Do\u011fal polisakkaritlerin anti-t\u00fcm\u00f6r metastaz etki mekanizmas\u0131 \u00fczerine ara\u015ft\u0131rma ilerlemesi
\nKanser, 2020 y\u0131l\u0131nda bildirilen 19,29 milyon yeni kanser vakas\u0131 ile d\u00fcnya \u00e7ap\u0131nda ikinci \u00f6nde gelen \u00f6l\u00fcm nedenidir ve insanlar\u0131n hayatta kalmas\u0131 ve sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdit olu\u015fturmaktad\u0131r. Metastaz, k\u00f6t\u00fc huylu t\u00fcm\u00f6rlerin \u00f6l\u00fcmc\u00fcl olmas\u0131na yol a\u00e7an \u00f6nemli bir fakt\u00f6rd\u00fcr ve \u00e7o\u011fu hasta birincil t\u00fcm\u00f6rden ziyade t\u00fcm\u00f6r\u00fcn di\u011fer organlara yay\u0131lmas\u0131 nedeniyle \u00f6lmektedir. Mevcut tedavi y\u00f6ntemleri temel olarak cerrahi rezeksiyon, kemoterapi ve radyoterapiyi i\u00e7erir, ancak hepsinin g\u00fc\u00e7l\u00fc toksik yan etkiler ve kolay n\u00fcks gibi s\u0131n\u0131rlamalar\u0131 vard\u0131r. Bu nedenle, yeni g\u00fcvenli ve etkili anti-t\u00fcm\u00f6r metastaz ila\u00e7lar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 \u00f6nemli klinik \u00f6neme sahiptir. Son y\u0131llarda, polisakkaritler anti-t\u00fcm\u00f6r, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme, antioksidan ve hipoglisemik etkiler gibi \u00f6nemli biyolojik aktiviteleri nedeniyle artan bir ilgi g\u00f6rmektedir. Polisakkaritler olarak da bilinen polisakkaritler, glikozidik zincirlerle ba\u011flanm\u0131\u015f 10'dan fazla monosakkaritten olu\u015fan b\u00fcy\u00fck do\u011fal aktif maddelerdir. Bitkilerin, hayvanlar\u0131n, mantarlar\u0131n ve bakterilerin h\u00fccre duvarlar\u0131nda yayg\u0131n olarak bulunurlar. Giderek daha fazla say\u0131da \u00e7al\u0131\u015fma do\u011fal polisakkaritlerin \u00e7e\u015fitli yollarla t\u00fcm\u00f6r metastaz\u0131n\u0131 inhibe edebildi\u011fini g\u00f6stermi\u015ftir, ancak \u015fu anda anti-t\u00fcm\u00f6r metastaz\u0131nda do\u011fal polisakkaritlerin mekanizmas\u0131 hakk\u0131nda g\u00f6receli bir inceleme eksikli\u011fi vard\u0131r. Bu makale, anti-t\u00fcm\u00f6r metastaz ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesi ve malign t\u00fcm\u00f6r metastaz\u0131n\u0131n tedavisi i\u00e7in yeni teorik temel sa\u011flamak amac\u0131yla son y\u0131llarda do\u011fal polisakkaritlerin anti-t\u00fcm\u00f6r metastaz etkilerini ve mekanizmalar\u0131n\u0131 g\u00f6zden ge\u00e7irmektedir.<\/p>\n
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\u00c7ok say\u0131da klinik \u00e7al\u0131\u015fma, kanser \u00f6l\u00fcmlerinin yakla\u015f\u0131k 90%'sinin t\u00fcm\u00f6r invazyonu ve metastaz\u0131na ba\u011fl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Mevcut tedavi se\u00e7enekleri hem anti-t\u00fcm\u00f6r metastaz\u0131n\u0131n etkinli\u011fi hem de toksik yan etkiler a\u00e7\u0131s\u0131ndan tatmin edici de\u011fildir. Anti-t\u00fcm\u00f6r metastaz\u0131nda g\u00fcvenli ve d\u00fc\u015f\u00fck toksisiteli do\u011fal polisakkaritler \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar etkili olsa da, do\u011fal polisakkaritlerin klinik tedavide daha fazla uygulanmas\u0131n\u0131 k\u0131s\u0131tlayan baz\u0131 sorunlar hala mevcuttur: \u2460 Polisakkarit yap\u0131s\u0131n\u0131n karma\u015f\u0131kl\u0131\u011f\u0131 nedeniyle, \u00e7o\u011fu \u00e7al\u0131\u015fma polisakkaritlerin biyolojik aktivite mekanizmas\u0131yla s\u0131n\u0131rl\u0131d\u0131r ve polisakkarit yap\u0131s\u0131 ile polisakkaritler aras\u0131ndaki ili\u015fkiyi g\u00f6z ard\u0131 etmektedir. Bu nedenle, gelecekteki ara\u015ft\u0131rmalar\u0131n polisakkaritlerin yap\u0131-aktivite ili\u015fkisine, \u00f6zellikle de daha y\u00fcksek yap\u0131lar\u0131n aktivite \u00fczerindeki etkisine odaklanmas\u0131 gerekmektedir; \u2461 EMT ve CSC aras\u0131nda yak\u0131n bir ili\u015fki vard\u0131r ve her ikisi taraf\u0131ndan ind\u00fcklenen uyaranlarda da y\u00fcksek derecede \u00f6rt\u00fc\u015fme vard\u0131r. \u015eu anda, do\u011fal polisakkaritlerin anti-t\u00fcm\u00f6r metastaz\u0131 \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar genellikle EMT ile s\u0131n\u0131rl\u0131d\u0131r ve CSC \u00fczerine, hatta ikisini tamamen ay\u0131ran \u00e7ok az ara\u015ft\u0131rma vard\u0131r. Bu nedenle, bu iki yol i\u00e7in ortak inhibit\u00f6rler bulmak, anti-t\u00fcm\u00f6r metastaz\u0131 i\u00e7in do\u011fal polisakkaritlerin gelece\u011finde bir ara\u015ft\u0131rma e\u011filimi olabilir.<\/p>","protected":false},"excerpt":{"rendered":"
Research progress on the mechanism of anti-tumor metastasis effect of natural polysaccharides Cancer is the second leading cause of death worldwide, with 19.29 million new cases of cancer reported in 2020, posing a serious threat to human survival and health. Metastasis is a key factor leading to the lethality of malignant tumors, with most patients […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n