{"id":7220,"date":"2024-08-06T19:04:29","date_gmt":"2024-08-06T19:04:29","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7220"},"modified":"2024-08-06T19:04:29","modified_gmt":"2024-08-06T19:04:29","slug":"chinese-medicine-component-compatibility","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/ci\u0307n-tibbi-bi\u0307lesen-uyumlulugu\/","title":{"rendered":"Qi'yi Beslemek, Yang'\u0131 Is\u0131tmak, Kan Dola\u015f\u0131m\u0131n\u0131 Te\u015fvik Etmek ve Suya Fayda Sa\u011flamak i\u00e7in A\u011f Farmakolojisi ve Deneysel Do\u011frulamaya Dayal\u0131 Kronik Kalp Yetmezli\u011finin \u00d6nlenmesi ve Tedavisi i\u00e7in Geleneksel \u00c7in T\u0131bb\u0131 Bile\u015fen Uyumlulu\u011funun Mekanizmas\u0131n\u0131n Ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>Qi'yi Beslemek, Yang'\u0131 Is\u0131tmak, Kan Dola\u015f\u0131m\u0131n\u0131 Te\u015fvik Etmek ve Suya Fayda Sa\u011flamak i\u00e7in A\u011f Farmakolojisi ve Deneysel Do\u011frulamaya Dayal\u0131 Kronik Kalp Yetmezli\u011finin \u00d6nlenmesi ve Tedavisi i\u00e7in Geleneksel \u00c7in T\u0131bb\u0131 Bile\u015fen Uyumlulu\u011funun Mekanizmas\u0131n\u0131n Ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nKronik kalp yetmezli\u011fi (KKY), \u00e7e\u015fitli kalp hastal\u0131klar\u0131 son a\u015famaya geldi\u011finde kalp yetmezli\u011finin neden oldu\u011fu klinik bir semptomdur. KKY'nin ba\u015fl\u0131ca klinik belirtileri s\u0131v\u0131 retansiyonu, dispne ve y\u00fczde y\u00fczen uzuv \u015fi\u015fmesidir. Hastal\u0131k ilerleyicidir, k\u00f6t\u00fc prognoz ve y\u00fcksek mortalite ile insan ya\u015fam g\u00fcvenli\u011fi i\u00e7in ciddi bir tehdit olu\u015fturmaktad\u0131r. Kronik kalp yetmezli\u011finin insan ya\u015fam g\u00fcvenli\u011fine verdi\u011fi zarar t\u00fcm\u00f6rlerinkini a\u015fm\u0131\u015f, te\u015fhis ve tedavisi 21. y\u00fczy\u0131lda t\u0131p camias\u0131n\u0131n kar\u015f\u0131 kar\u015f\u0131ya oldu\u011fu \u00f6nemli bir konu haline gelmi\u015ftir. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n h\u0131zla geli\u015fmesiyle birlikte, kardiyovask\u00fcler hastal\u0131klar konusundaki anlay\u0131\u015f\u0131 yeni bir seviyeye ula\u015fm\u0131\u015ft\u0131r. Re\u00e7etelerin uyumlulu\u011fu, tedavide benzersiz avantajlara sahip olan geleneksel \u00c7in t\u0131bb\u0131n\u0131n sendrom farkl\u0131la\u015ft\u0131rma ve tedavisinin \u00f6zel bir tezah\u00fcr\u00fcd\u00fcr. Uyumlulu\u011fun derin bilimsel anlam\u0131n\u0131 anlamak \u015fu anda \u00e7\u00f6z\u00fclmesi gereken bir sorundur.<br \/>\nAkademisyen Zhang Boli ve uzman ekibi, \u00c7in t\u0131bb\u0131 bile\u015fenlerini taramak i\u00e7in biyolojik kromatografi, a\u011f farmakolojisi ve polar segmentasyon taramas\u0131 gibi y\u00f6ntemleri kullanarak etkili \u00c7in t\u0131bb\u0131 bile\u015fen uyumlulu\u011funun teorik konseptini ilk kez a\u00e7\u0131k\u00e7a \u00f6nermi\u015ftir. \u00c7in t\u0131bb\u0131 bile\u015fenlerinin bilimsel ve tekrarlanabilir uyumlulu\u011fu onun avantaj\u0131d\u0131r. A\u011f farmakolojisi, ila\u00e7 bile\u015fenlerinin ilgili hastal\u0131klar ve belirli sinyal yollar\u0131 \u00fczerinde terap\u00f6tik etkileri olup olmad\u0131\u011f\u0131n\u0131 analiz etmek ve bulmak amac\u0131yla, ila\u00e7 etken maddeleri ve ilgili hastal\u0131klar aras\u0131nda ortak bir ba\u011flant\u0131ya sahip belirli sinyal d\u00fc\u011f\u00fcmlerini taramak i\u00e7in esas olarak a\u011f\u0131 kullan\u0131r. Ayn\u0131 zamanda, a\u011f farmakolojisinin b\u00fct\u00fcnsel \u00f6zellikleri, geleneksel \u00c7in t\u0131bb\u0131 alan\u0131ndaki avantajlar\u0131n\u0131 da yans\u0131tan geleneksel \u00c7in t\u0131bb\u0131n\u0131n b\u00fct\u00fcnsel konseptine benzer.