{"id":7174,"date":"2024-08-06T18:53:17","date_gmt":"2024-08-06T18:53:17","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7174"},"modified":"2024-08-06T18:53:17","modified_gmt":"2024-08-06T18:53:17","slug":"high-altitude-disease-model-rats","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/high-altitude-disease-model-rats\/","title":{"rendered":"Cistanche deserticola feniletanoid glikozitin kronik y\u00fcksek irtifa hastal\u0131\u011f\u0131 modeli s\u0131\u00e7anlar \u00fczerindeki terap\u00f6tik etkisi ve mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"<p>Cistanche deserticola feniletanoid glikozitin kronik y\u00fcksek irtifa hastal\u0131\u011f\u0131 modeli s\u0131\u00e7anlar \u00fczerindeki terap\u00f6tik etkisi ve mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma<br \/>\nY\u00fcksek irtifa hastal\u0131\u011f\u0131, v\u00fccudun y\u00fcksek irtifalardaki d\u00fc\u015f\u00fck bas\u0131n\u00e7l\u0131 hipoksiye uyum sa\u011flayamamas\u0131ndan kaynaklanan ve v\u00fccutta bir dizi patolojik ve fizyolojik de\u011fi\u015fikli\u011fe yol a\u00e7an \u00e7e\u015fitli klinik belirtiler i\u00e7in kullan\u0131lan genel bir terimdir. Bu hastal\u0131k genellikle akut ve kronik olmak \u00fczere iki kategoriye ayr\u0131l\u0131r. Kronik da\u011f hastal\u0131\u011f\u0131 (CMS), akut da\u011f hastal\u0131\u011f\u0131n\u0131n orijinal semptomlar\u0131n\u0131n devam etti\u011fi veya y\u00fcksek irtifaya ula\u015ft\u0131ktan alt\u0131 aydan daha uzun bir s\u00fcre sonra ortaya \u00e7\u0131kt\u0131\u011f\u0131 bir durumu ifade eder. Ara\u015ft\u0131rmac\u0131lar Tibet pop\u00fclasyonundaki Egl9 homolog 1 (EGLN1) ve peroksizom proliferat\u00f6r aktive resept\u00f6r alfa (PPAR - \u03b1) genlerinin d\u00fc\u015f\u00fck rak\u0131ml\u0131 b\u00f6lgelerdekilerden farkl\u0131 oldu\u011funu ve Tibet kan\u0131nda hemoglobini inhibe ederek d\u00fc\u015f\u00fck konsantrasyonda tutabildi\u011fini bulmu\u015flard\u0131r. Bu ayn\u0131 zamanda Tibetlilerin y\u00fcksek rak\u0131mlarda hayatta kalabilmelerinin nedenlerinden biridir. Bu \u00e7al\u0131\u015fma, yukar\u0131da bahsedilen iki genin hipoksi yan\u0131t yolundaki aday genler oldu\u011funu ve nihayetinde etkilerini hipoksi ind\u00fcklenebilir fakt\u00f6r 1 alfa (HIF-1 alfa) yolu \u00fczerinden g\u00f6sterdi\u011fini \u00f6ne s\u00fcrmektedir. EGLN1, HIF-1 \u03b1'n\u0131n yukar\u0131 ak\u0131\u015f genidir, PPAR - \u03b1 ise HIF-1 \u03b1'n\u0131n a\u015fa\u011f\u0131 ak\u0131\u015f hedefidir.<br \/>\nD\u00fc\u015f\u00fck oksijen, HIF-1 \u03b1'n\u0131n hidroksilasyonunu ve asetilasyonunu bloke edebilir, stabilitesini art\u0131rabilir ve vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF), endotelin-1 (ET-1) vb. gibi a\u015fa\u011f\u0131 ak\u0131\u015f genlerinin transkripsiyonunu ve ekspresyonunu d\u00fczenleyerek gen transkripsiyonu bilgi iletimini ind\u00fckleyebilir, b\u00f6ylece pulmoner vask\u00fcler yeniden \u015fekillenmeye neden olur ve ayr\u0131ca pulmoner \u00f6dem ve y\u00fcksek irtifa kalp hastal\u0131\u011f\u0131na yol a\u00e7ar. ET-1'in etkisinin aksine nitrik oksit (NO), nitrik oksit sentaz (NOS) taraf\u0131ndan L-arginin \u00fcretimini katalize eden ve \u00e7ok \u00e7e\u015fitli etkileri olan bir gaz sinyal molek\u00fcl\u00fcd\u00fcr.<br \/>\nBu \u00e7al\u0131\u015fmada, platonun d\u00fc\u015f\u00fck oksijenli ortam\u0131n\u0131 sim\u00fcle etmek i\u00e7in kuzeybat\u0131da \u00f6zel bir ortam yapay deney kabini kullan\u0131lm\u0131\u015ft\u0131r. Plato ve d\u00fczl\u00fck alanlar aras\u0131ndaki temel farkl\u0131l\u0131klar dikkate al\u0131narak, y\u00fcksek irtifa hastal\u0131\u011f\u0131n\u0131n patogenezinde HIF-1 \u03b1 yola\u011f\u0131n\u0131n rol\u00fcn\u00fc ve i\u00e7sel ili\u015fkisini ara\u015ft\u0131rmak i\u00e7in bir y\u00fcksek irtifa hastal\u0131\u011f\u0131 hayvan modeli olu\u015fturulmu\u015ftur. Buna dayanarak, Cistanche'den elde edilen feniletanoid glikozitlerin (PhGC'ler) y\u00fcksek irtifa hastal\u0131\u011f\u0131 \u00fczerindeki \u00f6nleyici