{"id":7268,"date":"2024-08-06T19:15:34","date_gmt":"2024-08-06T19:15:34","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7268"},"modified":"2024-08-06T19:15:34","modified_gmt":"2024-08-06T19:15:34","slug":"ulcerative-colitis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/ulcerative-colitis\/","title":{"rendered":"\u00dclseratif kolit tedavisinde a\u011f farmakolojisine dayal\u0131 yedi bile\u015fik re\u00e7etenin etki mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

\u00dclseratif kolit tedavisinde a\u011f farmakolojisine dayal\u0131 yedi bile\u015fik re\u00e7etenin etki mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma
\n\u00dclseratif kolit (\u00dcK) t\u0131p camias\u0131nda yayg\u0131n olarak tedavisi zor bir hastal\u0131k olarak kabul edilmektedir. Tekrarlayan ve inat\u00e7\u0131 do\u011fas\u0131 nedeniyle hastalar\u0131n i\u015f ve ya\u015fam kalitesini ciddi \u015fekilde etkilemektedir. \u015eu anda, spesifik bir ila\u00e7 mevcut de\u011fildir. Bat\u0131 t\u0131bb\u0131 \u00dcK'yi aktif faz ve remisyon faz\u0131 olarak ikiye ay\u0131rmakta ve aktif faz\u0131 hafif, orta ve \u015fiddetli \u00dcK olarak s\u0131n\u0131fland\u0131rmaktad\u0131r. Farkl\u0131 evreler ve dereceler i\u00e7in tedavi ila\u00e7lar\u0131 kabaca ayn\u0131d\u0131r ve genellikle aminosalisilik asit, glukokortikoidler ve imm\u00fcnosupresanlar\u0131 i\u00e7erir. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n UC'yi \u00f6nleme ve tedavi etme konusunda Sar\u0131 \u0130mparator'un \u0130\u00e7 Kanon'una kadar uzanan uzun bir ge\u00e7mi\u015fi vard\u0131r. UC \"ba\u011f\u0131rsak depresyonu\", \"ishal\", \"kronik dizanteri\" ve \"dizanteri\" olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r. Dalak eksikli\u011finin bu hastal\u0131\u011f\u0131n temel nedeni oldu\u011funa ve uzun s\u00fcreli hastal\u0131\u011f\u0131n b\u00f6brekleri etkileyerek dalak ve b\u00f6brek eksikli\u011fine yol a\u00e7t\u0131\u011f\u0131na inan\u0131lmaktad\u0131r. Bu nedenle, temel prensip ortay\u0131 \u0131s\u0131tmak ve dala\u011f\u0131 g\u00fc\u00e7lendirmek, b\u00f6brekleri \u0131s\u0131tmak ve yang'a yard\u0131mc\u0131 olmak olmal\u0131d\u0131r. Geleneksel \u00c7in t\u0131bb\u0131, sendrom farkl\u0131la\u015fmas\u0131na dayal\u0131 olarak bu hastal\u0131\u011f\u0131n tedavisinde benzersiz avantajlara sahiptir. 2017 y\u0131l\u0131nda, \u00c7in Geleneksel \u00c7in T\u0131bb\u0131 Derne\u011fi Dalak ve Mide Hastal\u0131klar\u0131 \u015eubesi, UC sendromu farkl\u0131la\u015fmas\u0131n\u0131 7 t\u00fcre ay\u0131ran \"\u00dclseratif Kolonilerin Geleneksel \u00c7in T\u0131bb\u0131 Te\u015fhis ve Tedavisine \u0130li\u015fkin Uzman Uzla\u015f\u0131 G\u00f6r\u00fc\u015f\u00fc (2017)\" (bundan b\u00f6yle \"Uzman Uzla\u015f\u0131 G\u00f6r\u00fc\u015f\u00fc (2017)\" olarak an\u0131lacakt\u0131r) yay\u0131nlam\u0131\u015ft\u0131r: kal\u0131n ba\u011f\u0131rsak nemli \u0131s\u0131 sendromu, \u0131s\u0131 toksin yo\u011fun sendromu, dalak eksikli\u011fi nemli birikim sendromu, kar\u0131\u015f\u0131k so\u011fuk ve \u0131s\u0131 sendromu, karaci\u011fer depresyonu ve dalak eksikli\u011fi sendromu, dalak b\u00f6brek yang eksikli\u011fi sendromu ve yin kan eksikli\u011fi sendromu. UC'nin 7 farkl\u0131 geleneksel \u00c7in t\u0131bb\u0131 sendromu tipi i\u00e7in, UC'nin \u00f6nlenmesi ve tedavisinde daha kesin olan kar\u015f\u0131l\u0131k gelen klasik \u00c7in t\u0131bb\u0131 form\u00fclleri vard\u0131r. Bununla birlikte, klasik \u00c7in t\u0131bb\u0131 form\u00fcllerinin karma\u015f\u0131k bile\u015fimi, \u00e7ok say\u0131da i\u00e7eri\u011fi ve karma\u015f\u0131k bilgi entegrasyonu nedeniyle, \u00dcK tedavisi i\u00e7in 7 klasik \u00c7in t\u0131bb\u0131 form\u00fcl\u00fcn\u00fcn ortak y\u00f6nleri ve farkl\u0131l\u0131klar\u0131 \u015fu anda mevcuttur. Cinsel bile\u015fenler sistematik ve kapsaml\u0131 bir \u015fekilde incelenmemi\u015ftir ve sendrom farkl\u0131la\u015fmas\u0131na kar\u015f\u0131l\u0131k gelen hedef yollar gibi spesifik de\u011ferlendirme g\u00f6stergeleri derinlemesine ara\u015ft\u0131r\u0131lmam\u0131\u015ft\u0131r.
