{"id":7485,"date":"2024-08-06T20:06:46","date_gmt":"2024-08-06T20:06:46","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7485"},"modified":"2024-08-06T20:06:46","modified_gmt":"2024-08-06T20:06:46","slug":"colon-tumors","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/colon-tumors\/","title":{"rendered":"Jolkinolide B'nin kolon t\u00fcm\u00f6rlerinin tedavisinde a\u011f farmakolojisi ve deneysel ara\u015ft\u0131rmalara dayanan mekanizmas\u0131"},"content":{"rendered":"

Jolkinolide B'nin kolon t\u00fcm\u00f6rlerinin tedavisinde a\u011f farmakolojisi ve deneysel ara\u015ft\u0131rmalara dayanan mekanizmas\u0131
\nKolorektal kanser (KRK) d\u00fcnyada en s\u0131k g\u00f6r\u00fclen \u00fc\u00e7\u00fcnc\u00fc malign t\u00fcm\u00f6rd\u00fcr ve insan sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdittir. 2015 y\u0131l\u0131nda kolon kanserinden \u00f6lenlerin say\u0131s\u0131 774000'e ula\u015fm\u0131\u015ft\u0131r. \u0130nsanlar\u0131n ya\u015fam tarz\u0131 ve beslenme yap\u0131s\u0131ndaki muazzam de\u011fi\u015fiklikler nedeniyle, kolon kanserinin g\u00f6r\u00fclme oran\u0131 ve \u00f6l\u00fcm oran\u0131 her ge\u00e7en y\u0131l artmaktad\u0131r. Kolon kanserinin \u00f6nlenmesi ve tedavisine y\u00f6nelik ara\u015ft\u0131rmalar\u0131n g\u00fc\u00e7lendirilmesi, \u00c7in'de kanser kontrol\u00fcn\u00fcn \u00f6nemli i\u00e7eriklerinden biridir. Kolon t\u00fcm\u00f6rlerini hedef alabilen ve t\u00fcm\u00f6r h\u00fccresi apoptozunu te\u015fvik edebilen do\u011fal kaynaklardan elde edilen \u00f6nc\u00fc bile\u015fiklerin ara\u015ft\u0131r\u0131lmas\u0131 giderek daha \u00f6nemli hale gelmektedir. Geleneksel \u00c7in ilac\u0131 \"wolfberry\" uzun bir kullan\u0131m ge\u00e7mi\u015fine sahiptir ve halk t\u0131bb\u0131nda kolon kanseri tedavisinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bu ila\u00e7 \u00c7in Farmakopesi'nin 2020 bask\u0131s\u0131nda yer almaktad\u0131r ve Euphorbiaceae familyas\u0131ndaki Euphorbia fis cheriana Steud ve Euphorbia ebracteolata Hayata bitkilerinin kurutulmu\u015f k\u00f6k\u00fcd\u00fcr. \u0130lk olarak \"Shennong Materia Medica \"da kaydedilmi\u015ftir ve esas olarak \u00f6ks\u00fcr\u00fck, birikintileri par\u00e7alamak, yaralar, fare nekrozu ve zehirlenme i\u00e7in kullan\u0131l\u0131r. Kuzeydo\u011fu halk\u0131 kolon kanserini tedavi etmek i\u00e7in kaynatma suyunu kullan\u0131r. Ara\u015ft\u0131rmalar, geleneksel \u00c7in ilac\u0131 \"wolfberry \"nin kolon kanserli hayvanlar\u0131n hayatta kalma oran\u0131n\u0131 47% kadar uzatabildi\u011fini g\u00f6stermi\u015ftir.<\/p>\n

Kurt zehrindeki aktif ikincil metabolitler esas olarak bol miktarda bulunan terpenoidlerdir. \u0130lk a\u015famada, deney grubumuz, kurt \u00fcz\u00fcm\u00fc t\u0131bbi bitki kayna\u011f\u0131 olan Euphorbia lanceolata'n\u0131n kurutulmu\u015f k\u00f6klerinden ent abietan, rosane ve diterpenoid dimerler gibi yap\u0131sal olarak \u00e7e\u015fitli diterpenler izole etmi\u015ftir. Bunlar aras\u0131nda, ent abietan diterpen Jolkinolite B (\u015eekil 1'de g\u00f6sterilen yap\u0131), kolon t\u00fcm\u00f6r h\u00fccresi SW480'in (IC50 = 9.5 \u03bc mpl \/ L) \u00e7o\u011falmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilir ve CRC tedavisi i\u00e7in maddi bir temel sa\u011flar, ancak etki mekanizmas\u0131 hen\u00fcz net de\u011fildir. \u00d6nceki ara\u015ft\u0131rmalar\u0131n temeli g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, CRC tedavisinde Jolkinolide B aktif maddesinin etki mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in in vitro h\u00fccre deneyleri ile birlikte a\u011f farmakolojisi y\u00f6ntemlerini kullanmay\u0131 ve sonraki ila\u00e7 geli\u015ftirme ve klinik uygulamalar i\u00e7in deneysel kan\u0131t sa\u011flamay\u0131 planl\u0131yoruz.