\u00c7in Kardiyovask\u00fcler Raporu 2017, \u00c7in'de kardiyovask\u00fcler hastal\u0131k prevalans\u0131n\u0131n son y\u0131llarda artmaya devam etti\u011fini ve \u015fu anda yakla\u015f\u0131k 290 milyon ki\u015finin kardiyovask\u00fcler hastal\u0131k hastas\u0131 oldu\u011funun tahmin edildi\u011fini ve kardiyovask\u00fcler hastal\u0131ktan kaynaklanan \u00f6l\u00fcmlerin kentsel ve k\u0131rsal kesimde ya\u015fayanlar\u0131n \u00f6l\u00fcm nedenleri aras\u0131nda ilk s\u0131rada yer ald\u0131\u011f\u0131n\u0131, hiperlipideminin ise kardiyovask\u00fcler hastal\u0131\u011fa yol a\u00e7an en \u00f6nemli risk fakt\u00f6rlerinden biri oldu\u011funu g\u00f6stermektedir.<\/p>\n
A\u015fa\u011f\u0131da, \u00e7e\u015fitli t\u0131bbi bitkilerin lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc fonksiyonel bile\u015fenleri ve farmakolojik mekanizmalar\u0131n\u0131n bir incelemesi ve bu t\u00fcr g\u0131dalar\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi i\u00e7in bir referans sa\u011flamak amac\u0131yla lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc g\u0131dalarda t\u0131bbi bitkilerin geli\u015ftirilmesine ili\u015fkin mevcut durum ve sorunlar\u0131n bir analizi ve \u00f6zeti yer almaktad\u0131r.<\/p>\n
Pueraria Mirifica<\/strong><\/p>\n Pueraria lobata, baklagil Pueraria lobata'n\u0131n kurutulmu\u015f k\u00f6k\u00fc olan yayg\u0131n bir t\u0131bbi g\u0131da bitkisidir ve suda \u00e7\u00f6z\u00fcn\u00fcr kat\u0131lar\u0131, flavonoid glikozitler, flavonoid glikozitler ve puerarin vb. dahil olmak \u00fczere yakla\u015f\u0131k 12% flavonoid i\u00e7erir. Pueraria lobata'n\u0131n kan lipidini d\u00fc\u015f\u00fcren g\u0131dalardaki aktif bile\u015fenleri \u00f6zetlenmi\u015ftir. Pueraria lobata hipolipidemik aktif bile\u015fenleri esas olarak izoflavonoidlerdir ve bunlardan puerarin en \u00f6nemli fonksiyonel bile\u015fenlerden biridir.<\/p>\n Zhang Ru ve arkada\u015flar\u0131, Puerarin uygulamas\u0131n\u0131n uyar\u0131c\u0131 amino asitlerin toksik etkilerini antagonize edebilece\u011fini, sinir h\u00fccresi hasar\u0131n\u0131 azaltabilece\u011fini ve iskemik serebrovask\u00fcler hastal\u0131\u011f\u0131 tedavi etmek i\u00e7in kullan\u0131labilece\u011fini bulmu\u015flard\u0131r.<\/p>\n Chen Dongfang ve arkada\u015flar\u0131, Pueraria lobata kaps\u00fcl\u00fcn\u00fcn hiperlipidemik ki\u015filer \u00fczerinde yard\u0131mc\u0131 lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc etkiye sahip oldu\u011funu g\u00f6stermi\u015f, Pueraria lobata kaps\u00fcl\u00fcn\u00fc 30 g\u00fcn boyunca s\u00fcrekli olarak ald\u0131ktan sonra, TC ve TG seviyesinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 ve HDL-C seviyesinin \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015fmedi\u011fi bulunmu\u015ftur. Deng Zuyue ve arkada\u015flar\u0131, hiperlipidemili s\u0131\u00e7anlara intraperitoneal Puerarin (50mg\/kg) enjeksiyonu yapm\u0131\u015f ve Puerarin'in hiperlipidemili s\u0131\u00e7anlarda TC, TG ve LDL-C plazma seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131n\u0131, HDL-C'yi y\u00fckseltti\u011fini ve kan lipidlerini d\u00fc\u015f\u00fcrme etkinli\u011fine sahip aterosklerotik indeksi d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fcn\u00fc bulmu\u015flard\u0131r.