{"id":8023,"date":"2024-08-11T17:51:51","date_gmt":"2024-08-11T17:51:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=8023"},"modified":"2024-08-11T17:51:51","modified_gmt":"2024-08-11T17:51:51","slug":"immunosuppressed-mice","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/bagisiklik-sistemi-baskilanmis-fareler\/","title":{"rendered":"Mirisetinin siklofosfamid ile ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f farelerin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu \u00fczerindeki etkisi"},"content":{"rendered":"

Mirisetinin siklofosfamid ile ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f farelerin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu \u00fczerindeki etkisi
\nBa\u011f\u0131\u015f\u0131kl\u0131k sistemi, dengeyi ve genel sa\u011fl\u0131\u011f\u0131 korumak i\u00e7in organizmalar\u0131 patojenlerin neden oldu\u011fu enfeksiyonlardan koruyabilir. \u0130mm\u00fcns\u00fcpresyon, uzun s\u00fcreli veya ge\u00e7ici bir imm\u00fcn fonksiyon bozuklu\u011fudur. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi hasar\u0131 nedeniyle organizmalar patojenlere kar\u015f\u0131 daha hassas hale gelir ve daha d\u00fc\u015f\u00fck dirence sahip olurlar. Genellikle ciddiye al\u0131nmayan k\u00fc\u00e7\u00fck patojenler bile kolayca enfeksiyonlara neden olabilir. \u015eu anda klinik uygulamada kullan\u0131lan bir\u00e7ok imm\u00fcnomod\u00fclat\u00f6r\u00fcn levamizol ve Bacillus subtilis gibi baz\u0131 yan etkileri vard\u0131r. Bu nedenle, ba\u011f\u0131\u015f\u0131kl\u0131k bask\u0131lanmas\u0131yla ilgili hastal\u0131klar\u0131n tedavisine yard\u0131mc\u0131 olmak i\u00e7in yeni imm\u00fcnomod\u00fclat\u00f6rlerin ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi hala gereklidir.<\/p>\n

18. y\u00fczy\u0131l\u0131n sonlar\u0131nda, Myriaceae familyas\u0131ndan Yangmei'nin kabu\u011fundan mirisetin (MYR) ad\u0131 verilen a\u00e7\u0131k sar\u0131 bir kristal \u00e7\u0131kar\u0131lm\u0131\u015ft\u0131r (bkz. \u015eekil 1). MYR meyvelerde, sebzelerde, \u00e7ayda ve \u015farapta bulunan flavonoid bir bile\u015fiktir ve bir\u00e7ok g\u0131dada \u00f6nemli bir aktif bile\u015fen ve katk\u0131 maddesidir. Modern farmakolojik ara\u015ft\u0131rmalar, MYR'nin farkl\u0131 kanser t\u00fcrleri, enflamatuar hastal\u0131klar, ateroskleroz, Alzheimer hastal\u0131\u011f\u0131 ve patojenik mikrobiyal enfeksiyon dahil olmak \u00fczere \u00e7e\u015fitli hastal\u0131klar \u00fczerinde terap\u00f6tik etkileri oldu\u011funu g\u00f6stermektedir. Bununla birlikte, bu flavonoidlerin i\u015flevi, \u00f6zellikle ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin d\u00fczenlenmesinde hala tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r.<\/p>\n