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nA\u011f farmakolojisi, biyomolek\u00fcller ve kimyasal bile\u015fenler aras\u0131ndaki karma\u015f\u0131k etkile\u015fimleri b\u00fcy\u00fck \u00f6l\u00e7\u00fcde yans\u0131tabilir. A\u011f farmakolojisi yoluyla etki hedefini tarayarak, geleneksel \u00c7in t\u0131bb\u0131 \u00fczerine daha hedefli ara\u015ft\u0131rmalar i\u00e7in bir temel sa\u011flayabilir, en uygun bile\u015fikleri ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n etki mekanizmalar\u0131n\u0131 netle\u015ftirebilir. Geleneksel \u00c7in t\u0131bb\u0131 kurt \u00fcz\u00fcm\u00fc, Euphorbiaceae familyas\u0131ndan Euphorbiaceae cinsine ait bir bitkidir. Su ve balgam\u0131 da\u011f\u0131tma, birikimi par\u00e7alama ve b\u00f6cekleri \u00f6ld\u00fcrme etkilerine sahiptir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131, diterpenoidlerin, anti-t\u00fcm\u00f6r, anti-inflamatuar, antibakteriyel ve \u00e7oklu ila\u00e7 direncinin tersine \u00e7evrilmesi gibi \u00e7e\u015fitli biyolojik aktivitelerle geleneksel \u00c7in t\u0131bb\u0131 kurt \u00fcz\u00fcm\u00fcn\u00fcn aktif madde temeli oldu\u011funu g\u00f6stermektedir. Geleneksel \u00c7in t\u0131bb\u0131 kurt \u00fcz\u00fcm\u00fc uzun bir kullan\u0131m ge\u00e7mi\u015fine sahiptir ve halk t\u0131bb\u0131nda kolon kanseri tedavisinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Buna dayanarak, farmakolojik mekanizma tahmini ger\u00e7ekle\u015ftirilmi\u015ftir. Geleneksel \u00c7in t\u0131bb\u0131 wolfberry'nin kimyasal bile\u015fenleri \u00fczerine yap\u0131lan \u00f6nceki ara\u015ft\u0131rmalara dayanarak, wolfberry'deki m\u00fckemmel bile\u015fik Jolkinolide B, in vitro sitotoksik aktivite taramas\u0131 ve in vivo biyolojik deneyler yoluyla taranm\u0131\u015ft\u0131r. Kurt \u00fcz\u00fcm\u00fcndeki m\u00fckemmel bile\u015fik Jolkinolide B hedefleri aras\u0131ndaki ili\u015fkiyi ke\u015ffetmek i\u00e7in bir Jolkinolide B-hedef a\u011f\u0131 olu\u015fturulmu\u015f ve hedeflerin fonksiyonel ek a\u00e7\u0131klamas\u0131 gen d\u00fczeyinde ger\u00e7ekle\u015ftirilmi\u015ftir. Bu, Jolkinolide B'nin \u00e7ok hedefli ve \u00e7ok yollu farmakolojik mekanizmalar\u0131 i\u00e7in bir ara\u015ft\u0131rma temeli sa\u011flar.<\/p>\n

Jolkinolide B-PPI etkile\u015fim a\u011f\u0131 analizi, ana hedeflerin ilgili literat\u00fcr ara\u015ft\u0131rmas\u0131yla do\u011frulanan STAT3, MAPK8 ve JUN oldu\u011funu g\u00f6stermektedir; Bu hedefler, h\u00fccre y\u00fczeyindeki resept\u00f6rlerden \u00e7ekirdekteki DNA'ya sinyaller ileterek h\u00fccre \u00f6l\u00fcm\u00fc ve h\u00fccre d\u00f6ng\u00fcs\u00fc gibi biyolojik s\u00fcre\u00e7lere kat\u0131lman\u0131n yan\u0131 s\u0131ra iltihaplanma ve stres yan\u0131t\u0131 gibi patolojik s\u00fcre\u00e7leri d\u00fczenler. MAPK1 ve MAPK3, MAPK'\u0131n \u00fcyeleridir. STAT3, MAPK taraf\u0131ndan aktive edilebilen ve h\u00fccre b\u00fcy\u00fcmesi ve apoptoz gibi bir\u00e7ok h\u00fccresel s\u00fcre\u00e7te kilit rol oynayan, t\u00fcm\u00f6rlerin olu\u015fumuna ve geli\u015fimine kat\u0131lan bir transkripsiyon fakt\u00f6r\u00fcd\u00fcr. Ayr\u0131ca STAT3, TH17 yard\u0131mc\u0131 T h\u00fccrelerinin farkl\u0131la\u015fmas\u0131 i\u00e7in \u00e7ok \u00f6nemlidir ve otoimm\u00fcn hastal\u0131klar, tekrarlayan enfeksiyonlar ve di\u011fer hastal\u0131klarla ili\u015fkilidir.<\/p>\n

