{"id":7523,"date":"2024-08-06T20:19:48","date_gmt":"2024-08-06T20:19:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7523"},"modified":"2024-08-06T20:19:48","modified_gmt":"2024-08-06T20:19:48","slug":"sophora-alopecuroides","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/sophora-alopecuroides\/","title":{"rendered":"Sophora alopecuroides'in RAW264.7 h\u00fccrelerinde lipopolisakkarit kaynakl\u0131 enflamasyon \u00fczerindeki anti-enflamatuar etkisi ve mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Sophora alopecuroides'in RAW264.7 h\u00fccrelerinde lipopolisakkarit kaynakl\u0131 enflamasyon \u00fczerindeki anti-enflamatuar etkisi ve mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma
\nEnflamasyon, v\u00fccut patojenler gibi zararl\u0131 i\u00e7 ve d\u0131\u015f uyaranlar taraf\u0131ndan sald\u0131r\u0131ya u\u011frad\u0131\u011f\u0131nda veya enfekte oldu\u011funda ortaya \u00e7\u0131kan bir savunma tepkisidir. V\u00fccudu korumak i\u00e7in bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini tetikler. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi a\u015f\u0131r\u0131 veya s\u00fcrekli olarak aktive oldu\u011funda, romatoid artrit, inflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131, t\u00fcm\u00f6rler gibi inflamasyonla ilgili bir dizi hastal\u0131\u011fa yol a\u00e7abilir ve sonu\u00e7ta kal\u0131c\u0131 veya ge\u00e7ici inflamasyonla sonu\u00e7lanabilir. Makrofajlar, enflamatuar yan\u0131tlar\u0131n ba\u015flat\u0131lmas\u0131, s\u00fcrd\u00fcr\u00fclmesi ve hafifletilmesinde merkezi bir rol oynar ve s\u00fcrekli birikimleri ve aktivasyonlar\u0131 kronik enflamasyonun g\u00f6stergesidir. Lipopolisakkarit (LPS) makrofajlar\u0131 aktive edebilir ve t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa (TNF - \u03b1), interl\u00f6kin-1 \u03b2 (IL-1 \u03b2), interl\u00f6kin-6 (IL-6), nitrik oksit (NO) gibi inflamatuar arac\u0131lar\u0131n salg\u0131lanmas\u0131n\u0131 te\u015fvik edebilir. Bu enflamatuar arac\u0131lar\u0131n a\u015f\u0131r\u0131 sal\u0131n\u0131m\u0131 organ hasar\u0131na ve kronik hastal\u0131klara yol a\u00e7abilir. NF - \u03ba B, h\u00fccre apoptozu ve enflamatuar yan\u0131t gibi s\u00fcre\u00e7lerin d\u00fczenlenmesinde \u00f6nemli bir rol oynar ve anti-enflamatuar tedavi i\u00e7in \u00f6nemli bir hedeftir.<\/p>\n

Sophora alopecuroides olarak da bilinen Sophora alopecuroides L, Sophora cinsinin Leguminosae familyas\u0131na ait bir bitkidir. Kuzeybat\u0131 \u00c7in ve Orta Asya \u00fclkelerinin \u00e7e\u015fitli eyaletlerinde da\u011f\u0131l\u0131m g\u00f6sterir ve \u0131s\u0131y\u0131 temizleme ve detoksifiye etme, a\u011fr\u0131 ve iltihab\u0131 hafifletme, rutubeti kurutma ve dizanteriyi durdurma i\u015flevlerine sahiptir. \u00c7in'in kuzeybat\u0131 b\u00f6lgesinde \u00f6nemli bir t\u0131bbi bitkidir. Sophora alopecuroides esas olarak alkaloidler, flavonoidler, organik asitler, polisakkaritler, u\u00e7ucu ya\u011flar, steroidler, fenoller ve di\u011fer bile\u015fenleri i\u00e7erir. Alkaloidlerin anti-enflamatuar, antikanser, antibakteriyel ve ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleyici etkileri vard\u0131r, flavonoidlerin anti-enflamatuar, antiviral, antioksidan etkileri vard\u0131r ve polisakkaritlerin ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleyici ve anti-t\u00fcm\u00f6r fonksiyonlar\u0131 vard\u0131r, bu da v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131 etkili bir \u015fekilde art\u0131rabilir ve anti-t\u00fcm\u00f6r ve ba\u011f\u0131\u015f\u0131kl\u0131k tan\u0131t\u0131m\u0131nda \u00f6nemli bir rol oynayabilir. Yukar\u0131daki \u00e7al\u0131\u015fmalar\u0131n hepsi Sophora alopecuroides'in belirli bir kimyasal bile\u015fim grubuna dayanmaktad\u0131r ve geleneksel \u00c7in t\u0131bb\u0131, etkili par\u00e7a uyumlulu\u011fu ve etkili bile\u015fen uyumlulu\u011fu dahil olmak \u00fczere daha d\u00fc\u015f\u00fck ila\u00e7 dozlar\u0131yla ayn\u0131 veya daha iyi terap\u00f6tik etkiyi elde edebilen \u00e7ok bile\u015fenli, \u00e7ok hedefli ve \u00e7ok yollu kombine etkilerin \u00f6zelliklerine sahiptir. Bu nedenle, Sophora alopecuroides'in farkl\u0131 kimyasal bile\u015fim gruplar\u0131n\u0131n etkinli\u011fi art\u0131r\u0131p art\u0131ramayaca\u011f\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir. Bu makalede, LPS ile ind\u00fcklenmi\u015f RAW 264.7 h\u00fccrelerini Sophora alopecuroides'teki anti-enflamatuar ila\u00e7lar\u0131n taranmas\u0131 i\u00e7in enflamatuar bir model olarak kullanmakta ve geleneksel su kaynatma ekstresi (WDE), su ultrasonik ekstresi (WUE), 75% etanol refl\u00fc ekstresi (ERE) ara\u015ft\u0131rmaktad\u0131r, 75% etanol ultrasonik ekstrakt\u0131n\u0131n (EUE) yan\u0131 s\u0131ra Sophora alopecuroides'in toplam alkaloid ekstrakt\u0131 (TAE), toplam flavonoid ekstrakt\u0131 (TFE), toplam polisakkarit ekstrakt\u0131 (TPE) ve bunlar\u0131n farkl\u0131 etkili k\u0131s\u0131mlar\u0131n\u0131n dokuz kombinasyonu. (1:1:1, 1:2:2, 1:3:3, 2:1:2, 2:2:3, 2:3:1, 3:1:3, 3:2:1, 3:3:2) anti-enflamatuar etkisi ve etki mekanizmas\u0131.<\/p>\n

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\nMakrofajlar v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k tepkisine kat\u0131l\u0131r. LPS taraf\u0131ndan uyar\u0131ld\u0131klar\u0131nda, makrofajlar NO, TNF - \u03b1, IL-1 \u03b2, IL-6, vb. gibi pro-inflamatuar arac\u0131lar\u0131n \u00fcretimini te\u015fvik etmek i\u00e7in sinyal yollar\u0131n\u0131 (NF - \u03ba B gibi) tetikler. A\u015f\u0131r\u0131 NO \u00fcretimi, enflamasyonun ortaya \u00e7\u0131kmas\u0131yla yak\u0131ndan ili\u015fkilidir. TNF - \u03b1 ve IL-6 seviyelerindeki bir art\u0131\u015f, h\u00fccreler taraf\u0131ndan daha fazla pro-inflamatuar sitokin salg\u0131lanmas\u0131n\u0131 te\u015fvik edebilir. IL-6, B h\u00fccrelerinin ve T h\u00fccrelerinin aktivasyonunu ind\u00fckleyebilen ve v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k tepkisine kat\u0131lan \u00f6nemli bir pro-enflamatuar sitokindir. IL-1 \u03b2 akut veya kronik enflamasyonda yukar\u0131 do\u011fru d\u00fczenlenir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, RAW 264.7'nin LPS tedavisinden sonra NO, TNF - \u03b1, IL-6 ve IL-1 \u03b2 sal\u0131n\u0131m\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 ve bir in vitro inflamasyon modelinin ba\u015far\u0131l\u0131 bir \u015fekilde kuruldu\u011funu g\u00f6stermi\u015ftir. Sophora alopecuroides WDE, WUE, EUE, ERE ve bunlar\u0131n TAE, TFE, TPE'si, LPS ile uyar\u0131lan RAW 264.7 h\u00fccrelerinde NO, TNF - \u03b1, IL-6 ve IL-1 \u03b2 \u00fcretimini inhibe edebilir, bunlar\u0131n