{"id":7447,"date":"2024-08-06T19:55:48","date_gmt":"2024-08-06T19:55:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7447"},"modified":"2024-08-06T19:55:48","modified_gmt":"2024-08-06T19:55:48","slug":"huanglian-jiedu-tang","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/huanglian-jiedu-tang\/","title":{"rendered":"Huanglian Jiedu Tang'\u0131n vask\u00fcler demans tedavisindeki mekanizmas\u0131n\u0131n a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>Huanglian Jiedu Tang'\u0131n vask\u00fcler demans tedavisindeki mekanizmas\u0131n\u0131n a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nVask\u00fcler demans (VD), \u00e7oklu serebrovask\u00fcler fakt\u00f6rlerin neden oldu\u011fu bir bili\u015fsel i\u015flev bozuklu\u011fu sendromudur ve Alzheimer hastal\u0131\u011f\u0131ndan sonra en b\u00fcy\u00fck ikinci demans t\u00fcr\u00fcd\u00fcr. Ara\u015ft\u0131rma, d\u00fcnyada 65 ya\u015f \u00fcst\u00fc ki\u015filer aras\u0131nda VD g\u00f6r\u00fclme oran\u0131n\u0131n 5%~10% kadar y\u00fcksek oldu\u011funu g\u00f6stermektedir. N\u00fcfusun ya\u015flanmas\u0131n\u0131n \u015fiddetlenmesiyle birlikte, VD hastalar\u0131n\u0131n 2050 y\u0131l\u0131nda \u00fc\u00e7 kat\u0131na \u00e7\u0131kmas\u0131 ve orta ya\u015fl\u0131 ve ya\u015fl\u0131 insanlar\u0131n sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdit olu\u015fturmas\u0131 beklenmektedir. \u015eu anda Bat\u0131 t\u0131bb\u0131nda VD i\u00e7in \u00f6zel bir ila\u00e7 bulunmamaktad\u0131r ve Bat\u0131 t\u0131bb\u0131n\u0131n uzun s\u00fcreli kullan\u0131m\u0131 ciddi yan etkilere neden olabilir. Bununla birlikte, geleneksel \u00c7in t\u0131bb\u0131 form\u00fclleri, \u00e7ok hedefli ve \u00e7ok mekanizmal\u0131 etkilerin avantajlar\u0131na sahiptir; bu da \u00e7ok hedefli, \u00e7ok yollu ve \u00e7ok sistemli m\u00fcdahaleler yoluyla VD'nin karma\u015f\u0131k patogenezine minimum toksik yan etki ve \u00f6nemli terap\u00f6tik etkilerle m\u00fcdahale edebilir.<\/p>\n<p>Modern toplum \"beyin meridyenindeki toksik hasar\u0131n\" VD'nin ana \u00e7ekirdek patogenezi oldu\u011funa ve ana tedavi y\u00f6ntemlerinin ate\u015ften ar\u0131nd\u0131rma ve detoksifikasyon oldu\u011funa inanmaktad\u0131r. Huanglian Jiedu Tang, Ge Hong'un \"Dirsek Rezervi i\u00e7in Acil Durum Form\u00fcl\u00fc \"nden kaynaklan\u0131r ve ad\u0131 ilk olarak \"D\u0131\u015f Platformun Gizli Temelleri \"nde ge\u00e7mi\u015ftir. Huanglian, Huangbai, Huangqin ve Gardenia'dan olu\u015fur ve ate\u015fin temizlenmesi ve detoksifikasyon i\u00e7in temsili bir form\u00fcld\u00fcr. \u0130nme sonras\u0131 bili\u015fsel bozukluk, vask\u00fcler demans\u0131n \u00f6nemli bir dal\u0131d\u0131r. Klinik \u00e7al\u0131\u015fmalar, Huanglian Jiedu Tang'\u0131n inme sonras\u0131 bili\u015fsel bozuklu\u011fu olan hastalarda C-reaktif protein, n\u00f6rospesifik enolaz, D-dimer ve geleneksel \u00c7in t\u0131bb\u0131 sendromu skorlar\u0131 \u00fczerinde olumlu bir etkiye sahip oldu\u011funu ve bili\u015fsel i\u015flevlerini iyile\u015ftirebilece\u011fini g\u00f6stermi\u015ftir; Huanglian Jiedu Tang, yaln\u0131zca \u0131s\u0131 toksisitesi ile s\u0131n\u0131rl\u0131 olmay\u0131p genel toksisitesi \u00fczerinde temizleyici bir etkiye sahiptir. Deneysel sonu\u00e7lar, Lianjiedu Tang'\u0131n skopolamin kaynakl\u0131 haf\u0131za edinme bozukluklar\u0131 olan farelerin \u00f6\u011frenme ve haf\u0131za yeteneklerini geli\u015ftirebilece\u011fini g\u00f6stermi\u015ftir. Mekanizma asetilkolinesteraz (AchE) aktivitesinin artt\u0131r\u0131lmas\u0131 ve asetilkolinesteraz (ChAT) aktivitesinin inhibe edilmesi ile ilgili olabilir. Geleneksel \u00c7in t\u0131bb\u0131 form\u00fclleri b\u00fct\u00fcnl\u00fck ve \u00e7e\u015fitlilik \u00f6zelliklerine sahiptir ve geleneksel farmakolojik y\u00f6ntemlerin karma\u015f\u0131k etki mekanizmalar\u0131n\u0131 de\u011ferlendirmesi zordur. A\u011f farmakolojisi ara\u015ft\u0131rma konsepti, \"geleneksel \u00c7in t\u0131bb\u0131 bile\u015fenleri, hedefleri, yollar\u0131 ve hastal\u0131k hedefleri\" aras\u0131ndaki etkile\u015fim ili\u015fkisini sistematik olarak analiz edebilen sistemik d\u00fczeyden ve biyolojik a\u011flar\u0131n genel perspektifinden ba\u015flamay\u0131 vurgulamaktad\u0131r. Geleneksel \u00c7in t\u0131bb\u0131 form\u00fcllerinin \u00e7oklu bile\u015fenleri, hedefleri ve yollar\u0131 aras\u0131ndaki etkile\u015fim ili\u015fkisini g\u00f6sterebilir, bu da geleneksel \u00c7in t\u0131bb\u0131 sendrom farkl\u0131la\u015fmas\u0131 ve tedavisinin genel fikri ile \u00f6rt\u00fc\u015f\u00fcr.<\/p>\n<p>Huanglian Jiedu Tang'\u0131n etkili bile\u015fenleri karma\u015f\u0131kt\u0131r ve birden fazla hedefi vard\u0131r, ancak Huanglian Jiedu Tang'\u0131n VD tedavisindeki etkili bile\u015fenleri ve mekanizmas\u0131 hala belirsizdir. Bu nedenle, bu \u00e7al\u0131\u015fmada Huanglian Jiedu Tang'\u0131n VD tedavisindeki potansiyel mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak ve ke\u015ffetmek i\u00e7in a\u011f farmakolojisi y\u00f6ntemleri ve in vitro farmakoloji do\u011frulamas\u0131 uygulanm\u0131\u015f ve Huanglian Jiedu Tang'\u0131n VD'yi nas\u0131l iyile\u015ftirdi\u011fine dair bilimsel soru incelenerek klinik uygulamas\u0131 i\u00e7in bir temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7448\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-305.png\" alt=\"\" width=\"703\" height=\"681\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7449\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-257.png\" alt=\"\" width=\"707\" height=\"508\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7450\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-242.png\" alt=\"\" width=\"702\" height=\"825\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-242.png 702w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-242-613x720.png 613w\" sizes=\"(max-width: 702px) 100vw, 702px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7451\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-222.png\" alt=\"\" width=\"699\" height=\"266\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7452\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-200.png\" alt=\"\" width=\"327\" height=\"376\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7453\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-183.png\" alt=\"\" width=\"309\" height=\"351\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7454\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-167.png\" alt=\"\" width=\"328\" height=\"238\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7455\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-150.png\" alt=\"\" width=\"323\" height=\"240\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7456\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-142.png\" alt=\"\" width=\"700\" height=\"821\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-142.png 700w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-142-614x720.png 