streptococcus iniae'nin b\u00fcy\u00fcmesini engelleyen A. tenuissima SCSIO41701 pirin\u00e7 besiyerinin fermantasyon \u00fcr\u00fcnlerindeki aktif bile\u015fikleri ara\u015ft\u0131rmak i\u00e7in aktivite izleme y\u00f6ntemi kullan\u0131lm\u0131\u015ft\u0131r.<\/p>\n<p>Bu \u00e7al\u0131\u015fmada, antibakteriyel aktivite takibi yoluyla, tilapia'da Streptococcus agalactiae ve Streptococcus iniae'nin b\u00fcy\u00fcmesini engelleyen A. tenuissima SCSIO41701 mantar\u0131ndaki ana aktif bile\u015fi\u011fin y\u00fcksek i\u00e7erikli aternariol (1) oldu\u011funu belirledik. HPLC analizi ve ince tabaka plaka analizi yoluyla, Fr.6~Fr.10 bile\u015fenlerinin, bile\u015fik 1 ana pik olmak \u00fczere, b\u00fcy\u00fck miktarda bile\u015fik 1 ve 2 i\u00e7erdi\u011fini bulduk. Daha iyi antibakteriyel aktiviteye sahip Fr.6~Fr.10 bile\u015fenlerinin esas olarak bile\u015fik 1 arac\u0131l\u0131\u011f\u0131yla antibakteriyel etki g\u00f6sterdi\u011fi tahmin edilmektedir. Bu bile\u015fenlerdeki bile\u015fik 1 ve 2'nin \u00e7apraz da\u011f\u0131l\u0131m\u0131n\u0131n nedeni, ham ekstrakt normal faz silika jel kolon ile ayr\u0131ld\u0131\u011f\u0131nda y\u0131kama i\u00e7in kullan\u0131lan diklorometan metanol \u00e7\u00f6z\u00fcc\u00fc sisteminde az \u00e7\u00f6z\u00fcn\u00fcr olan bile\u015fik 1 ve 2'nin y\u00fcksek i\u00e7eri\u011finden kaynaklanmaktad\u0131r. Bile\u015fik 1-6'n\u0131n t\u00fcm\u00fc benzopiranolid bile\u015fikleri s\u0131n\u0131f\u0131na aittir. Yap\u0131lar\u0131 ve tilapiye kar\u015f\u0131 anti streptokokal aktiviteleri kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, C-5 benzen halkas\u0131 \u00fczerindeki hidroksil grubu ile C7~C10a aras\u0131nda konjuge bir sistemin varl\u0131\u011f\u0131n\u0131n antibakteriyel aktivitelerinde \u00f6nemli bir rol oynad\u0131\u011f\u0131 tahmin edilmektedir.<br \/>\nBile\u015fik 1 ve 2, tah\u0131llar, meyveler, kolza tohumu, ay\u00e7i\u00e7e\u011fi tohumu, zeytin vb. g\u0131dalarda tespit edilebilen yayg\u0131n streptomisin toksinleridir. Bile\u015fik 1 ve 2'nin her ikisi de sitotoksik aktiviteye sahiptir ve genetik mutasyonlar\u0131 ind\u00fckleyebilir, in vitro DNA ipliklerinin genotoksik k\u0131r\u0131lmalar\u0131na yol a\u00e7abilir ve topoizomeraz I ve II \u03b1'y\u0131 inhibe edebilir. Ek olarak, bile\u015fik 2 insan kolon kanseri h\u00fccrelerinde mitokondriyal mutasyonlar\u0131 ind\u00fckleyebilir. Buna ek olarak, bile\u015fik 1, Staphylococcus aureus, Streptococcus lactiae, Escherichia coli ve Pseudomonas aeruginosa'y\u0131 inhibe etmede iyi bir aktiviteye sahiptir ve MIC de\u011ferleri 8,82 \u03bc g\/mL'dir. Ayr\u0131ca elma \u00e7\u00fcr\u00fckl\u00fc\u011f\u00fc, karpuz solgunlu\u011fu, domates gri k\u00fcf\u00fc ve biber fitoftoras\u0131 gibi bitki patojeni mantarlar\u0131n aktivitesini de 15.63, 7.82, 1.96 ve 3 MIC de\u011ferleriyle g\u00fc\u00e7l\u00fc bir \u015fekilde inhibe eder.91 \u03bc g\/mL; Bile\u015fik 2 ayr\u0131ca Bacillus subtilis, Pseudomonas aeruginosa, Ralstonia lactis, Pseudomonas aeruginosa ve Pseudomonas aeruginosa \u00fczerinde s\u0131ras\u0131yla 28.83, 34.29, 27.08, 29.21 ve 30.06 \u03bc g\/mL MIC50 de\u011ferleri ile antibakteriyel etkilere sahiptir. Bu \u00e7al\u0131\u015fmada, bile\u015fik 1'in tilapia patojenik bakterileri Streptococcus agalactiae ve Streptococcus dolphin'i \u00f6ld\u00fcrmede g\u00fc\u00e7l\u00fc bir aktiviteye sahip oldu\u011funu ve A. tenuissima SCSIO41701 su\u015funda y\u00fcksek bir verime sahip oldu\u011funu ilk kez bulduk. Bununla birlikte, bu bile\u015fi\u011fin bir mantar toksini olarak g\u00fc\u00e7l\u00fc toksisitesi g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, tilapia streptokok hastal\u0131\u011f\u0131n\u0131n \u00f6nlenmesi ve tedavisi i\u00e7in geli\u015ftirilip geli\u015ftirilemeyece\u011fini belirlemek