aras\u0131nda TFE, EUE, ERE TAE'nin inhibit\u00f6r etkisi daha belirgindir TFE ve TPE farkl\u0131 oranlarda kar\u0131\u015ft\u0131r\u0131ld\u0131ktan sonra, TNF - \u03b1 sal\u0131n\u0131m\u0131n\u0131 de\u011fi\u015fen derecelerde inhibe edebildikleri bulunmu\u015ftur. Bunlar aras\u0131nda, 1:1:1 ve 1:1:2 kombinasyonlar\u0131 hari\u00e7, di\u011fer yedi kombinasyon TNF - \u03b1 sal\u0131n\u0131m\u0131 \u00fczerinde tek ba\u015f\u0131na hareket ettiklerinden daha iyi inhibit\u00f6r etkilere sahipti. 2:1:2 kombinasyonu, \u00f6nemli bir sinerjik etki g\u00f6stererek en iyi inhibit\u00f6r etkiye sahip olmu\u015ftur.<\/p>\n

Sophora alopecuroides'in anti-enflamatuar aktivitesinin molek\u00fcler mekanizmas\u0131n\u0131 ke\u015ffetmek i\u00e7in bu \u00e7al\u0131\u015fmada, NF - \u03ba B sinyal yolundaki anahtar proteinler IkB \u03b1, NF - \u03ba B p65 ve p-IkB \u03b1, p-NF - \u03ba B p65'in ekspresyonunu tespit etmek i\u00e7in WB kullan\u0131lm\u0131\u015ft\u0131r. NF - \u03ba B, IL-1 \u03b2, IL-6, TNF - \u03b1, vb. gibi bir\u00e7ok \u00f6nemli enflamatuar arac\u0131n\u0131n transkripsiyonunu d\u00fczenleyebilen enflamasyonda \u00f6nemli bir d\u00fczenleyici fakt\u00f6rd\u00fcr. LPS, TLR4 resept\u00f6rlerine ba\u011flanarak NF - \u03ba B sinyal yolunu aktive eder, bu da makrofajlar\u0131n enflamatuar arac\u0131lar\u0131 salg\u0131lamas\u0131na neden olan \u00f6nemli bir ba\u011flant\u0131d\u0131r. H\u00fccreler uyar\u0131ld\u0131\u011f\u0131nda, NF - \u03ba B'ye ba\u011flanan inhibit\u00f6r protein IkBa, IkB \u03b1 kinaz\u0131n etkisi alt\u0131nda h\u0131zla p-IkB \u03b1'ya fosforile olur, aktif p-NF - \u03ba B p65'i \u00e7ekirde\u011fe salar ve b\u00f6ylece inflamasyonla ilgili fakt\u00f6rlerin sentezini ve salg\u0131lanmas\u0131n\u0131 te\u015fvik eder. Son y\u0131llarda, alkaloidlerin, flavonoidlerin ve polisakkaritlerin anti-enflamatuar etkileri hakk\u0131nda kapsaml\u0131 raporlar bulunmaktad\u0131r. \u00d6rne\u011fin, \u00e7al\u0131\u015fmalar Sophora flavescens alkaloidlerinin IkB \u03b1 fosforilasyonunu ve p-NF - \u03ba B p65 n\u00fckleer translokasyonunu inhibe ederek RAW 264.7 makrofajlar\u0131nda LPS kaynakl\u0131 inflamasyonu hafifletebilece\u011fini bulmu\u015ftur. Zhao ve arkada\u015flar\u0131 Sophora flavescens total alkaloidlerinin NF - \u03ba B aktivasyonunu inhibe ederek dekstran s\u00fclfat kaynakl\u0131 koliti hafifletebilece\u011fini bulmu\u015flard\u0131r. \u00c7al\u0131\u015fmalar, geleneksel \u00c7in t\u0131bb\u0131ndaki flavonoidlerin, anti-enflamatuar etkiler g\u00f6stermek i\u00e7in NF - \u03ba B sinyal yolundaki IkB \u03b1 ve p65 proteinlerinin fosforilasyon seviyelerini azaltabilece\u011fini g\u00f6stermi\u015ftir. Li ve arkada\u015flar\u0131, Sophora flavescens toplam flavonoidlerinin JAK2\/STAT3 sinyal yolunun aktivasyonunu inhibe ederek \u00fclseratif kolit \u00fczerinde imm\u00fcnomod\u00fclat\u00f6r etkiler g\u00f6sterebilece\u011fini ve Cistanche polisakkaritlerinin JAK2\/STAT3 sinyal yolunun aktivasyonunu inhibe edebilece\u011fini bulmu\u015ftur. NF - \u03ba B MAPK ve STAT3 aktivasyonu, RAW 264.7 makrofajlar\u0131nda LPS kaynakl\u0131 enflamasyonu inhibe etmek i\u00e7in kullan\u0131l\u0131rken, Qu ve arkada\u015flar\u0131n\u0131n \u00e7al\u0131\u015fmas\u0131 Pinus koraiensis'ten elde edilen