{"id":7514,"date":"2024-08-06T20:17:59","date_gmt":"2024-08-06T20:17:59","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7514"},"modified":"2024-08-06T20:17:59","modified_gmt":"2024-08-06T20:17:59","slug":"kaempferol","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/kaempferol\/","title":{"rendered":"Kaempferol\u00fcn \u00fc\u00e7l\u00fc negatif meme kanseri h\u00fccrelerinde mitokondriyal apoptoz yolu ile apoptozu ind\u00fckleme mekanizmas\u0131"},"content":{"rendered":"

Kaempferol\u00fcn \u00fc\u00e7l\u00fc negatif meme kanseri h\u00fccrelerinde mitokondriyal apoptoz yolu ile apoptozu ind\u00fckleme mekanizmas\u0131
\nMeme kanserinin \u00f6zel bir alt tipi olan \u00fc\u00e7l\u00fc negatif meme kanseri (TNBC), toplam meme kanseri say\u0131s\u0131n\u0131n 15%~20%'sini olu\u015fturmaktad\u0131r. K\u0131sa genel sa\u011fkal\u0131m s\u00fcresi, y\u00fcksek malignite, g\u00fc\u00e7l\u00fc invazyon, y\u00fcksek erken n\u00fcks oran\u0131 vb. klinik \u00f6zelliklere sahiptir. Metastaz olu\u015ftu\u011funda, hastalar\u0131n medyan sa\u011fkal\u0131m s\u00fcresi sadece 10~13 ayd\u0131r. TNBC'nin endokrin tedavisine ve hedefe y\u00f6nelik tedaviye duyars\u0131zl\u0131\u011f\u0131 nedeniyle kemoterapi ana tedavi y\u00f6ntemidir. Ancak, ila\u00e7 direnci ve tedaviye ba\u011fl\u0131 yan etkiler endi\u015fe kayna\u011f\u0131 olmaya devam etmektedir. Son y\u0131llarda, TNBC'nin \u00f6nlenmesi ve tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n rol\u00fc, benzersiz teorik sistemi ve bireyselle\u015ftirilmi\u015f tedavi planlar\u0131ndaki uzmanl\u0131\u011f\u0131 nedeniyle giderek daha fazla de\u011fer g\u00f6rmektedir. Ara\u015ft\u0131rma grubumuz, Chaihu Guizhi Decoction'\u0131n kapesitabin ile birlikte eklenmesinin ve azalt\u0131lmas\u0131n\u0131n, \u00e7\u0131plak farelerde \u00fc\u00e7l\u00fc negatif meme kanserinin subkutan transplante t\u00fcm\u00f6r\u00fcn\u00fcn b\u00fcy\u00fcmesini inhibe edebilece\u011fini \u00f6nceki ara\u015ft\u0131rmalarla bulmu\u015ftur. A\u011f farmakolojisi y\u00f6ntemi kullan\u0131larak yap\u0131lan ileri analizler, kaempferol\u00fcn (KA) Chaihu Guizhi Kaynatmas\u0131n\u0131n eklenmesi ve azalt\u0131lmas\u0131nda \u00f6nemli bir etkili bile\u015fen oldu\u011funu g\u00f6sterdi ve bu da \u00fc\u00e7l\u00fc negatif meme kanserini tedavi etmek i\u00e7in kaempferol kullanmam\u0131z i\u00e7in deneysel bir temel sa\u011flad\u0131.
