{"id":8709,"date":"2024-08-14T19:19:53","date_gmt":"2024-08-14T19:19:53","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8709"},"modified":"2024-08-14T19:19:53","modified_gmt":"2024-08-14T19:19:53","slug":"triterpenoid-components-of-lanostane","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/lanostanin-triterpenoid-bilesenleri\/","title":{"rendered":"Geleneksel \u00c7in t\u0131bb\u0131 Ganoderma lucidum'daki lanostan\u0131n triterpenoid bile\u015fenleri \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Geleneksel \u00c7in t\u0131bb\u0131 Ganoderma lucidum'daki lanostan\u0131n triterpenoid bile\u015fenleri \u00fczerine \u00e7al\u0131\u015fma
\n\u015eu anda rapor edilmi\u015f yakla\u015f\u0131k 100000 mantar t\u00fcr\u00fc vard\u0131r, ancak hala spesifik olarak tan\u0131mlanmam\u0131\u015f \u00e7ok daha fazla mantar oldu\u011fu tahmin edilmektedir. Bir\u00e7ok b\u00fcy\u00fck mantar (genellikle mantar olarak bilinir) yap\u0131sal olarak yeni ve\/veya olduk\u00e7a aktif bir\u00e7ok do\u011fal \u00fcr\u00fcn\u00fcn kayna\u011f\u0131d\u0131r ve Polyporus ailesinden Ganoderma lucidum da bunlardan biridir.
\nLingzhi, Basidiomycota filumunun Polyporus ailesindeki \u00e7e\u015fitli Lingzhi t\u00fcrlerinin kurutulmu\u015f meyve g\u00f6vdesidir. \u00c7in'de yayg\u0131n bir t\u0131bbi ve yenilebilir mantard\u0131r ve ilk olarak \"Shennong Bencao Jing \"de ila\u00e7 olarak kullan\u0131lm\u0131\u015ft\u0131r. Bin y\u0131l\u0131 a\u015fk\u0131n bir t\u0131bbi kullan\u0131m ge\u00e7mi\u015fine sahiptir. 1950'lerden beri Ganoderma lucidum meyve g\u00f6vdelerinin yapay olarak yeti\u015ftirilmesi ba\u015far\u0131lm\u0131\u015ft\u0131r. Ganoderma lucidum miselyumu i\u00e7in derin fermantasyon k\u00fclt\u00fcr\u00fc teknolojisinin geli\u015ftirilmesiyle, Ganoderma lucidum'un ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi giderek yayg\u0131nla\u015fm\u0131\u015ft\u0131r. Ganoderma lucidum, polisakkaritler, proteinler, organik asitler, k\u00fc\u00e7\u00fck molek\u00fcll\u00fc alkaloidler, seskiterpenler, triterpenler ve steroidler dahil olmak \u00fczere kimyasal bile\u015fenler a\u00e7\u0131s\u0131ndan zengindir. Bu bile\u015fikler anti-enflamatuar, anti-t\u00fcm\u00f6r ve antioksidan etkiler gibi \u00e7e\u015fitli farmakolojik aktiviteler sergiler. Triterpenler, Ganoderma lucidum meyve g\u00f6vdelerindeki ana aktif ikincil metabolitlerdir ve \u00e7ok \u00e7e\u015fitli farmakolojik aktivitelere sahiptir ve giderek insanlar\u0131n dikkatini \u00e7ekmektedir. \u015eu anda, Ganoderma lucidum'dan izole edilen triterpenoidler \u00e7o\u011funlukla 6\/6\/6\/5 konjuge tetrasiklolanostan olup, toplam say\u0131lar\u0131 200'\u00fcn \u00fczerindedir. Erken a\u015famada, farkl\u0131 Ganoderma lucidum t\u00fcrlerinden \u00e7ok say\u0131da yeni triterpenoid, az miktarda alkaloid ve seskiterpen ke\u015ffettik. Geleneksel \u00c7in t\u0131bb\u0131 Ganoderma lucidum'un farmakolojik madde temelini daha iyi anlamak ve kapsaml\u0131 kaynak kullan\u0131m verimlili\u011fini art\u0131rmak i\u00e7in, bu \u00e7al\u0131\u015fma Ganoderma lucidum meyve g\u00f6vdelerinin 95% etanol fraksiyonunun kimyasal bile\u015fenlerini izole etti, safla\u015ft\u0131rd\u0131 ve yap\u0131sal olarak tan\u0131mlad\u0131 ve daha fazla ara\u015ft\u0131rma de\u011feri olan aktif molek\u00fclleri ke\u015ffetmek i\u00e7in izole edilen bile\u015fiklerin in vitro anti-t\u00fcm\u00f6r aktivitesini test etti.<\/p>\n

