{"id":7379,"date":"2024-08-06T19:39:02","date_gmt":"2024-08-06T19:39:02","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7379"},"modified":"2024-08-06T19:39:02","modified_gmt":"2024-08-06T19:39:02","slug":"huangqi-jianzhong-decoction","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/huangqi-jianzhong-kaynatma\/","title":{"rendered":"Kokmu\u015f \u015fakay\u0131ktan feniletanolik glikozitlerin tan\u0131mlanmas\u0131 ve insan akci\u011fer adenokarsinomu A549 h\u00fccrelerine kar\u015f\u0131 in vitro mekanizma \u00e7al\u0131\u015fmas\u0131"},"content":{"rendered":"<p>Kokmu\u015f \u015fakay\u0131ktan feniletanolik glikozitlerin tan\u0131mlanmas\u0131 ve insan akci\u011fer adenokarsinomu A549 h\u00fccrelerine kar\u015f\u0131 in vitro mekanizma \u00e7al\u0131\u015fmas\u0131<br \/>\nAkci\u011fer kanseri, bron\u015fiyal mukoza ve bezlerde meydana gelen k\u00f6t\u00fc huylu bir t\u00fcm\u00f6rd\u00fcr. Ulusal Kanser Merkezi taraf\u0131ndan sa\u011flanan verilere g\u00f6re, 2022 y\u0131l\u0131nda \u00c7in'de akci\u011fer kanseri g\u00f6r\u00fclme oran\u0131 10,6% ve \u00f6l\u00fcm oran\u0131 24% olacak ve \u00c7in'deki k\u00f6t\u00fc huylu t\u00fcm\u00f6rlerin \u00f6l\u00fcm oran\u0131nda ilk s\u0131rada yer alacak ve kad\u0131n hastalar\u0131n oran\u0131 y\u0131ldan y\u0131la artacak ve daha gen\u00e7 olma e\u011filiminde olacakt\u0131r. Geleneksel \u00c7in t\u0131bb\u0131, \u00e7ok bile\u015fenli ve \u00e7ok hedefli avantajlar\u0131 nedeniyle, t\u00fcm\u00f6r ilerlemesini geciktirebilir, t\u00fcm\u00f6r h\u00fccresinin radyoterapi ve kemoterapiye duyarl\u0131l\u0131\u011f\u0131n\u0131 art\u0131rabilir, ameliyat sonras\u0131 enfeksiyonlar\u0131 azaltabilir ve \u00e7e\u015fitli yollarla radyoterapi ve kemoterapinin neden oldu\u011fu advers reaksiyonlar\u0131 en aza indirebilir, b\u00f6ylece t\u00fcm\u00f6r n\u00fcks\u00fcn\u00fc ve metastaz\u0131 ve uzun s\u00fcreli stabil t\u00fcm\u00f6rleri \u00f6nleme ve tedavi etme hedefine ula\u015fabilir. Kokmu\u015f \u015eakay\u0131k, k\u00f6t\u00fc huylu t\u00fcm\u00f6rlerin tedavisi i\u00e7in Hunan halk t\u0131bb\u0131nda ke\u015ffedilen etkili bir geleneksel \u00c7in ilac\u0131d\u0131r ve 40 y\u0131ldan fazla tekrarlanan klinik ve bilimsel ara\u015ft\u0131rma uygulamas\u0131 ile se\u00e7ilmi\u015ftir. Kokmu\u015f \u015fakay\u0131k hafif bir yap\u0131ya, keskin ve ac\u0131 bir tada sahiptir ve \"r\u00fczgar ve rutubeti giderme, detoksifiye etme ve kan staz\u0131n\u0131 da\u011f\u0131tma, \u015fi\u015flik ve a\u011fr\u0131y\u0131 azaltma\" etkilerine sahiptir. Hunan b\u00f6lgesinde ba\u015fta akci\u011fer kanseri olmak \u00fczere \u00e7e\u015fitli t\u00fcm\u00f6rlerin tedavisinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Ancak, kokmu\u015f \u015fakay\u0131\u011f\u0131n anti-t\u00fcm\u00f6r tedavisindeki etkili bile\u015fenleri ve mekanizmalar\u0131 hen\u00fcz net de\u011fildir. Ara\u015ft\u0131rma grubunun \u00f6n deneylerinde, Paeonia lactiflora'n\u0131n feniletanolik glikozitler a\u00e7\u0131s\u0131ndan zengin oldu\u011fu ve iyi bir anti-t\u00fcm\u00f6r aktivitesine sahip oldu\u011fu bulunmu\u015ftur. Bu \u00e7al\u0131\u015fmada, Paeonia lactiflora feniletanolik glikozitlerinin anti-t\u00fcm\u00f6r etkisini ve mekanizmas\u0131n\u0131 daha fazla incelemek ve etkili ve d\u00fc\u015f\u00fck toksisiteli geleneksel \u00c7in t\u0131bb\u0131 preparatlar\u0131n\u0131n geli\u015ftirilmesi i\u00e7in temel olu\u015fturmak amac\u0131yla Paeonia lactiflora'daki feniletanolik glikozitleri daha fazla tan\u0131mlayaca\u011f\u0131z ve A549 h\u00fccre proliferasyonunu in vitro olarak inhibe etme mekanizmalar\u0131n\u0131 ara\u015ft\u0131raca\u011f\u0131z.