GO'nun a\u00e7\u0131klama sonu\u00e7lar\u0131, Jolkinolite B'nin hedeflerinin \u00e7o\u011funun h\u00fccresel matris ve transkripsiyon komplekslerinde bulundu\u011funu ve h\u00fccrelerdeki \u00e7e\u015fitli stres tepkileri ve biyolojik s\u00fcre\u00e7lerde yer ald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Bu sonu\u00e7, Jolkinolite B'nin \u00e7o\u011fu h\u00fccresel ya\u015fam aktivitesinin d\u00fczenlenmesinde rol oynayabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. KEGG zenginle\u015ftirme analizi sonu\u00e7lar\u0131, Jolkinolite B'nin farmakolojik etkilerinin IL-17 sinyal yolu, PD-1\/PD-L1 sinyal yolu ve HIF-1 sinyal yolu dahil olmak \u00fczere \u00e7oklu yollar\u0131n etkile\u015fimini i\u00e7erdi\u011fini g\u00f6stermektedir. Molek\u00fcler kenetlenme sonu\u00e7lar\u0131, Jolkinolide B'nin \u00e7ekirdek proteinler STAT3, MAPK8 ve JUN ile hidrojen ve hidrofobik etkile\u015fimler olu\u015fturdu\u011funu, stabil yap\u0131ya ve potansiyel ara\u015ft\u0131rma de\u011ferine sahip oldu\u011funu ve Jolkinolide B'nin KRK tedavisinde \u00e7oklu hedef ve \u00e7oklu yol \u00f6zelliklerine sahip oldu\u011funu g\u00f6stermektedir.<\/p>\n

Anti-t\u00fcm\u00f6r ila\u00e7lar\u0131n ana etki mekanizmalar\u0131 t\u00fcm\u00f6r h\u00fccresi apoptozunu ind\u00fcklemek, h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fc inhibe etmek ve g\u00f6\u00e7\u00fc bask\u0131lamakt\u0131r. H\u00fccresel d\u00fczeydeki deneysel sonu\u00e7lar, Jolkinolite B'nin HCT116 h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde engelledi\u011fini, h\u00fccre apoptozunu te\u015fvik etti\u011fini ve h\u00fccre g\u00f6\u00e7\u00fcn\u00fc engelledi\u011fini g\u00f6stermi\u015ftir. Bax h\u00fccrelerde y\u00fcksek oranda ifade edildi\u011finde, h\u00fccreler \u00f6l\u00fcm sinyallerine duyarl\u0131yd\u0131 ve apoptozu te\u015fvik etti. Bcl-2 y\u00fcksek oranda ifade edildi\u011finde, Bcl-2, Bax ile heterodimerler olu\u015fturarak h\u00fccre apoptozunu inhibe edebilir. Dolay\u0131s\u0131yla, h\u00fccrelerdeki Bax\/Bcl-2 oran\u0131 h\u00fccre apoptozunun hassasiyetini belirlemede \u00f6nemli bir rol oynamaktad\u0131r. Bu nedenle, h\u00fccresel d\u00fczeyde Western blot do\u011frulama deneyleri, Jolkinolite B'nin HCT116 h\u00fccrelerinde apoptozu te\u015fvik ederek Bax\/Bcl-2 oran\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. A\u011f farmakolojisi analizinin sonu\u00e7lar\u0131na dayanarak, Jolkinolide B, CRC'ye birden fazla hedef ve yolak arac\u0131l\u0131\u011f\u0131yla m\u00fcdahale edebilir ve anti-t\u00fcm\u00f6r aktivitesi, apoptotik genler Bax ve Bcl-2'nin ekspresyonu \u00fczerindeki etkisiyle ili\u015fkili olabilir.<\/p>\n

