{"id":7605,"date":"2024-08-06T20:40:40","date_gmt":"2024-08-06T20:40:40","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7605"},"modified":"2024-08-06T20:40:40","modified_gmt":"2024-08-06T20:40:40","slug":"panlong-seven-tablets","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/panlong-seven-tablets\/","title":{"rendered":"Panlong Seven Tabletlerde anti-enflamatuar ve analjezik alkaloidlerin e\u015fzamanl\u0131 tayini \u00fczerine metodolojik \u00e7al\u0131\u015fma"},"content":{"rendered":"<p>Panlong Seven Tabletlerde anti-enflamatuar ve analjezik alkaloidlerin e\u015fzamanl\u0131 tayini \u00fczerine metodolojik \u00e7al\u0131\u015fma<br \/>\nPanlong Seven Tablet, geleneksel \u00c7in t\u0131bb\u0131nda kemik hasar\u0131 uygulay\u0131c\u0131lar\u0131 olarak tan\u0131nm\u0131\u015f bir aile olan Wang Jiacheng taraf\u0131ndan sunulan gizli tariften t\u00fcretilen 29 geleneksel \u00c7in ilac\u0131ndan olu\u015fan bir bile\u015fik preparatt\u0131r. Klinik olarak, esas olarak romatizma, bel kas\u0131 gerginli\u011fi ve yumu\u015fak doku yaralanmas\u0131n\u0131n neden oldu\u011fu a\u011fr\u0131, \u015fi\u015fme ve di\u011fer durumlar\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131r. Ara\u015ft\u0131rmalar, alkaloidlerin Panlong Seven Tablet'in ana bile\u015fenlerinden biri oldu\u011funu ve enflamatuar fakt\u00f6rleri azaltarak, makrofaj polarizasyonunu ve di\u011fer yollar\u0131 d\u00fczenleyerek anti-enflamatuar ve analjezik etkiler g\u00f6sterdi\u011fini g\u00f6stermi\u015ftir. Modern farmakolojinin sonu\u00e7lar\u0131, baz\u0131 alkaloidlerin hem aktif hem de toksik bile\u015fenler oldu\u011funu ve yanl\u0131\u015f kullan\u0131ld\u0131\u011f\u0131nda ciddi advers reaksiyonlara yol a\u00e7abilece\u011fini g\u00f6stermektedir. \u015eu anda, Panlongqi Tabletlerinin kalite kontrol standard\u0131 (Ulusal geleneksel \u00c7in patentli ila\u00e7lar ve basit preparatlar \u00dcr\u00fcn Standard\u0131 WS3-B-3998-98-1) alkaloidlerin i\u00e7eri\u011fini belirlememektedir. Bu nedenle, Panlong Yedi Tablet'in kalite kontrol seviyesini iyile\u015ftirmek ve klinik g\u00fcvenli\u011fini ve etkinli\u011fini sa\u011flamak i\u00e7in, bu \u00e7al\u0131\u015fmada Panlong Yedi Tablet'teki anti-enflamatuar ve analjezik etkilere sahip alkaloid bile\u015fenlerini karakterize etmek i\u00e7in UPLC-Q-TOF-MS\/MS kullan\u0131lm\u0131\u015f ve ard\u0131ndan i\u00e7eriklerinin e\u015fzamanl\u0131 olarak belirlenmesi i\u00e7in nicel bir y\u00f6ntem olu\u015fturularak Panlong Yedi Tablet'in kalite kontrol seviyesini iyile\u015ftirmek i\u00e7in bir veri temeli sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7606\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-319.png\" alt=\"\" width=\"663\" height=\"331\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7607\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-271.png\" alt=\"\" width=\"664\" height=\"230\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7608\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-256.png\" alt=\"\" width=\"663\" height=\"217\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7609\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-236.png\" alt=\"\" width=\"659\" height=\"484\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7610\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-212.png\" alt=\"\" width=\"665\" height=\"834\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-212.png 665w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-212-574x720.png 574w\" sizes=\"(max-width: 665px) 100vw, 665px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7611\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-18.jpg\" alt=\"\" width=\"656\" height=\"788\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-18.jpg 656w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-18-599x720.jpg 599w\" sizes=\"(max-width: 656px) 100vw, 