Ganoderma lucidum'daki triterpenoidlerin ba\u011f\u0131l molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131 genellikle 400~600'd\u00fcr ve hidroksil, karboksil, keton, metoksi, asetoksi gibi oksijen i\u00e7eren fonksiyonel gruplar ana \u00e7ekirdek \u00fczerinde yayg\u0131n olarak bulunur. \u0130skelet \u00fczerindeki karbon atomu say\u0131s\u0131na g\u00f6re Ganoderma triterpenoidleri C30, C27 ve C24 olarak ayr\u0131labilir; ba\u011fl\u0131 farkl\u0131 fonksiyonel gruplara ve yan zincir yap\u0131lar\u0131na g\u00f6re ganoderik asitler, alkoller, aldehitler, laktonlar vb. gibi \u00e7e\u015fitli kategorilere ayr\u0131labilir. Ganoderma lucidum'un (G. lingzhi) meyve veren g\u00f6vdelerinin ekstrakte edilmesi ve ayr\u0131\u015ft\u0131r\u0131lmas\u0131yla, toplam be\u015f adet y\u00fcksek oranda oksitlenmi\u015f lanostan triterpenoid elde edilmi\u015ftir. Bunlar aras\u0131nda, 1 ve 2 numaral\u0131 bile\u015fikler, 3 numaral\u0131 bile\u015fikle birlikte C27 s\u0131n\u0131f\u0131na ait yeni 24 lanostan triterpenoiddir; 4 ve 5 numaral\u0131 bile\u015fikler ise C24 lanostan triterpenoid s\u0131n\u0131f\u0131na aittir. Ganoderma lucidum'daki triterpenoidler karma\u015f\u0131k ve \u00e7e\u015fitli yap\u0131lara sahiptir ve \u00f6zellikle anti-t\u00fcm\u00f6r aktivitesi olmak \u00fczere zengin biyolojik aktiviteler sergilemektedir. Bu nedenle, 1-5 bile\u015fikleri in vitro anti-t\u00fcm\u00f6r aktivitesi (HL-60 A549\u3001SMMC-7721\u3001MCF-7\u3001SW480)\uff0c a\u00e7\u0131s\u0131ndan tarand\u0131, ancak hi\u00e7biri \u00f6nemli sitotoksik aktivite g\u00f6stermedi. G. Lingzhi, ilk olarak 2012 y\u0131l\u0131nda Profes\u00f6r Dai Yucheng taraf\u0131ndan \u00f6nerilen ve daha sonra ayn\u0131 \u00e7e\u015fit olan G Schuensei ile ili\u015fkili oldu\u011fu d\u00fc\u015f\u00fcn\u00fclen yeni bir Ganoderma lucidum t\u00fcr\u00fcd\u00fcr ve kimyasal bile\u015fimi hakk\u0131nda nispeten az rapor vard\u0131r. Bu \u00e7al\u0131\u015fma, Ganoderma lucidum'un daha iyi geli\u015ftirilmesi ve kullan\u0131lmas\u0131, mantar\u0131n kimyasal bile\u015fen t\u00fcrlerinin zenginle\u015ftirilmesi ve etkili aktif bile\u015fenlerinin ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in teorik bir temel olu\u015fturmaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the triterpenoid components of lanostane in traditional Chinese medicine Ganoderma lucidum There are currently about 100000 reported fungal species, but it is estimated that there are still many more fungi that have not been specifically identified. Many large fungi (commonly known as mushrooms) are sources of many structurally novel and\/or highly active natural […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the triterpenoid components of lanostane in traditional Chinese medicine Ganoderma lucidum - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/lanostanin-triterpenoid-bilesenleri\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the triterpenoid components of lanostane in traditional Chinese medicine Ganoderma lucidum - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the triterpenoid components of lanostane in traditional Chinese medicine Ganoderma lucidum There are currently about 100000 reported fungal species, but it is estimated that there are still many more fungi that have not been specifically identified. 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