{"id":7943,"date":"2024-08-11T09:53:27","date_gmt":"2024-08-11T09:53:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7943"},"modified":"2024-08-11T09:53:27","modified_gmt":"2024-08-11T09:53:27","slug":"licorice-polysaccharide-alcohol","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/licorice-polysaccharide-alcohol\/","title":{"rendered":"Meyan k\u00f6k\u00fc polisakkarit alkol \u00e7\u00f6keltme i\u015fleminin TOPSIS modeli ve BPNN modellemesi ile birlikte geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131k y\u00f6ntemine dayal\u0131 optimizasyonu"},"content":{"rendered":"

Meyan k\u00f6k\u00fc polisakkarit alkol \u00e7\u00f6keltme i\u015fleminin TOPSIS modeli ve BPNN modellemesi ile birlikte geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131k y\u00f6ntemine dayal\u0131 optimizasyonu
\nLiterat\u00fcr raporlar\u0131na g\u00f6re, meyan k\u00f6k\u00fc polisakkaritleri, anti-t\u00fcm\u00f6r, anti-inflamatuar, antiviral ve ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi gibi fizyolojik aktivitelere sahip meyan k\u00f6k\u00fcn\u00fcn ana aktif bile\u015fenlerinden biridir. Meyan k\u00f6k\u00fcn\u00fcn farmakolojik aktif bile\u015fenlerini ke\u015ffetmek i\u00e7in bir ara\u015ft\u0131rma noktas\u0131 haline gelmi\u015flerdir. \u015eu anda meyan k\u00f6k\u00fc polisakkaritleri \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar temel olarak ekstraksiyon s\u00fcre\u00e7lerine, safla\u015ft\u0131rma tekniklerine ve farmakolojik aktivite \u00e7al\u0131\u015fmalar\u0131na odaklanmaktad\u0131r. Ara\u015ft\u0131rmalar, suda \u00e7\u00f6z\u00fcnebilen meyan k\u00f6k\u00fc polisakkaritlerinin \u00e7ok bile\u015fenli, y\u00fcksek oranda dallanm\u0131\u015f ve protein ba\u011flant\u0131l\u0131 bir heteropolisakkarit oldu\u011funu g\u00f6stermi\u015ftir. Farmakolojik ara\u015ft\u0131rmalar, safla\u015ft\u0131r\u0131lm\u0131\u015f polisakkaritlerin ham polisakkaritlerden daha d\u00fc\u015f\u00fck farmakolojik aktiviteye sahip oldu\u011funu bulmu\u015ftur. Kimyasal reaktiflerin eklenmesi, karma\u015f\u0131k safla\u015ft\u0131rma ad\u0131mlar\u0131 ve protein kayb\u0131n\u0131n ana nedenler oldu\u011fu tahmin edilmektedir. Bu makale meyan k\u00f6k\u00fc, meyan k\u00f6k\u00fc polisakkaritlerindeki suda \u00e7\u00f6z\u00fcnen bile\u015fenlerin alkol \u00e7\u00f6keltme i\u015fleminin optimize edilmesine odaklanacakt\u0131r.<\/p>\n

Bilgi entropisi teorisi, objektif bir a\u011f\u0131rl\u0131kland\u0131rma y\u00f6ntemi olarak, geleneksel \u00c7in t\u0131bb\u0131 ve bile\u015fik form\u00fcllerin ekstraksiyon s\u00fcrecinde yer alan \u00e7oklu g\u00f6stergelerin optimizasyon ara\u015ft\u0131rmalar\u0131nda yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bununla birlikte, geleneksel entropi a\u011f\u0131rl\u0131k y\u00f6nteminin entropi a\u011f\u0131rl\u0131\u011f\u0131 0,5'ten b\u00fcy\u00fck oldu\u011funda, bireysel verilerdeki