\nA\u011f farmakolojisi, ila\u00e7lar\u0131n sistematik olarak incelenmesi i\u00e7in yapay zeka ve b\u00fcy\u00fck veri \u00e7a\u011f\u0131nda ortaya \u00e7\u0131kan, disiplinler aras\u0131 ve son teknoloji bir disiplindir. Hastal\u0131k mekanizmalar\u0131n\u0131n ve ila\u00e7 etki mekanizmalar\u0131n\u0131n bir b\u00fct\u00fcn olarak biyolojik a\u011flar perspektifinden yorumlanmas\u0131n\u0131 vurgular. Ara\u015ft\u0131rma felsefesi, geleneksel \u00c7in t\u0131bb\u0131n\u0131n b\u00fct\u00fcnsel d\u00fc\u015f\u00fcncesiyle \u00f6rt\u00fc\u015fmekte ve geleneksel \u00c7in t\u0131bb\u0131 form\u00fcllerinin sistematik olarak incelenmesi i\u00e7in yeni bir y\u00f6ntem sa\u011flamaktad\u0131r. Bu \u00e7al\u0131\u015fma, UC tedavisinde kullan\u0131lan yedi klasik \u00c7in t\u0131bb\u0131 form\u00fcl\u00fcne odaklanmaktad\u0131r. A\u011f farmakolojisi y\u00f6ntemleri arac\u0131l\u0131\u011f\u0131yla, \u00dcK tedavisinde klasik form\u00fcllerin ortak ve farkl\u0131 etki mekanizmalar\u0131, bu form\u00fcllerin ortak ve benzersiz \u00f6nemli bile\u015fenlerini, hedeflerini ve yolaklar\u0131n\u0131 ke\u015ffetmeye odaklan\u0131larak analiz edilmektedir. Bu hastal\u0131\u011f\u0131n temel patogenezine dayanarak, \"ortay\u0131 \u0131s\u0131tmak ve dala\u011f\u0131 g\u00fc\u00e7lendirmek, b\u00f6bre\u011fi \u0131s\u0131tmak ve yang'a yard\u0131mc\u0131 olmak\" temel tedavi y\u00f6nteminin temsili bir klasik form\u00fcl\u00fc olan Fuzi Lizhong Pill (FLZP), potansiyel ila\u00e7 ke\u015ffi ve UC'nin farkl\u0131 TCM sendromlar\u0131n\u0131n klinik hassas tedavisi i\u00e7in referans sa\u011flamak ve UC sendromu farkl\u0131la\u015fmas\u0131n\u0131n potansiyel spesifik de\u011ferlendirme g\u00f6stergeleri i\u00e7in yeni fikirler sa\u011flamak amac\u0131yla dalak b\u00f6brek yang eksikli\u011fi tipi UC'nin temel hedeflerinin deneysel do\u011frulamas\u0131n\u0131 yapmak i\u00e7in se\u00e7ilmi\u015ftir.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"1. Yedi klasik bile\u015fik form\u00fcl\u00fcn \u00f6nemli hedefleri<\/p>\n

(1) Ortak \u00f6nemli hedefler<\/p>\n

PPI a\u011f\u0131nda, derece s\u0131ralamas\u0131na g\u00f6re 42 \u00f6nemli hedef se\u00e7ilmi\u015ftir ve bunlar temel olarak 5 kategoriye ayr\u0131lm\u0131\u015ft\u0131r: protein tirozin fosfatazlar (PTPN1, PTPN2, PTPN6, PTPN11, vb.), fosfatidilinositol 3-kinazlar (PIK3R1, PIK3CB, PIK3CA, vb.), mitojen aktive protein kinazlar (MAPK1, MAPK3, MAPK8, MAPK14, vb.), siklin ba\u011f\u0131ml\u0131 kinazlar (CDK1, CDK2, CDK4, vb.) ve di\u011fer \u00f6nemli hedefler (VEGFA, HSP90AA1, LCK, vb.). Bu \u00f6nemli hedefler, UC'nin hedefe y\u00f6nelik tedavisi i\u00e7in referans sa\u011flayabilir.<\/p>\n

Protein tirozin fosfataz (PTPs) ailesi, h\u00fccre \u00e7o\u011falmas\u0131, farkl\u0131la\u015fmas\u0131 ve hayatta kalmas\u0131 dahil olmak \u00fczere temel h\u00fccresel sinyal yollar\u0131n\u0131n d\u00fczenlenmesinde \u00f6nemli bir rol oynar. PTPN2'nin kolon h\u00fccresi d\u00fczeyinde UC'nin ana hedefi oldu\u011fu g\u00f6sterilmi\u015ftir. Fosfatidilinositol 3-kinaz (PI3K), b\u00fcy\u00fcme fakt\u00f6r\u00fc taraf\u0131ndan d\u00fczenlenen sinyal yola\u011f\u0131nda \u00f6nemli bir molek\u00fcld\u00fcr ve h\u00fccre d\u0131\u015f\u0131 uyaranlara yan\u0131t olarak h\u00fccre i\u00e7i sinyalle\u015fmede \u00e7ok \u00f6nemli bir rol oynar. Sun ve arkada\u015flar\u0131, ters transkripsiyon polimeraz zincir reaksiyonu ve protein imm\u00fcnoblotlama kullanarak UC s\u0131\u00e7anlar\u0131n\u0131n kolon dokusunda PIK3CA protein ekspresyonunda bir art\u0131\u015f tespit etmi\u015ftir.