Siklofosfamid (CTX), baz\u0131 solid t\u00fcm\u00f6rler, lenfomalar ve baz\u0131 otoimm\u00fcn hastal\u0131klarla m\u00fccadele etmek i\u00e7in kemoterapi ve hastal\u0131k de\u011fi\u015ftirici olarak yayg\u0131n \u015fekilde kullan\u0131lan bir imm\u00fcnosupresif ind\u00fckleyicidir. CTX normal h\u00fccrelerin DNA's\u0131na zarar verebilir, bu da imm\u00fcnosupresyon yapabilmesinin nedenlerinden biridir. \u015eu anda, klinik ortamlarda bir imm\u00fcnosupresan olarak da kullan\u0131lmaktad\u0131r. MYR ayr\u0131ca \u00e7e\u015fitli laboratuvarlarda ba\u011f\u0131\u015f\u0131kl\u0131k yetersizli\u011finin ideal hayvan modellerini olu\u015fturmak i\u00e7in yayg\u0131n olarak kullan\u0131lan bir modelleme ilac\u0131d\u0131r.<\/p>\n

Bu nedenle, ba\u011f\u0131\u015f\u0131kl\u0131klar\u0131n\u0131 azaltmak ve imm\u00fcnosupresif bir model olu\u015fturmak i\u00e7in farelere intraperitoneal olarak enjekte etmek \u00fczere CTX kulland\u0131k. Model fareleri MYR ile tedavi ettik ve MYR'yi yeni bir imm\u00fcnomod\u00fclat\u00f6r ajan olarak geli\u015ftirmek i\u00e7in dalak ve timus indekslerini, dalak lenfosit proliferasyon yetene\u011fini, serum hemolizin seviyelerini, antikor olu\u015fturan h\u00fccre yetene\u011fini ve ayr\u0131ca serum sitokin interl\u00f6kin-2 (IL-2), interferon - \u03b3 (IFN - \u03b3), interl\u00f6kin-4 (IL-4), interl\u00f6kin-6 (IL-6) salg\u0131lama seviyelerini de\u011ferlendirdik.<\/p>\n

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\u0130mm\u00fcnosupresyon, insan v\u00fccudundaki imm\u00fcn fonksiyon bozuklu\u011funun bir tezah\u00fcr\u00fcd\u00fcr. Bir veya daha fazla fakt\u00f6r\u00fcn birle\u015fik etkisi alt\u0131nda, insan v\u00fccudundaki ba\u011f\u0131\u015f\u0131kl\u0131k hasar\u0131 onu enfeksiyona kar\u015f\u0131 daha duyarl\u0131 hale getirebilir ve ba\u011f\u0131\u015f\u0131kl\u0131kla ilgili lezyonlarla sonu\u00e7lanabilir. MYR, bir\u00e7ok g\u0131dada bulunan ve karaci\u011fer korumas\u0131, anti-t\u00fcm\u00f6r, anti-inflamatuar, antitrombotik, antioksidan gibi etkileri olan flavonoid bir maddedir. Klinik \u00f6ncesi ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi hakk\u0131nda da bir\u00e7ok rapor bulunmaktad\u0131r. MYR, atopik dermatit farelerinde kalsitriol taraf\u0131ndan ind\u00fcklenen cilt hasar\u0131 semptomlar\u0131n\u0131 iyile\u015ftirebilir, lokal Th1\/Th2 dengesini d\u00fczenleyebilir ve hasarl\u0131 cilt bariyerlerini onarabilir. Hou ve arkada\u015flar\u0131, in vitro deneylerde MYR'nin t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc - \u03b1 (TNF - \u03b1)\/IFN - \u03b3 taraf\u0131ndan ind\u00fcklenen insan immortalize keratinositlerinde inflamatuar fakt\u00f6rler \u00fczerinde inhibe edici bir etkiye sahip oldu\u011funu ve STAT1 ve NF - \u03ba B sinyal yollar\u0131n\u0131 bloke edebilece\u011fini bulmu\u015flard\u0131r. MYR, Treg h\u00fccrelerinin oran\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rm\u0131\u015f ve kolit farelerinde imm\u00fcn dengenin restorasyonunu desteklemi\u015ftir.