656px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7612\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-178.png\" alt=\"\" width=\"662\" height=\"788\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-178.png 662w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-178-605x720.png 605w\" sizes=\"(max-width: 662px) 100vw, 662px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7613\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-159.png\" alt=\"\" width=\"661\" height=\"682\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7614\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-145.png\" alt=\"\" width=\"664\" height=\"460\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7615\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-115.png\" alt=\"\" width=\"662\" height=\"333\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7616\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-108.png\" alt=\"\" width=\"663\" height=\"115\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7617\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-90.png\" alt=\"\" width=\"660\" height=\"658\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-90.png 660w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-90-200x200.png 200w\" sizes=\"(max-width: 660px) 100vw, 660px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7618\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-76.png\" alt=\"\" width=\"336\" height=\"393\" \/><br \/>\nTest \u00e7\u00f6zeltisi i\u00e7in test ko\u015fullar\u0131n\u0131n ve haz\u0131rlama y\u00f6ntemlerinin se\u00e7imi. Alkaloid bile\u015fenlerinin yap\u0131sal ve polar \u00f6zellikleri dikkate al\u0131narak, pozitif ve negatif iyon modlar\u0131n\u0131n ayr\u0131 ayr\u0131 tespit edildi\u011fi MRM tarama modu benimsenmi\u015ftir. Pozitif iyon modu, yan\u0131t de\u011ferlerine ve kromatografik piklerin say\u0131s\u0131na g\u00f6re tespit i\u00e7in se\u00e7ilir. Ekstraksiyon y\u00f6ntemlerinin (ultrason, \u0131s\u0131tma refl\u00fcs\u00fc) ve ekstraksiyon \u00e7\u00f6z\u00fcc\u00fclerinin (susuz etanol, 70% metanol, 100% metanol) Panlong Seven Tablet'ten alkaloidlerin ekstraksiyonu \u00fczerindeki etkileri ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Kapsaml\u0131 kromatografik pik \u015fekilleri ve yan\u0131t de\u011ferlerine dayanarak, bu \u00e7al\u0131\u015fmada Panlong Seven Tablet'teki alkaloidler i\u00e7in ekstraksiyon y\u00f6ntemi olarak 25 dakika s\u00fcreyle metanol ultrason ekstraksiyonu se\u00e7ilmi\u015ftir.<br \/>\nPotansiyel kalite kontrol bile\u015fen g\u00f6stergelerinin taranmas\u0131. Alkaloidler, Panlong Seven Tablet'in anti-enflamatuar ve analjezik etki g\u00f6steren \u00f6nemli bile\u015fenlerinden biridir. Bunlar aras\u0131nda, y\u00fcksek i\u00e7erikli monoester alkaloidler benzoil akonitin, benzoil neoakonitin ve benzoil hipakonitin, diester alkaloidler akonitin, neoakonitin ve hipakonitinden hidrolize edilir. Anti-enflamatuar, anti romatizmal ve artrit tedavisi gibi farmakolojik etkilerini korurken, toksisiteleri b\u00fcy\u00fck \u00f6l\u00e7\u00fcde azal\u0131r. Alkaloid g\u00f6sterge bile\u015fenleri \u00fczerine yap\u0131lan ilgili ara\u015ft\u0131rmalara dayanarak, bu makale benzoil akonitin, benzoil neoakonitin ve benzoil akonitini potansiyel kalite g\u00f6sterge bile\u015fenleri olarak se\u00e7mektedir. Akonitin alkaloidlerinin hidroliz modu \u015eekil 3'te g\u00f6sterilmektedir.<br \/>\n\u0130zokinolin alkaloidleri i\u00e7eri\u011findeki farkl\u0131l\u0131klar. \u0130zokinolin alkaloidlerin i\u00e7eri\u011findeki farkl\u0131l\u0131klar\u0131n 8 parti numunede kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131yla, berberin hidroklor\u00fcr, dihidroberin hidroklor\u00fcr, berberin hidroklor\u00fcr, dihidrokersetin hidroklor\u00fcr i\u00e7eri\u011finin y\u00fcksek oldu\u011fu bulunmu\u015ftur, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine hydrochloride, berberine. Bunun olas\u0131 nedeni, berberinin termal karars\u0131zl\u0131k nedeniyle serbest halde berberine ayr\u0131\u015fan bir kuaterner amonyum alkaloidi olmas\u0131 olabilir. Panlong Seven Tablet'teki flavonoidler gibi asidik bile\u015fenlerle birle\u015ferek tuzlar olu\u015fturur ve berberin hidroklor\u00fcr i\u00e7eri\u011finde de\u011fi\u015fikliklere neden olur.