{"id":7504,"date":"2024-08-06T20:14:42","date_gmt":"2024-08-06T20:14:42","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7504"},"modified":"2024-08-06T20:14:42","modified_gmt":"2024-08-06T20:14:42","slug":"selenium-rich-ganoderma-lucidum-mycelium","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/selenium-rich-ganoderma-lucidum-mycelium\/","title":{"rendered":"Selenyumca zengin Ganoderma lucidum miselyumundan polisakkarit ve proteinlerin ekstraksiyonu ve bunlar\u0131n in vitro antioksidan ve anti-t\u00fcm\u00f6r aktiviteleri"},"content":{"rendered":"

Selenyumca zengin Ganoderma lucidum miselyumundan polisakkarit ve proteinlerin ekstraksiyonu ve bunlar\u0131n in vitro antioksidan ve anti-t\u00fcm\u00f6r aktiviteleri
\nSon y\u0131llarda, k\u00f6t\u00fc huylu t\u00fcm\u00f6r\u00fc olan hastalar\u0131n 90%'si kanser h\u00fccresi metastaz\u0131 nedeniyle \u00f6lm\u00fc\u015ft\u00fcr. T\u00fcm\u00f6rlerin olu\u015fumu ve geli\u015fimi ile v\u00fccudun d\u00fc\u015f\u00fck ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu aras\u0131nda nedensel bir ili\u015fki vard\u0131r. Raporlara g\u00f6re, selenyum v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendirebilir ve t\u00fcm\u00f6r hastal\u0131klar\u0131n\u0131n olu\u015fumuna direnebilir, ancak insan v\u00fccudu yaln\u0131zca esas olarak selenyum polisakkaritleri ve selenyum proteinlerinden olu\u015fan organik selenyumun d\u0131\u015f al\u0131m\u0131na g\u00fcvenebilir. \u00d6nceki raporlara g\u00f6re, siyah mantar ve \u00e7aydan elde edilen selenyum polisakkaritleri g\u00fc\u00e7l\u00fc antioksidan aktiviteye sahiptir. Selenyum polisakkarit ayr\u0131ca t\u00fcm\u00f6r h\u00fccrelerinin aktivitesini de inhibe edebilir: Shang ve arkada\u015flar\u0131, balkaba\u011f\u0131 selenyum polisakkaritinin meme kanseri h\u00fccrelerinin b\u00fcy\u00fcmesi \u00fczerinde belirli bir inhibit\u00f6r etkiye sahip oldu\u011funu bulmu\u015flard\u0131r. Serbest radikalleri temizlemek i\u00e7in belirli bir yetene\u011fe sahip olman\u0131n yan\u0131 s\u0131ra, selenoproteinler de t\u00fcm\u00f6r b\u00fcy\u00fcmesini engellemede \u00f6nemli bir role sahiptir: Brassica napus'tan elde edilen selenoprotein g\u00fc\u00e7l\u00fc serbest radikal temizleme yetene\u011fine ve toplam indirgeme g\u00fcc\u00fcne sahiptir; Selenyum a\u00e7\u0131s\u0131ndan zengin soya proteini peptidleri farelerde t\u00fcm\u00f6r b\u00fcy\u00fcmesini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilir.<\/p>\n

Ganoderma lucidum, Basidiomycota filumuna, Actinobacteriaceae familyas\u0131na ve Ganoderma (Leyss. ex Fr.) Karst cinsine aittir T\u0131bbi mantarlar, \u00c7in'de triterpenler, polisakkaritler, proteinler vb. gibi \u00e7e\u015fitli aktif bile\u015fenler i\u00e7eren geleneksel g\u0131da ve ila\u00e7 \u00e7ift kullan\u0131ml\u0131 mantarlard\u0131r. Anti-t\u00fcm\u00f6r, antioksidan ve ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi gibi \u00e7ok \u00e7e\u015fitli farmakolojik aktivitelere sahiptirler. Lingzhi selenyumu zenginle\u015ftirmek i\u00e7in g\u00fc\u00e7l\u00fc bir yetene\u011fe sahiptir. Selenyum a\u00e7\u0131s\u0131ndan zengin Ganoderma lucidum, Ganoderma lucidum ve selenyumun biyolojik aktivitesini birle\u015ftiren selenyum d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in bir ta\u015f\u0131y\u0131c\u0131 olarak Ganoderma lucidum'un k\u00fclt\u00fcrlenmesiyle elde edilir. \u015eu anda, akademisyenlerin ara\u015ft\u0131rmalar\u0131 esas olarak selenyum bak\u0131m\u0131ndan zengin Ganoderma lucidum'un yeti\u015ftirilmesi ve su\u015f yeti\u015ftirilmesine odaklanmaktad\u0131r ve ilgili biyolojik aktivite ara\u015ft\u0131rmalar\u0131, nispeten az say\u0131da in vitro anti-t\u00fcm\u00f6r deneyi ile esas olarak hayvan deneyleri yoluyla y\u00fcr\u00fct\u00fclmektedir. Bu \u00e7al\u0131\u015fmada, selenyum bak\u0131m\u0131ndan zengin Ganoderma lucidum miselyumundan polisakkaritleri \u00e7\u0131karmak i\u00e7in ultrason destekli alkali ekstraksiyon, su ekstraksiyonu ve alkol \u00e7\u00f6keltme y\u00f6ntemleri kullan\u0131lm\u0131\u015f ve \u00e7\u00f6z\u00fcc\u00fc olarak fosfat tampon \u00e7\u00f6zeltisi kullan\u0131larak miselyumdan \u00e7\u00f6z\u00fcn\u00fcr proteinler \u00e7\u0131kar\u0131lm\u0131\u015ft\u0131r. Selenyumca zengin Ganoderma lucidum miselyum polisakkaritlerinin ve proteinlerinin DPPH serbest radikallerine ve ABTS serbest radikallerine kar\u015f\u0131 temizleme kabiliyetini, demir indirgeme kabiliyetini ve karaci\u011fer kanseri h\u00fccreleri HCCLM, akci\u011fer kanseri h\u00fccreleri A549 ve a\u011f\u0131z kanseri h\u00fccreleri HSC-3'\u00fcn proliferasyonu \u00fczerindeki inhibit\u00f6r etkisini ara\u015ft\u0131rd\u0131k. Selenyum grubu, selenyumun Ganoderma lucidum'un aktif bile\u015fenleri ve antioksidan ve anti-t\u00fcm\u00f6r aktiviteleri \u00fczerindeki etkilerini ara\u015ft\u0131rmak i\u00e7in kontrol olarak kullan\u0131lm\u0131\u015ft\u0131r. Selenyum kaynaklar\u0131n\u0131n daha da geli\u015ftirilmesi ve uygulanmas\u0131 i\u00e7in teorik temel sa\u011flamak.<\/p>\n

