{"id":7309,"date":"2024-08-06T19:22:43","date_gmt":"2024-08-06T19:22:43","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7309"},"modified":"2024-08-06T19:22:43","modified_gmt":"2024-08-06T19:22:43","slug":"artesunate","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/artesunate\/","title":{"rendered":"Artesunat'\u0131n Tip 2 Diyabetli S\u0131\u00e7anlarda Dalak Fibrozisini Hafifletme Mekanizmas\u0131 TGF - \u03b2\/Smad Yola\u011f\u0131na Dayan\u0131yor"},"content":{"rendered":"<p>Artesunat'\u0131n Tip 2 Diyabetli S\u0131\u00e7anlarda Dalak Fibrozisini Hafifletme Mekanizmas\u0131 TGF - \u03b2\/Smad Yola\u011f\u0131na Dayan\u0131yor<br \/>\nTip 2 diyabet (T2DM) kronik bir metabolik hastal\u0131kt\u0131r. T2DM'nin g\u00f6r\u00fclme oran\u0131 artmaya devam ederken, d\u00fcnyada insan sa\u011fl\u0131\u011f\u0131n\u0131 tehdit eden \u00fc\u00e7\u00fcnc\u00fc kronik hastal\u0131k haline gelmi\u015ftir. Ayr\u0131ca, gen\u00e7lerde g\u00f6r\u00fclme oran\u0131 ve prevalans\u0131 d\u00fcnya \u00e7ap\u0131nda art\u0131\u015f g\u00f6stermektedir. Zaman\u0131nda tedavi edilmezse, diyabet hastalar\u0131n\u0131n \u00f6mr\u00fcn\u00fc k\u0131saltacak bir dizi ciddi hastal\u0131k ve hedef organ hasar\u0131 ortaya \u00e7\u0131kacakt\u0131r. T2DM hastalar\u0131nda y\u00fcksek kan \u015fekeri seviyeleri oksidatif strese ve y\u00fcksek inflamatuar fakt\u00f6r seviyelerine neden oldu\u011funda, dalak h\u00fccresi apoptozuna ve imm\u00fcn fonksiyon bozuklu\u011funa yol a\u00e7arak sonu\u00e7ta dalak hasar\u0131na neden olabilir. Ayn\u0131 zamanda, a\u015f\u0131r\u0131 inflamatuar yan\u0131t dalak fibrozisine neden olabilir ve kolajen liflerinin \u00e7o\u011falmas\u0131 dalak kan ak\u0131\u015f\u0131n\u0131 daha da k\u0131s\u0131tlayarak hastalarda geri d\u00f6n\u00fc\u015f\u00fc olmayan hasara neden olabilir. Ancak, \u015fu anda T2DM hastalar\u0131nda dalak hasar\u0131n\u0131 ve fibrozisi \u00f6nlemek ve tedavi etmek i\u00e7in etkili bir y\u00f6ntem bulunmamaktad\u0131r. Bununla birlikte, d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc b\u00fcy\u00fcme fakt\u00f6r\u00fc beta (TGF - \u03b2) ve onun ana yolu olan TGF - \u03b2\/Smad, fibrozis ilerlemesiyle yak\u0131ndan ili\u015fkilidir. \u00c7al\u0131\u015fmalar, TGF - \u03b2\/Smad'\u0131n pulmoner fibroz, renal fibroz, karaci\u011fer fibrozu ve pankreatik fibroz gibi \u00e7e\u015fitli organlardaki fibroz s\u00fcre\u00e7lerinde \u00f6nemli bir d\u00fczenleyici rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bununla birlikte, dalak fibrozisi ile ili\u015fkili olup olmad\u0131\u011f\u0131na dair yurti\u00e7i ve yurtd\u0131\u015f\u0131nda az say\u0131da rapor bulunmaktad\u0131r.<br \/>\nBir \u00c7in bitkisel ilac\u0131 olan artemisinin'den elde edilen do\u011fal bir seskiterpen lakton bile\u015fi\u011fi olan Artesunat (ART), antimalaryal ajanlar i\u00e7in birinci basamak tedavi ilac\u0131d\u0131r. Son y\u0131llarda yap\u0131lan ara\u015ft\u0131rmalar ART'nin anti-t\u00fcm\u00f6r, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme, anti-vir\u00fcs, anti-fibrozis ve di\u011fer etkilere sahip oldu\u011funu da ortaya koymu\u015ftur. Ara\u015ft\u0131rma grubunun ilk ara\u015ft\u0131rmalar\u0131nda, ART'nin sadece diyabet s\u0131\u00e7anlar\u0131n\u0131n kan \u015fekerini d\u00fc\u015f\u00fcrmekle kalmad\u0131\u011f\u0131, ayn\u0131 zamanda b\u00f6brek, akci\u011fer