{"id":7563,"date":"2024-08-06T20:32:26","date_gmt":"2024-08-06T20:32:26","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7563"},"modified":"2024-08-06T20:32:26","modified_gmt":"2024-08-06T20:32:26","slug":"immobilized-betulinic-acid-affinity-integral-column","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/immobilized-betulinic-acid-affinity-integral-column\/","title":{"rendered":"\u0130mmobilize betulinik asit afinite integral kolonu haz\u0131rlama y\u00f6ntemi ve uygulamas\u0131"},"content":{"rendered":"<p>\u0130mmobilize betulinik asit afinite integral kolonu haz\u0131rlama y\u00f6ntemi ve uygulamas\u0131<br \/>\n23 hidroksi betulinik asit (23-HBA), Ranunculaceae familyas\u0131ndaki geleneksel \u00c7in t\u0131bb\u0131 bitkisi Pulsatilla chinensis'ten izole edilen lupin tipi pentasiklik triterpenoid bir bile\u015fiktir. Betula pubescens, Ziziphus mauritiana, Prunella vulgaris, Apocynaceae gibi \u00e7e\u015fitli bitkilerde de da\u011f\u0131l\u0131m g\u00f6sterir ve \u00f6zellikle Betula ailesinde bol miktarda bulunur. Modern farmakolojik ara\u015ft\u0131rmalar, antiviral, t\u00fcm\u00f6r h\u00fccresi proliferasyon inhibisyonu, anjiyogenez inhibisyonu ve kombine hassasiyet gibi bir dizi etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. \u00d6rne\u011fin, bu t\u00fcr bir bile\u015fik benzersiz bir etki mekanizmas\u0131na, son derece d\u00fc\u015f\u00fck toksisiteye ve minimum yan etkiye sahiptir, bu da onu anti-HIV-1 tedavisi i\u00e7in olduk\u00e7a umut verici bir aday bile\u015fik haline getirir; \u00d6rne\u011fin, 23-HBA'n\u0131n bir\u00e7ok t\u00fcrevi, ornitin dekarboksilaz gibi h\u00fccre hayatta kalmas\u0131 ve b\u00fcy\u00fcmesi i\u00e7in gerekli olan spesifik enzimleri inhibe ederek rektal kanser, akci\u011fer kanseri, l\u00f6semi, lenfoma, prostat kanseri, yumurtal\u0131k kanseri gibi \u00e7e\u015fitli t\u00fcm\u00f6rlerin ve kanser h\u00fccrelerinin biyolojik aktivitesini de inhibe edebilir. Bu nedenle, 23-HBA \u00f6nemli ara\u015ft\u0131rma de\u011ferine sahip lider bir bile\u015fik olarak kabul edilir.<br \/>\nSon y\u0131llarda, ara\u015ft\u0131rma grubumuz 23-HBA'n\u0131n t\u00fcrevlendirilmesi \u00fczerine sistematik \u00e7al\u0131\u015fmalar y\u00fcr\u00fctm\u00fc\u015f ve daha iyi aktiviteye sahip 23-HBA'n\u0131n \u00f6nemli t\u00fcrevi 3,23-diasetil-17-asetik asit betulinik asidi (bundan sonra T\u00fcretilmi\u015f BA olarak an\u0131lacakt\u0131r) elde etmi\u015ftir. Bununla birlikte, bu t\u00fcr 23-HBA t\u00fcrevlerinin etki mekanizmas\u0131 \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar hen\u00fcz emekleme a\u015famas\u0131ndad\u0131r ve hedefleri hakk\u0131nda \u00e7ok az rapor vard\u0131r, bu da belirsiz hedefler ve mekanizmalar ikilemiyle kar\u015f\u0131 kar\u015f\u0131yad\u0131r. Bu nedenle, do\u011fal \u00fcr\u00fcnlerin protein\/enzim hedeflerini belirlemek ve tan\u0131mlamak i\u00e7in etkili, h\u0131zl\u0131 ve basit bir y\u00f6ntem geli\u015ftirmek \u00e7ok geni\u015f ve \u00f6nemli bir uygulama beklentisine sahiptir. Son y\u0131llarda, ila\u00e7 hedef proteinlerinin ke\u015ffi ve ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in \u00e7e\u015fitli teknolojik ara\u00e7lar\u0131n bulundu\u011funu belirtmek gerekir; Bunlar aras\u0131nda, afinite zenginle\u015ftirme bal\u0131k\u00e7\u0131l\u0131\u011f\u0131na dayanan kimyasal proteomik teknolojisi, biyomolek\u00fcller aras\u0131ndaki spesifik etkile\u015fimleri kullanabilir veya sim\u00fcle edebilir ve karma\u015f\u0131k kar\u0131\u015f\u0131mlardan belirli maddeleri se\u00e7ici olarak analiz etmek ve safla\u015ft\u0131rmak i\u00e7in kromatografi i\u00e7in sabit bir faz g\u00f6revi g\u00f6rebilir. Bu nedenle, y\u00fcksek verim ve d\u00fc\u015f\u00fck maliyet gibi \u00f6nemli avantajlarla k\u00fc\u00e7\u00fck