\"\"\"\"\"\"\"\"\"\"<\/p>\n

Ganoderma lucidum ana tohumlar\u0131 hammadde olarak kullan\u0131larak, selenyumca zengin Ganoderma lucidum miselyumu elde etmek i\u00e7in s\u0131v\u0131 fermantasyon i\u00e7in uygun eksojen selenyum eklenmi\u015f ve polisakkarit ve protein aktiviteleri ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Deney s\u0131ras\u0131nda, selenyum i\u00e7ermeyen Ganoderma lucidum ilgili kontrol olarak kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, ultrason destekli alkali ekstraksiyon ile ekstrakte edilen polisakkaritlerin i\u00e7eri\u011finin su ekstraksiyonu ile ekstrakte edilenden daha y\u00fcksek oldu\u011funu; selenyum polisakkaritlerinin i\u00e7eri\u011finin polisakkaritlerden daha y\u00fcksek oldu\u011funu ve selenyum proteinlerinin i\u00e7eri\u011finin proteinlerden daha y\u00fcksek oldu\u011funu; selenoproteinlerdeki selenyum i\u00e7eri\u011finin selenyum polisakkaritlerindekinden daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Selenyum ilavesi, selenoproteinlerin olu\u015fumu i\u00e7in faydal\u0131d\u0131r ve hem selenoproteinlerin hem de selenyum polisakkaritlerinin belirli antioksidan etkileri vard\u0131r. \u0130n vitro anti-t\u00fcm\u00f6r deneylerinde, hem selenyum polisakkaritlerinin hem de selenoproteinlerin belirli anti-t\u00fcm\u00f6r etkileri vard\u0131r ve selenyum polisakkaritleri, polisakkaritlere k\u0131yasla \u00f6nemli bir anti-t\u00fcm\u00f6r etkiye sahipken, selenoproteinlerin daha zay\u0131f anti-t\u00fcm\u00f6r etkileri vard\u0131r.<\/p>\n

Bu \u00e7al\u0131\u015fma, Ganoderma lucidum selenyum polisakkaritlerinin ve selenoproteinlerinin antioksidan ve anti-t\u00fcm\u00f6r aktivitelerini ara\u015ft\u0131rmakta olup, Ganoderma lucidum ekstrakt aktivitesinin ara\u015ft\u0131r\u0131lmas\u0131nda belirli bir referans de\u011fere sahiptir ve selenyum a\u00e7\u0131s\u0131ndan zengin Ganoderma lucidum ve selenyum kaynaklar\u0131n\u0131n daha da geli\u015ftirilmesini ve kullan\u0131lmas\u0131n\u0131 te\u015fvik etmeye yard\u0131mc\u0131 olmaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Extraction of polysaccharides and proteins from selenium rich Ganoderma lucidum mycelium and their in vitro antioxidant and anti-tumor activities In recent years, 90% of patients with malignant tumors have died from cancer cell metastasis. There is a causal relationship between the occurrence and development of tumors and the low immune function of the body. According […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExtraction of polysaccharides and proteins from selenium rich Ganoderma lucidum mycelium and their in vitro antioxidant and anti-tumor activities - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/selenium-rich-ganoderma-lucidum-mycelium\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extraction of polysaccharides and proteins from selenium rich Ganoderma lucidum mycelium and their in vitro antioxidant and anti-tumor activities - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Extraction of polysaccharides and proteins from selenium rich Ganoderma lucidum mycelium and their in vitro antioxidant and anti-tumor activities In recent years, 90% of patients with malignant tumors have died from cancer cell metastasis. 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