de\u011fi\u015fiklikler a\u011f\u0131rl\u0131\u011f\u0131n iki kat\u0131na \u00e7\u0131kmas\u0131na neden olacak ve b\u00f6ylece i\u015flem parametrelerinin belirlenmesini etkileyecektir. Bu nedenle, bu makale, eksikliklerinin etkili bir \u015fekilde \u00fcstesinden gelmek, karar verme do\u011frulu\u011funu art\u0131rmak, daha g\u00fcvenilir veriler elde etmek ve sonu\u00e7lar\u0131 daha bilimsel ve makul hale getirmek i\u00e7in geli\u015ftirilmi\u015f bir entropi a\u011f\u0131rl\u0131k y\u00f6ntemini benimsemektedir. TOPSIS y\u00f6ntemi, de\u011ferlendirme nesnesi ile idealle\u015ftirilmi\u015f hedef aras\u0131ndaki yak\u0131nl\u0131\u011fa dayal\u0131 olarak deney planlar\u0131n\u0131 s\u0131ralar ve \u00e7oklu g\u00f6stergeleri kapsaml\u0131 g\u00f6stergelere d\u00f6n\u00fc\u015ft\u00fcr\u00fcr. \u00d6rneklemin genel durumunu yans\u0131tabilen \u00e7ok g\u00f6stergeli bir karar analizi y\u00f6ntemidir. Son y\u0131llarda, akademisyenler de\u011ferlendirme g\u00f6stergelerine a\u011f\u0131rl\u0131k atamak i\u00e7in TOPSIS y\u00f6ntemini entropi a\u011f\u0131rl\u0131k y\u00f6ntemiyle birle\u015ftirmi\u015f ve b\u00f6ylece deneysel planlar\u0131 kapsaml\u0131 bir \u015fekilde de\u011ferlendirmi\u015flerdir. Bu y\u00f6ntem, deneysel sonu\u00e7larda insan fakt\u00f6rlerinin \u00f6znel m\u00fcdahalesini etkili bir \u015fekilde \u00f6nleyerek de\u011ferlendirme sonu\u00e7lar\u0131n\u0131 daha nesnel ve kapsaml\u0131 hale getirebilir. Bu y\u00f6ntem, geleneksel \u00c7in t\u0131bb\u0131 kalitesinin kapsaml\u0131 bir \u015fekilde de\u011ferlendirilmesinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r ve bu \u00e7al\u0131\u015fmadaki s\u00fcre\u00e7 optimizasyonu problemi i\u00e7in uygundur. BP sinir a\u011f\u0131 (BPNN), \u00f6nceden belirlenmi\u015f bir seviyede optimum parametreleri optimize etmede ortogonal tasar\u0131m ve y\u0131ld\u0131z noktas\u0131 tasar\u0131m\u0131 gibi geleneksel deneysel tasar\u0131mlar\u0131n s\u0131n\u0131rlamalar\u0131n\u0131 k\u0131rabilir. Karma\u015f\u0131k bilgilerin insan beyni sinir sistemi taraf\u0131ndan i\u015flenmesini sim\u00fcle ederek, karma\u015f\u0131k do\u011frusal olmayan ili\u015fkileri incelemek i\u00e7in matematiksel bir model olu\u015fturulabilir.<\/p>\n

Literat\u00fcr taramas\u0131 sonucunda alkol \u00e7\u00f6keltme s\u00fcresinin, etanol hacim fraksiyonunun ve konsantre \u00e7\u00f6zeltinin ba\u011f\u0131l yo\u011funlu\u011funun polisakkaritlerin alkol \u00e7\u00f6keltme etkisi \u00fczerinde \u00f6nemli bir etkiye sahip oldu\u011fu bulunmu\u015ftur. Bu nedenle, ara\u015ft\u0131rma grubumuz meyan k\u00f6k\u00fc polisakkaritlerini, monosakkaritleri, toplam \u015feker i\u00e7eri\u011fini ve ekstraksiyon miktar\u0131n\u0131 de\u011ferlendirme g\u00f6stergeleri olarak kulland\u0131, deneysel verileri geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131k y\u00f6ntemi ve entropi a\u011f\u0131rl\u0131k TOPSIS