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7380\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-299.png\" alt=\"\" width=\"785\" height=\"737\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-299.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-299-768x721.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-299-767x720.png 767w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7381\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-251.png\" alt=\"\" width=\"782\" height=\"298\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-251.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-251-768x293.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7382\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-236.png\" alt=\"\" width=\"784\" height=\"209\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-236.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-236-768x205.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7383\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-216.png\" alt=\"\" width=\"351\" height=\"271\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7384\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-195.png\" alt=\"\" width=\"343\" height=\"209\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7385\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-178.png\" alt=\"\" width=\"785\" height=\"398\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-178.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-178-768x389.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7386\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-163.png\" alt=\"\" width=\"785\" height=\"242\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-163.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-163-768x237.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7387\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-147.png\" alt=\"\" width=\"345\" height=\"180\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7388\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-139.png\" alt=\"\" width=\"783\" height=\"345\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-139.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-139-768x338.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7389\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-109.png\" alt=\"\" width=\"783\" height=\"301\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-109.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-109-768x295.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7390\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-102.png\" alt=\"\" width=\"783\" height=\"237\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-102.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-102-768x232.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/>Akci\u011fer kanseri, geleneksel \u00c7in t\u0131bb\u0131nda \"akci\u011fer birikimi\" ve \"akci\u011fer ta\u015f\u0131\" kategorilerine ait olan, bron\u015fiyal mukoza ve bezlerde meydana gelen k\u00f6t\u00fc huylu bir t\u00fcm\u00f6rd\u00fcr. \u00c7a\u011fda\u015f t\u0131p uzmanlar\u0131, akci\u011fer kanserinin s\u00fcrekli art\u0131\u015f\u0131n\u0131n, akci\u011ferlerde toksik patojenlerin birikmesine yol a\u00e7an \u00e7evre kirlili\u011fi veya uzun s\u00fcreli sigara i\u00e7iminden kaynakland\u0131\u011f\u0131na inanmaktad\u0131r. Akci\u011ferlerin qi hareketi bozulur ve toksinler ile qi ve kan\u0131n birle\u015fimi zamanla akci\u011fer birikimine yol a\u00e7ar. En temel patolojik mekanizma kanser toksini, balgam ve kan staz\u0131n\u0131n konsolidasyonudur; eksiklik ve fazlal\u0131k kombinasyonu ana patolojik de\u011fi\u015fikliklerdir. \u00dcnl\u00fc bir geleneksel \u00c7in t\u0131bb\u0131 uygulay\u0131c\u0131s\u0131 ve Hu Xiang Ouyang'\u0131n \u00e7e\u015fitli hastal\u0131klar ekol\u00fcn\u00fcn miras\u00e7\u0131s\u0131 olan Profes\u00f6r Ouyang Qi'nin akci\u011fer kanseri tedavisi ve ameliyat sonras\u0131 n\u00fcks\u00fcn \u00f6nlenmesi konusundaki deneyimlerinden yararlan\u0131lm\u0131\u015ft\u0131r, Akci\u011fer kanserinin etiyolojisi ve patogenezinin patojenik toksinlerin istilas\u0131na, akci\u011fer fonksiyonunun kayb\u0131na yol a\u00e7an yetersiz pozitif qi'ye, balgam birikimine ve zamanla durgunlu\u011fa ba\u011fl\u0131 oldu\u011funa, v\u00fccutta hem qi hem de kan yin ve yang eksikli\u011fine yol a\u00e7t\u0131\u011f\u0131na ve sonu\u00e7ta akci\u011fer kanserinin ortaya \u00e7\u0131kmas\u0131na neden oldu\u011funa inan\u0131yoruz. Akci\u011fer kanserinin ana patogenezi, patojenik fakt\u00f6rler, balgam, p\u0131ht\u0131la\u015fma ve toksin gibi patojenik fakt\u00f6rlerin yan\u0131 s\u0131ra qi durgunlu\u011fu ve kan staz\u0131 birikimi ile karakterizedir. Tedavi prensibi detoksifiye etmek ve kan staz\u0131n\u0131 gidermek, balgam\u0131 ortadan kald\u0131rmak ve nod\u00fclleri da\u011f\u0131tmakt\u0131r. Kokmu\u015f \u015fakay\u0131k, Verbenaceae familyas\u0131ndan bir bitki olan Clerodendrum bungei Steud'un g\u00f6vdesi ve yapra\u011f\u0131d\u0131r. \u00c7in'de yayg\u0131n olarak bulunur ve bol miktarda t\u0131bbi kayna\u011fa sahiptir. Do\u011fas\u0131 sakin, keskin ve ac\u0131 bir tada sahiptir. Antik literat\u00fcr, akci\u011fer kanseri i\u00e7in \"detoksifikasyon ve kan staz\u0131n\u0131 giderme, balgam\u0131 ortadan kald\u0131rma ve nod\u00fclleri da\u011f\u0131tma\" tedavi prensibi ile uyumlu olan \"r\u00fczgar ve nemi da\u011f\u0131tma, kan staz\u0131n\u0131 detoksifiye etme ve da\u011f\u0131tma, \u015fi\u015fli\u011fi azaltma ve a\u011fr\u0131y\u0131 hafifletme\" i\u015flevlerine sahip oldu\u011funu kaydeder. Ara\u015ft\u0131rmalar, hem kokmu\u015f \u015fakay\u0131k bile\u015fi\u011finin hem de ekstrakt\u0131n\u0131n iyi bir anti-t\u00fcm\u00f6r aktivitesine, \u00f6zellikle de akci\u011fer kanserine kar\u015f\u0131 en iyi anti-t\u00fcm\u00f6r aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. \u00d6n ara\u015ft\u0131rmada, ara\u015ft\u0131rma ekibi kokmu\u015f \u015fakay\u0131\u011f\u0131n kaynatma ve farkl\u0131 ekstrakte edilmi\u015f bile\u015fenleri \u00fczerinde \u00e7oklu s\u0131v\u0131 kalite analizleri ger\u00e7ekle\u015ftirdi ve kokmu\u015f \u015fakay\u0131\u011f\u0131n ana bile\u015fenlerinin feniletanolik glikozitler oldu\u011funu ve bunlar\u0131n aras\u0131nda ana bile\u015fenlerin yaprak benzeri ve heterojen yaprak benzeri glikozitler oldu\u011funu buldu. Deneysel tarama ve g\u00f6sterimden sonra, kokulu \u015fakay\u0131k feniletanolik glikozitlerinin iyi anti-t\u00fcm\u00f6r etkilere sahip oldu\u011fu bulunmu\u015ftur. Bu nedenle, esas olarak yaprak benzeri ve heterojen yaprak benzeri glikozitlerden olu\u015fan feniletanolik glikozitlerin, kokulu \u015fakay\u0131klar\u0131n anti-t\u00fcm\u00f6r etkilerinin ana bile\u015fenleri olabilece\u011fi tahmin edilmektedir.