{"id":8107,"date":"2024-08-11T19:12:37","date_gmt":"2024-08-11T19:12:37","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8107"},"modified":"2024-08-11T19:12:37","modified_gmt":"2024-08-11T19:12:37","slug":"poria-cocos-2","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/poria-cocos-2\/","title":{"rendered":"UPLC-Q-TOF-MS\/MS ve a\u011f farmakolojisine dayal\u0131 olarak Poria cocos'un meme kanserine kar\u015f\u0131 mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>UPLC-Q-TOF-MS\/MS ve a\u011f farmakolojisine dayal\u0131 olarak Poria cocos'un meme kanserine kar\u015f\u0131 mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nMeme kanseri (MK), t\u00fcm kanser vakalar\u0131n\u0131n 11.7%'sini olu\u015fturarak k\u00fcresel kanser insidans oran\u0131n\u0131n ana nedeni olarak akci\u011fer kanserini geride b\u0131rakm\u0131\u015ft\u0131r ve k\u00fcresel kanser \u00f6l\u00fcmlerinin be\u015finci \u00f6nde gelen nedenidir. G\u00fcn\u00fcm\u00fczde kemoterapi, cerrahi ve radyasyon gibi yayg\u0131n tedavi y\u00f6ntemleri, insan v\u00fccudunun karaci\u011fer ve b\u00f6brekleri \u00fczerinde toksik yan etkiler ve ba\u011f\u0131rsak sistemi homeostaz\u0131n\u0131n bozulmas\u0131 gibi g\u00fc\u00e7l\u00fc yan etkilere sahiptir. Bu durum meme kanseri tedavisinin etkisini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde s\u0131n\u0131rlamaktad\u0131r, bu nedenle d\u00fc\u015f\u00fck toksisiteli ve y\u00fcksek verimli anti-t\u00fcm\u00f6r ila\u00e7lar\u0131 bulmak \u00f6nemlidir. \u00c7o\u011fu geleneksel \u00c7in ilac\u0131 ve form\u00fclleri d\u00fc\u015f\u00fck toksisite ve y\u00fcksek verimlilik avantajlar\u0131na sahiptir. Makul kullan\u0131m, kanser hastalar\u0131n\u0131n toksik yan etkilerini azaltmaya ve a\u011fr\u0131lar\u0131n\u0131 hafifletmeye yard\u0131mc\u0131 olur.<\/p>\n<p>Poria cocos (Schw. Modern ara\u015ft\u0131rmalar, Poria cocos'un anti-t\u00fcm\u00f6r etkiye sahip oldu\u011funu ve ekstrakt\u0131n\u0131n insan karaci\u011fer kanseri, akci\u011fer kanseri, meme kanseri ve rahim a\u011fz\u0131 kanserinin proliferasyonu \u00fczerinde belirgin inhibit\u00f6r etkiye sahip oldu\u011funu g\u00f6stermektedir. Bu, Poria cocos'un bir anti-t\u00fcm\u00f6r ilac\u0131na d\u00f6n\u00fc\u015fmek i\u00e7in b\u00fcy\u00fck bir potansiyele sahip oldu\u011funu g\u00f6stermektedir. Bununla birlikte, Poria cocos'un meme kanserine kar\u015f\u0131 molek\u00fcler mekanizmas\u0131 ve etki hedefi bu a\u015famada hala net de\u011fildir. Bu nedenle, UPLC-Q-TOF-MS\/MS'ye dayanan bu makale, Poria cocos ve meme kanseri aras\u0131ndaki ili\u015fkiyi a\u011f farmakolojisi y\u00f6ntemleriyle tart\u0131\u015fmakta ve daha ileri deneysel ara\u015ft\u0131rmalara temel olu\u015fturmak i\u00e7in h\u00fccre deneyleriyle \u00f6n do\u011frulama ger\u00e7ekle\u015ftirmektedir.