\nCTX, geni\u015f anti-t\u00fcm\u00f6r \u00f6zelliklere sahip bir t\u00fcr alkilleyici ajand\u0131r. \u0130lk olarak T h\u00fccrelerine kar\u015f\u0131 se\u00e7icili\u011fi olan ve in vivo DNA hasar\u0131 ve onar\u0131m\u0131n\u0131 ind\u00fckleyebilen \"gizli\" geni\u015f spektrumlu bir anti-kanser ilac\u0131 olarak an\u0131lm\u0131\u015ft\u0131r. Otoimm\u00fcn hastal\u0131klar\u0131 tedavi etme ve a\u015f\u0131r\u0131 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 d\u00fczenleme kabiliyetinin yan\u0131 s\u0131ra modellemedeki y\u00fcksek kolayl\u0131\u011f\u0131 ve basit malzeme gereksinimleri nedeniyle CTX \u015fu anda laboratuvarlarda ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f hayvan modelleri i\u00e7in yayg\u0131n olarak kullan\u0131lan bir ind\u00fckleyicidir. Bu deneyde MYR'nin ba\u011f\u0131\u015f\u0131kl\u0131k seviyesini de\u011ferlendirmek i\u00e7in CTX modellemesi kullan\u0131lm\u0131\u015ft\u0131r. Normal kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, Mod tedavi grubunda dalak, timus indeksi ve sitokin salg\u0131lama seviyesi gibi ba\u011f\u0131\u015f\u0131kl\u0131k tepkisiyle ilgili g\u00f6stergeler \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r ve bu da ba\u011f\u0131\u015f\u0131kl\u0131k yetersizli\u011fi olan fare modelinin ba\u015far\u0131l\u0131 bir \u015fekilde kuruldu\u011funu g\u00f6stermektedir. V\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu, dalak ve timus gibi ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131n i\u015flevsel durumuyla yak\u0131ndan ili\u015fkilidir ve kar\u015f\u0131l\u0131kl\u0131 olarak etkilenir. V\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k yetene\u011fi bask\u0131land\u0131\u011f\u0131nda, dalak ve timus k\u00fc\u00e7\u00fclecektir. Bu \u00e7al\u0131\u015fmada, MYR'nin farelerde MYR'nin neden oldu\u011fu dalak ve timus ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131n atrofisini hafifletti\u011fi ve ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131n a\u011f\u0131rl\u0131\u011f\u0131nda ve indeksinde bir art\u0131\u015fa yol a\u00e7t\u0131\u011f\u0131 bulunmu\u015ftur. Bu, MYR'nin farelerin ba\u011f\u0131\u015f\u0131kl\u0131k seviyesini bir dereceye kadar art\u0131rabilece\u011fini g\u00f6stermektedir. Mod grubu verileriyle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, MYR tedavisinin her \u00fc\u00e7 grubu da dalak ve timus endekslerini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rm\u0131\u015ft\u0131r ve bu e\u011filimdeki art\u0131\u015f derecesi, tedavi etkinli\u011finin ila\u00e7 dozaj\u0131na belirli bir ba\u011f\u0131ml\u0131l\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Y\u00fcksek dozlarda MYR uyguland\u0131ktan sonra her iki de\u011ferin de kontrol grubu seviyesine yak\u0131n oldu\u011funu belirtmek gerekir. Sonu\u00e7lar, MYR'nin CTX'in neden oldu\u011fu ba\u011f\u0131\u015f\u0131kl\u0131k organ\u0131 hasar\u0131n\u0131 hafifletebilece\u011fini ve ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131 \u00fczerinde ba\u011f\u0131\u015f\u0131kl\u0131k artt\u0131r\u0131c\u0131 bir etkiye sahip oldu\u011funu g\u00f6stermektedir.