y\u00f6ntemi kullanarak i\u015fledi, meyan k\u00f6k\u00fc polisakkarit alkol \u00e7\u00f6keltmesinin ana fakt\u00f6rlerini inceledi, ortogonal tasar\u0131mda iki analiz y\u00f6nteminin uygulanabilirli\u011fini kar\u015f\u0131la\u015ft\u0131rd\u0131, Optimal alkol \u00e7\u00f6keltme s\u00fcrecini belirlemi\u015f ve ard\u0131ndan meyan k\u00f6k\u00fc polisakkaritlerinin haz\u0131rlanmas\u0131 i\u00e7in istikrarl\u0131 ve uygulanabilir bir alkol \u00e7\u00f6keltme s\u00fcreci se\u00e7mek ve daha fazla geli\u015ftirilmesi, kullan\u0131lmas\u0131 ve kapsaml\u0131 kalite kontrol\u00fc i\u00e7in bilimsel temel sa\u011flamak amac\u0131yla meyan k\u00f6k\u00fc polisakkaritleri i\u00e7in optimum alkol \u00e7\u00f6keltme s\u00fcreci parametrelerini aramak \u00fczere sim\u00fclasyon optimizasyonu i\u00e7in BP sinir a\u011f\u0131 modellemesini kullanm\u0131\u015ft\u0131r.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nGeleneksel \u00c7in t\u0131bb\u0131n\u0131n farmakolojik etkileri, birden fazla bile\u015fenin koordineli hareketinin sonucudur ve geleneksel \u00c7in t\u0131bb\u0131 \u00f6z\u00fctlerinde bulunan kar\u0131\u015f\u0131k toplam \u015fekerler, polisakkaritlerin farmakolojik etkilerini daha iyi g\u00f6stermelerini sa\u011flamak i\u00e7in birlikte \u00e7al\u0131\u015f\u0131r. Sekt\u00f6rde \"polisakkaritler ne kadar safsa, aktivite o kadar d\u00fc\u015f\u00fckt\u00fcr\" \u015feklinde bir g\u00f6r\u00fc\u015f vard\u0131r. Meyan k\u00f6k\u00fcndeki polisakkaritlerin ekstraksiyonu ve alkolle \u00e7\u00f6kt\u00fcr\u00fclmesi s\u00fcrecine ili\u015fkin \u00f6nceki literat\u00fcr, esas olarak ekstraksiyon miktar\u0131n\u0131 ve polisakkarit i\u00e7eri\u011fini (veya verimini) g\u00f6sterge olarak de\u011ferlendirmi\u015ftir ve optimizasyon sonu\u00e7lar\u0131n\u0131n polisakkaritlerin karma\u015f\u0131k yap\u0131s\u0131n\u0131 yans\u0131tmas\u0131 zordur. Mevcut ara\u015ft\u0131rmalarda ekstraksiyon hammaddesi olarak \u00e7o\u011funlukla meyan k\u00f6k\u00fc tozu kullan\u0131lmakta ve sonraki a\u015famada elde edilen ham polisakkaritlerin Savage y\u00f6ntemi, eter, aseton, metanol ve di\u011fer kimyasal reaktif y\u00f6ntemleri ile safla\u015ft\u0131r\u0131lmas\u0131 gerekmektedir. Safla\u015ft\u0131rma i\u015fleminde kullan\u0131lan reaktifler insan v\u00fccudu i\u00e7in nispeten zararl\u0131d\u0131r. Erken k\u0131rma i\u015flemi, etanol veya eter ya\u011f giderme i\u015flemleri sadece \u00fcretim maliyetlerini ve zaman\u0131 art\u0131rmakla kalmaz, ayn\u0131 zamanda operat\u00f6rlerin fiziksel ve zihinsel sa\u011fl\u0131\u011f\u0131n\u0131 da ciddi \u015fekilde tehlikeye atar. Ayr\u0131ca, safs\u0131zl\u0131k giderme ve ya\u011f giderme i\u00e7in kullan\u0131lan kimyasal reaktifler \u00e7o\u011funlukla geleneksel \u00c7in t\u0131bb\u0131 preparatlar\u0131n\u0131n \u00fcretiminde yasaklanm\u0131\u015ft\u0131r. Bu nedenle, meyan k\u00f6k\u00fc polisakkaritlerinin