<br \/>\nBu \u00e7al\u0131\u015fmada, Astragalus membranaceus'un toplam saponinleri, Salvia miltiorrhiza'n\u0131n toplam fenolik asitleri, Scutellaria baicalensis'in su ekstresi ve sinnamaldehit dahil olmak \u00fczere d\u00f6rt ila\u00e7 bile\u015feninin aktif bile\u015fenleri taranm\u0131\u015ft\u0131r. Aktif bile\u015fenlerin ilgili hastal\u0131klarla etkile\u015fime giren hedefleri belirlenmi\u015f ve geleneksel \u00c7in t\u0131bb\u0131 bile\u015fenlerinin KKY tedavisindeki olas\u0131 etki mekanizmas\u0131 molek\u00fcler yerle\u015ftirme ve deneysel do\u011frulama yoluyla ortaya \u00e7\u0131kar\u0131lm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7221\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-289.png\" alt=\"\" width=\"786\" height=\"235\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-289.png 786w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-289-768x230.png 768w\" sizes=\"(max-width: 786px) 100vw, 786px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7222\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-241.png\" alt=\"\" width=\"785\" height=\"196\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-241.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-241-768x192.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7223\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-227.png\" alt=\"\" width=\"784\" height=\"331\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-227.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-227-768x324.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7224\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-205.png\" alt=\"\" width=\"785\" height=\"896\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-205.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-205-768x877.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-205-631x720.png 631w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7225\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-185.png\" alt=\"\" width=\"778\" height=\"305\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-185.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-185-768x301.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7226\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-169.png\" alt=\"\" width=\"788\" height=\"585\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-169.png 788w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-169-768x570.png 768w\" sizes=\"(max-width: 788px) 100vw, 788px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7227\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-154.png\" alt=\"\" width=\"785\" height=\"869\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-154.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-154-768x850.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-154-650x720.png 650w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7228\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-139.png\" alt=\"\" width=\"784\" height=\"909\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-139.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-139-768x890.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-139-621x720.png 621w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7229\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-131.png\" alt=\"\" width=\"776\" height=\"623\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-131.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-131-768x617.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7230\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-103.png\" alt=\"\" width=\"782\" height=\"909\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-103.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-103-768x893.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-103-619x720.png 619w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7231\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-98.png\" alt=\"\" width=\"782\" height=\"281\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-98.