molek\u00fcll\u00fc ila\u00e7 protein hedeflerini incelemek i\u00e7in ana y\u00f6ntemlerden biri haline gelmi\u015ftir. \u015eimdiye kadar, afinite kromatografisi takrolimus, siklosporin, metotreksat gibi \u00e7e\u015fitli ila\u00e7lar\u0131n hedef proteinlerinin ara\u015ft\u0131r\u0131lmas\u0131nda ba\u015far\u0131yla uygulanm\u0131\u015ft\u0131r. 23-HBA t\u00fcrevleri ile ba\u011flanm\u0131\u015f yeni bir afinite kromatografi kolonu haz\u0131rlayarak, ilgili hedef proteinleri ke\u015ffetmek i\u00e7in h\u00fccrelerden veya dokulardan ekstrakte edilen proteinlerin afinite taramas\u0131n\u0131 ara\u015ft\u0131r\u0131yoruz. Bunun, do\u011fal \u00fcr\u00fcnlerin hedef proteinlerini aramak ve incelemek i\u00e7in yeni fikirler ve y\u00f6ntemler olu\u015fturmas\u0131 beklenmektedir; Ayn\u0131 zamanda, k\u00fc\u00e7\u00fck molek\u00fcll\u00fc do\u011fal \u00fcr\u00fcnler ile farkl\u0131 hedefler aras\u0131ndaki etkile\u015fimi incelemek i\u00e7in de \u00f6nemli bir ara\u015ft\u0131rma platformu sa\u011flamaktad\u0131r.<br \/>\nYayg\u0131n afinite zenginle\u015ftirme matris malzemeleri aras\u0131nda silika jel iyi kromatografik performansa sahiptir, ancak asit ve alkali direnci zay\u0131ft\u0131r; Re\u00e7ine ve agaroz geni\u015f bir pH aral\u0131\u011f\u0131 i\u00e7in uygundur, ancak zay\u0131f mekanik mukavemete sahiptir. Monolitik kolon, h\u0131zl\u0131 analiz ve ak\u0131\u015f h\u0131z\u0131 gradyan modu i\u00e7in uygun olan bir kromatografik kolonda monomerler, \u00e7apraz ba\u011flay\u0131c\u0131lar, ba\u015flat\u0131c\u0131lar ve g\u00f6zenek olu\u015fturucu maddelerin bir kar\u0131\u015f\u0131m\u0131n\u0131n yerinde polimerizasyonu ile olu\u015fturulan s\u00fcrekli yatakl\u0131 bir sabit fazd\u0131r. Geleneksel paketlenmi\u015f kolonlarla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, basit haz\u0131rlama y\u00f6ntemi, kolay modifikasyon, y\u00fcksek kolon verimlili\u011fi, iyi ge\u00e7irgenlik, d\u00fc\u015f\u00fck geri bas\u0131n\u00e7 ve h\u0131zl\u0131 k\u00fctle aktar\u0131m h\u0131z\u0131 avantajlar\u0131na sahiptir; Ayn\u0131 zamanda, biyomolek\u00fcllerin ayr\u0131lmas\u0131 ve analizinde b\u00fcy\u00fck avantajlara sahip olan kontrol edilebilir g\u00f6zenek boyutu avantaj\u0131na da sahiptir. Bu nedenle, asit ve alkali direncine ve iyi biyouyumlulu\u011fa dayanan yeni polimer bazl\u0131 d\u00f6kme malzeme afinite kromatografisinin geli\u015ftirilmesi \u00f6nemli teorik ve pratik \u00f6neme sahiptir.<br \/>\n\u015eu anda 23-HBA bile\u015fikleri ile ba\u011flanm\u0131\u015f organik polimer monolitik kolonlar hakk\u0131nda literat\u00fcrde herhangi bir rapor bulunmamaktad\u0131r. Bu \u00e7al\u0131\u015fmada, 100 \u03bcm I.D. (i\u00e7 \u00e7ap) kapiler kolonda in-situ termal polimerizasyon yoluyla yeni bir immobilize 23 HBA hedef polimer monolitik kolon poli (GMA-EDA-BA-co EDMA) haz\u0131rlamak i\u00e7in daha \u00f6nce bildirilen \"tek pot y\u00f6ntemi\" kullan\u0131lm\u0131\u015ft\u0131r; Ayn\u0131 zamanda, haz\u0131rlanan monolitik kolonun bile\u015fimini ve oran\u0131n\u0131 kapsaml\u0131 bir \u015fekilde ara\u015ft\u0131rd\u0131k ve etki mekanizmas\u0131n\u0131 ara\u015ft\u0131rd\u0131k.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7564\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-315.png\" alt=\"\" width=\"1052\" height=\"372\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-315.png 1052w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-315-768x272.png 768w\" sizes=\"(max-width: 1052px) 100vw, 1052px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7565\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-267.png\" alt=\"\" width=\"1052\" height=\"315\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-267.png 1052w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-267-768x230.png 