<\/p>\n Puerarin karaci\u011ferde LDL emilimini artt\u0131rmak, kolesterol sentezini azaltmak ve potansiyel olarak kolesterol y\u0131k\u0131m\u0131n\u0131 artt\u0131rmak da dahil olmak \u00fczere birden fazla mekanizmaya ula\u015fabilir ve sonu\u00e7ta hipolipidemik bir etki g\u00f6sterir.<\/p>\n Karahindiba<\/strong><\/p>\n Karahindiba Asteraceae familyas\u0131na aittir, t\u0131bbi de\u011feri y\u00fcksektir, t\u00fcm bitki ila\u00e7 olarak kullan\u0131labilir, karahindiba sterol, karahindiba sikloheksimid, karahindiba ac\u0131lar\u0131, kafeik asit, kolin, in\u00fclin ve di\u011fer bile\u015fenleri i\u00e7erir, anti-enflamatuar, antioksidan, antikanser, antihiperglisemik, antihiperlipidemik ve di\u011fer farmakolojik etkileri vard\u0131r. Zhao Jianhua ve arkada\u015flar\u0131 hammadde olarak kurutulmu\u015f karahindibadan karahindiba sa\u011fl\u0131k i\u00e7ece\u011fi yapm\u0131\u015f ve sonu\u00e7lar hiperlipidemik model farelerin serum TG ve TC'sinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 ve HDL-C'nin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir, bu da karahindiba i\u00e7ece\u011finin hayvan testlerinden sonra hipolipidemik etkiye sahip oldu\u011funu kan\u0131tlam\u0131\u015ft\u0131r.<\/p>\n Karahindiban\u0131n kan lipitlerini d\u00fc\u015f\u00fcrmedeki etkili bile\u015feni esas olarak klorojenik asittir. Wang Yuejiao ve arkada\u015flar\u0131, karahindiba kaynatman\u0131n fare hiperlipidemi modelinin kan lipit seviyesi \u00fczerindeki etkisinin TC'yi d\u00fc\u015f\u00fcrmede ve HDL-C'yi \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rmada \u00e7ok \u00f6nemli oldu\u011funu, ancak TG ve LDL-C \u00fczerindeki etkinin belirgin olmad\u0131\u011f\u0131n\u0131 bulmu\u015flard\u0131r.<\/p>\n Zhao Jianhua ve arkada\u015flar\u0131, karahindiba \u00f6z\u00fct\u00fcn\u00fcn farelerde TG'yi son derece \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini ve belirli hipolipidemik kabiliyete sahip HDL-C'yi etkili bir \u015fekilde y\u00fckseltebildi\u011fini bulmu\u015flard\u0131r.<\/p>\n Dut Yapraklar\u0131<\/strong><\/p>\n Dut yapraklar\u0131, fenoller ve flavonoidler, alkaloidler, amino asitler, polisakkaritler ve steroidler a\u00e7\u0131s\u0131ndan zengin dutun kurutulmu\u015f yapraklar\u0131d\u0131r. Dut yapraklar\u0131 \"ginseng s\u0131cak tonik, dut yapraklar\u0131 berrak tonik\" etkisine sahiptir. Ekdisteroiddeki dut yapraklar\u0131 \u00fcretimi te\u015fvik edebilir, insan protein sentezini te\u015fvik edebilir, v\u00fccut kolesterol\u00fcn\u00fc hari\u00e7 tutabilir, kan lipitlerini azaltabilir.