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-98-768x276.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7232\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-82.png\" alt=\"\" width=\"781\" height=\"221\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-82.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-82-768x217.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7233\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-69.png\" alt=\"\" width=\"784\" height=\"247\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-69.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-69-768x242.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7234\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-53.png\" alt=\"\" width=\"785\" height=\"126\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-53.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-53-768x123.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7235\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-40.png\" alt=\"\" width=\"783\" height=\"87\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-40.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-40-768x85.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7236\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-28.png\" alt=\"\" width=\"778\" height=\"493\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-28.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-28-768x487.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7237\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-23.png\" alt=\"\" width=\"785\" height=\"390\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-23.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-23-768x382.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7238\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-16.png\" alt=\"\" width=\"784\" height=\"173\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-16.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-16-768x169.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7239\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-13.png\" alt=\"\" width=\"783\" height=\"376\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-13.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-13-768x369.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7240\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-10.png\" alt=\"\" width=\"346\" height=\"220\" \/><br \/>\nKKY klasik \u00c7in t\u0131p literat\u00fcr\u00fcnde a\u00e7\u0131k\u00e7a belirtilmemi\u015ftir. Klinik belirtilerine dayanarak \"kalp t\u0131kan\u0131kl\u0131\u011f\u0131\", \"\u00e7arp\u0131nt\u0131\", \"g\u00f6\u011f\u00fcs t\u0131kan\u0131kl\u0131\u011f\u0131\", \"\u00e7arp\u0131nt\u0131\", \"\u00f6dem\" ve di\u011fer hastal\u0131k sendromlar\u0131 olarak s\u0131n\u0131fland\u0131r\u0131labilir. KKY tedavisinde geleneksel \u00c7in t\u0131bb\u0131, sendrom farkl\u0131la\u015ft\u0131rmas\u0131 ve b\u00fct\u00fcnsel kavramlar\u0131 birle\u015ftirmektedir. \"Kronik Kalp Yetersizli\u011finin Entegre Geleneksel \u00c7in ve Bat\u0131 T\u0131bb\u0131 Te\u015fhis ve Tedavisi \u00dczerine Uzman Konsens\u00fcs\u00fc\", KKY'nin temel patogenezinin eksiklik, kan staz\u0131 ve su oldu\u011funa i\u015faret etmektedir. Eksikli\u011fin tamamlanmas\u0131 ve temelin g\u00fc\u00e7lendirilmesi bu hastal\u0131\u011f\u0131n tedavisinin anahtar\u0131d\u0131r. Eksikli\u011fin tamamlanmas\u0131 temelinde, kan dola\u015f\u0131m\u0131n\u0131n te\u015fvik edilmesi ve staz\u0131n giderilmesi, di\u00fcrezin te\u015fvik edilmesi ve \u015fi\u015fli\u011fin azalt\u0131lmas\u0131 da \u00f6nemlidir. Bu nedenle, qi'yi tonifiye etme ve yang'\u0131 \u0131s\u0131tma, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve di\u00fcrezi te\u015fvik etme tedavi y\u00f6nteminin olu\u015fturulmas\u0131 