\nMitojenle aktive olan protein kinaz (MAPK) \u00e7e\u015fitli ya\u015fam aktiviteleriyle ili\u015fkilidir, \u00e7e\u015fitli uyaranlara kar\u015f\u0131 h\u00fccresel yan\u0131tlara kat\u0131l\u0131r, h\u00fccre \u00e7o\u011falmas\u0131n\u0131 ve farkl\u0131la\u015fmas\u0131n\u0131 d\u00fczenler ve h\u00fccre sa\u011fkal\u0131m\u0131n\u0131 ve apoptozu etkiler. Zhu ve arkada\u015flar\u0131, MAPK ailesinin \u00fcyeleri olan ekstrasel\u00fcler sinyalle d\u00fczenlenen pro tein kinaz 1 (ERK1) ve ERK2'nin UC modeli s\u0131\u00e7anlar\u0131n ba\u011f\u0131rsak mukozas\u0131nda yukar\u0131 do\u011fru d\u00fczenlendi\u011fini bulmu\u015flard\u0131r.
\nSiklin ba\u011f\u0131ml\u0131 ki kinazlar (CDK'lar) h\u00fccre d\u00f6ng\u00fcs\u00fc d\u00fczenleyici a\u011f\u0131nda \u00f6nemli bir rol oynamaktad\u0131r. Buna ek olarak, \u0131s\u0131 \u015fok proteini (HSP) 90AA1 ve resept\u00f6r olmayan tirozin kinaz ailesi kinazlar\u0131 (LCK) gibi son derece y\u00fcksek derece de\u011ferlerine sahip baz\u0131 hedefler, mevcut ara\u015ft\u0131rmalarda net bir \u015fekilde do\u011frulanmam\u0131\u015ft\u0131r ve dikkatimizi hak etmektedir.
\n(2) Her bile\u015fi\u011fin kendine \u00f6zg\u00fc \u00f6nemli hedefleri vard\u0131r
\nSTRING platformu ve Cytoscape yaz\u0131l\u0131m\u0131 arac\u0131l\u0131\u011f\u0131yla, h\u00fccre adezyon fakt\u00f6rlerinin ekspresyonunu te\u015fvik edebilen, lenfosit agregasyonuna yol a\u00e7an, enflamatuar reaksiyonlar\u0131 \u015fiddetlendiren ve UC s\u0131\u00e7anlar\u0131n\u0131n kolon dokusunda ekspresyonu \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131ran \u00f6nemli bir sinyal proteini olan Sinyal \u0130letim Transkripsiyon Aktivasyon Fakt\u00f6r\u00fc 1 (STAT1, Kal\u0131n Ba\u011f\u0131rsak Nemli Is\u0131 Form\u00fcl\u00fcne \u00f6zg\u00fc) gibi 14 benzersiz \u00f6nemli hedef elde edilmi\u015ftir; Toll benzeri resept\u00f6r 4'\u00fcn (TLR4, kar\u0131\u015f\u0131k so\u011fuk ve s\u0131cak form\u00fcl\u00fcne \u00f6zg\u00fc) anormal aktivasyonu, UC'nin olu\u015fumu ve geli\u015fimi ile yak\u0131ndan ili\u015fkilidir ve bir dizi enflamatuar fakt\u00f6r\u00fcn sal\u0131nmas\u0131na ve doku enflamatuar hasar\u0131n\u0131n \u00fcretilmesine veya \u015fiddetlenmesine yol a\u00e7ar; Dalak b\u00f6brek yang eksikli\u011fi form\u00fcl\u00fcndeki benzersiz t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 protein P53 (TP53) ve b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r\u00fc ba\u011flay\u0131c\u0131 protein 2 (GRB2), t\u00fcm\u00f6rlerle yak\u0131ndan ili\u015fkili hedeflerdir. TP53 geni \u015fu anda ke\u015ffedilen en t\u00fcm\u00f6r ili\u015fkili t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 gendir; GRB2 h\u00fccrelerde yayg\u0131n olarak ifade edilen bir adapt\u00f6r proteindir ve \u00e7e\u015fitli t\u00fcm\u00f6r dokular\u0131nda y\u00fcksek oranda ifade edilir. Baz\u0131 UC