Kara S\u00fcm\u00fckl\u00fcb\u00f6ceklerin Kimyasal Bile\u015fimi \u00dczerine \u00c7al\u0131\u015fma (II)
\nS\u00fcm\u00fckl\u00fc b\u00f6cekler gastropod s\u0131n\u0131f\u0131na, gastropod s\u0131n\u0131f\u0131na ve s\u00fcm\u00fckl\u00fc b\u00f6cek ailesine aittir. Akci\u011ferleri olan yumu\u015fak v\u00fccutlu hayvanlard\u0131r ve v\u00fccutlar\u0131 mukusla kapl\u0131 oldu\u011fu i\u00e7in genellikle \"bal\u00e7\u0131k solucanlar\u0131, s\u00fcm\u00fckl\u00fc b\u00f6cekler, yusuf\u00e7uklar, solucanlar ve ba\u011fl\u0131 salyangozlar\" olarak bilinirler. Geleneksel \u00c7in t\u0131bb\u0131nda s\u00fcm\u00fckl\u00fc b\u00f6cekler tuzlu ve so\u011fuk bir tada sahiptir ve akci\u011fer, karaci\u011fer ve kal\u0131n ba\u011f\u0131rsak meridyenlerine girerler. R\u00fczgar\u0131 da\u011f\u0131tmak ve sinirleri yat\u0131\u015ft\u0131rmak, \u0131s\u0131y\u0131 temizlemek ve detoksifiye etmek ve kan staz\u0131n\u0131 k\u0131rmak ve meridyen dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek gibi i\u015flevleri vard\u0131r. Esas olarak merkezi r\u00fczgar durgunlu\u011fu, kas spazm\u0131, n\u00f6betler, h\u0131r\u0131lt\u0131l\u0131 solunum, bo\u011faz t\u0131kan\u0131kl\u0131\u011f\u0131, yutak \u015fi\u015fmesi, apse, balgam \u00e7ekirde\u011fi, hemoroid \u015fi\u015fmesi ve a\u011fr\u0131 gibi durumlar\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131rlar. Modern farmakolojik \u00e7al\u0131\u015fmalar, s\u00fcm\u00fckl\u00fc b\u00f6cek \u00f6z\u00fct\u00fcn\u00fcn \u00e7\u0131plak farelerde rahim a\u011fz\u0131 kanseri HeLa h\u00fccre ksenograftlar\u0131n\u0131n b\u00fcy\u00fcmesini engelleyebildi\u011fini, ayr\u0131ca telomeraz geni hTERT'yi bask\u0131layabildi\u011fini ve akci\u011fer kanseri h\u00fccrelerinde mutant P53 ekspresyonunu de\u011fi\u015ftirebildi\u011fini g\u00f6stermi\u015ftir. Ayn\u0131 zamanda, dondurularak kurutulmu\u015f s\u00fcm\u00fckl\u00fc b\u00f6cek tozu, \u00f6ks\u00fcr\u00fc\u011f\u00fcn gizli s\u00fcresini \u00f6nemli \u00f6l\u00e7\u00fcde uzatabilir, \u00f6ks\u00fcrme s\u0131kl\u0131\u011f\u0131n\u0131 azaltabilir ve \u00f6ks\u00fcr\u00fc\u011f\u00fc durdurma, balgam\u0131 \u00e7\u00f6zme ve ast\u0131m\u0131 hafifletme etkisine sahiptir. Ayr\u0131ca ast\u0131ml\u0131 kobaylar\u0131n akci\u011fer dokusunda eozinofil infiltrasyonunu \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir ve bron\u015fiyal ast\u0131m ve kronik bron\u015fit \u00fczerinde iyi bir terap\u00f6tik etkiye sahiptir. Bu projenin ilk a\u015famas\u0131nda, DPPH serbest radikal temizleme, h\u00fccre anti-enflamatuar ve enzim aktivitesi taramas\u0131 \u00fczerine deneyler yap\u0131lm\u0131\u015ft\u0131r. Kara s\u00fcm\u00fckl\u00fcb\u00f6ce\u011fin metanol ekstresinin lipitte \u00e7\u00f6z\u00fcnen k\u0131s\u0131mlar\u0131n\u0131n antioksidan, anti-enflamatuar ve kan \u015fekeri ve lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc gibi \u00e7e\u015fitli biyolojik aktivitelere sahip oldu\u011fu bulunmu\u015ftur. \u00c7\u00f6z\u00fcc\u00fc olarak n-hekzan