polisakkaritlerin Nrf2\/HO-1 sinyal yolunu d\u00fczenleyerek LPS kaynakl\u0131 enflamasyonu inhibe edebilece\u011fini g\u00f6stermi\u015ftir. \u015eu anda, alkaloidler, flavonoidler ve polisakkaritlerin kombinasyonunun inflamasyon \u00fczerindeki etkileri konusunda nispeten az ara\u015ft\u0131rma bulunmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, Sophora alopecuroides'teki TAE, TFE ve TPE kombinasyonu kullan\u0131ld\u0131\u011f\u0131nda, NF - \u03ba B p65 ve IkB \u03b1 proteinlerinin fosforilasyonunun \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 ve p-IkB \u03b1 ve p-NF - \u03ba B p65 proteinlerinin ekspresyonunun inhibe edildi\u011fi bulunmu\u015ftur. Bu durum, Sophora alopecuroides toplam biyok\u00fctle, toplam flavonoidler ve toplam polisakkarit kombinasyonunun NF - \u03ba B yola\u011f\u0131n\u0131n aktivasyonunu inhibe ederek RAW 264.7 makrofajlar\u0131nda LPS kaynakl\u0131 enflamasyonu hafifletebilece\u011fini g\u00f6stermektedir.<\/p>\n

\u00d6zet olarak, bu \u00e7al\u0131\u015fmada Sophora alopecuroides'in geleneksel WDE, WUE, EUE, ERE ve bunlar\u0131n farkl\u0131 etkili k\u0131s\u0131mlar\u0131 TAE, TFE, TPE ve dokuz kombinasyonunun (1:1:1, 1:2:2, 1:3:3, 2:1:2, 2:2:3, 2:3:1, 3:1:3, 3:2:1, 3:3:2) anti-enflamatuar aktivitesi in vitro olarak kar\u015f\u0131la\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. TAE, TFE, TPE (2:1:2) kombinasyonunun RAW 264.7 h\u00fccrelerinde LPS kaynakl\u0131 enflamasyon \u00fczerinde en iyi inhibit\u00f6r etkiye sahip oldu\u011fu ve NF - \u03ba B enflamatuar yolunun aktivasyonunu inhibe ederek in vitro anti-enflamatuar etkiler g\u00f6sterdi\u011fi bulunmu\u015ftur. Bu deney sadece h\u00fccresel d\u00fczeyde anti-enflamatuar ila\u00e7lar\u0131n taranmas\u0131n\u0131 tamamlam\u0131\u015f ve sadece Sophora alopecuroides'in farkl\u0131 farmakolojik k\u0131s\u0131mlar\u0131n\u0131n uyumluluk kombinasyonlar\u0131n\u0131 taram\u0131\u015ft\u0131r. Bununla birlikte, karma\u015f\u0131k kimyasal bile\u015fim, net olmayan farmakolojik bile\u015fenler ve etkilerinin maddi temeli gibi daha fazla ara\u015ft\u0131rma gerektiren sorunlar hala mevcuttur.<\/p>","protected":false},"excerpt":{"rendered":"

Sophora alopecuroides'in RAW264.7 h\u00fccrelerinde lipopolisakkarit kaynakl\u0131 enflamasyon \u00fczerindeki anti-enflamatuar etkisi ve mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma Enflamasyon, v\u00fccut patojenler gibi zararl\u0131 i\u00e7 ve d\u0131\u015f uyaranlar taraf\u0131ndan sald\u0131r\u0131ya u\u011frad\u0131\u011f\u0131nda veya enfekte oldu\u011funda ortaya \u00e7\u0131kan savunma ama\u00e7l\u0131 bir yan\u0131tt\u0131r. V\u00fccudu korumak i\u00e7in bir ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini tetikler. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi a\u015f\u0131r\u0131 oldu\u011funda [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/sophora-alopecuroides\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the anti-inflammatory effect and mechanism of Sophora alopecuroides on lipopolysaccharide induced inflammation in RAW264.7 cells Inflammation is a defensive response that occurs when the body is attacked or infected by harmful internal and external stimuli such as pathogens. 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