<\/p>\n Zhu Yejing ve arkada\u015flar\u0131, dut yapraklar\u0131ndaki flavonoidlerin ateroskleroz olu\u015fumunu ve hiperlipidemide serum lipitlerinin art\u0131\u015f\u0131n\u0131 engelleme etkisine sahip oldu\u011funu bulmu\u015flard\u0131r. Dut yapra\u011f\u0131 ekstrelerinin ana bile\u015fenleri, kan lipitlerini d\u00fc\u015f\u00fcrme, v\u00fccuttaki serbest radikalleri temizleme ve lipit peroksidasyonunu engelleme aktivitelerine sahip olan kuersetin, kaempferol ve lignanlard\u0131r.<\/p>\n Li Xiangrong ve arkada\u015flar\u0131, akut hiperlipidemi fare modeli olu\u015fturmak i\u00e7in TritonWR-1399 ve hiperlipidemi s\u0131\u00e7an modeli olu\u015fturmak i\u00e7in y\u00fcksek ya\u011fl\u0131 yem kullanm\u0131\u015f ve Morus alba'n\u0131n (MTF) toplam flavonoidlerinin TC, TG, LDL-C'yi azaltabildi\u011fini ve hiperlipidemili farelerin ve s\u0131\u00e7anlar\u0131n plazmas\u0131ndaki HDL-C'yi y\u00fckseltebildi\u011fini ve hiperlipidemi geli\u015fimini etkili bir \u015fekilde \u00f6nleyebildi\u011fini bulmu\u015flard\u0131r.<\/p>\n Sinameki tohumu<\/strong><\/p>\n Sinameki tohumu, olgunla\u015fma ve kurutmadan sonra bir baklagil k\u00fc\u00e7\u00fck sinameki veya sinameki tohumudur, modern farmakolojik \u00e7al\u0131\u015fmalar sinamekinin hipolipidemik, hipotansif ve di\u011fer etkilere sahip oldu\u011funu ve obtusifolia, orangish sinameki, obtusifolia sinameki glukozit, obtusifolia glukozit ve soya fasulyesi glikozit gibi sinameki antrakinonlar\u0131 i\u00e7in hipolipidemik etkili bile\u015fenleri oldu\u011funu g\u00f6stermi\u015ftir. Yanping Feng, oryzanthocortin'in hastalar\u0131n kan lipid seviyelerini kontrol etmede sinameki tohumunun ana etkili bile\u015feni oldu\u011funu bulmu\u015ftur.<\/p>\n Lu Zongliang ve arkada\u015flar\u0131 hiperlipidemili 114 hastay\u0131 ara\u015ft\u0131rma nesnesi olarak alm\u0131\u015f ve klinik olarak sinameki tohumu dispersiyonlar\u0131 alan hastalar\u0131n serum TC, TG ve LDL-C'sinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 ve HDL-C i\u00e7eri\u011finin artt\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Klinik olarak, ana bile\u015fen olarak sinameki tohumu i\u00e7eren Yishou lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc tabletler, hiperlipidemili 130 hastay\u0131 tedavi etmek i\u00e7in kullan\u0131lm\u0131\u015f ve hastalar\u0131n 87.0%'sinin serum TC'sinde ve 80.8%'sinin TG'sinde \u00f6nemli bir azalma oldu\u011fu ve sinameki tohumunun lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc bir etkiye sahip oldu\u011fu bulunmu\u015ftur.Yen ve arkada\u015flar\u0131, cassia tohumu proteinlerinin ve antrakinon bile\u015fenlerinin hiperlipidemili s\u0131\u00e7anlarda TC, TG ve LDL-C'yi \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini, ancak hangi lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc protein s\u0131n\u0131f\u0131n\u0131n spesifiklerinin hala daha fazla izolasyon \u00e7al\u0131\u015fmas\u0131na ihtiya\u00e7 duydu\u011funu bulmu\u015flard\u0131r.