\nH\u00fccresel ve humoral ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131tlar\u0131n\u0131 i\u00e7eren adaptif ba\u011f\u0131\u015f\u0131kl\u0131k sistemi, v\u00fccudu belirli patojenlerin istilas\u0131ndan koruyabilir. Lenfosit proliferasyonu, adaptif ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n aktivasyonunda \u00e7ok \u00f6nemli bir rol oynar ve genellikle hayvanlar\u0131n imm\u00fcn yan\u0131t yetene\u011fini de\u011ferlendirmek i\u00e7in kullan\u0131l\u0131r. ConA ve LPS s\u0131ras\u0131yla T ve B lenfositlerinin \u00e7o\u011falmas\u0131n\u0131 uyarabilir. MYR'nin ba\u011f\u0131\u015f\u0131kl\u0131k etkisini daha da do\u011frulamak i\u00e7in, ConA ve LPS etkisi alt\u0131ndaki lenfositlerin salg\u0131 seviyelerini tespit ettik. Deneysel sonu\u00e7lar, MYR uygulamas\u0131n\u0131n CTX'in lenfositler \u00fczerindeki inhibisyonunu \u00f6nemli \u00f6l\u00e7\u00fcde hafifletebilece\u011fini ve farkl\u0131 MYR konsantrasyonlar\u0131n\u0131n uygulanmas\u0131ndan g\u00f6zlemlenen de\u011fi\u015fikliklerin bir \u015fekilde ilac\u0131n dozaj\u0131na ba\u011fl\u0131 oldu\u011funu g\u00f6stermektedir. Ara\u015ft\u0131rmalar, CD4+T lenfositlerin CD8+T lenfositlere oran\u0131ndaki dengesizli\u011fin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu \u00fczerinde etkisi oldu\u011funu g\u00f6stermi\u015ftir. Ak\u0131\u015f sitometrisi analizi yoluyla, CTX ile tedavi edilen farelerin CD4+ve CD8+ alt gruplar\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 ve CD4+\/CD8+ alt grup oran\u0131n\u0131n d\u00fc\u015ft\u00fc\u011f\u00fc (P<0,05 veya P<0,01) bulunmu\u015ftur, bu da farelerin imm\u00fcnosupresif bir durumda oldu\u011funu g\u00f6stermektedir. Mod model grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, MYR'nin her doz grubu CD4+ve CD8+T h\u00fccre alt gruplar\u0131n\u0131n say\u0131s\u0131n\u0131 ve CD4+\/CD8+alt grup oran\u0131n\u0131 art\u0131rabilir (P<0.05 veya P<0.01), y\u00fcksek doz grubu \u00f6nemli bir doza ba\u011fl\u0131 etki g\u00f6sterir. MYR, CD4+ve CD8+h\u00fccrelerinin seviyelerini etkilemede, ba\u011f\u0131\u015f\u0131kl\u0131k dengesizliklerini d\u00fczenlemede ve normal seviyelere geri getirmede rol oynayabilir. Bu nedenle, MYR'nin hem h\u00fccresel hem de humoral ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 art\u0131rabildi\u011fini g\u00f6stermektedir ki bu da dalak ve timus indeksleri \u00fczerindeki etkilerinden \u00e7\u0131kar\u0131lan sonu\u00e7la tutarl\u0131d\u0131r.
\nSerum hemolizindeki de\u011fi\u015fiklikler molek\u00fcler d\u00fczeyde v\u00fccutta \u00fcretilen antikor miktar\u0131n\u0131 yans\u0131tabilir ve serum hemolizindeki bir art\u0131\u015f timusa ba\u011fl\u0131 h\u00fccre antijenlerine kar\u015f\u0131 spesifik antikor yan\u0131t\u0131n\u0131 art\u0131rabilir. Kontrol deneyinin veri sonu\u00e7lar\u0131na dayanarak, bo\u015f grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, CTX ile ind\u00fcklenen imm\u00fcnosupresif fare grubundaki hemolizin i\u00e7eri\u011finin azald\u0131\u011f\u0131n\u0131 ve antikor \u00fcreten h\u00fccrelerin say\u0131s\u0131n\u0131n azald\u0131\u011f\u0131n\u0131 bulduk. Farkl\u0131 MYR dozlar\u0131, CTX ile ind\u00fcklenen imm\u00fcnosupresif farelerde serum hemolizin olu\u015fumunu \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rm\u0131\u015f ve ayr\u0131ca spesifik antikor \u00fcreten h\u00fccrelerin say\u0131s\u0131 \u00fczerinde belirli bir art\u0131r\u0131c\u0131 etkiye sahip olmu\u015ftur, bu da MYR'nin farelerin h\u00fccresel ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu art\u0131rabilece\u011fini g\u00f6stermektedir. Bu art\u0131\u015fla ili\u015fkili mekanizmalar\u0131 ara\u015ft\u0131rmak i\u00e7in, MYR'nin lenfositler ve enflamatuar fakt\u00f6rler \u00fczerindeki etkileri \u00fczerine daha derinlemesine bir in vivo \u00e7al\u0131\u015fma y\u00fcr\u00fctt\u00fck.