kullan\u0131ld\u0131\u011f\u0131nda, aktif bile\u015fenler etkili bir \u015fekilde ekstrakte edilebilir. Literat\u00fcr, s\u00fcm\u00fckl\u00fc b\u00f6ceklerin polisakkaritler, amino asitler, steroller ve di\u011fer bile\u015fenleri i\u00e7erdi\u011fini bildirmektedir. Bitki sterolleri, insan v\u00fccudundaki kolesterol\u00fcn emilimi, bozunma metabolizmas\u0131 ve biyokimyasal sentezi ile yak\u0131ndan ili\u015fkilidir ve kan \u015fekeri ve kan lipidlerindeki de\u011fi\u015fiklikleri etkiler. Bununla birlikte, \u015fu anda hayvansal sterollerin fizyolojik aktivitesi hakk\u0131nda \u00e7ok az rapor bulunmaktad\u0131r. Kara s\u00fcm\u00fckl\u00fcb\u00f6ceklerin (Agriolimax agrestis Linnaeus) n-hekzan \u00f6z\u00fct\u00fcn\u00fcn maddi temelini kapsaml\u0131 bir \u015fekilde anlamak i\u00e7in, bu deneyde kara s\u00fcm\u00fckl\u00fcb\u00f6ceklerin n-hekzan \u00f6z\u00fct\u00fc sistematik olarak izole edilmi\u015f, safla\u015ft\u0131r\u0131lm\u0131\u015f ve \u03b1-glukozidaz inhibit\u00f6r aktivitesi i\u00e7in bile\u015fiklerin \u00f6n taramas\u0131 yap\u0131lm\u0131\u015ft\u0131r.<\/p>\n
Kara s\u00fcm\u00fckl\u00fcb\u00f6ceklerin n-hekzan ekstrakt\u0131ndan, esas olarak uzun zincirli ya\u011f asitleri ve sterollerden olu\u015fan on be\u015f bile\u015fik izole edilmi\u015ftir. Bunlar aras\u0131nda, sterol 9 ve 14 ana bile\u015fenler olmak \u00fczere alt\u0131 sterol tan\u0131mlanm\u0131\u015ft\u0131r. Bile\u015fik 9 hari\u00e7, di\u011fer t\u00fcm bile\u015fikler ilk kez bu hayvan ilac\u0131ndan izole edilmi\u015ftir. Bitki sterolleri, insan v\u00fccudu taraf\u0131ndan kolesterol emilimini engellemek, kolesterol y\u0131k\u0131m metabolizmas\u0131n\u0131 te\u015fvik etmek ve kolesterol biyokimyasal sentezini engellemek gibi \u00e7e\u015fitli biyolojik aktivitelere sahiptir. Ancak, \u015fu anda hayvansal sterollerin fizyolojik aktiviteleri hakk\u0131nda \u00e7ok az rapor bulunmaktad\u0131r. Bu deneyde, y\u00fcksek safl\u0131\u011fa sahip 7 bile\u015fi\u011fin alfa glukozidaz inhibit\u00f6r aktivitesi \u00f6n taramadan ge\u00e7irilmi\u015ftir. Sonu\u00e7lar, 6 ve 10 numaral\u0131 bile\u015fiklerin alfa glukozidaza kar\u015f\u0131 zay\u0131f inhibit\u00f6r aktiviteye sahip oldu\u011funu, di\u011fer bile\u015fiklerin ise alfa glukozidaz \u00fczerinde \u00e7ok az inhibit\u00f6r etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. \u00d6n deneysel sonu\u00e7lar, aktif b\u00f6lgenin alfa glukozidaza kar\u015f\u0131 inhibit\u00f6r aktiviteye sahip oldu\u011funu ve aktif bile\u015fenlerin tespit edilen \u00e7e\u015fitli terpenoidler olabilece\u011fini g\u00f6stermi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"
Study on the Chemical Composition of Black Slugs (II) Slugs belong to the gastropod class, gastropod class, and slug family. They are soft bodied animals with lungs and are commonly known as “slime worms, slugs, dragonflies, earthworms, and attached snails” because their bodies are covered in mucus. Slugs, as a traditional Chinese medicine, have a […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n