<\/p>\n<p>&nbsp;<\/p>\n<p>\"\u0130la\u00e7 bile\u015fimi hedef hastal\u0131\u011f\u0131\" a\u011f analizi ve taramas\u0131, pachymarac acid A, thumomic acid, 3-keto-linostero-7,9 (11), 24-triene-21-acid'in, pachymarac ile meme kanseri tedavisinde potansiyel aktif bir rol oynayabilecek ilgili hedeflerle y\u00fcksek derecede ba\u011flant\u0131ya sahip oldu\u011funu g\u00f6stermi\u015ftir. Ara\u015ft\u0131rma, tetrasiklik triterpenler taraf\u0131ndan temsil edilen bile\u015fenlerin \u00f6nemli anti-t\u00fcm\u00f6r aktivitesine sahip oldu\u011funu g\u00f6stermektedir. \u015eu anda, pakimasik asit gibi tetrasiklik triterpenlerin ana bile\u015fenleri, yay\u0131nlanan literat\u00fcrdeki ana ara\u015ft\u0131rma nesneleridir. Bu \u00e7al\u0131\u015fmada taranan anti meme kanseri aktif bile\u015fenleri, pakimasik asit A, fumarik asit, pakimasik aside benzer yap\u0131da olan 3-ketol-lanoste-7,9 (11), 24-trien-21-asit, hepsi lanostan tipi tetrasiklik triterpenlerdir ve belirli ara\u015ft\u0131rma de\u011ferine sahiptir.<\/p>\n<p>Bu \u00e7al\u0131\u015fmada, Poria cocos etken maddelerinin 301 etki hedefi elde edilmi\u015f ve meme kanserinin diferansiyel genleri ile kesi\u015ferek 30 ortak etki hedefi elde edilmi\u015ftir. Poria cocos'un aktif bile\u015fenlerinin anti meme kanseri \u00e7ekirdek ba\u011flay\u0131c\u0131 proteinleri (PPARG, PPARA) taranm\u0131\u015ft\u0131r. Bu iki hedef t\u00fcm\u00f6rlerle yak\u0131ndan ili\u015fkilidir. KEGG yola\u011f\u0131n\u0131n zenginle\u015ftirme analizi, meme kanseri hedefinde esas olarak yer alan sinyal yolaklar\u0131n\u0131n n\u00f6roaktif ligand resept\u00f6r etkile\u015fimi, kalsiyum sinyal yola\u011f\u0131, PPAR sinyal yola\u011f\u0131 vb. oldu\u011funu g\u00f6stermi\u015ftir. En dikkat \u00e7ekici olan\u0131, tahmin edilen \u00e7ekirdek hedef sonu\u00e7lar\u0131m\u0131zla tutarl\u0131 olan PPAR sinyal yoludur. PPAR, ya\u011f asitleri ve t\u00fcrevleri taraf\u0131ndan aktive edilen ve \u00fc\u00e7 alt tipi olan bir n\u00fckleer hormon resept\u00f6r\u00fcd\u00fcr. PPARG alt tiplerden biridir ve resept\u00f6r agonisti meme kanseri i\u00e7in \u00f6nleyici bir ila\u00e7 olarak \u00f6nerilmi\u015ftir. PPARG yola\u011f\u0131, insan t\u00fcm\u00f6rlerinin proliferasyon, invazyon, uzak metastaz gibi \u00e7e\u015fitli malign \u00f6zellikleri ile a\u00e7\u0131k\u00e7a ili\u015fkilendirilmi\u015ftir ve birden fazla mekanizmay\u0131 i\u00e7erir. Baz\u0131 \u00e7al\u0131\u015fmalar, hesperidinin meme kanseri k\u00f6k h\u00fccrelerini inhibe etme mekanizmas\u0131nda PPARG'nin \u00f6nemli bir potansiyel hedef oldu\u011funu ve h\u00fccre proliferasyonu ve metabolizmas\u0131nda \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Yeterli oksijen ko\u015fullar\u0131 alt\u0131nda, t\u00fcm\u00f6r h\u00fccreleri tercihen ATP ve glikoliz yoluyla b\u00fcy\u00fck miktarda laktat \u00fcreterek t\u00fcm\u00f6r h\u00fccrelerinin \u00e7o\u011falmas\u0131 ve metastaz\u0131 i\u00e7in enerji sa\u011flayacakt\u0131r. ATP i\u00e7eri\u011fi ve laktat \u00fcretiminin incelenmesi, Poria cocos'un t\u00fcm\u00f6r h\u00fccrelerindeki enerji metabolizmas\u0131 \u00fczerindeki etkisini yans\u0131tabilir. Bu nedenle, bu deney ilgili ara\u015ft\u0131rmay\u0131 y\u00fcr\u00fctmek i\u00e7in PPARG'ye odaklanm\u0131\u015ft\u0131r. H\u00fccre fonksiyonu deneyinde, Poria cocos'un meme kanseri h\u00fccrelerinin proliferasyonu, metastaz\u0131 ve metabolik kapasitesi \u00fczerindeki etkisini do\u011frulamak i\u00e7in CCK8, \u00e7izik testi ve kit y\u00f6ntemi kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, Poria cocos \u00f6z\u00fct\u00fcn\u00fcn (160 \uff5e 640 \u03bc g \/ mL) meme kanseri h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebilece\u011fini g\u00f6stermi\u015ftir (P&lt;0.01); \u00c7izik testi sonu\u00e7lar\u0131, h\u00fccre g\u00f6\u00e7\u00fcn\u00fcn \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edildi\u011fini g\u00f6stermi\u015ftir (P&lt;0.01); Kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, Poria cocos \u00f6z\u00fct\u00fcn\u00fcn farkl\u0131 konsantrasyonlar\u0131 h\u00fccrelerdeki laktat i\u00e7eri\u011finde bir azalmaya neden olurken, ATP seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde etkilenmemi\u015ftir. Poria cocos ekstresi esas olarak di\u011fer metabolik s\u00fcre\u00e7leri etkileyebilir ve b\u00f6ylece h\u00fccre metabolizmas\u0131n\u0131 etkileyebilir; H\u00fccresel imm\u00fcnofloresan sonu\u00e7lar\u0131, PPARG proteininin esas olarak \u00e7ekirdekte da\u011f\u0131ld\u0131\u011f\u0131n\u0131 ve floresan yo\u011funlu\u011funun Poria cocos ekstresi ile uyar\u0131ld\u0131ktan sonra \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.<\/p>\n<p>\u00d6zetle, bu \u00e7al\u0131\u015fma, a\u011f farmakolojisi analizine dayal\u0131 olarak Poria cocos'un aktif bile\u015fenlerinin hedeflerini ve potansiyel mekanizmalar\u0131n\u0131 ortaya koymu\u015f, aktif bile\u015fenler ve hedef proteinler aras\u0131ndaki afinite ili\u015fkisini molek\u00fcler yerle\u015ftirme teknolojisi ile do\u011frulam\u0131\u015f ve \u00e7ekirdek hedeflerin ilgili etkilerini deneysel olarak do\u011frulam\u0131\u015ft\u0131r. Sonu\u00e7lar, Poria cocos'un PPARG ekspresyonunu d\u00fczenleyerek, t\u00fcm\u00f6r h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 ve g\u00f6\u00e7\u00fcn\u00fc engelleyerek ve h\u00fccre metabolizmas\u0131n\u0131 etkileyerek meme kanseri kar\u015f\u0131t\u0131 bir rol oynayabilece\u011fini g\u00f6stermi\u015ftir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131 ve mevcut literat\u00fcrdeki ilgili raporlar birbirini desteklemektedir. \u00c7al\u0131\u015fma, Poria cocos'un meme kanserini \u00f6nleme ve tedavi etmedeki etkinli\u011finin maddi temeli ve mekanizmas\u0131 hakk\u0131nda yeni bilgiler sa\u011flayarak veriler arac\u0131l\u0131\u011f\u0131yla modern ila\u00e7lar\u0131n ke\u015ffine rehberlik etmi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the mechanism of Poria cocos against breast cancer based on UPLC-Q-TOF-MS\/MS and network pharmacology Breast cancer (BC) has surpassed lung cancer as the main cause of global cancer incidence rate, accounting for 11.7% of all cancer cases, and is the fifth leading cause of global cancer death. At present, common treatment methods such as [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the mechanism of Poria cocos against breast cancer based on UPLC-Q-TOF-MS\/MS and network pharmacology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/poria-cocos-2\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Poria cocos against breast cancer based on UPLC-Q-TOF-MS\/MS and network pharmacology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Poria cocos against breast cancer based on UPLC-Q-TOF-MS\/MS and network pharmacology Breast cancer (BC) has surpassed lung cancer as the main cause of global cancer incidence rate, accounting for 11.7% of all cancer cases, and is the fifth leading cause of global cancer death. 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