\u00c7uha \u00e7i\u00e7e\u011findeki yeni bir gallik asit t\u00fcrevi
\nPulmoner fibrozis (PF) bir t\u00fcr y\u0131k\u0131c\u0131 ve geri d\u00f6n\u00fc\u015f\u00fcms\u00fcz yayg\u0131n interstisyel akci\u011fer hastal\u0131\u011f\u0131d\u0131r. A\u011f\u0131r solunum sendromu koronavir\u00fcs ve yeni koronavir\u00fcs (COVID-19) enfeksiyonunun yan\u0131 s\u0131ra \u00e7e\u015fitli enflamatuar akci\u011fer hastal\u0131klar\u0131 pulmoner fibrozise neden olabilir. Bat\u0131 t\u0131bb\u0131 tedavi i\u00e7in genellikle glukokortikoidler, imm\u00fcnosupresanlar, sitokin inhibit\u00f6rleri vb. kullan\u0131r, ancak bir\u00e7ok yan etki vard\u0131r. \u00c7in t\u0131bb\u0131n\u0131n s\u00fcrekli geli\u015fimi ve \u00c7in t\u0131bb\u0131n\u0131n COVID-19 ile m\u00fccadeledeki temel rol\u00fc ile. Giderek daha fazla deneysel \u00e7al\u0131\u015fma, geleneksel \u00c7in t\u0131bb\u0131n\u0131n ve \u00f6zlerinin pulmoner fibroz \u00fczerinde iyi terap\u00f6tik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Yerel kitaplara dan\u0131\u015ft\u0131ktan sonra, \u00e7uha \u00e7i\u00e7e\u011finin akci\u011ferle ilgili hastal\u0131klar\u0131 tedavi edebilece\u011fi bulunmu\u015ftur. \u00d6rne\u011fin, Quanzhou Materia Medica, \u00e7uha \u00e7i\u00e7e\u011fi kullan\u0131m\u0131n\u0131n akci\u011fer hastal\u0131klar\u0131, skrofula ve di\u011fer durumlar\u0131 tedavi edebilece\u011fini kaydetmektedir.
\nOenothera biennis L., Onagraceae familyas\u0131ndan Oenothera L. cinsine ait \u00e7ok y\u0131ll\u0131k otsu bir bitkidir. Ak\u015fam 7-9 saatleri aras\u0131nda \u00e7i\u00e7ek a\u00e7t\u0131\u011f\u0131 i\u00e7in Oenothera L. olarak adland\u0131r\u0131l\u0131r. Ya\u011f, s\u00fcs ve t\u0131bbi ama\u00e7lar i\u00e7in kullan\u0131labilen \u00e7ok i\u015flevli bir bitkidir. Yayg\u0131n olarak kullan\u0131lan bir geleneksel \u00c7in ilac\u0131d\u0131r ve bitki genelinde ila\u00e7 olarak kullan\u0131labilir. Bu bitki esas olarak \u00c7in'in kuzeydo\u011fu ve g\u00fcney b\u00f6lgelerinin yan\u0131 s\u0131ra do\u011fudaki da\u011fl\u0131k alanlarda da da\u011f\u0131l\u0131m g\u00f6sterir. \u00c7uha \u00e7i\u00e7e\u011fi tohum ya\u011f\u0131, insan v\u00fccudu i\u00e7in temel ya\u011f asitleri olan ve g\u00fc\u00e7l\u00fc biyolojik aktiviteye sahip gama linolenik asit gibi \u00e7e\u015fitli doymam\u0131\u015f ya\u011f asitleri bak\u0131m\u0131ndan zengindir. Literat\u00fcr taramas\u0131yla, \u00e7uha \u00e7i\u00e7e\u011finin kimyasal bile\u015fimi hakk\u0131nda nispeten az say\u0131da rapor oldu\u011fu ve \u00e7uha \u00e7i\u00e7e\u011finin kimyasal bile\u015fimi hakk\u0131nda sistematik ara\u015ft\u0131rma eksikli\u011fi oldu\u011fu tespit edilmi\u015ftir. \u00c7uha \u00e7i\u00e7e\u011finin kimyasal bile\u015fimini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak ve daha sonraki geli\u015fimi ve kullan\u0131m\u0131 i\u00e7in temel olu\u015fturmak amac\u0131yla, bu \u00e7al\u0131\u015fma t\u00fcm \u00e7uha \u00e7i\u00e7e\u011fi bitkisinin kimyasal bile\u015fenlerini izole etmi\u015f ve tan\u0131mlam\u0131\u015ft\u0131r.<\/p>\n
<\/p>\n
Bu makalede, \u00e7uha \u00e7i\u00e7e\u011finin kimyasal bile\u015fenlerini izole etmek ve safla\u015ft\u0131rmak i\u00e7in \u00e7e\u015fitli kromatografik ay\u0131rma teknikleri kullan\u0131larak, aralar\u0131nda bile\u015fik 1'in yeni bir bile\u015fik oldu\u011fu 10 bile\u015fik (1-10) elde edilmi\u015ftir; Bile\u015fik 1-10'un TGF - \u03b2 1- ile ind\u00fcklenen BEAS-2B h\u00fccre hasar\u0131 \u00fczerindeki etkileri MTT testi kullan\u0131larak belirlenmi\u015ftir. Sonu\u00e7lar, bile\u015fik 2 ve 3'\u00fcn TGF - \u03b2 1 ile ind\u00fcklenen BEAS2B h\u00fccrelerinin aktivitesini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bu makale \u00e7uha \u00e7i\u00e7e\u011finin kimyasal bile\u015fimini daha da zenginle\u015ftirmektedir. \u00d6nceki \u00e7al\u0131\u015fmalar a\u011f\u0131rl\u0131kl\u0131 olarak \u00e7uha \u00e7i\u00e7e\u011fi ya\u011f\u0131n\u0131n farmakolojik aktivitelerine odaklanm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fman\u0131n aktivite testi sonu\u00e7lar\u0131 da \u00e7uha \u00e7i\u00e7e\u011finin t\u0131bbi de\u011ferini geni\u015fletmi\u015f ve geli\u015ftirilmesi ve kullan\u0131m\u0131 i\u00e7in temel verileri biriktirmi\u015ftir. Ayn\u0131 zamanda ara\u015ft\u0131rma grubu, \u00e7uha \u00e7i\u00e7e\u011finin toplam ekstrakt\u0131n\u0131n anti pulmoner fibrozis aktivitesi \u00fczerine \u00f6n tarama \u00e7al\u0131\u015fmalar\u0131 y\u00fcr\u00fctm\u00fc\u015ft\u00fcr. Farmakolojik madde temelini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak i\u00e7in, bu \u00e7al\u0131\u015fma kimyasal bile\u015fenlerini izole etti ve safla\u015ft\u0131rd\u0131, daha fazla geli\u015ftirilmesi ve kullan\u0131lmas\u0131 i\u00e7in temel olu\u015fturdu.<\/p>","protected":false},"excerpt":{"rendered":"
A new derivative of gallic acid in evening primrose Pulmonary fibrosis (PF) is a type of destructive and irreversible diffuse interstitial lung disease. The severe respiratory syndrome coronavirus and novel coronavirus (COVID-19) infection, as well as a variety of inflammatory lung diseases, can cause pulmonary fibrosis. Western medicine often uses glucocorticoids, immunosuppressants, cytokine inhibitors, etc. […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n