614w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/>Tart\u0131\u015fma ve Sonu\u00e7: Etkili bile\u015fen hedef a\u011f\u0131, Huanglian Jiedu Tang'\u0131n VD i\u00e7in \u00e7ok bile\u015fenli ve \u00e7ok hedefli tedavi \u00f6zelliklerine sahip oldu\u011funu g\u00f6stermektedir. Sonu\u00e7lar berberin, kuersetin, ferulik asit ve geniposidin temel aktif bile\u015fenler oldu\u011funu g\u00f6stermektedir. Ara\u015ft\u0131rmalar, berberinin hipokamp\u00fcste enflamatuar kemokin monosit kemoatraktan protein-1 (MCP-1) ve P38MAPK yola\u011f\u0131 proteinlerinin ekspresyonunu inhibe ederek VD s\u0131\u00e7anlar\u0131nda \u00f6\u011frenme ve haf\u0131zay\u0131 iyile\u015ftirebilece\u011fini bulmu\u015ftur. Ara\u015ft\u0131rmalar, kuersetinin beyin dokusundaki nitrik oksit (NO) i\u00e7eri\u011fini azaltmas\u0131, nitrik oksit sentaz (NOS) aktivitesini inhibe etmesi, beyin enerji metabolizmas\u0131n\u0131 te\u015fvik etmesi, endotelin-1 (endothelin-1) ve kalsitonin geniyle ili\u015fkili peptid (CGRP) aras\u0131ndaki dengeyi d\u00fczenlemesi ve hemoreolojiyi iyile\u015ftirmesiyle ili\u015fkili olabilecek VD s\u0131\u00e7anlar\u0131nda \u00f6\u011frenme ve haf\u0131za bozuklu\u011funu hafifletebilece\u011fini g\u00f6stermi\u015ftir. Ara\u015ft\u0131rmalar, ferulik asidin kolinerjik sistem fonksiyonunu, antioksidan aktiviteyi art\u0131rabildi\u011fini ve VD s\u0131\u00e7anlar\u0131nda uyar\u0131c\u0131 amino asitleri d\u00fczenleyebildi\u011fini ve b\u00f6ylece n\u00f6roprotektif etkiler uygulayabildi\u011fini g\u00f6stermi\u015ftir. Ara\u015ft\u0131rmalar, geniposidin VD s\u0131\u00e7anlar\u0131nda kortikal ve hipokampal n\u00f6ronlar\u0131n apoptozunu ve nekrozunu hafifletebilece\u011fini g\u00f6stermi\u015ftir.<br \/>\nHuanglian Jiedu Tang'\u0131n aktif bile\u015fenlerinin VD hedefleriyle kesi\u015ftirilmesiyle 105 ila\u00e7 hastal\u0131\u011f\u0131 ortak etkili hedef gen elde edilmi\u015ftir. Huanglian Jiedu Tang'\u0131n en \u00f6nemli \u00fc\u00e7 hedefi MAPK8, MAPK9 ve MAPK10'dur. MAPK8, MAPK9 ve MAPK10 s\u0131ras\u0131yla JNK1, JNK2 ve JNK3 olarak da bilinir. Mitojen aktive protein kinaz MAPK sinyal yolunun \u00f6nemli \u00fcyeleridir, h\u00fccre \u00e7o\u011falmas\u0131, farkl\u0131la\u015fmas\u0131, hayatta kalmas\u0131 ve apoptozunda \u00f6nemli bir rol oynarlar ve Alzheimer hastal\u0131\u011f\u0131n\u0131n olu\u015fumu ve geli\u015fimi ile yak\u0131ndan ili\u015fkilidirler.<br \/>\nBu \u00e7al\u0131\u015fmada taranan KEGG sinyal yolaklar\u0131 aras\u0131nda, MAPK sinyal yola\u011f\u0131 Huanglian Jiedu Tang'\u0131n etkili hedefleriyle en y\u00fcksek korelasyona sahiptir ve bunu FoxO sinyal yola\u011f\u0131 takip etmektedir. Ara\u015ft\u0131rmalar, klasik MAPK sinyal yolunun \u00f6nemli bir bile\u015feni olan JNK sinyal yolunun h\u00fccresel otofaji, apoptoz, enflamatuar yan\u0131t ve vask\u00fcler demans\u0131n olu\u015fumu ve geli\u015fiminde \u00e7ok \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. FoxO1, esas olarak h\u00fccre \u00e7o\u011falmas\u0131, farkl\u0131la\u015fma, otofaji, apoptoz, oksidatif stres, DNA hasar\u0131\/onar\u0131m\u0131 ve di\u011fer ilgili mekanizmalar\u0131 d\u00fczenleyen Forkhead Box O (FoxO) transkripsiyon fakt\u00f6r\u00fc ailesinin ana temsilcisidir. Ara\u015ft\u0131rmalar, aktive edilmi\u015f JNK'n\u0131n FoxO1'in ifadesini d\u00fczenleyebilece\u011fini g\u00f6stermi\u015ftir. JNK, FoxO1'in ortak protein 14-3-3'e ba\u011flanmas\u0131n\u0131 