ve tedavi edici etkileri ve mekanizmalar\u0131 g\u00f6zlemlenmi\u015f, y\u00fcksek irtifa hastal\u0131\u011f\u0131n\u0131n patogenezini incelemek ve yeni anti-y\u00fcksek irtifa hastal\u0131\u011f\u0131 ila\u00e7lar\u0131 geli\u015ftirmek i\u00e7in teorik bir temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7175\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-286.png\" alt=\"\" width=\"359\" height=\"220\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7176\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-238.png\" alt=\"\" width=\"785\" height=\"237\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-238.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-238-768x232.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7177\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-224.png\" alt=\"\" width=\"784\" height=\"203\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-224.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-224-768x199.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7178\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-202.png\" alt=\"\" width=\"782\" height=\"210\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-202.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-202-768x206.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7179\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-182.png\" alt=\"\" width=\"782\" height=\"226\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-182.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-182-768x222.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7180\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-166.png\" alt=\"\" width=\"782\" height=\"272\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-166.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-166-768x267.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7181\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-151.png\" alt=\"\" width=\"787\" height=\"239\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-151.png 787w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-151-768x233.png 768w\" sizes=\"(max-width: 787px) 100vw, 787px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7182\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-136.png\" alt=\"\" width=\"785\" height=\"201\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-136.png 785w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-136-768x197.png 768w\" sizes=\"(max-width: 785px) 100vw, 785px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7183\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-128.png\" alt=\"\" width=\"781\" height=\"307\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-128.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-128-768x302.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7184\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-100.png\" alt=\"\" width=\"781\" height=\"311\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-100.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-100-768x306.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7185\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-95.png\" alt=\"\" width=\"355\" height=\"198\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-7186\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-79.png\" alt=\"\" width=\"365\" height=\"276\" \/>PhGC'ler Sincan'\u0131n g\u00fcneyindeki Cistanche deserticola'dan elde edilmi\u015f ve ekinakozit, verbascoside, isoverbascoside, 2 '- asetil verbascoside, Cistanche deserticola glikozit A ve salidroside dahil olmak \u00fczere \u00e7e\u015fitli feniletanolik glikozitler ilgili ara\u015ft\u0131rmalar yoluyla ba\u015far\u0131yla izole edilmi\u015ftir. Uzun y\u0131llard\u0131r, PhGC'lerin antioksidan, serbest radikal temizleme ve ya\u015flanma kar\u015f\u0131t\u0131 gibi farmakolojik etkileri \u00fczerine derinlemesine ara\u015ft\u0131rmalar yap\u0131lm\u0131\u015ft\u0131r. Bu deneyde, PhGCs-M grubu