\nKaempferol, sebzelerde, meyvelerde ve geleneksel \u00c7in t\u0131bb\u0131nda yayg\u0131n olarak bulunan flavonoid bir bile\u015fiktir. Anti-kanser, anti-inflamatuar, antioksidan ve antiviral gibi \u00e7e\u015fitli etkileri vard\u0131r. H\u00fccre apoptozunu ind\u00fckleyerek, h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fc d\u00fczenleyerek, anjiyogenezi ve t\u00fcm\u00f6r metastaz\u0131n\u0131 inhibe ederek t\u00fcm\u00f6r h\u00fccrelerinin proliferasyonunu ve invazyonunu inhibe edebilir. Ara\u015ft\u0131rmalar, KA'n\u0131n MEK-MAPK'\u0131 aktive ederek akci\u011fer kanseri h\u00fccrelerinde b\u00fcy\u00fcme inhibisyonunu ve apoptozu ind\u00fckledi\u011fini bulmu\u015ftur. \u0130n vitro ve in vivo olarak KA, AKT\/PI3K ve ERK yolaklar\u0131n\u0131 inhibe eder, mitokondriyal apoptoz yola\u011f\u0131n\u0131 aktive eder ve akci\u011fer kanseri h\u00fccrelerinin radyasyonla \u00f6ld\u00fcr\u00fclmesini art\u0131r\u0131r. Kolon kanserinde KA, kolon kanseri h\u00fccrelerinde ba\u011flant\u0131 proteini 43'\u00fcn ekspresyonunu ve fosforilasyonunu art\u0131rarak bo\u015fluk ba\u011flant\u0131lar\u0131n\u0131n h\u00fccreler aras\u0131 ileti\u015fimini yeniden yap\u0131land\u0131r\u0131r ve b\u00f6ylece h\u00fccre apoptozunu ind\u00fckler. KA ayr\u0131ca PI3K\/AKT ve hTERT yolaklar\u0131n\u0131 a\u015fa\u011f\u0131 d\u00fczenleyerek insan rahim a\u011fz\u0131 kanseri h\u00fccrelerinde apoptozu ve ya\u015flanmay\u0131 ind\u00fckleyebilir. Meme kanserinde, KA'n\u0131n farkl\u0131 mekanizmalar yoluyla anti-t\u00fcm\u00f6r rol\u00fc oynad\u0131\u011f\u0131 bildirilmi\u015ftir. KA, PKC \u03b4\/MAPK\/AP-1 kaskad\u0131n\u0131n ve ard\u0131ndan matriks metalloproteinaz-9'un (MMP-9) ekspresyonunu ve aktivitesini bloke ederek meme kanseri h\u00fccrelerinin invazyonunu inhibe edebilir. Li ve arkada\u015flar\u0131, KA'n\u0131n Notch1 proteinini d\u00fczenleyerek meme kanseri SK-BR-3 h\u00fccrelerinin proliferasyonunu inhibe edebilece\u011fini bulmu\u015flard\u0131r. Ayr\u0131ca KA, triklosan taraf\u0131ndan ind\u00fcklenen MCF-7 meme kanseri h\u00fccrelerinin epitelyal mezenkimal d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fc (EMT) ve metastazla ilgili davran\u0131\u015flar\u0131n\u0131 da inhibe edebilir. KA'n\u0131n \u00e7e\u015fitli t\u00fcm\u00f6rlerdeki antikanser etkisi do\u011frulanm\u0131\u015f olmas\u0131na ra\u011fmen, KA'n\u0131n \u00fc\u00e7l\u00fc negatif meme kanseri h\u00fccrelerinin apoptozunu ind\u00fckleyip ind\u00fckleyemeyece\u011fi ve molek\u00fcler mekanizmas\u0131 hakk\u0131nda bir rapor bulunmamaktad\u0131r. Bu \u00e7al\u0131\u015fma, kaempferol\u00fcn MDA-MB-231 h\u00fccre apoptozu \u00fczerindeki etkisini ve olas\u0131 mekanizman\u0131n mitokondriyal apoptoz yolu ile ili\u015fkili olup olmad\u0131\u011f\u0131n\u0131 g\u00f6zlemlemek i\u00e7in ara\u015ft\u0131rma nesnesi olarak insan TNBC h\u00fccresi MDA-MB-231'i alacak ve b\u00f6ylece \u00fc\u00e7l\u00fc negatif meme kanseri tedavisinde kaempferol\u00fcn klinik kullan\u0131m\u0131 i\u00e7in teorik temel ve deneysel temel sa\u011flayacakt\u0131r.<\/p>\n

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\n\u00c7e\u015fitli bitkilerde yayg\u0131n olarak bulunan bir poliol hidroksi flavonoid bile\u015fi\u011fi olan Kaempferol, yaln\u0131zca t\u00fcm\u00f6r h\u00fccresi b\u00fcy\u00fcmesini etkili bir \u015fekilde inhibe etmek ve apoptozu ind\u00fcklemekle kalmaz, ayn\u0131 zamanda normal h\u00fccrelerin b\u00fcy\u00fcme canl\u0131l\u0131\u011f\u0131n\u0131 da korur. Chen ve arkada\u015flar\u0131, KA'n\u0131n prostat kanseri h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fcn durmas\u0131na neden olabilece\u011fini, h\u00fccre \u00e7o\u011falmas\u0131n\u0131 engelleyebilece\u011fini ve normal insan s\u00fcnnet derisi fibroblastlar\u0131n\u0131n (HFF) canl\u0131l\u0131\u011f\u0131 \u00fczerinde hi\u00e7bir etkisi olmad\u0131\u011f\u0131n\u0131 tespit ederek KA'n\u0131n iyi bir anti-t\u00fcm\u00f6r etkinli\u011fine ve d\u00fc\u015f\u00fck toksisiteye sahip oldu\u011funu g\u00f6stermi\u015ftir. Tu ve arkada\u015flar\u0131, KA'n\u0131n insan rahim a\u011fz\u0131 kanseri h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 ve metastaz\u0131n\u0131 etkili bir \u015fekilde inhibe edebildi\u011fini, karsinoembriyonik b\u00f6brek h\u00fccreleri ve normal karaci\u011fer h\u00fccreleri \u00fczerindeki sitotoksik etkisinin nispeten k\u00fc\u00e7\u00fck oldu\u011funu ve KA'n\u0131n y\u00fcksek kanser h\u00fccresi hedefleme yetene\u011fine sahip oldu\u011funu g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. \u00dc\u00e7l\u00fc negatif meme kanseri h\u00fccrelerinde KA ile ilgili az say\u0131da \u00e7al\u0131\u015fma bulunmaktad\u0131r. Bu nedenle, bu \u00e7al\u0131\u015fma KA'n\u0131n TNBC h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebildi\u011fini ve MDA-MB-231 ve MCF-10A h\u00fccreleri \u00fczerinde in vitro \u00e7al\u0131\u015fmalar yoluyla h\u00fccre apoptozunu te\u015fvik edebildi\u011fini, ancak normal meme epitelyal MCF-10A h\u00fccrelerinin \u00e7o\u011falmas\u0131 \u00fczerinde hi\u00e7bir etkisi olmad\u0131\u011f\u0131n\u0131 do\u011frulam\u0131\u015ft\u0131r.