<\/p>\n Al\u0131\u00e7<\/strong><\/p>\n Shanli meyvesi ve Shanlihong olarak da bilinen al\u0131\u00e7, Rosaceae familyas\u0131ndan Shanlihong'un kurutulmu\u015f olgun meyvesidir. Sindirimi te\u015fvik edebilen ve haz\u0131ms\u0131zl\u0131\u011f\u0131 tedavi edebilen glikozitler, flavonoidler, al\u0131\u00e7 asidi ve di\u011fer aktif bile\u015fenler bak\u0131m\u0131ndan zengindir. Al\u0131\u00e7 ayr\u0131ca antioksidan, kan lipidini d\u00fc\u015f\u00fcr\u00fcc\u00fc, anti-t\u00fcm\u00f6r, antibakteriyel ve anti-inflamatuar sa\u011fl\u0131k etkilerine sahiptir. Li Haigui ve arkada\u015flar\u0131, al\u0131\u00e7taki toplam triterpenik asit ve al\u0131\u00e7 flavonoidlerinin serum TCH'yi \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini ve farelerde HDL \/ TCH oran\u0131n\u0131 y\u00fckseltebildi\u011fini ve etkilerinin HDL ve SOD aktivitesinin y\u00fczde de\u011ferinin y\u00fckselmesiyle ili\u015fkili oldu\u011funu bulmu\u015flard\u0131r.<\/p>\n Oleanolik asit ve ursolik asit, al\u0131\u00e7taki triterpenik asidin ana bile\u015fenleridir. Al\u0131\u00e7 triterpenik asit, \u00e7ok d\u00fc\u015f\u00fck yo\u011funluklu lipoprotein (VLDL) ve LDL seviyesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir ve lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc etkisi \u00f6nemlidir; oleanolik asit ve ursolik asit tek ba\u015f\u0131na kullan\u0131ld\u0131\u011f\u0131nda VLDL, LDL ve TC \u00fczerinde belirli etkilere sahiptir, ancak kombinasyon halinde kullan\u0131ld\u0131\u011f\u0131nda etki daha \u00f6nemlidir.<\/p>\n Zhu ve arkada\u015flar\u0131 al\u0131\u00e7 pektin pentasakkaritinin TC ve LDL-C'yi \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilece\u011fini bulmu\u015ftur. Al\u0131\u00e7 yapra\u011f\u0131n\u0131n toplam flavonoidlerinin belirli bir dozu, hiperlipidemili s\u0131\u00e7anlarda serumun yan\u0131 s\u0131ra karaci\u011fer TG ve TC'yi azaltabilir ve ya\u011f birikimini etkili bir \u015fekilde iyile\u015ftirebilir, bu da al\u0131\u00e7 yapra\u011f\u0131n\u0131n toplam flavonoidlerinin kan lipitlerini d\u00fc\u015f\u00fcrme etkinli\u011fine sahip oldu\u011funu ve y\u00fcksek ya\u011fl\u0131 diyetin neden oldu\u011fu hiperlipidemi ve ya\u011fl\u0131 karaci\u011fer \u00fczerinde \u00f6nleyici ve iyile\u015ftirici bir etkiye sahip oldu\u011funu kan\u0131tlar.<\/p>\n Yam<\/strong><\/p>\n Dioscorea opposita, \u00c7in yer elmas\u0131, Huai Shan vb. olarak da bilinen yam, Dioscoreaceae bitkisi Dioscorea opposita'n\u0131n kurutulmu\u015f rizomudur. Yam, yam polisakkaritleri, allantoin, kolin, diosgenin ve glikozidi diosgenin, yam alkaloidleri, steroller ve di\u011fer aktif bile\u015fenler gibi kimyasal bile\u015fenlerin \u00e7e\u015fitli t\u0131bbi ve \u00e7e\u015fitli sa\u011fl\u0131k i\u015flevlerini i\u00e7erir, ancak ayn\u0131 zamanda dehidroepiandrosteron kimyasal maddelerine benzer bir yap\u0131 i\u00e7erir, dehidroepiandrosteron \"hormonlar\u0131n anas\u0131\" olarak bilinir, insan v\u00fccudunun ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131 art\u0131rabilir, haf\u0131zay\u0131 geli\u015ftirebilir, sinirleri d\u00fczenleyebilir (yat\u0131\u015ft\u0131r\u0131c\u0131, uyku), kemik ve kas ya\u015flanmas\u0131n\u0131 \u00f6nleyebilir, kan lipitlerini d\u00fc\u015f\u00fcrebilir, damar sertli\u011fini \u00f6nleyebilir vb. Yam art\u0131k Susuzluk Hap\u0131 ve Alt\u0131 aromal\u0131 Di Huang Hap\u0131 gibi klinik form\u00fcllerde kullan\u0131lmaktad\u0131r.