s\u0131\u00e7anlarda sa\u011f ventrik\u00fcl hipertrofi indeksini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilmi\u015ftir, bu da Cistanche deserticola feniletanolik asidin CMS s\u0131\u00e7anlar\u0131nda hemodinami\u011fi ve sa\u011f ventrik\u00fcl hipertrofisinin derecesini iyile\u015ftirebilece\u011fini ve CMS \u00fczerinde belirli bir terap\u00f6tik etkiye sahip oldu\u011funu g\u00f6stermektedir. Bu \u00e7al\u0131\u015fma, kan oksijen sat\u00fcrasyonu ile ilgili g\u00f6stergelerden yola \u00e7\u0131karak, PhGC'lerin kan oksijen sat\u00fcrasyonunu art\u0131rd\u0131\u011f\u0131n\u0131, hipoksinin v\u00fccuda verdi\u011fi zarar\u0131 azaltt\u0131\u011f\u0131n\u0131 ve ayn\u0131 k\u0131rm\u0131z\u0131 kan h\u00fccresi say\u0131s\u0131 ve hemoglobin i\u00e7eri\u011fi alt\u0131nda v\u00fccudun hipoksi hasar\u0131na kar\u015f\u0131 tolerans\u0131n\u0131 art\u0131rd\u0131\u011f\u0131n\u0131 ve b\u00f6ylece irtifa hastal\u0131\u011f\u0131n\u0131 tedavi etme hedefine ula\u015ft\u0131\u011f\u0131n\u0131 tahmin etmektedir. PhGC'ler ile tedaviden sonra, CMS s\u0131\u00e7anlar\u0131nda \u00f6l\u00fcm oran\u0131 ve uzuv \u00f6demi insidans\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015f ve CMS tedavisindeki etkinli\u011fini daha da g\u00f6stermi\u015ftir.<\/p>\n<p>Endotel ba\u011f\u0131ml\u0131 bir vazodilat\u00f6r olan NO, endotelyal vazodilatasyonda \u00f6nemli bir rol oynar \u00e7\u00fcnk\u00fc pulmoner vask\u00fcler d\u00fcz kas\u0131 do\u011frudan gev\u015feterek \u00f6nemli \u00f6l\u00e7\u00fcde pulmoner vazodilatasyona neden olur. Ayr\u0131ca pulmoner vask\u00fcler d\u00fcz kas h\u00fccrelerinin proliferasyonunu ve migrasyonunu inhibe etme, trombosit agregasyonunu bask\u0131lama yetene\u011fine sahiptir ve pulmoner dola\u015f\u0131m stabilitesinin korunmas\u0131nda \u00f6nemli bir rol oynar. Bu \u00e7al\u0131\u015fmada Mod akci\u011fer dokusu homojenat\u0131ndaki NO i\u00e7eri\u011finin azald\u0131\u011f\u0131 ve T-NOS, iNOS ve eNOS aktivitelerinin azald\u0131\u011f\u0131 bulunmu\u015ftur. PhGC'ler TNOS, iNOS ve eNOS aktivitelerini art\u0131rarak akci\u011fer dokusundaki NO i\u00e7eri\u011fini art\u0131rabilir, pulmoner arter d\u00fcz kas\u0131n\u0131n proliferasyonu ve miyometrizasyonuyla m\u00fccadelede ve CMS tedavisinde rol oynayabilir.<br \/>\nET-1 \u015fimdiye kadar ke\u015ffedilen en g\u00fc\u00e7l\u00fc vazokonstrikt\u00f6rd\u00fcr ve hipoksi kandaki ET-1 seviyesini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabilir. Rajput ve arkada\u015flar\u0131, y\u00fcksek irtifa ve d\u00fczl\u00fck sakinleri aras\u0131ndaki ET-1 alellerindeki farkl\u0131l\u0131klar\u0131 kar\u015f\u0131la\u015ft\u0131rm\u0131\u015f ve y\u00fcksek irtifa sakinlerinde ET-1'in belirli alellerinin a\u015f\u0131r\u0131 eksprese edildi\u011fini ve ET-l alelinin ekspresyonunun plazma ET-1 seviyeleri ile \u00f6nemli \u00f6l\u00e7\u00fcde ili\u015fkili oldu\u011funu bulmu\u015ftur. Bu makalede, Mod s\u0131\u00e7anlar\u0131n akci\u011fer dokusundaki ET-1 i\u00e7eri\u011fi \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r, bu da hipoksinin di\u011fer \u00e7al\u0131\u015fmalarla tutarl\u0131 olarak akci\u011fer dokusunda ET-1 salg\u0131lanmas\u0131n\u0131n artmas\u0131na neden oldu\u011funu g\u00f6stermektedir. PhGC'lerin uygulanmas\u0131 CMS s\u0131\u00e7anlar\u0131n\u0131n akci\u011fer dokusundaki ET-1 i\u00e7eri\u011fini azaltabilir, bu da PhGC'lerin ET-1 taraf\u0131ndan ind\u00fcklenen vask\u00fcler konstriksiyonu inhibe edebilece\u011fini, pulmoner arter bas\u0131nc\u0131n\u0131 azaltabilece\u011fini ve CMS \u00fczerinde terap\u00f6tik etkiler g\u00f6sterebilece\u011fini g\u00f6sterir.