hastalar\u0131nda kolon kanseri geli\u015febilir ve geleneksel \u00c7in t\u0131bb\u0131, altta yatan eksikli\u011fin asl\u0131nda patogenezi oldu\u011funa inanarak kanseri \"birikim\" ve \"patolojik de\u011fi\u015fiklikler\" olarak kategorize eder. \"Jingyue Quanshu \"da belirtildi\u011fi gibi, altta yatan ana eksiklik dalak ve b\u00f6brek eksikli\u011fidir: \"Dalak ve b\u00f6brek eksikli\u011fi ve zay\u0131f dengesizli\u011fi olan ki\u015filerde genellikle birikim hastal\u0131klar\u0131 g\u00f6r\u00fcl\u00fcr.\" Bu, dalak ve b\u00f6brek yang eksikli\u011fi tipi UC'nin geleneksel \u00c7in t\u0131bb\u0131 patogenezine benzer. Bu nedenle, t\u00fcm\u00f6rlerle yak\u0131ndan ili\u015fkili olan TP53 ve GRB2 hedefleri, UC'nin dalak ve b\u00f6brek yang eksikli\u011fi form\u00fclleriyle tedavisi i\u00e7in benzersiz ve \u00f6nemli hedeflerdir. Bu sonu\u00e7, geleneksel \u00c7in t\u0131bb\u0131n\u0131n genel konseptini ve diyalektik tedavi \u00f6zelliklerini bir dereceye kadar yans\u0131tmaktad\u0131r. Yukar\u0131da bahsedilen benzersiz protein hedefleri, UC'nin farkl\u0131 TCM sendromlar\u0131 i\u00e7in hassas tedavi ara\u015ft\u0131rmalar\u0131nda dikkat edilmeye de\u011ferdir ve ayr\u0131ca UC'nin TCM sendrom s\u0131n\u0131fland\u0131rmas\u0131 i\u00e7in spesifik de\u011ferlendirme g\u00f6stergeleri olarak hizmet edebilir.
\n2. Yedi klasik bile\u015fik form\u00fcl\u00fcn \u00f6nemli bile\u015fenleri
\n(1) Ortak \u00f6nemli bile\u015fenler<\/p>\n

Yedi klasik bile\u015fik bile\u015fenin kar\u015f\u0131l\u0131kl\u0131 haritalanmas\u0131nda, kaempferol, \u03b2 - sitosterol, betulinik asit ve stigmasterol dahil olmak \u00fczere d\u00f6rt \u00f6nemli bile\u015fen tarand\u0131 ve hepsi \u00f6nemli hedeflerle kenetlenmede iyi sonu\u00e7lar g\u00f6sterdi. Kaempferol, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 restore ederek ve TLR4 ile ilgili sinyal yollar\u0131n\u0131 d\u00fczenleyerek farelerde deneysel UC'yi hafifletebilir; \u03b2 - sitosterol, DSS ile ind\u00fcklenen kolit farelerinde TNF - \u03b1, IL-6 ve IL-1 \u03b2 seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir ve deneysel UC \u00fczerinde terap\u00f6tik etkilere sahiptir; Betulinik asit, 2,4,6-trinitrobenzens\u00fclfonik asit (TNBS) ile ind\u00fcklenen inflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131 modeli s\u0131\u00e7anlarda kolit kaynakl\u0131 hasar\u0131 inhibe edebilir; Dougesterol, kolon k\u0131salmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebilir, kolitin \u015fiddetini azaltabilir, IL-1 \u03b2 ve IL-6 gibi inflamatuar fakt\u00f6rleri \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir ve b\u00f6ylece farelerde DSS kaynakl\u0131 koliti iyile\u015ftirebilir. Bu bile\u015fenler, UC tedavisine y\u00f6nelik ila\u00e7lar\u0131n ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in \u00f6nemli referanslar olarak hizmet edebilir.