<\/p>\n Farelerin hiperlipidemik yemle beslenmesiyle olu\u015fturulan bir hiperlipidemi fare modelinde, farkl\u0131 k\u00f6kenlerden d\u00f6rt t\u00fcr yam kaynatma yedirilmi\u015f ve ard\u0131\u015f\u0131k 10 g\u00fcn sonra, \u00c7in yer elmas\u0131, \u00c7in yer elmas\u0131 ve Guangxi huai yer elmas\u0131n\u0131n TG ve TC'sinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131, ancak Guangdong huai yer elmas\u0131n\u0131n TG ve TC'sinde \u00f6nemli bir de\u011fi\u015fiklik olmad\u0131\u011f\u0131 bulunmu\u015ftur. Gao Qiyu ve arkada\u015flar\u0131, yer elmas\u0131 polisakkaritlerinin tetroksin-diyabetik farelerde kan glikozunu ve kan lipitlerini etkili bir \u015fekilde azaltabildi\u011fini, bunun da diyabetik farelerin iyile\u015fmesine yard\u0131mc\u0131 olabilece\u011fini ve normal TC, TG ve HDL seviyelerini koruyabilece\u011fini g\u00f6stermi\u015ftir.<\/p>\n Perilla<\/strong><\/p>\n Gui eba, beyaz perilla, k\u0131rm\u0131z\u0131 perilla vb. olarak da bilinen Perilla frutescens, Labiatae familyas\u0131ndan Perilla frutescens'in steroller, flavonoidler ve glikozitleri, monoterpenler, triterpenler ve glikozitleri, lignanlar, organik asitler fenolik glikozitler ve di\u011fer aktif bile\u015fenleri i\u00e7eren kurutulmu\u015f yapraklar\u0131d\u0131r. Compendium of Materia Medica, \"qi'yi hareket ettirdi\u011fini ve ortay\u0131 geni\u015fletti\u011fini, balgam\u0131 temizledi\u011fini ve akci\u011ferlere fayda sa\u011flad\u0131\u011f\u0131n\u0131, kan\u0131 uyumlu hale getirdi\u011fini, ortay\u0131 \u0131s\u0131tt\u0131\u011f\u0131n\u0131, a\u011fr\u0131y\u0131 hafifletti\u011fini, ast\u0131m\u0131 d\u00fczeltti\u011fini ve fet\u00fcs\u00fc yat\u0131\u015ft\u0131rd\u0131\u011f\u0131n\u0131\" kaydeder.<\/p>\n Perilla yapra\u011f\u0131 d\u0131\u015f etkiyi hafifletme ve so\u011fu\u011fu da\u011f\u0131tma, akci\u011feri destekleme ve balgam\u0131 \u00e7\u00f6zme, qi'yi hareket ettirme ve ortay\u0131 uyumla\u015ft\u0131rma, fet\u00fcs\u00fc sakinle\u015ftirme ve bal\u0131k ve yengeci detoksifiye etme; Perilla tohumu qi'yi d\u00fc\u015f\u00fcrme, balgam\u0131 ortadan kald\u0131rma, ast\u0131m\u0131 yat\u0131\u015ft\u0131rma ve ba\u011f\u0131rsaklar\u0131 nemlendirme; ve Perilla sap\u0131 qi'yi d\u00fczenleme ve ortay\u0131 geni\u015fletme, fet\u00fcs\u00fc sakinle\u015ftirme ve kan\u0131 uyumla\u015ft\u0131rma etkisine sahiptir.