fibrozu ve oksidatif stres \u00fczerinde de \u00f6nleyici bir etkiye sahip oldu\u011fu bulunmu\u015ftur. Bununla birlikte, ART'nin T2DM'nin dalak dokusu ve fibrozu \u00fczerinde bir etkisi olup olmad\u0131\u011f\u0131 ara\u015ft\u0131r\u0131lmam\u0131\u015f ve ilgili mekanizmas\u0131 ortaya \u00e7\u0131kar\u0131lmam\u0131\u015ft\u0131r. Bu nedenle, bu deney T2DM s\u0131\u00e7an modeli olu\u015fturarak ART'nin T2DM s\u0131\u00e7anlar\u0131n\u0131n dalak yap\u0131s\u0131 ve fibrozu \u00fczerindeki etkisini g\u00f6zlemlemektir. Ve bunun TGF - \u03b2\/Smad yola\u011f\u0131 ile ili\u015fkili olup olmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmakt\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7310\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-35.jpg\" alt=\"\" width=\"756\" height=\"202\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7311\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-247.png\" alt=\"\" width=\"759\" height=\"211\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7312\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-232.png\" alt=\"\" width=\"750\" height=\"178\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7313\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-211.png\" alt=\"\" width=\"761\" height=\"195\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7314\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-16.jpg\" alt=\"\" width=\"765\" height=\"372\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7315\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-174.png\" alt=\"\" width=\"753\" height=\"385\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7316\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-159.png\" alt=\"\" width=\"764\" height=\"379\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7317\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-144.png\" alt=\"\" width=\"762\" height=\"374\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7318\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-136.png\" alt=\"\" width=\"739\" height=\"338\" \/><br \/>\nDalak, insan v\u00fccudundaki en b\u00fcy\u00fck ba\u011f\u0131\u015f\u0131kl\u0131k organ\u0131d\u0131r ve i\u015flevleri temel olarak kan filtrasyonu, k\u0131rm\u0131z\u0131 kan h\u00fccreleri, antijenlerin ve yabanc\u0131 cisimlerin ya\u015flanmas\u0131 ve ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini i\u00e7erir. T2DM bir grup metabolik hastal\u0131kt\u0131r ve uzun s\u00fcreli hiperglisemi oksidatif strese ve birden fazla organda hasara neden olabilir. Oksidatif stres ko\u015fullar\u0131 alt\u0131nda, dalak dokusunda anormal sitokinler \u00fcretilerek dalak b\u00fcy\u00fcmesine ve fibrozise yol a\u00e7arak hastalarda dalak hasar\u0131na neden olur. Dalak dokusu fibrozise u\u011frad\u0131\u011f\u0131nda, merkezi arterin intimas\u0131 kal\u0131nla\u015f\u0131r ve \u00e7evresindeki kolajen lifleri \u00e7o\u011falarak dalak sin\u00fczoidlerinin geni\u015flemesini s\u0131n\u0131rlar ve kan depolama i\u015flevinde azalmaya yol a\u00e7arak yetersiz kan ak\u0131\u015f\u0131na ve orijinal fizyolojik i\u015flevlerinde hasara neden olur. Ara\u015ft\u0131rma grubunun \u00f6n ara\u015ft\u0131rmas\u0131, T2DM s\u0131\u00e7anlar\u0131n\u0131n 50 mg\/kg ART konsantrasyonunda karaci\u011fer toksisitesine neden olmadan ila\u00e7 etkilerini etkili