<br \/>\nPanlong Seven Tablet, klinik uygulamada romatizmal ve kemik a\u011fr\u0131s\u0131 hastal\u0131klar\u0131n\u0131n tedavisinde \u00f6nemli bir ila\u00e7t\u0131r. Toksik alkaloid bile\u015fenleri nedeniyle, ilac\u0131n g\u00fcvenli\u011fine daha fazla dikkat edilmelidir. Bu nedenle, UPLC-Q-TOF-MS teknolojisi kullan\u0131larak Panlong Seven Tablet'teki 17 alkaloid bile\u015fenin karakterizasyonuna dayanan bu makale, Panlong Seven Tablet'teki alkaloid bile\u015fenlerin e\u015fzamanl\u0131 tayini i\u00e7in bir s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi y\u00f6ntemi olu\u015fturmu\u015ftur. Olu\u015fturulan y\u00f6ntem do\u011fru ve g\u00fcvenilirdir ve Panlong Seven Tablet'in kalite kontrol seviyesini iyile\u015ftirmek i\u00e7in bir temel sa\u011flayabilir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Methodological study on simultaneous determination of anti-inflammatory and analgesic alkaloids in Panlong Seven Tablets Panlong Seven Tablets is a compound preparation composed of 29 traditional Chinese medicines, derived from the secret recipe presented by Wang Jiacheng, a renowned family of bone injury practitioners in traditional Chinese medicine. Clinically, it is mainly used to treat pain, [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Methodological study on simultaneous determination of anti-inflammatory and analgesic alkaloids in Panlong Seven Tablets - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/panlong-seven-tablets\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Methodological study on simultaneous determination of anti-inflammatory and analgesic alkaloids in Panlong Seven Tablets - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Methodological study on simultaneous determination of anti-inflammatory and analgesic alkaloids in Panlong Seven Tablets Panlong Seven Tablets is a compound preparation composed of 29 traditional Chinese medicines, derived from the secret recipe presented by Wang Jiacheng, a renowned family of bone injury practitioners in traditional Chinese medicine. 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Clinically, it is mainly used to treat pain, [&hellip;]","og_url":"https:\/\/longchangextracts.com\/tr\/panlong-seven-tablets\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-06T20:40:40+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-319.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"6 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/","url":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/","name":"Panlong Seven Tabletlerde anti-enflamatuar ve analjezik alkaloidlerin e\u015fzamanl\u0131 tayini \u00fczerine metodolojik \u00e7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-319.png","datePublished":"2024-08-06T20:40:40+00:00","dateModified":"2024-08-06T20:40:40+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/panlong-seven-tablets\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-319.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-319.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/panlong-seven-tablets\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Methodological study on simultaneous determination of anti-inflammatory and analgesic alkaloids in Panlong Seven Tablets"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/7605"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=7605"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/7605\/revisions"}],"predecessor-version":[{"id":7619,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/7605\/revisions\/7619"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=7605"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=7605"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=7605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}