\nBa\u011f\u0131\u015f\u0131kl\u0131k sistemindeki unsurlardan biri olan sitokinler, ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131tlar\u0131nda h\u00fccreler aras\u0131nda k\u00f6pr\u00fc ve ba\u011flant\u0131 g\u00f6revi g\u00f6rerek ba\u011f\u0131\u015f\u0131kl\u0131k ve enflamatuar yan\u0131tlar\u0131n koordine edilmesinde \u00f6nemli bir rol oynar. \u00d6rne\u011fin, TH2 h\u00fccre alt k\u00fcmeleri taraf\u0131ndan anti-enflamatuar sitokin IL-4 salg\u0131lanmas\u0131n\u0131n art\u0131r\u0131lmas\u0131, enflamasyonu kontrol edebilir ve alerjik rinit semptomlar\u0131n\u0131 iyile\u015ftirebilir. IFN - \u03b3, imm\u00fcn yan\u0131tlar\u0131n d\u00fczenlenmesinde, T h\u00fccresi olu\u015fumunun ind\u00fcklenmesinde, makrofajlar\u0131n aktive edilmesinde ve TH1 ve TH2 h\u00fccrelerinin \u00e7apraz d\u00fczenlenmesinde \u00f6nemli bir rol oynar. IL-2, imm\u00fcnosupresif veya imm\u00fcnostim\u00fclat\u00f6r etkiler g\u00f6stermek i\u00e7in Treg'i d\u00fczenleyebilir ve imm\u00fcn homeostaz s\u0131ras\u0131nda \u00f6nemli bir rol oynar. IL-4'\u00fcn hem uyar\u0131c\u0131 hem de inhibe edici \u00e7oklu imm\u00fcnomod\u00fclat\u00f6r etkileri vard\u0131r ve B h\u00fccre proliferasyonunu uyarabilir. Hematopoetik h\u00fccre geli\u015fimi ve farkl\u0131la\u015fmas\u0131n\u0131n yan\u0131 s\u0131ra IgG ve IgE imm\u00fcnoglobulin olu\u015fumunu te\u015fvik etmede \u00f6nemli bir fakt\u00f6rd\u00fcr. IL-6'n\u0131n h\u00fccreye \u00f6zg\u00fc ifadesi \u00e7e\u015fitli biyolojik reaksiyonlara yol a\u00e7abilir, akut enflamatuar yan\u0131tlarda \u00f6nemli bir arac\u0131 rol oynayabilir ve IFN - \u03b3 \u00fcretimini azaltarak efekt\u00f6r CD8 + T h\u00fccre yan\u0131tlar\u0131n\u0131 inhibe edebilir. Deneysel sonu\u00e7lar, CTX enjekte edilen farelerde IL-2 ve IL-4, IL-6 ve IFN - \u03b3 sitokinlerinin ifade seviyelerinin kontrol grubuna k\u0131yasla \u00f6nemli bir d\u00fc\u015f\u00fc\u015f e\u011filimi g\u00f6sterdi\u011fini ve IL-4 hari\u00e7 di\u011fer \u00fc\u00e7 grubun verilerindeki farkl\u0131l\u0131klar\u0131n son derece \u00f6nemli oldu\u011funu g\u00f6stermi\u015ftir. MYR, IL-2 ve IL-4, IL-6 ve IFN - \u03b3 sitokinlerinin salg\u0131lanma seviyelerini doza ba\u011fl\u0131 olarak kontrol grubunun normal aral\u0131\u011f\u0131na yakla\u015ft\u0131rarak bu fenomeni tersine \u00e7evirebilir ve farelerde CTX kaynakl\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k eksikli\u011fi \u00fczerinde iyi bir d\u00fczenleyici etkiye sahiptir. Bunlar aras\u0131nda, y\u00fcksek doz ila\u00e7 grubundaki IL-6 ve TNF - \u03b3 konsantrasyonlar\u0131 kontrol grubunun seviyelerine geri getirilmi\u015ftir. Bu sonu\u00e7, MYR'nin v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin dengesini geri kazand\u0131rd\u0131\u011f\u0131n\u0131 ve ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri ile sitokinler aras\u0131ndaki etkile\u015fimleri d\u00fczenleyerek ba\u011f\u0131\u015f\u0131kl\u0131k eksikli\u011fi semptomlar\u0131n\u0131 iyile\u015ftirdi\u011fini