<\/p>\n Wang Jingyu ve arkada\u015flar\u0131 hiperlipidemi grubundaki fareleri s\u0131ras\u0131yla 10ml\/(kg-d) gavaj salin ve 3, 6, 9g\/(kg-d) perilla su \u00f6z\u00fct\u00fc olmak \u00fczere d\u00f6rt gruba ay\u0131rm\u0131\u015f, 6 hafta boyunca s\u00fcrekli gavaj uygulam\u0131\u015f, test sonucunda perilla su \u00f6z\u00fct\u00fcn\u00fcn serum TC, TG, LDL-C'yi etkili bir \u015fekilde azaltabildi\u011fi ve hiperlipidemik farelerde serum HDL-C'yi art\u0131rabildi\u011fi ve ayr\u0131ca farelerde serum ve karaci\u011feri iyile\u015ftirdi\u011fi bulunmu\u015ftur. Hidrojen peroksidaz, glutatyon peroksidaz ve s\u00fcperoksit dismutaz aktivitesi, y\u00fcksek doz Perilla frutescens sulu ekstrakt\u0131n\u0131n en iyi hipolipidemik etkiye ve antioksidan etkiye sahip oldu\u011fu malondialdehit aktivitesini inhibe eder.<\/p>\n Perilla ya\u011f\u0131ndaki \u03b1-linolenik asit kan lipitlerini etkili bir \u015fekilde d\u00fc\u015f\u00fcrebilir ve Li Yongli ve arkada\u015flar\u0131, perilla ya\u011f\u0131n\u0131n yemle doldurulmas\u0131n\u0131n farelerin serumundaki TG ve TC'yi azaltabilece\u011fini bulmu\u015flard\u0131r, bu da perilla tohumu ya\u011f\u0131n\u0131n kan lipitlerini d\u00fc\u015f\u00fcrmede belirli bir \u00f6nleyici rol\u00fc oldu\u011funu kan\u0131tlamaktad\u0131r.<\/p>\n Lotus yapra\u011f\u0131<\/strong><\/p>\n Lotus yapra\u011f\u0131, lotus alkaloidleri, protohiperisin ve hollandin gibi alkaloidler ve flavonoidler a\u00e7\u0131s\u0131ndan zengin olan ve kan lipidlerini d\u00fczenleyen, antibakteriyel, antioksidan, hemostatik ve lipaz\u0131 inhibe eden belirgin hipolipidemik etkiye sahip Lotus japonicus'un kurutulmu\u015f yapra\u011f\u0131d\u0131r.<\/p>\n Guo Huiling ve arkada\u015flar\u0131 lotus yapra\u011f\u0131n\u0131n sulu ekstrakt\u0131n\u0131n TC ve TG seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini ve ayn\u0131 zamanda HDL-C seviyesini art\u0131rabildi\u011fini bulmu\u015flard\u0131r. Ara\u015ft\u0131rma nesnesi olarak y\u00fcksek ya\u011fl\u0131 yemle beslenen s\u0131\u00e7anlar al\u0131nd\u0131\u011f\u0131nda, lotus yapra\u011f\u0131 ekstresi 25 g\u00fcn boyunca s\u00fcrekli olarak beslendikten sonra, test \u00f6ncesine k\u0131yasla TC de\u011ferinde \u00f6nemli bir azalma olmu\u015ftur, bu da lotus yapra\u011f\u0131 ekstrakt\u0131n\u0131n serum kolesterol\u00fcn\u00fc d\u00fc\u015f\u00fcrme ve kilo verme etkisine sahip oldu\u011funu g\u00f6stermi\u015ftir. Al\u0131\u00e7 k\u0131rm\u0131z\u0131 frenk \u00fcz\u00fcm\u00fc ve lotus yapra\u011f\u0131 \u00e7orbas\u0131, s\u0131\u00e7anlarda vask\u00fcler d\u00fcz kas h\u00fccrelerinin proliferasyonu \u00fczerinde inhibit\u00f6r etkiye sahiptir ve hiperlipideminin neden oldu\u011fu aterosklerozun \u00f6nlenmesi ve tedavisi \u00fczerinde belirli bir etkiye sahiptir.<\/p>\n Rafflesia<\/strong><\/p>\n Turp tohumu, Luo Bai Zi, sebze ba\u015f\u0131 tohumu vb. olarak da bilinen Rafflesia, ast\u0131m, \u00f6ks\u00fcr\u00fck bast\u0131rma, balgam s\u00f6kt\u00fcr\u00fcc\u00fc, antioksidan, kan bas\u0131nc\u0131, kan lipidi, antibakteriyel, gastrointestinal sistemin g\u00fcc\u00fcn\u00fc art\u0131ran, \u00fcriner sistemi iyile\u015ftiren ve di\u011fer bir\u00e7ok farmakolojik etkiye sahip turpgiller bitkisinin kurutulmu\u015f olgun tohumlar\u0131d\u0131r.