T\u00fcm\u00f6rlerin invazyonu ve metastaz\u0131, h\u00fccreler aras\u0131 etkile\u015fimleri ve ekstrasel\u00fcler matriksin degradasyonunu i\u00e7eren karma\u015f\u0131k bir s\u00fcre\u00e7tir. H\u00fccre d\u0131\u015f\u0131 matrisin bozulmas\u0131, matris bile\u015fenlerini bozan enzimlerin sentezine ve aktivasyonuna ba\u011fl\u0131d\u0131r. Matriks metalloproteinazlar (MMP'ler) yap\u0131sal homolojiye sahip \u00e7inko ba\u011f\u0131ml\u0131 proteolitik enzimler s\u0131n\u0131f\u0131d\u0131r. Ana fizyolojik i\u015flevleri kolajen, jelatin, elastin, fibronektin ve proteoglikanlar gibi h\u00fccre d\u0131\u015f\u0131 matris bile\u015fenlerini bozmakt\u0131r. Ara\u015ft\u0131rmalar, matriks metalloproteinaz-3 (MMP-3) ve matriks metalloproteinaz-12'nin (MMP-12) t\u00fcm\u00f6r h\u00fccrelerinin arac\u0131l\u0131k etti\u011fi h\u00fccre d\u0131\u015f\u0131 matriksin par\u00e7alanmas\u0131nda \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 ve insanlarda \u00e7e\u015fitli malign t\u00fcm\u00f6rlerin potansiyel invazyonu, metastaz\u0131 ve prognozu ile yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. Bu nedenle, h\u00fccresel d\u00fczeyde Western blot do\u011frulama deneyleri, Jolkinolide B'nin t\u00fcm\u00f6r invazyonunu ve metastaz\u0131n\u0131 inhibe etmek i\u00e7in MMP-2 ve MMP-12 ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 reg\u00fcle etti\u011fini g\u00f6stermi\u015ftir. A\u011f farmakolojisi analizinin sonu\u00e7lar\u0131na g\u00f6re, Jolkinolide B, birden fazla hedef ve yolak arac\u0131l\u0131\u011f\u0131yla CRC'ye m\u00fcdahale edebilir ve t\u00fcm\u00f6r invazyonu ve metastaz\u0131n\u0131 inhibe etmesi, MMP-2 ve MMP-12 ekspresyonu \u00fczerindeki etkisiyle ili\u015fkili olabilir.<\/p>\n

\u00d6zetle, bu \u00e7al\u0131\u015fmada, geleneksel \u00c7in t\u0131bb\u0131 kurt \u00fcz\u00fcm\u00fcndeki aktif bile\u015fen Jolkinolide B ile ilgili hedef proteinler, sinyal yollar\u0131 ve biyolojik i\u015flevler aras\u0131ndaki a\u011f korelasyonuna dayal\u0131 olarak kolorektal kanserin (CRC) \u00f6nlenmesi ve tedavisinde Jolkinolide B'nin mekanizmas\u0131n\u0131 analiz etmek i\u00e7in aktivite taramas\u0131, biyoinformatik ve molek\u00fcler yerle\u015ftirme teknikleri uygulanm\u0131\u015ft\u0131r. Sonu\u00e7lar, bu bile\u015fi\u011fin CRC'yi birden fazla hedef, yol ve biyolojik i\u015flevle tedavi etti\u011fini ve CRC'nin \u00f6nlenmesi ve tedavisinde Jolkinolide B mekanizmas\u0131 hakk\u0131nda daha fazla ara\u015ft\u0131rma i\u00e7in y\u00f6n sa\u011flad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bunu g\u00f6z \u00f6n\u00fcnde bulundurarak, bu proje gelecekte molek\u00fcler biyoloji ve patofizyoloji y\u00f6ntemlerini birle\u015ftirerek mekanizma ara\u015ft\u0131rmas\u0131 yapmaya devam edecektir.<\/p>","protected":false},"excerpt":{"rendered":"

Jolkinolide B'nin a\u011f farmakolojisi ve deneysel ara\u015ft\u0131rmalara dayal\u0131 olarak kolon t\u00fcm\u00f6rlerinin tedavisindeki mekanizmas\u0131 Kolorektal kanser (KRK), d\u00fcnyada en s\u0131k g\u00f6r\u00fclen \u00fc\u00e7\u00fcnc\u00fc k\u00f6t\u00fc huylu t\u00fcm\u00f6rd\u00fcr ve insan sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdittir. 