<\/p>\n<p>EphA2, resept\u00f6r tirozin kinazlar\u0131n (RKT'ler) en b\u00fcy\u00fck alt ailesi olan Eph ailesinin ana \u00fcyesidir ve \u00e7e\u015fitli malign t\u00fcm\u00f6rlerde, \u00f6zellikle y\u00fcksek malignite ve g\u00fc\u00e7l\u00fc invazyon ve metastaz kabiliyetine sahip t\u00fcm\u00f6rlerde a\u015f\u0131r\u0131 eksprese edilir ve akci\u011fer kanserinin invazyonu ve metastaz\u0131nda rol oynar. Ara\u015ft\u0131rmalar, EphA2 resept\u00f6rlerinin akci\u011fer kanseri hastalar\u0131nda ve akci\u011fer kanseri h\u00fccre hatlar\u0131nda \u00f6nemli \u00f6l\u00e7\u00fcde ifade edildi\u011fini ve ifade seviyesi ne kadar y\u00fcksekse, hastalar\u0131n prognozunun o kadar k\u00f6t\u00fc oldu\u011funu bulmu\u015ftur. Akci\u011fer kanseri dokusunda, epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fcnde (EGFR) fosforile EphA2 S897'de bir mutasyon g\u00f6zlenmi\u015f ve h\u00fccre zar\u0131nda ekson 19 delesyonu bulunmu\u015ftur. EphA2 biyolojik etkilerini iki \u015fekilde g\u00f6sterir: ligand ba\u011f\u0131ml\u0131 ve ligand ba\u011f\u0131ms\u0131z. Bir yandan, EphrinA1 ligand\u0131 EphA2 resept\u00f6r\u00fcne ba\u011fland\u0131\u011f\u0131nda, EphA2 internalizasyona u\u011frar ve daha sonra ubikitinasyon yoluyla bozunur; Ayn\u0131 zamanda, EphA2 fosforilasyon i\u00e7in tirozin kinaz taraf\u0131ndan aktive edilirken, EphA2 S897 b\u00f6lgesi defosforile edilir, b\u00f6ylece PI3K\/ATK ve Ras\/MAPK gibi sinyal yollar\u0131n\u0131 inhibe ederek ligand ba\u011f\u0131ml\u0131 antit\u00fcm\u00f6r etkiler g\u00f6sterir. \u00d6te yandan, EphrinA1 ligand\u0131 d\u00fc\u015f\u00fck eksprese edildi\u011finde ve EphA2 y\u00fcksek eksprese edildi\u011finde, EphA2 fosforile olur ve S897 b\u00f6lgesi yoluyla aktive olurken, tirozin fosforilasyon seviyesi azal\u0131r, b\u00f6ylece PI3K\/ATK\/mTOR ve Pyk2\/c-Src sinyal yollar\u0131n\u0131 aktive ederek liganddan ba\u011f\u0131ms\u0131z t\u00fcm\u00f6rijenik etkiler g\u00f6sterir. Ligand ba\u011f\u0131ml\u0131 olmayan EphA2 sinyali t\u00fcm\u00f6r proliferasyonunu ve metastaz\u0131n\u0131 te\u015fvik edebilir, t\u00fcm\u00f6r ila\u00e7 direncini art\u0131rabilir ve t\u00fcm\u00f6r k\u00f6k h\u00fccresi benzeri \u00f6zellikleri koruyabilir. EphA2'nin ligandla aktive edilen antikanser ve ligandla aktive edilmeyen pro kanser olmak \u00fczere ikili aktiviteye sahip oldu\u011fu ve EphA2 S897 b\u00f6lgesinin defosforilasyonu veya fosforilasyonunun iki z\u0131t biyolojik etkiyi kontrol eden anahtar oldu\u011fu g\u00f6r\u00fclebilir. EphA2 S897'nin defosforilasyonu ligand EphrinA1 ile ilgiliyken, EphA2 S897 \u00fczerindeki fosforilasyon en erken ve tan\u0131nan \u00f6nemli fakt\u00f6r olan ATK ile ilgilidir. ATK fosforilasyonu, EphA2 fakt\u00f6r\u00fcn\u00fcn h\u00fccre g\u00f6\u00e7\u00fcn\u00fc ve istilas\u0131n\u0131 te\u015fvik etmesinde \u00f6nemli bir fakt\u00f6rken, EphrinA1 ligand\u0131n\u0131n EphrinA1'e ba\u011flanmas\u0131 ATK aktivasyonunu inhibe eder ve t\u00fcm\u00f6r h\u00fccresi g\u00f6\u00e7\u00fcn\u00fc bask\u0131lar. EphA2'nin ATK'n\u0131n hem yukar\u0131 ak\u0131\u015f negatif d\u00fczenleyicisi hem de a\u015fa\u011f\u0131 ak\u0131\u015f efekt\u00f6r\u00fc oldu\u011funa dair raporlar vard\u0131r. PI3K\/ATK\/mTOR yola\u011f\u0131n\u0131n aktivasyonu, ligand EphrinA1'lerin yoklu\u011fu ile birle\u015fti\u011finde, EphA2'nin bir t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131dan ATK taraf\u0131ndan fosforile edilen ve malign t\u00fcm\u00f6r geli\u015fimini destekleyen bir pro t\u00fcm\u00f6r fakt\u00f6r\u00fcne ge\u00e7mesine neden olur. Raporlara g\u00f6re, EphA2, Wnt - \u03b2 - katenin yolu arac\u0131l\u0131\u011f\u0131yla mide kanseri h\u00fccrelerinde EMT'nin ilerlemesini te\u015fvik etmektedir.