\n(2) Her bile\u015fik benzersiz \u00f6nemli bile\u015fenler i\u00e7erir
\nBenzersiz \u00f6nemli bile\u015fenlerini elde etmek i\u00e7in \u00e7e\u015fitli klasik bile\u015fik form\u00fcllerin \u00f6nemli bile\u015fenlerini kar\u015f\u0131la\u015ft\u0131r\u0131n ve analiz edin. Kal\u0131n ba\u011f\u0131rsakta nemli \u0131s\u0131 form\u00fcl\u00fc, her ikisi de anti-enflamatuar, antioksidan, anti alerjik ve anti-t\u00fcm\u00f6r etkilere sahip olan baicalein ve baicalein gibi bile\u015fenler i\u00e7erir. Baicalin, UC s\u0131\u00e7anlar\u0131nda enflamatuar yan\u0131t\u0131 ve kolonik mukozal enflamatuar patolojik hasar\u0131 etkili bir \u015fekilde hafifletebilir ve etki mekanizmas\u0131, kolonik mukozal dokuda \u0131s\u0131 \u015fok proteini 70 (HSP70) ekspresyonunun etkili bir \u015fekilde yukar\u0131 reg\u00fclasyonu ile ili\u015fkili olabilir; Dalak eksikli\u011fi ve nem birikimi form\u00fcl\u00fc, insan kan\u0131nda yayg\u0131n olarak da\u011f\u0131lan ve v\u00fccutta hormon \u00fcretimi i\u00e7in \u00f6nemli bir hammadde olan kolesterol\u00fc i\u00e7erir. T\u00fcrevleri ayr\u0131ca antibakteriyel, antiviral, anti-enflamatuar ve di\u011fer etkilere sahiptir; Kar\u0131\u015f\u0131k so\u011fuk ve s\u0131cak form\u00fcl\u00fcnde, Sichuan biberine ait olan yam alkaloidleri gibi alkaloidler vard\u0131r. Sichuan biberindeki alkaloidler, anti-enflamatuar ve analjezik etkilerin yan\u0131 s\u0131ra trombosit agregasyonunu inhibe etme yetene\u011fine sahiptir; Dalak b\u00f6brek yang eksikli\u011fi form\u00fcl\u00fc, kolon mukozas\u0131ndaki patolojik hasar\u0131 hafifletebilen ve ba\u011f\u0131rsaktaki d\u00fcz kas hareketini inhibe edebilen ve b\u00f6ylece deneysel \u00fclseratif kolit \u00fczerinde terap\u00f6tik bir etki g\u00f6steren wuzhuzi alkaloidleri gibi bile\u015fenler i\u00e7erir; Yin kan eksikli\u011finde, anti-enflamatuar, antioksidan ve anti-t\u00fcm\u00f6r gibi farmakolojik etkilere sahip bir polihidroksiflavonol bile\u015fi\u011fi olan yangmei keton gibi bile\u015fenler vard\u0131r. A\u011f farmakolojisinin sonu\u00e7lar\u0131na dayanarak, bu bile\u015fenler farkl\u0131 UC t\u00fcrlerinin hassas tedavisinde potansiyel ila\u00e7 ara\u015ft\u0131rmalar\u0131 i\u00e7in \u00f6nemli referanslar olarak hizmet edebilir.
\n3. Yedi Klasik Bile\u015fik Form\u00fcl\u00fcn \u00d6nemli Yollar\u0131
\n(1) Ortak \u00f6nemli yollar
\nKEGG yol analizi, ortak \u00f6nemli hedeflerin esas olarak iltihapla ilgili yollar\u0131 ve hastal\u0131kla ilgili yollar\u0131 i\u00e7erdi\u011fini g\u00f6stermektedir. Enflamasyonla ilgili yolaklar temel olarak PI3K Akt, renin-anjiyotensin sistemi (RAS), VEGF ve di\u011fer sinyal yolaklar\u0131n\u0131 i\u00e7erir; PI3K Akt sinyali, h\u00fccre b\u00fcy\u00fcmesi ve geli\u015fimi gibi s\u00fcre\u00e7lere kat\u0131larak kanserin olu\u015fumunu ve ilerlemesini kontrol eder ve UC'nin olu\u015fumuna ve geli\u015fimine arac\u0131l\u0131k edebilir. Aktive Akt, NF - \u03ba B'yi aktive edebilir, pro-inflamatuar fakt\u00f6rlerin transkripsiyon seviyesini art\u0131rabilir ve inflamatuar yan\u0131t\u0131 geni\u015fletebilir; RAS esas olarak v\u00fccut s\u0131v\u0131lar\u0131n\u0131n d\u00fczenlenmesinden sorumludur ve \u00e7oklu hormonlar\u0131 i\u00e7eren bir kaskad reaksiyon sistemidir. Ara\u015ft\u0131rmalar, UC farelerinin olu\u015fumunun ve geli\u015fiminin kolondaki lokal RAS ekspresyonunu etkileyerek d\u00fczenlenebilece\u011fini bulmu\u015ftur; UC'nin enflamatuar dokular\u0131nda VEGF ekspresyonundaki \u00f6nemli art\u0131\u015f, ba\u011f\u0131rsak mukozal mikrosirk\u00fclasyonunu etkileyebilir, ba\u011f\u0131rsak mukozal hipoksi hasar\u0131n\u0131 \u015fiddetlendirebilir ve UC taraf\u0131ndan ind\u00fcklenen VEGF sinyal yolunun aktivasyonunu g\u00f6sterir. Bu durum, \u00e7e\u015fitli klasik bile\u015fik form\u00fcllerinin ortak mekanizmas\u0131n\u0131n PI3K Akt, RAS, VEGF vb. gibi enflamasyonla ilgili yollar\u0131 d\u00fczenleyerek UC'yi \u00f6nlemek ve tedavi etmek olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Hastal\u0131kla ilgili yolaklar temel olarak hepatosel\u00fcler karsinom, pankreas kanseri, hepatit B, prostat kanseri ve UC'nin kanserle\u015fme e\u011filimi ile ilgili olabilecek kanserle ilgili yolaklar\u0131 i\u00e7eren di\u011fer yolaklar\u0131 i\u00e7erir.