\nBu temelde, bu deney KA'n\u0131n MDA-MB-231 h\u00fccreleri \u00fczerindeki apoptoz ind\u00fcksiyon mekanizmas\u0131n\u0131 daha fazla ara\u015ft\u0131rmaktad\u0131r. \u015eu anda, ara\u015ft\u0131rmalar h\u00fccre apoptozunun esas olarak ba\u015flatma s\u00fcrecine dayal\u0131 \u00fc\u00e7 yol i\u00e7erdi\u011fini bulmu\u015ftur: mitokondriyal yol, \u00f6l\u00fcm resept\u00f6r\u00fc yolu ve endoplazmik retikulum yolu ve mitokondriyal yol h\u00fccre apoptozuna arac\u0131l\u0131k etmede \u00f6nemli bir rol oynamaktad\u0131r. Mitokondriyal membran potansiyeli, mitokondriyal i\u00e7 membran\u0131n ge\u00e7irgenli\u011fini yans\u0131tan en iyi g\u00f6stergelerden biridir. Mitokondriyal membran potansiyelindeki d\u00fc\u015f\u00fc\u015f, h\u00fccre apoptozunun kademeli reaksiyonundaki en erken olay olarak kabul edilir. Mitokondriyal membran potansiyeli bir kez \u00e7\u00f6kt\u00fc\u011f\u00fcnde, h\u00fccre apoptozu geri d\u00f6nd\u00fcr\u00fclemez hale gelir. Feng ve arkada\u015flar\u0131, Artemisia scoparia'dan mitokondriyal membran potansiyeli kayb\u0131na neden olarak insan nazofaringeal karsinom CNE-2 h\u00fccrelerini \u00f6ld\u00fcrebilen bir arabinogalaktan izole etmi\u015flerdir. Bu \u00e7al\u0131\u015fma, KA'n\u0131n MDA-MB-231 h\u00fccrelerinde mitokondriyal membran potansiyelini azaltma etkisine sahip oldu\u011funu bulmu\u015f ve kaempferol\u00fcn h\u00fccre proliferasyonunu inhibe etti\u011fi ve apoptozu te\u015fvik etti\u011fi mekanizmalardan birinin mitokondriyal arac\u0131l\u0131 apoptotik yolak yoluyla elde edilebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrm\u00fc\u015ft\u00fcr. MDA-MB-231 h\u00fccrelerinin KA ile ind\u00fcklenen apoptozu ile mitokondriyal apoptoz sinyal yolu aras\u0131ndaki ili\u015fkiyi daha fazla ara\u015ft\u0131rmak i\u00e7in, bu \u00e7al\u0131\u015fmada Bcl-2, Bax, CytC, Cyclin D1 ekspresyonunun yan\u0131 s\u0131ra Caspase-3 ve Caspase-9 aktivitesi tespit edilmi\u015ftir.<\/p>\n

Bcl-2 protein ailesi, anti apoptotik protein Bcl-2 ve pro apoptotik protein Bax'\u0131 i\u00e7erir. Mitokondriyal d\u0131\u015f membran b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fcn d\u00fczenleyicileri olarak, mitokondriyal apoptoz yolunun d\u00fczenlenmesinde \u00f6nemli bir rol oynarlar. Apoptotik sinyali ald\u0131ktan sonra, sitoplazmadaki Bax mitokondriye yer de\u011fi\u015ftirir ve anti apoptotik protein Bcl-2, mitokondriden sitokrom C sal\u0131n\u0131m\u0131na rehberlik ederek Caspase-9 \u00f6nc\u00fcs\u00fcn\u00fcn kendi kendine aktivasyonunu te\u015fvik eder. Aktive Caspase-9, Caspase-3'\u00fc aktive ederek sonu\u00e7ta h\u00fccre apoptozuna yol a\u00e7ar. Liu ve arkada\u015flar\u0131, KA'n\u0131n insan safra kesesi kanseri h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelledi\u011fini ve mitokondriyal apoptoz yolu ile apoptozlar\u0131n\u0131 ind\u00fckledi\u011fini bulmu\u015flard\u0131r. Bu \u00e7al\u0131\u015fmada, KA'n\u0131n MDA-MB-231 h\u00fccrelerinde Bax ekspresyonunu art\u0131rd\u0131\u011f\u0131n\u0131 ve Bcl-2 ekspresyonunu azaltt\u0131\u011f\u0131n\u0131, mitokondriyal apoptoz yolu arac\u0131l\u0131\u011f\u0131yla CytC'nin sitoplazmaya sal\u0131nmas\u0131n\u0131 te\u015fvik etti\u011fini ve bunun da ekspresyonun artmas\u0131na neden oldu\u011funu g\u00f6zlemledik. Ayn\u0131 zamanda, mitokondriyal membran ge\u00e7irgenli\u011fi