i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Tilapia'n\u0131n ba\u011f\u0131rsak mantar\u0131 Alternaria tenuissima SCSIO41701'deki antibakteriyel bile\u015fikler Streptococcus agalatae ve Streptococcus iniae'nin neden oldu\u011fu tilapia streptokok hastal\u0131\u011f\u0131, tilapia yeti\u015ftiricili\u011fi end\u00fcstrisinde ciddi ekonomik kay\u0131plara neden olmu\u015ftur. \u015eu anda, tilapia yeti\u015ftiricili\u011fi streptokok hastal\u0131\u011f\u0131n\u0131 \u00f6nlemek ve tedavi etmek i\u00e7in \u00e7o\u011funlukla antibiyotik ve di\u011fer kimyasal ila\u00e7lar\u0131 kullanmaktad\u0131r, ancak geni\u015f spektrumlu antibiyotiklerin uzun s\u00fcreli kullan\u0131m\u0131 [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/bagirsak-mantari-alternaria-tenuissima\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia The tilapia streptococcal disease caused by Streptococcus agalatae and Streptococcus iniae has caused serious economic losses to the tilapia farming industry. At present, tilapia farming mainly uses antibiotics and other chemical drugs to prevent and treat streptococcal disease, but prolonged use of broad-spectrum antibiotics [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/bagirsak-mantari-alternaria-tenuissima\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-14T20:12:26+00:00\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/\",\"url\":\"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/\",\"name\":\"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"datePublished\":\"2024-08-14T20:12:26+00:00\",\"dateModified\":\"2024-08-14T20:12:26+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tilapia'n\u0131n ba\u011f\u0131rsak mantar\u0131 Alternaria tenuissima SCSIO41701'deki antibakteriyel bile\u015fikler - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/bagirsak-mantari-alternaria-tenuissima\/","og_locale":"tr_TR","og_type":"article","og_title":"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia - China Chemical Manufacturer","og_description":"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia The tilapia streptococcal disease caused by Streptococcus agalatae and Streptococcus iniae has caused serious economic losses to the tilapia farming industry. At present, tilapia farming mainly uses antibiotics and other chemical drugs to prevent and treat streptococcal disease, but prolonged use of broad-spectrum antibiotics [&hellip;]","og_url":"https:\/\/longchangextracts.com\/tr\/bagirsak-mantari-alternaria-tenuissima\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-14T20:12:26+00:00","author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"3 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/","url":"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/","name":"Tilapia'n\u0131n ba\u011f\u0131rsak mantar\u0131 Alternaria tenuissima SCSIO41701'deki antibakteriyel bile\u015fikler - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"datePublished":"2024-08-14T20:12:26+00:00","dateModified":"2024-08-14T20:12:26+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/the-intestinal-fungus-alternaria-tenuissima\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Antibacterial compounds in the intestinal fungus Alternaria tenuissima SCSIO41701 of tilapia"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/8803"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=8803"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/8803\/revisions"}],"predecessor-version":[{"id":8804,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/8803\/revisions\/8804"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=8803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=8803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=8803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}