\n(2) Her bile\u015fi\u011fin kendine ait \u00f6nemli bir yolu vard\u0131r
\n\u00c7e\u015fitli klasik form\u00fcllerin \u00f6nemli yolaklar\u0131n\u0131 kar\u015f\u0131la\u015ft\u0131r\u0131p analiz ederek, her form\u00fcl\u00fcn potansiyel benzersiz \u00f6nemli yolaklar\u0131 elde edilmi\u015ftir: kal\u0131n ba\u011f\u0131rsak nemli \u0131s\u0131 form\u00fcl\u00fc Janus kinaz\/sinyal d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc ve transkripsiyon aktivat\u00f6r\u00fc (JAK-STAT) gibi yolaklara sahiptir. Ara\u015ft\u0131rmalar, kal\u0131n ba\u011f\u0131rsak nemli \u0131s\u0131 form\u00fcl\u00fcn\u00fcn, nemli \u0131s\u0131 UC s\u0131\u00e7anlar\u0131n\u0131n kolon mukozal dokusundaki patolojik de\u011fi\u015fikliklerin derecesini iyile\u015ftirebilece\u011fini, enflamatuar reaksiyonlar\u0131 etkili bir \u015fekilde azaltabilece\u011fini ve JAK2\/STAT3 sinyal yolunu inhibe ederek negatif geri besleme d\u00fczenlemesi \u00fcretebilece\u011fini ve aktivasyonunu azaltabilece\u011fini g\u00f6stermi\u015ftir; S\u0131cak Zehir Chisheng Form\u00fcl\u00fc, kanserde tiroid hormonlar\u0131 ve kolin metabolizmas\u0131 gibi yollara sahiptir. Plazma serbest tiroid hormonlar\u0131 dolayl\u0131 olarak gastrointestinal sistemin enflamatuar tepkisini etkileyebilirken, kolin metabolitleri enflamatuar tepkiyi te\u015fvik etmek ve kanser geli\u015fimini h\u0131zland\u0131rmak i\u00e7in ya\u011f asidi sentez yolunu etkileyebilir. S\u0131cak Zehir Chisheng Form\u00fcl\u00fcn\u00fcn anti-enflamatuar ve \u00fclser iyile\u015ftirici etkileri vard\u0131r. Bunlar, S\u0131cak Zehir Chisheng Form\u00fcl\u00fcn\u00fcn terap\u00f6tik etkisi i\u00e7in benzersiz yollar olabilir; Dalak eksikli\u011fi ve rutubet birikimi form\u00fcl\u00fc, AD gibi yollara sahiptir ve ba\u011f\u0131rsak mikrobiyotas\u0131 AD'nin ba\u015flang\u0131c\u0131nda \u00f6nemli bir rol oynar. Beyin ba\u011f\u0131rsak ekseninin n\u00f6ral, endokrin, ba\u011f\u0131\u015f\u0131kl\u0131k ve metabolik yollar\u0131 arac\u0131l\u0131\u011f\u0131yla beynin fizyolojik, davran\u0131\u015fsal ve bili\u015fsel i\u015flevlerini d\u00fczenleyebilir. Dalak eksikli\u011fi ve rutubet birikimi form\u00fcl\u00fc, dalak eksikli\u011fi ve rutubet durgunlu\u011fu tipi UC hastalar\u0131nda ba\u011f\u0131rsak mikrobiyota yap\u0131s\u0131n\u0131n disbiyozunu d\u00fczenleyebilir ve b\u00f6ylece hasarl\u0131 ba\u011f\u0131rsak dokusunun iyile\u015fmesini te\u015fvik edebilir. Bu, dalak eksikli\u011fi ve rutubet birikimi tipi UC'nin AD ile yak\u0131ndan ili\u015fkili olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir; So\u011fuk ve s\u0131ca\u011f\u0131n kar\u0131\u015f\u0131k form\u00fcl\u00fc HIF-1 gibi yollar\u0131 i\u00e7erir. Enflamatuar b\u00f6lge, hipoksik bir ortamda HIF-1 yola\u011f\u0131 taraf\u0131ndan aktive edilir ve HIF-1 hedef genlerinin ekspresyon seviyesi yukar\u0131 do\u011fru d\u00fczenlenir, bu da vask\u00fcler yeniden \u015fekillenmeye, ge\u00e7irgenlikte de\u011fi\u015fikliklere ve enflamatuar fakt\u00f6rlerin sal\u0131n\u0131m\u0131n\u0131n artmas\u0131na neden olur. V\u00fccut daha sonra kronik bir enflamatuar duruma ge\u00e7er; karaci\u011fer depresyonu ve dalak eksikli\u011fi form\u00fcl\u00fc \u00f6strojen gibi sinyal yollar\u0131na sahiptir. \u00d6strojen, \u00f6strojene ba\u011flanarak \u00f6strojen resept\u00f6r\u00fc \u03b2 1 (ER \u03b2 1) resept\u00f6r\u00fcn\u00fc aktive edebilir, P38 \/ MAPK yolunu inhibe edebilir ve UC hastalar\u0131nda IL-6 ve nitrik oksit (NO) seviyelerinin ekspresyonunu azaltabilir, b\u00f6ylece UC hastal\u0131\u011f\u0131n\u0131n geli\u015fimini engelleyebilir; Dalak b\u00f6brek yang eksikli\u011fi form\u00fcl\u00fc, T h\u00fccre resept\u00f6rleri gibi yolaklara sahiptir. UC hastalar\u0131nda TCR - \u03b2 eksprese eden T h\u00fccrelerinin klonal geni\u015flemesi hastal\u0131k \u015fiddeti ile ili\u015fkilidir ve ba\u011f\u0131rsak iltihab\u0131na arac\u0131l\u0131k etmeye kat\u0131l\u0131r. Bu benzersiz yollar, UC'deki farkl\u0131 TCM sendromlar\u0131n\u0131n kesin tedavi ara\u015ft\u0131rmalar\u0131nda dikkati hak etmektedir.