2015 y\u0131l\u0131nda kolon kanserinden \u00f6lenlerin say\u0131s\u0131 774000'e ula\u015fm\u0131\u015ft\u0131r. D\u00fcnyadaki muazzam de\u011fi\u015fiklikler nedeniyle [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/colon-tumors\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research Colorectal cancer (CRC) is the third most common malignant tumor in the world, which is a serious threat to human health. In 2015, the number of deaths from colon cancer reached 774000. Because of the tremendous changes in […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/colon-tumors\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-06T20:06:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/colon-tumors\/\",\"url\":\"https:\/\/longchangextracts.com\/colon-tumors\/\",\"name\":\"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/colon-tumors\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/colon-tumors\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg\",\"datePublished\":\"2024-08-06T20:06:46+00:00\",\"dateModified\":\"2024-08-06T20:06:46+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/colon-tumors\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/colon-tumors\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/colon-tumors\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/colon-tumors\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Jolkinolide B'nin a\u011f farmakolojisi ve deneysel ara\u015ft\u0131rmalara dayal\u0131 olarak kolon t\u00fcm\u00f6rlerinin tedavisindeki mekanizmas\u0131 - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/colon-tumors\/","og_locale":"tr_TR","og_type":"article","og_title":"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research - China Chemical Manufacturer","og_description":"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research Colorectal cancer (CRC) is the third most common malignant tumor in the world, which is a serious threat to human health. In 2015, the number of deaths from colon cancer reached 774000. Because of the tremendous changes in […]","og_url":"https:\/\/longchangextracts.com\/tr\/colon-tumors\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-06T20:06:46+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"9 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/colon-tumors\/","url":"https:\/\/longchangextracts.com\/colon-tumors\/","name":"Jolkinolide B'nin a\u011f farmakolojisi ve deneysel ara\u015ft\u0131rmalara dayal\u0131 olarak kolon t\u00fcm\u00f6rlerinin tedavisindeki mekanizmas\u0131 - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/colon-tumors\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/colon-tumors\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg","datePublished":"2024-08-06T20:06:46+00:00","dateModified":"2024-08-06T20:06:46+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/colon-tumors\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/colon-tumors\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/colon-tumors\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-37.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/colon-tumors\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Mechanism of Jolkinolide B in the treatment of colon tumors based on network pharmacology and experimental research"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/7485"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=7485"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/7485\/revisions"}],"predecessor-version":[{"id":7502,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/7485\/revisions\/7502"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=7485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=7485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=7485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}