768w\" sizes=\"(max-width: 1052px) 100vw, 1052px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7566\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-252.png\" alt=\"\" width=\"1052\" height=\"308\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-252.png 1052w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-252-768x225.png 768w\" sizes=\"(max-width: 1052px) 100vw, 1052px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7567\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-232.png\" alt=\"\" width=\"1062\" height=\"427\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-232.png 1062w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-232-768x309.png 768w\" sizes=\"(max-width: 1062px) 100vw, 1062px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7568\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-208.png\" alt=\"\" width=\"1110\" height=\"361\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-208.png 1110w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-208-768x250.png 768w\" sizes=\"(max-width: 1110px) 100vw, 1110px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7569\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-191.png\" alt=\"\" width=\"1100\" height=\"330\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-191.png 1100w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-191-768x230.png 768w\" sizes=\"(max-width: 1100px) 100vw, 1100px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7570\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-175.png\" alt=\"\" width=\"670\" height=\"455\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7571\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-156.png\" alt=\"\" width=\"1100\" height=\"368\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-156.png 1100w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-156-768x257.png 768w\" sizes=\"(max-width: 1100px) 100vw, 1100px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7572\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-144.png\" alt=\"\" width=\"640\" height=\"415\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7573\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-114.png\" alt=\"\" width=\"1062\" height=\"430\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-114.png 1062w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-114-768x311.png 768w\" sizes=\"(max-width: 1062px) 100vw, 1062px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7574\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-107.png\" alt=\"\" width=\"660\" height=\"510\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7575\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-89.png\" alt=\"\" width=\"1068\" height=\"446\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-89.png 1068w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-89-768x321.png 768w\" sizes=\"(max-width: 1068px) 100vw, 1068px\" \/><br \/>\nBu makalede, do\u011fal \u00fcr\u00fcnlerin k\u00fc\u00e7\u00fck molek\u00fcllerini immobilize etmek i\u00e7in bir afinite kromatografi kolonu haz\u0131rlamak i\u00e7in bir y\u00f6ntem ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. \u0130lk olarak, aktif etilendiamin gruplar\u0131na sahip EDA-BA fonksiyonel monomerleri (ligandlar), aktiviteyi \u00f6nemli \u00f6l\u00e7\u00fcde etkilemeyen 28 pozisyonu de\u011fi\u015ftirilerek sentezlenmi\u015ftir. Poli (GMA-EDA-BA co EDMA) integral kromatografi kolonlar\u0131, di\u011fer monomerler ve \u00e7apraz ba\u011flama ajanlar\u0131 ile \"tek pot y\u00f6ntemi\" ile haz\u0131rlanm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fman\u0131n \u00f6z\u00fc, tan\u0131t\u0131m de\u011feri olan do\u011fal \u00fcr\u00fcnlerin k\u00fc\u00e7\u00fck molek\u00fcllerini immobilize etmek i\u00e7in bir