\nGeleneksel \u00c7in T\u0131bb\u0131, UC hastal\u0131\u011f\u0131n\u0131n genellikle dala\u011f\u0131n rutubeti ve durgunlu\u011fu, anormal sa\u011fl\u0131k hareketleri, ba\u011f\u0131rsaklar\u0131n patojenik durgunlu\u011fu, qi ve kan dola\u015f\u0131m\u0131n\u0131n t\u0131kanmas\u0131, organlar\u0131n ve qi'nin durgunlu\u011fu, kan kayb\u0131 ve et \u00e7\u00fcr\u00fcmesi ve ishal, k\u0131rm\u0131z\u0131, beyaz, irin ve kandan kaynakland\u0131\u011f\u0131na inanmaktad\u0131r. Zamanla, genellikle b\u00f6brek yang\u0131n\u0131 etkileyerek dalak ve b\u00f6brek eksikli\u011fine yol a\u00e7ar ve daha sonra dalak ve b\u00f6brek yang eksikli\u011fi tipi UC'ye d\u00f6n\u00fc\u015f\u00fcr. Dalak ve b\u00f6brek eksikli\u011fi, geleneksel \u00c7in t\u0131bb\u0131nda \u00dcK patogenezinin ana ak\u0131m anlay\u0131\u015f\u0131 haline gelmi\u015ftir ve ayn\u0131 zamanda \u00dcK'nin tedavisini zorla\u015ft\u0131ran temel fakt\u00f6rlerdir. Bu nedenle, hayvan deneyi b\u00f6l\u00fcm\u00fcnde, bu makale ke\u015fif i\u00e7in UC - dalak b\u00f6brek yang eksikli\u011fi tipi UC'nin temsili TCM sendrom tipini se\u00e7mi\u015ftir. Dalak b\u00f6brek yang eksikli\u011fi tip UC olarak kendini g\u00f6sterir. Dalak ve b\u00f6brek eksikli\u011fi, geleneksel \u00c7in t\u0131bb\u0131nda \u00dcK patogenezinin ana ak\u0131m anlay\u0131\u015f\u0131 haline gelmi\u015ftir ve ayn\u0131 zamanda \u00dcK'nin tedavisini zorla\u015ft\u0131ran temel fakt\u00f6rlerdir. Bu nedenle, hayvan deneyi b\u00f6l\u00fcm\u00fcnde, bu makale ke\u015fif i\u00e7in temsili TCM sendrom tipi UC - dalak b\u00f6brek yang eksikli\u011fi tipi UC'yi se\u00e7mi\u015ftir.
\nTNF - \u03b1 ve IL-6 gibi pro-inflamatuar sitokinlerin salg\u0131lanmas\u0131, \u00dcK'nin ortaya \u00e7\u0131kmas\u0131nda ve geli\u015fmesinde \u00f6nemli bir rol oynamaktad\u0131r. TNF - \u03b1 epitel h\u00fccrelerini aktive edebilir, kemokinleri ind\u00fckleyebilir, n\u00f6trofil agregasyonuna neden olabilir, inflamatuar etkileri art\u0131rabilir ve ba\u011f\u0131rsak mukozal dokusuna zarar verebilir. Serum seviyeleri UC'nin \u015fiddeti ile pozitif korelasyon g\u00f6sterir; IL-6 sitokinlerin ekspresyonunu ind\u00fckleyebilir, TNF - \u03b1'n\u0131n biyolojik aktivitesini art\u0131rabilir ve inflamatuar yan\u0131t\u0131 k\u00f6t\u00fcle\u015ftirebilir. Serum seviyesi \u00dcK'nin \u015fiddetini yans\u0131tabilir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, Fuzi Lizhong Wan'\u0131n dalak b\u00f6brek yang eksikli\u011fi tipi UC'li s\u0131\u00e7anlar\u0131n serumundaki TNF - \u03b1 ve IL-6 aktivitesini \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebildi\u011fini ve anti-enflamatuar etkisini g\u00f6sterdi\u011fini g\u00f6stermi\u015ftir. Ayr\u0131ca bu \u00e7al\u0131\u015fmada, \u00f6nemli \u015fifal\u0131 bitkileri elde etmek i\u00e7in 7 klasik bile\u015fik \u015fifal\u0131 bitkinin kullan\u0131m s\u0131kl\u0131\u011f\u0131 \u00fczerinde istatistiksel analiz yap\u0131lm\u0131\u015ft\u0131r. Dalak B\u00f6brek Yang Eksikli\u011fi Form\u00fcl\u00fcndeki Fuzi Lizhong Wan'\u0131 olu\u015fturan be\u015f \u015fifal\u0131 bitkinin hepsinin \u00f6nemli \u015fifal\u0131 bitkiler oldu\u011fu bulunmu\u015ftur. Yazar\u0131n \u00f6nceki ara\u015ft\u0131rmalar\u0131, Fuzi Lizhong Wan'\u0131n UC i\u00e7in \u00e7ok bile\u015fenli, \u00e7ok hedefli ve \u00e7ok yollu tedavi \u00f6zelliklerine sahip oldu\u011funu g\u00f6stermi\u015ftir.