<br \/>\nDaha sonra, PhGC'lerin hipoksi ile ind\u00fcklenen yolakta HIF-1 \u03b1, VEGF ve PPAR - \u03b1 \u00fczerindeki etkilerini g\u00f6zlemlemeye odakland\u0131k. Her gruptaki s\u0131\u00e7anlar\u0131n akci\u011fer dokular\u0131ndaki mRNA ve protein ekspresyonu imm\u00fcnohistokimya, floresan kantitatif PCR ve Western blot y\u00f6ntemleri kullan\u0131larak tespit edilmi\u015ftir. \u0130mm\u00fcnohistokimyasal sonu\u00e7lar, Mod s\u0131\u00e7anlar\u0131n pulmoner arterlerindeki VEGF ekspresyon seviyesinin Con'dan daha y\u00fcksek oldu\u011funu, PPAR - \u03b1 ekspresyon seviyesinin ise Con'dan daha d\u00fc\u015f\u00fck oldu\u011funu g\u00f6stermi\u015ftir. PhGCs d\u00fc\u015f\u00fck, orta, PhGCs-H ve RC gruplar\u0131n\u0131n pulmoner arterlerindeki VEGF ekspresyon seviyeleri Mod'unkinden daha d\u00fc\u015f\u00fckken, PPAR - \u03b1 ekspresyon seviyesi artm\u0131\u015ft\u0131r. Bu, PhGC'lerin ve Rhodiola rosea'n\u0131n hipoksi taraf\u0131ndan ind\u00fcklenen VEGF ekspresyonunu inhibe edebilece\u011fini, PPAR - \u03b1 ekspresyonunu te\u015fvik edebilece\u011fini ve pulmoner vask\u00fcler proliferasyonu ve miyogenezi hafifletebilece\u011fini, b\u00f6ylece CMS'de terap\u00f6tik bir rol oynayabilece\u011fini g\u00f6stermektedir. Akci\u011fer dokusunda HIF-1 \u03b1 proteini ve mRNA ekspresyonunun deneysel \u00f6l\u00e7\u00fcm\u00fc yoluyla, CMS model s\u0131\u00e7anlar\u0131n akci\u011fer dokusunda HIF-1 \u03b1 proteini ekspresyonunun \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131, mRNA ve Con ekspresyonunun ise farkl\u0131l\u0131k g\u00f6stermedi\u011fi bulunmu\u015ftur. Bu, hipoksinin esas olarak HIF-1 \u03b1 proteininin ekspresyonunu d\u00fczenledi\u011fini g\u00f6steren ilgili ara\u015ft\u0131rma sonu\u00e7lar\u0131yla tutarl\u0131d\u0131r. PhGC'ler HIF-1 \u03b1 protein ve mRNA ekspresyon seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir, bu da HIF-1 \u03b1'n\u0131n transkripsiyonu ve translasyonu \u00fczerinde bir etkiye sahip olabileceklerini g\u00f6sterir. Bununla birlikte, Rhodiola rosea'n\u0131n HIF-1 \u03b1 mRNA ekspresyonu \u00fczerinde \u00f6nemli bir etkisi yoktu, bu da esas olarak hipoksi gibi protein ekspresyonunu etkiledi\u011fini g\u00f6sterir.<br \/>\nGenel olarak, \u00fc\u00e7 PhGC dozu aras\u0131nda, PhGCs-M grubu CMS \u00fczerinde en iyi etkiyi g\u00f6sterirken, PhGCs-H tedavisi, PhGCs-H'nin ba\u011f\u0131rsak emilim oran\u0131ndaki azalmayla ili\u015fkili olabilecek \u00f6nemli bir art\u0131\u015f g\u00f6stermemi\u015ftir. Rhodiola rosea ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda PhGCs-M, HIF-1 \u03b1 mRNA ve VEGF mRNA g\u00f6stergeleri \u00fczerinde daha iyi bir terap\u00f6tik etkiye sahiptir. Kaynak avantajlar\u0131 ile birle\u015fti\u011finde, PhGC'lerin belirli geli\u015fme beklentileri vard\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Cistanche deserticola phenylethanoid glycoside'in kronik y\u00fcksek irtifa hastal\u0131\u011f\u0131 modeli s\u0131\u00e7anlar \u00fczerindeki terap\u00f6tik etkisi ve mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma Y\u00fcksek irtifa hastal\u0131\u011f\u0131, v\u00fccudun y\u00fcksek irtifalarda d\u00fc\u015f\u00fck bas\u0131n\u00e7l\u0131 hipoksiye uyum sa\u011flayamamas\u0131ndan kaynaklanan ve v\u00fccutta bir dizi patolojik ve fizyolojik de\u011fi\u015fiklikle sonu\u00e7lanan \u00e7e\u015fitli klinik belirtiler i\u00e7in kullan\u0131lan genel bir terimdir. [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the therapeutic effect and mechanism of Cistanche deserticola phenylethanoid glycoside on chronic high altitude disease model rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/high-altitude-disease-model-rats\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the therapeutic effect and mechanism of Cistanche deserticola phenylethanoid glycoside on chronic high altitude disease model rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the therapeutic effect and mechanism of Cistanche deserticola phenylethanoid glycoside on chronic high altitude disease model rats High altitude disease is a general term for various clinical manifestations caused by the body&#8217;s inability to adapt to low-pressure hypoxia at high altitudes, resulting in a series of pathological and physiological changes in the body. 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