alkol \u00e7\u00f6keltme s\u00fcrecini optimize etmek i\u00e7in, bu \u00e7al\u0131\u015fma meyan k\u00f6k\u00fc kaynatma par\u00e7alar\u0131n\u0131 ara\u015ft\u0131rma nesnesi olarak almaktad\u0131r. Tek fakt\u00f6rl\u00fc deneylere dayanarak, konsantrasyon oran\u0131, alkol \u00e7\u00f6keltme s\u00fcresi ve etanol hacim fraksiyonu gibi ana fakt\u00f6rler se\u00e7ilmi\u015f ve meyan k\u00f6k\u00fc polisakkaritleri, toplam \u015fekerler, monosakkarit i\u00e7eri\u011fi ve ekstraksiyon miktar\u0131 de\u011ferlendirme g\u00f6stergeleri olarak kullan\u0131lm\u0131\u015ft\u0131r. Ortogonal deneysel verileri i\u015flemek i\u00e7in TOPSIS model y\u00f6ntemi ile birle\u015ftirilmi\u015f geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131k y\u00f6ntemi ve proses optimizasyonu i\u00e7in BPNN modelleme sim\u00fclasyonu kullan\u0131lm\u0131\u015ft\u0131r. Geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131\u011f\u0131 y\u00f6ntemini tek ba\u015f\u0131na kullanma sonu\u00e7lar\u0131 ile geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131\u011f\u0131 ile birle\u015ftirilmi\u015f TOPSIS y\u00f6nteminin sonu\u00e7lar\u0131 kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131\u011f\u0131 TOPSIS y\u00f6nteminin orijinal veri bilgilerini tam olarak kullanabildi\u011fi, optimum parametre kombinasyonunu elde etmek i\u00e7in ortogonal deney sonu\u00e7lar\u0131n\u0131 kapsaml\u0131 bir \u015fekilde de\u011ferlendirebildi\u011fi, optimizasyon s\u00fcrecinde \u00f6znel fakt\u00f6rlerden etkili bir \u015fekilde ka\u00e7\u0131nabildi\u011fi, karar verme do\u011frulu\u011funu ve bilimselli\u011fini geli\u015ftirdi\u011fi ve sonu\u00e7lar\u0131 daha g\u00fcvenilir hale getirdi\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Son olarak, meyan k\u00f6k\u00fc polisakkaritleri i\u00e7in en uygun alkol \u00e7\u00f6keltme i\u015flemi, ekstraksiyon \u00e7\u00f6zeltisini 2,5 mL\/g'a konsantre etmek, etanol hacim oran\u0131n\u0131 70%'ye ayarlamak ve 20 saat boyunca \u00e7\u00f6keltmek olarak belirlenmi\u015ftir.
\nOrtogonal deneyler temelinde, Matlab 12.0 yaz\u0131l\u0131m\u0131 kullan\u0131larak bir BP sinir a\u011f\u0131 modeli olu\u015fturulmu\u015ftur. Ortogonal deney verilerinin \u00f6\u011frenilmesi ve e\u011fitilmesiyle, iyi do\u011fruluk, kararl\u0131l\u0131k ve g\u00fcvenilirli\u011fe sahip bir a\u011f modeli elde edilmi\u015ftir. Sim fonksiyonu sim\u00fclasyon optimizasyonu kullan\u0131larak optimum s\u00fcre\u00e7 \u015fu \u015fekilde elde edilmi\u015ftir: ekstraksiyon \u00e7\u00f6zeltisini 2,0 mL\/g'a konsantre etmek, etanol hacim oran\u0131n\u0131 67%'ye ayarlamak ve 24 saat boyunca alkol ile \u00e7\u00f6keltmek. S\u00fcre\u00e7 do\u011frulamas\u0131ndan sonra, BPNN modelleme optimizasyon sonucunun kapsaml\u0131 puan\u0131n\u0131n, kapsaml\u0131 puanlama y\u00f6nteminden ve geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131\u011f\u0131 