<\/p>\n Zeng Zaifan, 38 hiperlipidemi hastas\u0131n\u0131 k\u0131zarm\u0131\u015f Laptopus ile a\u011f\u0131zdan tedavi etti\u011fi testte, TG'deki d\u00fc\u015f\u00fc\u015f oran\u0131n\u0131n 50%, TC d\u00fc\u015f\u00fc\u015f oran\u0131n\u0131n 38% oldu\u011funu ve bunlardan 6 y\u00fcksek tansiyon hastas\u0131n\u0131n tedaviden sonra d\u00fc\u015ft\u00fc\u011f\u00fcn\u00fc tespit etti. Hiperlipidemik hastalar\u0131n 0.5g likopodyum kaps\u00fcl ile tedavisi, bir ay sonra hastane incelemesi ile kan lipitleri vb. normale d\u00fc\u015f\u00fcr\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n Rafflesia'daki hardalinin kan lipid seviyesini d\u00fc\u015f\u00fcrmede belirgin bir etkisi vard\u0131r. Wistar s\u0131\u00e7anlara 5 g\u00fcn boyunca y\u00fcksek ya\u011fl\u0131 em\u00fclsiyon s\u00fcrekli olarak gavajla verilmi\u015f ve 28 g\u00fcn sonra kan toplanm\u0131\u015f ve model grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, hardal\u0131n d\u00fc\u015f\u00fck, orta ve y\u00fcksek doz gruplar\u0131n\u0131n TC, TG, HDL-C ve LDL-C'sinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 bulunmu\u015ftur.<\/p>\n Lycoris radiata'n\u0131n suda \u00e7\u00f6z\u00fcnen alkaloidleri, kan lipitlerini d\u00fc\u015f\u00fcrmede lycoris radiata'n\u0131n ana etkili bile\u015fenleridir ve baz\u0131 \u00e7al\u0131\u015fmalar, suda \u00e7\u00f6z\u00fcnen alkaloidlerinin y\u00fcksek ya\u011fl\u0131 diyetle beslenen farelerde kan lipitlerini d\u00fczenleme etkisine sahip oldu\u011fu sonucuna varm\u0131\u015ft\u0131r. Li Tieyun ve arkada\u015flar\u0131, Rafflesia chinensis'in suda \u00e7\u00f6z\u00fcn\u00fcr alkaloidlerinin s\u0131\u00e7anlar\u0131n serum SOD aktivitesini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve antioksidan etki yoluyla kan lipitlerini d\u00fc\u015f\u00fcrme amac\u0131na ula\u015fmak i\u00e7in MDA'y\u0131 azaltabildi\u011fini bulmu\u015flard\u0131r.<\/p>\n Ey\u00fcp'\u00fcn g\u00f6zya\u015flar\u0131<\/strong><\/p>\n Job's tears, Coix lacryma, six grain seeds olarak da bilinen Coix lacryma bitkisinin tohum \u00e7ekirdekleridir. Coix tohumu, anti-t\u00fcm\u00f6r, kan \u015fekeri ve kan ya\u011f\u0131, anti-enflamatuar ve analjezik gibi \u00e7e\u015fitli farmakolojik aktivitelere sahiptir ve v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131 geli\u015ftirir.<\/p>\n Job'un g\u00f6zya\u015flar\u0131nda bulunan polisakkarit, kan lipitlerini d\u00fc\u015f\u00fcrmek i\u00e7in aktif bile\u015fendir. Yu ve arkada\u015flar\u0131, Job's tears'daki suda \u00e7\u00f6z\u00fcn\u00fcr polisakkaritin, kan lipitlerini d\u00fc\u015f\u00fcrme amac\u0131na ula\u015fmak i\u00e7in test hayvanlar\u0131nda TC, TG ve LDL-C seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilece\u011fini bulmu\u015flard\u0131r. Hiperlipidemi s\u0131\u00e7an modeli olu\u015fturmak i\u00e7in y\u00fcksek kolesterol ve lipitle beslenen hayvanlarla, Coix lacryma etanol \u00f6z\u00fct\u00fcn\u00fcn, aterosklerozun azalt\u0131lmas\u0131, lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc etki ile TC, LDL-C s\u0131\u00e7anlar\u0131n\u0131n serum seviyesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilece\u011fi bulunmu\u015ftur.