artar, membran potansiyeli azal\u0131r, apoptotik fakt\u00f6rler serbest kal\u0131r, Caspase-3 ve Caspase-9'un a\u015fa\u011f\u0131 ak\u0131\u015f aktivasyonunu tetikler ve sonu\u00e7ta h\u00fccre apoptozuna yol a\u00e7ar. Ayr\u0131ca, apoptoz anormal h\u00fccre \u00e7o\u011falmas\u0131 ile yak\u0131ndan ili\u015fkilidir ve h\u00fccre \u00e7o\u011falmas\u0131n\u0131n ana nedeni anormal h\u00fccre d\u00f6ng\u00fcs\u00fcd\u00fcr. H\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fcn \u00f6nemli bir d\u00fczenleyici proteini olan Cyclin D1, h\u00fccrelerin G1 faz\u0131ndan S faz\u0131na ge\u00e7i\u015fini te\u015fvik edebilir, h\u00fccre d\u00f6ng\u00fcs\u00fc s\u00fcrecini h\u0131zland\u0131rabilir ve yukar\u0131 reg\u00fclasyonu anormal h\u00fccre \u00e7o\u011falmas\u0131na neden olabilir, mitokondriyal membran potansiyelinde de\u011fi\u015fikliklere neden olabilir ve t\u00fcm\u00f6r geli\u015fimine yol a\u00e7abilir. Bu deneyin sonu\u00e7lar\u0131, KA'n\u0131n MDA-MB-231 h\u00fccrelerinde apoptozla ilgili proteinler Cyclin D1 ve Bcl-2'nin ekspresyonunu azaltabilece\u011fini, mitokondriyal membran potansiyelini azaltabilece\u011fini, h\u00fccre proliferasyonunu inhibe edebilece\u011fini ve h\u00fccre apoptozunu te\u015fvik edebilece\u011fini g\u00f6stermektedir.<\/p>\n

\u00d6zetle, bu \u00e7al\u0131\u015fma kaempferol\u00fcn in vitro \u00fc\u00e7l\u00fc negatif meme kanseri h\u00fccreleri \u00fczerindeki antikanser etkisini ve belirli bir g\u00fcvenli\u011fe sahip oldu\u011funu a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmu\u015f ve KA'n\u0131n mitokondriyal apoptoz sinyal yolu arac\u0131l\u0131\u011f\u0131yla MDA-MB-231 h\u00fccrelerinin apoptozunu ind\u00fckleme mekanizmas\u0131n\u0131 netle\u015ftirmi\u015ftir. Daha sonra, KA'n\u0131n TNBC \u00fczerindeki inhibit\u00f6r etkisi in vivo deneyler yoluyla daha fazla incelenebilir ve KA'n\u0131n geli\u015ftirilmesi ve klinik uygulamas\u0131 i\u00e7in deneysel temel sa\u011flanabilir.<\/p>","protected":false},"excerpt":{"rendered":"

Kaempferol\u00fcn mitokondriyal apoptoz yolu ile \u00fc\u00e7l\u00fc negatif meme kanseri h\u00fccrelerinin apoptozunu ind\u00fckleme mekanizmas\u0131 Meme kanserinin \u00f6zel bir alt t\u00fcr\u00fc olan \u00fc\u00e7l\u00fc negatif meme kanseri (TNBC), toplam meme kanseri say\u0131s\u0131n\u0131n 15%~20%'sini olu\u015fturmaktad\u0131r. K\u0131sa genel sa\u011fkal\u0131m s\u00fcresi, y\u00fcksek malignite, g\u00fc\u00e7l\u00fc invazyon, y\u00fcksek erken rek\u00fcrrens gibi klinik \u00f6zelliklere sahiptir [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe mechanism of kaempferol inducing apoptosis of triple negative breast cancer cells through mitochondrial apoptosis pathway - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/kaempferol\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The mechanism of kaempferol inducing apoptosis of triple negative breast cancer cells through mitochondrial apoptosis pathway - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The mechanism of kaempferol inducing apoptosis of triple negative breast cancer cells through mitochondrial apoptosis pathway Triple negative breast cancer (TNBC), as a special subtype of breast cancer, accounts for 15%~20% of the total number of breast cancer. 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