tavsiye edilir. Ara\u015ft\u0131rma grubunun \u00f6n ara\u015ft\u0131rmas\u0131 ayr\u0131ca KKY'nin patogenezinin Zong Qi eksikli\u011fine dayand\u0131\u011f\u0131n\u0131, kan staz\u0131, balgam bulan\u0131kl\u0131\u011f\u0131 ve su tutma kriterlerinin k\u00f6kte eksiklik ve fazlal\u0131kta fazlal\u0131k sendromlar\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Mate analizine dayanarak, kronik kalp yetmezli\u011fi tedavisinde qi'yi tonifiye etme, yang'\u0131 \u0131s\u0131tma, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve di\u00fcrez form\u00fcl\u00fcn\u00fcn etkinli\u011fi do\u011frulanm\u0131\u015ft\u0131r. Ara\u015ft\u0131rmalar, qi'yi tonifiye etme, yang'\u0131 \u0131s\u0131tma, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve di\u00fcrezi te\u015fvik etme etkilerine sahip klinik modifiye form\u00fcllerin kronik kalp yetmezli\u011fi ve di\u00fcretik direnci olan hastalar \u00fczerinde iyi bir terap\u00f6tik etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. Hastalar\u0131n kardiyak fonksiyonlar\u0131n\u0131 etkili bir \u015fekilde iyile\u015ftirebilir ve hastalar\u0131n prognozunu iyile\u015ftirebileceklerini \u00f6ne s\u00fcrerler.<br \/>\nTarama yoluyla elde edilen d\u00f6rt bile\u015fen, yani Astragalus membranaceus'un toplam saponinleri, Salvia miltiorrhiza'n\u0131n toplam fenolik asitleri, Scutellaria baicalensis'in su ekstresi ve sinnamaldehit, qi'yi beslemek, yang'\u0131 \u0131s\u0131tmak, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve suya fayda sa\u011flamak i\u00e7in temsili ila\u00e7lard\u0131r. Modern farmakolojik \u00e7al\u0131\u015fmalar ayr\u0131ca Astragalus membranaceus'un toplam saponinlerinin KKY s\u0131\u00e7anlar\u0131nda ventrik\u00fcler yeniden \u015fekillenmeyi engelleyebildi\u011fini ve kalp fonksiyonunu iyile\u015ftirebildi\u011fini ve etki g\u00fcc\u00fcn\u00fcn doza ba\u011fl\u0131 oldu\u011funu g\u00f6stermi\u015ftir; Danshen toplam fenolik asit h\u00fccre i\u00e7i kalsiyum dola\u015f\u0131m\u0131n\u0131 iyile\u015ftirebilir ve miyokardiyal diyastolik ve sistolik i\u015flevi art\u0131rabilir. Platycodon grandiflorus'un su ekstresi, kalp yetmezli\u011fi olan s\u0131\u00e7anlarda metabolik bozukluklar\u0131 de\u011fi\u015ftirerek anti kalp yetmezli\u011fi etkileri g\u00f6sterebilir. Sinnamaldehit, s\u0131\u00e7an kalp fonksiyonunu etkili bir \u015fekilde iyile\u015ftirebilir, enflamatuar fakt\u00f6rlerin sal\u0131n\u0131m\u0131n\u0131 engelleyebilir ve b\u00f6ylece kalp \u00fczerinde koruyucu bir etki g\u00f6sterebilir.<br \/>\nBu \u00e7al\u0131\u015fma, hastal\u0131k hedefleriyle y\u00fcksek derecede kesi\u015fen d\u00f6rt bile\u015fen hedefinin AKT1, TNF, PPAR, CASP3, BCL2L1, HIF1A, MTOR, IL6, vb. oldu\u011funu bulmu\u015ftur. Ara\u015ft\u0131rmalar, AKT'nin pro apoptotik proteinleri veya transkripsiyon fakt\u00f6rlerini inhibe ederek sinyal d\u00fczenlemesini sa\u011flad\u0131\u011f\u0131n\u0131 ve b\u00f6ylece kardiyomiyosit apoptozunu azaltt\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Miyokardiyal h\u00fccrelerde AKT'nin aktivasyonu h\u00fccre apoptozunu inhibe edebilir, I\/R hasar\u0131ndan sonra miyokard enfarkt\u00fcs\u00fcn\u00fc hafifletebilir ve kardiyak fonksiyonu koruyabilir. Ayn\u0131 zamanda AKT1, d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc b\u00fcy\u00fcme fakt\u00f6r\u00fc - \u03b2'n\u0131n (TGF - \u03b2 1) anahtar ifadesini d\u00fczenleyerek h\u00fccre apoptozu ve ventrik\u00fcler yeniden \u015fekillenme gibi s\u00fcre\u00e7lere kat\u0131l\u0131r. AKT, miyokardiyal h\u00fccre apoptozunu d\u00fczenler ve AKT\/mTOR yolunu aktive ederek inflamasyonun azalt\u0131lmas\u0131nda rol oynar. Klasik apoptoz fakt\u00f6rleri Bcl-2 ve Caspase-3, AKT\/mTOR'un a\u015fa\u011f\u0131 ak\u0131\u015f fakt\u00f6rleridir. Ara\u015ft\u0131rmalar, NFkB'nin miyokardiyal hasar\u0131n erken a\u015famalar\u0131nda aktive olabilece\u011fini, kemokinlerin ve adezyon molek\u00fcllerinin ekspresyonunu ind\u00fckleyerek miyokardiyal inflamasyona ve hasara yol a\u00e7abilece\u011fini bulmu\u015ftur.