g\u00f6stermektedir. Genel olarak, MYR'nin Th1 h\u00fccre alt k\u00fcmeleri taraf\u0131ndan salg\u0131lanan sitokin IFN - \u03b3 \u00fcretimi \u00fczerinde Th2 h\u00fccre alt k\u00fcmeleri taraf\u0131ndan salg\u0131lanan sitokin IL-4 ve IL-6'dan daha b\u00fcy\u00fck bir etkisi vard\u0131r, bu da MYR'nin esas olarak h\u00fccresel ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu g\u00fc\u00e7lendirerek ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f model farelerin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu geli\u015ftirdi\u011fini g\u00f6sterir.
\n\u00d6zetle, MYR'nin ba\u011f\u0131\u015f\u0131kl\u0131k sistemi \u00fczerindeki etkisi karma\u015f\u0131kt\u0131r, \u00e7\u00fcnk\u00fc \u00e7e\u015fitli lenfositlerin ve enflamatuar fakt\u00f6rlerin ekspresyonunda de\u011fi\u015fikliklere neden olabilir ve bu fakt\u00f6rler aras\u0131ndaki etkile\u015fimleri d\u00fczenleyebilir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131na dayanarak, MYR'nin \u00f6zellikle y\u00fcksek doz ko\u015fullar\u0131 alt\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunda olumlu bir rol oynad\u0131\u011f\u0131 sonucuna vard\u0131k. MYR'nin CTX taraf\u0131ndan ind\u00fcklenen imm\u00fcn bask\u0131lanmay\u0131 tersine \u00e7evirebilece\u011fini g\u00f6sterdik. Bu nedenle, deneysel sonu\u00e7lar\u0131m\u0131z MYR'nin ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendirici etkisi i\u00e7in kan\u0131t ve daha fazla geli\u015ftirilmesi ve potansiyel klinik uygulamalar\u0131 i\u00e7in bilimsel temel sa\u011flamaktad\u0131r. Gelecekteki ara\u015ft\u0131rmalarda, MYR'nin d\u00fc\u015f\u00fck ba\u011f\u0131\u015f\u0131kl\u0131k veya ba\u011f\u0131\u015f\u0131kl\u0131k bozukluklar\u0131n\u0131n neden oldu\u011fu baz\u0131 hastal\u0131klar \u00fczerindeki etkisini ke\u015ffetmeye devam etmeyi umuyoruz.<\/p>","protected":false},"excerpt":{"rendered":"

The effect of myricetin on the immune function of cyclophosphamide induced immunosuppressed mice The immune system can protect organisms from infections caused by pathogens to maintain balance and overall health. Immunosuppression is a long-term or temporary immune dysfunction. Due to immune system damage, organisms become more sensitive to pathogens and have lower resistance. Even minor […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe effect of myricetin on the immune function of cyclophosphamide induced immunosuppressed mice - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/bagisiklik-sistemi-baskilanmis-fareler\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of myricetin on the immune function of cyclophosphamide induced immunosuppressed mice - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The effect of myricetin on the immune function of cyclophosphamide induced immunosuppressed mice The immune system can protect organisms from infections caused by pathogens to maintain balance and overall health. 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