<\/p>\n K\u0131rm\u0131z\u0131 Frenk \u00dcz\u00fcm\u00fc<\/strong><\/p>\n K\u0131rm\u0131z\u0131 maya pirin\u00e7le a\u015f\u0131lan\u0131r ve kan dola\u015f\u0131m\u0131n\u0131 aktive etme, t\u0131kan\u0131kl\u0131\u011f\u0131 giderme, dala\u011f\u0131 g\u00fc\u00e7lendirme, yiyecekleri ortadan kald\u0131rma, bulan\u0131kl\u0131\u011f\u0131 giderme ve lipitleri d\u00fc\u015f\u00fcrme etkisine sahip danqu olarak da bilinen mor k\u0131rm\u0131z\u0131 maya pirincine fermente edilir. K\u0131rm\u0131z\u0131 maya, kan lipitlerini ve kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrmek i\u00e7in do\u011fal bir ila\u00e7t\u0131r ve ayn\u0131 zamanda SFDA'ya kay\u0131tl\u0131 yard\u0131mc\u0131 lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc sa\u011fl\u0131kl\u0131 g\u0131dalarda en s\u0131k kullan\u0131lan bile\u015fenlerden biridir.<\/p>\n \u00c7in Bilimler Akademisi ara\u015ft\u0131rmac\u0131lar\u0131, hammaddesi k\u0131rm\u0131z\u0131 maya olan, etkinli\u011fi Amerikan \u015firketleri taraf\u0131ndan geli\u015ftirilen statin ila\u00e7lar\u0131yla kar\u015f\u0131la\u015ft\u0131r\u0131labilir yeni bir lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc ila\u00e7 \"Le Lipopin\" geli\u015ftirdi ve bu ila\u00e7 yurtd\u0131\u015f\u0131nda \"\u00c7in statini\" olarak adland\u0131r\u0131l\u0131yor.<\/p>\n Song Hongtao ve arkada\u015flar\u0131, k\u0131rm\u0131z\u0131 tah\u0131l\u0131n hiperlipidemili b\u0131ld\u0131rc\u0131n serumunda TC, TG ve LDL-C'yi \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini ve bunun da kan lipitlerini d\u00fc\u015f\u00fcrme etkisine sahip oldu\u011funu bulmu\u015flard\u0131r. Daha ileri ara\u015ft\u0131rmalar, kan lipitlerini d\u00fc\u015f\u00fcrmede k\u0131rm\u0131z\u0131 tah\u0131l\u0131n aktif bile\u015feninin lovastatin oldu\u011funu bulmu\u015ftur. \u0130nsan deney g\u0131das\u0131 \u00e7al\u0131\u015fmas\u0131nda, k\u0131rm\u0131z\u0131 b\u0131ld\u0131rc\u0131ndan elde edilen lovastatinin TC, TG'yi d\u00fc\u015f\u00fcrme etkisine sahip oldu\u011fu bulunmu\u015ftur, bu da k\u0131rm\u0131z\u0131 b\u0131ld\u0131rc\u0131n kaps\u00fcl\u00fcn\u00fcn kan lipitlerini d\u00fczenlemede \u00f6nemli bir etkinli\u011fe sahip oldu\u011funu g\u00f6stermektedir.<\/p>","protected":false},"excerpt":{"rendered":" The China Cardiovascular Report 2017 shows that the prevalence of cardiovascular disease in China has continued to rise in recent years, and it is projected that about 290 million people are currently ill with cardiovascular disease, and deaths caused by cardiovascular disease occupy the first place in the causes of death of urban and rural […]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"yoast_head":"\n