bir \u015fekilde uygulayabildi\u011fini ortaya koymu\u015ftur. Bu nedenle, deneyin nihai konsantrasyonu olarak belirlenmi\u015ftir. Bu deneyde, bir SD s\u0131\u00e7an modeli olu\u015fturulmu\u015f ve T2DM tedavisinde yayg\u0131n olarak kullan\u0131lan bir ila\u00e7 olan metformin pozitif kontrol olarak kullan\u0131lm\u0131\u015ft\u0131r. HE boyamas\u0131, T2DM s\u0131\u00e7anlar\u0131nda dala\u011f\u0131n merkezi arterinin kal\u0131nla\u015ft\u0131\u011f\u0131n\u0131 ve dalak kordonu kenar\u0131n\u0131n dar oldu\u011funu g\u00f6stermi\u015ftir. \u0130la\u00e7 tedavisinden sonra dalak yap\u0131s\u0131 d\u00fczelmi\u015ftir. Masson boyamas\u0131, DM grubunda merkezi arter ve ven etraf\u0131ndaki kolajen liflerinin CON grubuna k\u0131yasla artt\u0131\u011f\u0131n\u0131, her ila\u00e7 grubunda mavi lif birikiminin azald\u0131\u011f\u0131n\u0131 ve fark\u0131n istatistiksel olarak anlaml\u0131 oldu\u011funu g\u00f6stermi\u015ftir; bu da bir dereceye kadar ART'nin dalak yap\u0131s\u0131 ve fibrozis \u00fczerinde koruyucu bir etkisi oldu\u011funu d\u00fc\u015f\u00fcnd\u00fcrmektedir.<br \/>\nFibrozis ilkesi, enflamasyon, anormal art\u0131\u015f ve dokularda h\u00fccre d\u0131\u015f\u0131 matrisin (ECM) a\u015f\u0131r\u0131 birikiminin neden oldu\u011fu organ parankimal h\u00fccrelerinin nekrozunun patolojik s\u00fcrecidir ve bu da renal fibroz, pulmoner fibroz, karaci\u011fer fibrozu vb. dahil olmak \u00fczere T2DM'nin yayg\u0131n bir semptomudur. Dokularda ne kadar fazla fibr\u00f6z ba\u011f dokusu olursa, h\u00fccrelerin \u00f6lmesi o kadar kolay olur ve sonu\u00e7ta organ yetmezli\u011fine yol a\u00e7ar. Fibrozis mekanizmas\u0131 temel olarak TGF - \u03b2\/Smad yola\u011f\u0131 ile ili\u015fkilidir. TGF - \u03b2 fibroziste \u00f6nemli bir fakt\u00f6rd\u00fcr, h\u00fccre b\u00fcy\u00fcmesini ve apoptozu d\u00fczenler, \u00fc\u00e7 alt tipi vard\u0131r. Bunlar aras\u0131nda TGF - \u03b2 1 en g\u00fc\u00e7l\u00fc aktiviteye sahiptir ve fibrozis s\u00fcrecinde \u00f6nemli bir rol oynar. Bir yandan ECM \u00fcretimini te\u015fvik eder ve kendi sinyal yolu arac\u0131l\u0131\u011f\u0131yla fibrozisi ind\u00fckler. \u00d6te yandan, matriks metaloproteinazlar\u0131n (MMP'ler) \u00fcretimini inhibe edebilir ve kolajen art\u0131\u015f\u0131n\u0131 te\u015fvik ederek fibrozu \u015fiddetlendirebilir. Rekombinant insan protein ailesi (smad ailesi \u00fcyesi), Smad2, Smad3, Smad5 gibi aktive edilmi\u015f tipler ve esas olarak smad7 dahil olmak \u00fczere inhibit\u00f6r tipler dahil olmak \u00fczere TGF - \u03b2'n\u0131n a\u015fa\u011f\u0131 ak\u0131\u015f anahtar resept\u00f6r protein ailesidir. TGF - \u03b2 sinyalinin \u00f6nemli bir negatif d\u00fczenleyicisi olan Smad7, resept\u00f6r aktivitesini bloke ederek, resept\u00f6r degradasyonunu ind\u00fckleyerek veya Smad2\/3-DNA ba\u011flanmas\u0131na m\u00fcdahale ederek fibrozu inhibe edebilir. Diyabetli hastalarda doku fibrozu olu\u015ftu\u011funda, TGF - \u03b2 1 ekspresyonu artar ve \u00f6zellikle Smad2 ve Smad3'e ba\u011flan\u0131r. Smad7 inhibe edilir, bu da h\u00fccre zar\u0131ndan \u00e7ekirde\u011fe sinyal iletimini art\u0131r\u0131r, b\u00f6ylece fibrozu te\u015fvik etmek i\u00e7in a\u015fa\u011f\u0131 ak\u0131\u015f hedef genini aktive eder. Ara\u015ft\u0131rmalar, TGF - \u03b2\/Smad yolu aktive edildi\u011finde, a\u015fa\u011f\u0131 ak\u0131\u015f hedef geni Collagen I'in de doku birikiminde artaca\u011f\u0131n\u0131 ve b\u00f6ylece doku fibrozunun derecesini a\u011f\u0131rla\u015ft\u0131raca\u011f\u0131n\u0131 g\u00f6stermektedir.