art\u0131rarak n\u00fckleer translokasyonu te\u015fvik eder ve transkripsiyonel aktiviteyi azalt\u0131r. Bu \u00e7al\u0131\u015fmada, VD patogenezi ile birlikte, otofaji, enflamatuar yan\u0131t, oksidatif stres yan\u0131t\u0131, h\u00fccre apoptozu ve JNK\/FoxO1 yolu, Huanglian Jiedu Tang'\u0131n in vitro h\u00fccre deneylerinde VD'ye m\u00fcdahalesi i\u00e7in olas\u0131 mekanizmalar olarak taranm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, Huanglian Jiedu Tang'\u0131n PC12 h\u00fccrelerinde glutamat taraf\u0131ndan ind\u00fcklenen enflamatuar ve oksidatif stres tepkilerini \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebildi\u011fini ve bunun da literat\u00fcr bulgular\u0131yla tutarl\u0131 olarak JNK\/FoxO1 yola\u011f\u0131n\u0131n inhibisyonuyla ili\u015fkili olabilece\u011fini g\u00f6stermektedir. LC3-II, Beclin-1 ve P62 proteinleri otofagozomlar\u0131n olu\u015fumunda rol oynar ve otofajiyi \u00f6l\u00e7mek i\u00e7in \u00f6nemli g\u00f6sterge proteinleridir. Atg, otofajiyi d\u00fczenleyebilir ve Atg1, Atg5, Atg6, Atg7, vb. gibi bir dizi d\u00fczenleyici fakt\u00f6r i\u00e7erir. Otofaji ilerledik\u00e7e, sitoplazmadaki LC3-I'in \u00e7\u00f6z\u00fcn\u00fcr formu, Atg7'nin etkisi alt\u0131nda fosfatidiletanolamine kovalent olarak ba\u011flanarak otofagozom membran\u0131na ba\u011flanan ve otofajiyi te\u015fvik eden LC3-II'yi olu\u015fturur. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 Huanglian Jiedu Tang'\u0131n JNK, p-JNK, FoxO1, LC3II\/I, Beclin-1, Atg7, Caspase-3 ve Caspase-9'un protein ifadesini azaltabildi\u011fini ve p-FoxO1 ve P62'nin protein ifadesini art\u0131rabildi\u011fini g\u00f6stermektedir. Bu, Huanglian Jiedu Tang'\u0131n literat\u00fcrdeki sonu\u00e7lara benzer \u015fekilde JNK\/FoxO1 yolunu bask\u0131layarak otofajiyi ve h\u00fccre apoptozunu inhibe edebilece\u011fini g\u00f6stermektedir.<br \/>\n\u00d6zetle, bu \u00e7al\u0131\u015fmada Huanglian Jiedu Tang'\u0131n VD tedavisindeki olas\u0131 mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in a\u011f farmakolojisi ve deneysel do\u011frulama y\u00f6ntemleri kullan\u0131lm\u0131\u015ft\u0131r. Huanglian Jiedu Tang'\u0131n VD \u00fczerindeki terap\u00f6tik etkisini JNK\/FoxO1 yola\u011f\u0131n\u0131 inhibe ederek ve b\u00f6ylece enflamasyon, oksidatif stres, otofaji ve h\u00fccre apoptozunu bask\u0131layarak g\u00f6sterebilece\u011fi sonucuna var\u0131lm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma, Huanglian Jiedu Tang'\u0131n VD tedavisindeki etkinli\u011fi i\u00e7in bir temel olu\u015fturmakta ve ayr\u0131ca gelecekte Huanglian Jiedu Tang'\u0131n VD \u00fczerindeki etki mekanizmas\u0131 i\u00e7in yeni fikirler sunmaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification Vascular dementia (VD) is a cognitive dysfunction syndrome caused by multiple cerebrovascular factors, and is the second largest type of dementia after Alzheimer&#8217;s disease. The survey shows that the incidence rate of VD among people over 65 [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/huanglian-jiedu-tang\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Huanglian Jiedu Tang in treating vascular dementia based on network pharmacology and experimental verification Vascular dementia (VD) is a cognitive dysfunction syndrome caused by multiple cerebrovascular factors, and is the second largest type of dementia after Alzheimer&#8217;s disease. 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