<br \/>\nHuangqi toplam saponinleri esas olarak kalsiyum sinyal yolu, cGMPPKG, PI3K Akt, cAMP sinyal yolu vb. bak\u0131m\u0131ndan zenginle\u015ftirilmi\u015ftir. \u00d6nceki deneyler, Astragalus membranaceus'un toplam saponinlerinin s\u0131\u00e7an miyokard\u0131ndaki oksidatif stresi hafifletebilece\u011fini, kardiyomiyosit apoptozunu inhibe edebilece\u011fini ve AKL \/ p38MAPK yolunu d\u00fczenleyerek kalp fonksiyonunu iyile\u015ftirebilece\u011fini g\u00f6stermi\u015ftir. Huangqi IV glikozit trombosit agregasyonunu inhibe edebilir ve vask\u00fcler restenozun \u00f6nlenmesinde rol oynayabilir, bu da geleneksel \u00c7in t\u0131bb\u0131n\u0131n \"qi dola\u015f\u0131m\u0131 kan dola\u015f\u0131m\u0131na yol a\u00e7ar\" ilkesinin makul oldu\u011funu g\u00f6stermektedir. Danshen toplam fenolik asitleri esas olarak PI3K Akt sinyal yolunda zenginle\u015ftirilmi\u015ftir ve \u00e7al\u0131\u015fmalar Danshen fenolik asit A'n\u0131n AKT\/mTOR\/4EBP1 yolunu aktive ederek H9c2 kardiyomiyositlerinde lipopolisakkarit kaynakl\u0131 apoptoz ve oksidatif stresi hafifletti\u011fini g\u00f6stermi\u015ftir. Scutellaria baicalensis'in su ekstresi, MAPK sinyal yolu, kalsiyum sinyal yolu vb. bak\u0131m\u0131ndan zenginle\u015ftirilmi\u015ftir. \u00c7al\u0131\u015fmalar, Scutellaria baicalensis \u00f6z\u00fct\u00fcn\u00fcn MAPK sinyal yolunu aktive edebilece\u011fini, h\u00fccre apoptozunu inhibe edebilece\u011fini ve miyokardiyal hasara kar\u015f\u0131 koruyabilece\u011fini bulmu\u015ftur. Sinnamaldehit, Toll benzeri resept\u00f6rler, TNF sinyal yollar\u0131 vb. bak\u0131m\u0131ndan zenginle\u015ftirilmi\u015ftir. Sinnamaldehit, miyokardiyal dokudaki ROS i\u00e7eri\u011fini azaltabilir, miyokardiyal h\u00fccre otofajisini hafifletebilir ve miyokard\u0131 koruyarak bu \u00e7al\u0131\u015fman\u0131n a\u011f tahmin sonu\u00e7lar\u0131n\u0131 k\u0131smen do\u011frulayabilir.<br \/>\n\u00d6zetle, bu \u00e7al\u0131\u015fmada Huangqi toplam saponinleri, Danshen toplam fenolik asitleri, Tangzi su ekstresi ve sinnamaldehitte KKY hastal\u0131\u011f\u0131na kar\u015f\u0131l\u0131k gelen etken madde hedeflerini taramak i\u00e7in a\u011f farmakolojisi y\u00f6ntemleri kullan\u0131lm\u0131\u015f ve kesi\u015fen hedefler elde edilmi\u015ftir. Y\u00fcksek derece de\u011ferlerine sahip hedefler AKT1, TNF, INS, IL1B, PTGS2, PPAR, CASP3, MTOR vb. idi. \u0130lgili anahtar yolaklar PI3K Akt, MAPK, Toll benzeri resept\u00f6r sinyal yolu, kalsiyum sinyal yolu, cGMP PKG, vb. olup, h\u00fccre d\u00f6ng\u00fcs\u00fc, apoptoz, otofaji, oksidatif stres ve enflamatuar yan\u0131t gibi \u00e7oklu biyolojik s\u00fcre\u00e7lerle ilgilidir ve KKY tedavisi i\u00e7in potansiyel mekanizmalard\u0131r. Bu \u00e7al\u0131\u015fmada, KKY tedavisinde HGDT bile\u015fenlerinin maddi temelini ve etki mekanizmas\u0131n\u0131 tahmin etmek i\u00e7in a\u011f farmakolojisi molek\u00fcler yerle\u015ftirme teknolojisi kullan\u0131lm\u0131\u015f ve a\u011f tahmin sonu\u00e7lar\u0131 deneysel olarak do\u011frulanarak KKY tedavisinde geleneksel \u00c7in t\u0131bb\u0131 bile\u015fenlerinin mekanizmas\u0131n\u0131n incelenmesi i\u00e7in temel olu\u015fturulmu\u015ftur.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the Mechanism of Traditional Chinese Medicine Component Compatibility for the Prevention and Treatment of Chronic Heart Failure Based on Network Pharmacology and Experimental Validation to Nourish Qi, Warm Yang, Promote Blood Circulation and Benefit Water Chronic heart failure (CHF) is a clinical symptom caused by cardiac insufficiency when various heart diseases develop to the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - 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