afinite kromatografi kolonu haz\u0131rlama y\u00f6ntemi geli\u015ftirmektir. \"Tek pot y\u00f6ntemi\", sadece zamandan tasarruf etmek ve monomer bile\u015fiklerinin safla\u015ft\u0131rma maliyetini d\u00fc\u015f\u00fcrmekle kalmay\u0131p ayn\u0131 zamanda kromatografik kolonun afinitesini de koruyarak haz\u0131rl\u0131k verimlili\u011finde b\u00fcy\u00fck avantajlara sahiptir. Bununla birlikte, fonksiyonel monomerlerin (ligandlar\u0131n) ticarile\u015ftirilme seviyesi, y\u00f6ntemin daha fazla tan\u0131t\u0131m de\u011ferini belirler; \u015eu anda, baz\u0131 eksiklikleri olan her k\u00fc\u00e7\u00fck molek\u00fcle dayal\u0131 t\u00fcrev tasar\u0131m\u0131 yapmak hala gereklidir. Bu afinite kromatografi kolonunun karma\u015f\u0131k sistemlerde pratik uygulamas\u0131 ve tan\u0131t\u0131m\u0131 i\u00e7in, sonraki deneylerde daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.<br \/>\nDo\u011fal \u00fcr\u00fcnler her zaman yeni ila\u00e7 ke\u015ffi i\u00e7in \u00f6nemli bir kaynak olmu\u015ftur ve ilgili afinite kromatografi kolonlar\u0131n\u0131 haz\u0131rlamak i\u00e7in do\u011fal \u00fcr\u00fcnlerin immobilize edilmesi, do\u011fal \u00fcr\u00fcnlerin geli\u015ftirilmesine yard\u0131mc\u0131 olmakta ve b\u00f6ylece ara\u015ft\u0131rma s\u0131cak noktalar\u0131ndan biri haline gelmektedir. Bu makale, do\u011fal \u00fcr\u00fcnlerin hedef proteinlerini aramak ve incelemek i\u00e7in h\u0131zl\u0131, etkili ve uygulanabilir bir y\u00f6ntem olu\u015fturmay\u0131 ama\u00e7lamaktad\u0131r; Ayn\u0131 zamanda, k\u00fc\u00e7\u00fck molek\u00fcll\u00fc do\u011fal \u00fcr\u00fcnler ile hastal\u0131klarda iyi bir etkinlik g\u00f6stermesi beklenen farkl\u0131 hedefler aras\u0131ndaki etkile\u015fimi ke\u015ffetmek i\u00e7in \u00f6nemli bir ara\u015ft\u0131rma y\u00f6ntemi ve platformu da sa\u011flar. Etkiyi elde etmenin ana yolu, alfa amilaz ve alfa glukozidaz\u0131 inhibe etmek, b\u00f6ylece polisakkaritlerin hidrolizini azaltmak ve glikan sentezini te\u015fvik etmektir. Bu, BA'n\u0131n alfa glukozidaz ile bir afinite ili\u015fkisi olu\u015fturabilece\u011fini ve b\u00f6ylece \u00f6nemli kromatografik tutma etkisi elde edebilece\u011fini g\u00f6stermektedir. Bu \u00e7al\u0131\u015fma, bu integral kolonun etki mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in bilimsel bir temel sa\u011flamaktad\u0131r, ancak ger\u00e7ek \u00f6rneklerdeki spesifik uygulamas\u0131n\u0131n sonraki \u00e7al\u0131\u015fmalarda daha da geli\u015ftirilmesi gerekmektedir.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u0130mmobilize betulinik asit afinite integral kolonunun haz\u0131rlama y\u00f6ntemi ve uygulamas\u0131 23 hidroksi betulinik asit (23-HBA), Ranunculaceae familyas\u0131ndaki geleneksel \u00c7in t\u0131bb\u0131 bitkisi Pulsatilla chinensis'ten izole edilen lupin tipi bir pentasiklik triterpenoid bile\u015fi\u011fidir. Betula pubescens, Ziziphus mauritiana, Prunella vulgaris, Apocynaceae gibi \u00e7e\u015fitli bitkilerde de da\u011f\u0131l\u0131m g\u00f6sterir ve \u00f6zellikle [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Preparation method and application of immobilized betulinic acid affinity integral column - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/immobilized-betulinic-acid-affinity-integral-column\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation method and application of immobilized betulinic acid affinity integral column - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Preparation method and application of immobilized betulinic acid affinity integral column 23 hydroxy betulinic acid (23-HBA) is a lupine type pentacyclic triterpenoid compound isolated from the traditional Chinese medicine plant Pulsatilla chinensis in the Ranunculaceae family. 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