TOPSIS y\u00f6nteminden biraz daha d\u00fc\u015f\u00fck oldu\u011fu, ancak RSD de\u011ferinin k\u00fc\u00e7\u00fck oldu\u011fu bulunmu\u015ftur. BP sinir a\u011f\u0131 g\u00fc\u00e7l\u00fc bir kendi kendine \u00f6\u011frenme yetene\u011fine sahiptir ve ortaya \u00e7\u0131kan s\u00fcre\u00e7 daha kararl\u0131d\u0131r. Bu nedenle, BPNN modelleme optimizasyon sonucunun meyan k\u00f6k\u00fc polisakkarit alkol \u00e7\u00f6keltmesi i\u00e7in en uygun s\u00fcre\u00e7 oldu\u011fu belirlenmi\u015ftir.<\/p>\n

Bu deney, meyan k\u00f6k\u00fc polisakkaritlerinin alkol \u00e7\u00f6kelmesini etkileyen fakt\u00f6rlerin seviyesini tek fakt\u00f6rl\u00fc bir \u00e7al\u0131\u015fma ile belirlemi\u015f, deneyi ortogonal tasar\u0131m kullanarak d\u00fczenlemi\u015f ve deneysel verileri, belirli bir g\u00f6stergenin entropi a\u011f\u0131rl\u0131\u011f\u0131ndaki k\u00fc\u00e7\u00fck de\u011fi\u015fikliklerin kar\u015f\u0131l\u0131k gelen a\u011f\u0131rl\u0131k ikiye katlama de\u011fi\u015fikliklerine neden oldu\u011fu geleneksel entropi a\u011f\u0131rl\u0131k y\u00f6ntemlerinin eksikliklerinin \u00fcstesinden gelmek i\u00e7in geli\u015ftirilmi\u015f bir entropi a\u011f\u0131rl\u0131k y\u00f6ntemi kullanarak i\u015flemi\u015ftir. Meyan k\u00f6k\u00fc polisakkaritlerinin alkol \u00e7\u00f6keltme s\u00fcrecini optimize etmek amac\u0131yla kapsaml\u0131 de\u011ferlendirme i\u00e7in birden fazla g\u00f6sterge se\u00e7ilmi\u015ftir. Kapsaml\u0131 puanlama y\u00f6ntemi ve geli\u015ftirilmi\u015f entropi a\u011f\u0131rl\u0131\u011f\u0131 TOPSIS y\u00f6nteminin sonu\u00e7lar\u0131 kar\u015f\u0131la\u015ft\u0131r\u0131larak meyan k\u00f6k\u00fc polisakkarit alkol \u00e7\u00f6keltmesini etkileyen fakt\u00f6rlerin \u00f6nemi belirlenmi\u015ftir. Ortogonal parametre \u00f6\u011frenimi, sim\u00fclasyon optimizasyonu i\u00e7in bir B sinir a\u011f\u0131 kullan\u0131larak e\u011fitilmi\u015ftir. Do\u011frusal olmayan problemler modellenmi\u015f ve deney say\u0131s\u0131n\u0131 art\u0131rmadan optimize edilerek \u00f6nceki optimizasyon deneylerinin eksiklikleri giderilmi\u015ftir. Elde edilen proses parametreleri daha bilimsel ve g\u00fcvenilirdi, meyan k\u00f6k\u00fc polisakkaritlerinin daha fazla geli\u015ftirilmesi, ara\u015ft\u0131r\u0131lmas\u0131 ve b\u00fcy\u00fck \u00f6l\u00e7ekli \u00fcretimi i\u00e7in nesnel bir temel sa\u011flad\u0131 ve ilgili proses optimizasyonu sorunlar\u0131 i\u00e7in yeni fikirler sa\u011flad\u0131.<\/p>","protected":false},"excerpt":{"rendered":"

Optimization of licorice polysaccharide alcohol precipitation process based on improved entropy weight method combined with TOPSIS model and BPNN modeling According to literature reports, licorice polysaccharides are one of the main active ingredients of licorice, with physiological activities such as anti-tumor, anti-inflammatory, antiviral, and immune regulation. 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