<\/p>\n<p>Ara\u015ft\u0131rma ekibi taraf\u0131ndan yap\u0131lan \u00f6nceki ara\u015ft\u0131rmalar, kokulu \u015fakay\u0131k \u00f6z\u00fct\u00fcn\u00fcn akci\u011fer kanserinde EMT ile ilgili fakt\u00f6rler Vimentin, Slug, Snail, Twist ve Cmyc'nin ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilece\u011fini ve Wnt - \u03b2 - catenin yolunu d\u00fczenleyerek akci\u011fer kanserinin EMT s\u00fcrecini inhibe edebilece\u011fini g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fmada, Paeonia lactiflora feniletanolik glikozitlerinin ekstraktlar\u0131n\u0131n A549 h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131, g\u00f6\u00e7\u00fcn\u00fc ve istilas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebildi\u011fini ve ayr\u0131ca EphA2, mTOR, p-mTOR, \u03b2 - catenin, GSK-3 \u03b2, P-GSK-3 \u03b2 ve P-ATK proteinlerinin ekspresyonunu bask\u0131lad\u0131\u011f\u0131n\u0131 bulduk. Bunlar aras\u0131nda, P-ATK'nin a\u015fa\u011f\u0131 reg\u00fclasyonu \u00f6zellikle \u00f6nemlidir ve EphA2 proteininin a\u015fa\u011f\u0131 reg\u00fclasyonu da EphrinA1'in ekspresyonunu yukar\u0131 reg\u00fcle edebilir. Kokmu\u015f \u015fakay\u0131k feniletanolik glikozit ekstresi, EphA2'nin ligand EphrinA1 ile ba\u011flanmas\u0131n\u0131 ind\u00fckleyebilir, ligand EphrinA1 ba\u011f\u0131ml\u0131 anti-kanser yolunu te\u015fvik edebilir ve EphA2, P-ATK, mTOR ve di\u011fer fakt\u00f6rleri inhibe ederek, EphA2\/ATK\/mTOR sinyal yolunu bloke ederek antit\u00fcm\u00f6r etki g\u00f6sterebilir. P-EphA2'nin art\u0131\u015f\u0131 ligand ba\u011f\u0131ml\u0131l\u0131\u011f\u0131ndan kaynaklanmaktad\u0131r. EphA2 \u00fczerindeki S897 b\u00f6lgesi defosforilasyona u\u011framas\u0131na ra\u011fmen, EphA2 tirozin kinaz fosforilasyon ile aktive edilir, bu nedenle genel P-EphA2 yukar\u0131 reg\u00fcle edilebilir. Ancak anti-t\u00fcm\u00f6r mekanizmas\u0131 \u00e7ok karma\u015f\u0131kt\u0131r ve t\u00fcm\u00f6r h\u00fccrelerinin kaderi tek bir yolla belirlenmez. Bu \u00e7al\u0131\u015fma, kokulu \u015fakay\u0131\u011f\u0131n anti-t\u00fcm\u00f6r molek\u00fcler mekanizmas\u0131n\u0131 belirlemek ve EphA2 hedeflerini hedefleyen y\u00fcksek verimli ve d\u00fc\u015f\u00fck toksisiteli geleneksel \u00c7in t\u0131bb\u0131 \u00f6zleri geli\u015ftirmek i\u00e7in deneysel kan\u0131tlar sunmaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells Lung cancer is a malignant tumor that occurs in the bronchial mucosa and glands. According to the data provided by the National Cancer Center, in 2022, the incidence rate of lung cancer in China will be [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/huangqi-jianzhong-kaynatma\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Identification of phenylethanolic glycosides from stinky peony and mechanism study of in vitro anti human lung adenocarcinoma A549 cells Lung cancer is a malignant tumor that occurs in the bronchial mucosa and glands. 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