<br \/>\nZhang ve arkada\u015flar\u0131, y\u00fcksek doz \u00e7inkonun dalak fibrozisini \u00f6nleyip tedavi edebildi\u011fini ve bunun mekanizmas\u0131n\u0131n dalak dokusunda TGF - \u03b2, Kolajen I ve \u03b1 - d\u00fcz kas aktin (\u03b1 - SMA) i\u00e7eri\u011fini azaltarak ve b\u00f6ylece ECM y\u0131k\u0131m\u0131n\u0131 art\u0131rarak sa\u011flanabilece\u011fini bulmu\u015ftur. Baz\u0131 ara\u015ft\u0131rmac\u0131lar da TGF - \u03b2\/Smad sinyal yola\u011f\u0131n\u0131n diyabet hedef organ fibrozisi s\u00fcrecinde rol oynad\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Tedaviden sonra, Kolajen I, TGF - \u03b2, Smad2, Smad3 ekspresyonunu azaltarak diyabet hedef organ fibrozisini iyile\u015ftirebilir. Bu deneyde, imm\u00fcnohistokimya, Western blot ve qRT PCR ile DM grubu s\u0131\u00e7anlar\u0131n dalak dokusunda TGF - \u03b2 1, Smad2 ve Kolajen I i\u00e7eri\u011finin CON grubuna g\u00f6re \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011fu, Smad7 ekspresyonunun ise azald\u0131\u011f\u0131 bulunmu\u015ftur. TGF - \u03b2 1, Smad2 ve Kolajen I'in protein ve mRNA ekspresyon seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015f ve Smad7 i\u00e7eri\u011fi, yukar\u0131daki sonu\u00e7larla tutarl\u0131 istatistiksel farkl\u0131l\u0131klarla her ila\u00e7 grubunda \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r.<br \/>\n\u00d6zetle, ART sadece T2DM s\u0131\u00e7anlar\u0131n\u0131n kan \u015fekeri seviyesini d\u00fc\u015f\u00fcrmekle kalmaz, ayn\u0131 zamanda T2DM s\u0131\u00e7anlar\u0131n\u0131n dalak indeksi, dalak a\u011f\u0131rl\u0131\u011f\u0131 ve dalak yap\u0131s\u0131ndaki de\u011fi\u015fiklikler i\u00e7in de b\u00fcy\u00fck umutlara sahiptir. Ayr\u0131ca ART'nin T2DM s\u0131\u00e7anlar\u0131nda dalak fibrozisinin \u00f6nlenmesi ve tedavisinde belirli bir rol\u00fc oldu\u011funu ve kombinasyon grubunun etkisinin daha \u00f6nemli oldu\u011funu ve mekanizmas\u0131n\u0131n da TGF - \u03b2 \/ Smad sinyal yolunun inhibisyonu ile ilgili olabilece\u011fini ortaya koymaktad\u0131r. tip 2 diyabet s\u0131\u00e7anlar\u0131nda dalak hasar\u0131 ve fibrozisin ila\u00e7 tedavisi \u00e7al\u0131\u015fmas\u0131 i\u00e7in teorik bir temel sa\u011flar.<\/p>","protected":false},"excerpt":{"rendered":"<p>The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF &#8211; \u03b2\/Smad Pathway Type 2 diabetes (T2DM) is a chronic metabolic disease. As the incidence rate of T2DM continues to rise, it has become the third chronic disease threatening human health in the world. In addition, the incidence rate and [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF - \u03b2\/Smad Pathway - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/artesunate\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF - \u03b2\/Smad Pathway - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The Mechanism of Artesunate Alleviating Spleen Fibrosis in Type 2 diabetes Rats Based on TGF &#8211; \u03b2\/Smad Pathway Type 2 diabetes (T2DM) is a chronic metabolic disease. As the incidence rate of T2DM continues to rise, it has become the third chronic disease threatening human health in the world. 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