\n\u00d6zetle, yedi klasik bile\u015fik form\u00fcl\u00fcndeki \u03b2 - sitosterol, stigmasterol, betulinik asit ve kaempferol\u00fcn d\u00f6rt \u00f6nemli bile\u015feni PTPN1, MAPK1, CDK1 ve VEGFA gibi 42 \u00f6nemli hedef \u00fczerinde etkili olabilir. PI3K Akt, RAS ve VEGF gibi enflamatuar sinyal yollar\u0131n\u0131 d\u00fczenleyerek ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 d\u00fczenleyebilir, enflamasyonu ortadan kald\u0131rabilir, h\u00fccre apoptozunu d\u00fczenleyebilir ve kanserle sava\u015fabilirler. Bu, UC i\u00e7in ila\u00e7 ara\u015ft\u0131rmas\u0131 ve hedefe y\u00f6nelik tedavi i\u00e7in bir referans sa\u011flar; Fuzi Lizhong Hap\u0131, TNF - \u03b1 ve IL-6 gibi enflamatuar hedeflere etki ederek dalak b\u00f6brek yang eksikli\u011fi tipi UC'yi tedavi edebilir ve mekanizmas\u0131 T h\u00fccre resept\u00f6rleri gibi enflamatuar yollar\u0131n d\u00fczenlenmesiyle ilgili olabilir. \u00dcK durumu geli\u015ftik\u00e7e, \u00dcK i\u00e7in klasik form\u00fcllerin farkl\u0131 TCM sendromu t\u00fcrleri aras\u0131nda hedefler, yollar ve bile\u015fenler a\u00e7\u0131s\u0131ndan farkl\u0131l\u0131klar vard\u0131r. STAT1 (kal\u0131n ba\u011f\u0131rsak nemli \u0131s\u0131 form\u00fcl\u00fc), TLR4 (so\u011fuk \u0131s\u0131 kar\u0131\u015f\u0131k form\u00fcl\u00fc), TP53, GRB2 (dalak b\u00f6brek yang eksikli\u011fi form\u00fcl\u00fc) gibi 14 benzersiz ve \u00f6nemli hedef; baicalein ve baicalein gibi 30 benzersiz \u00f6nemli bile\u015fen ve JAK-STAT gibi 14 benzersiz \u00f6nemli yol, dolayl\u0131 olarak geleneksel \u00c7in t\u0131bb\u0131 sendrom tiplerinde farkl\u0131l\u0131klar oldu\u011funu ve kesin tedavinin sendrom farkl\u0131la\u015fmas\u0131na dayanmas\u0131 gerekti\u011fini g\u00f6stermektedir. Ayn\u0131 zamanda, bu benzersiz \u00f6nemli hedefler, bile\u015fenler ve yolaklar, UC'deki farkl\u0131 TCM sendromlar\u0131n\u0131n kesin tedavi ara\u015ft\u0131rmalar\u0131nda dikkat edilmeye de\u011ferdir ve benzersiz hedef proteinler, UC'nin TCM sendromu farkl\u0131la\u015fmas\u0131 i\u00e7in potansiyel de\u011ferlendirme g\u00f6stergeleri olarak da hizmet edebilir.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the mechanism of action of seven compound prescriptions based on network pharmacology in the treatment of ulcerative colitis Ulcerative colitis (UC) is widely recognized as a difficult to treat disease in the medical community. Due to its recurrent and persistent nature, it seriously affects patients’ work and quality of life. Currently, there are […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the mechanism of action of seven compound prescriptions based on network pharmacology in the treatment of ulcerative colitis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/ulcerative-colitis\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of action of seven compound prescriptions based on network pharmacology in the treatment of ulcerative colitis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of action of seven compound prescriptions based on network pharmacology in the treatment of ulcerative colitis Ulcerative colitis (UC) is widely recognized as a difficult to treat disease in the medical community. 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