{"id":7041,"date":"2024-08-06T18:24:00","date_gmt":"2024-08-06T18:24:00","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=7041"},"modified":"2024-08-06T18:24:00","modified_gmt":"2024-08-06T18:24:00","slug":"honokiol-on-hif-1-%ce%b1-vegf-pathway-in-pc12-cells","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/honokiol-on-hif-1-%ce%b1-vegf-pathway-in-pc12-cells\/","title":{"rendered":"Honokiol\u00fcn PC12 h\u00fccrelerinde HIF-1 \u03b1 - VEGF yola\u011f\u0131 \u00fczerindeki d\u00fczenleyici etkisinin a\u011f farmakolojisi ve h\u00fccre deneylerine dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Honokiol\u00fcn PC12 h\u00fccrelerinde HIF-1 \u03b1 - VEGF yola\u011f\u0131 \u00fczerindeki d\u00fczenleyici etkisinin a\u011f farmakolojisi ve h\u00fccre deneylerine dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131
\nMagnolia officinalis, rutubeti kurutabilen, balgam\u0131 ortadan kald\u0131rabilen ve a\u015f\u0131r\u0131 Qi'yi rahatlatabilen Qi d\u00fczenleyici bir ila\u00e7 olarak, son y\u0131llarda hem yurt i\u00e7inde hem de uluslararas\u0131 alanda yayg\u0131n olarak incelenmi\u015ftir. Magnolia officinalis'in ana bile\u015fenleri ve magnolol, minimal toksisiteye ve anti-enflamatuar, analjezik, anti-t\u00fcm\u00f6r ve anti patojenik mikroorganizmalar gibi farmakolojik etkilere sahip y\u00fcksek biyoaktif fenolik bile\u015fikler s\u0131n\u0131f\u0131d\u0131r. Houpo fenol, kan-beyin bariyeri yoluyla merkezi sinir sistemine girebilir ve sinir dokusu \u00fczerinde do\u011frudan bir etkiye sahip olabilir, bu da onu n\u00f6rolojik hastal\u0131klar i\u00e7in umut verici bir ila\u00e7 haline getirir; \u00d6te yandan, honokiol ayr\u0131ca mide kanseri, akci\u011fer kanseri, karaci\u011fer kanseri ve pankreas kanseri gibi \u00e7e\u015fitli kanserler \u00fczerinde terap\u00f6tik etkilere sahiptir.
\nHIF-1 \u03b1 ekspresyonunun aktive edilmesi anjiyogenezi, n\u00f6roproteksiyonu ve n\u00f6ral onar\u0131m\u0131 te\u015fvik edebilir ve b\u00f6ylece serebral iskemik s\u0131\u00e7anlar\u0131 tedavi edebilir. Ayr\u0131ca, HIF-1 t\u00fcm\u00f6r anjiyogenezinin d\u00fczenlenmesinde de \u00f6nemli bir fakt\u00f6rd\u00fcr ve magnolol \u00e7o\u011fu t\u00fcm\u00f6rde ve retinal iskemik hastal\u0131kta HIF yola\u011f\u0131n\u0131n ve hipoksi arac\u0131l\u0131 pro anjiyojenik genlerin ekspresyonunu inhibe eder. Yukar\u0131daki \u00e7al\u0131\u015fmalar, magnolol ile HIF-1 \u03b1'n\u0131n farkl\u0131 durumlarda d\u00fczenlenmesinin farmakolojik etkileri i\u00e7in anahtar mekanizma oldu\u011funu g\u00f6stermektedir. Bu \u00e7al\u0131\u015fmada \"HIF-1 \u03b1\" ba\u015flang\u0131\u00e7 noktas\u0131 olarak al\u0131nm\u0131\u015f ve normoksik ve hipoksik ko\u015fullar alt\u0131nda PC12 h\u00fccrelerinde honokiol\u00fcn HIF-1 \u03b1 - VEGF yolu \u00fczerindeki d\u00fczenleyici etkilerini ara\u015ft\u0131rmak i\u00e7in a\u011f farmakolojisi ve deneysel do\u011frulama kullan\u0131lm\u0131\u015ft\u0131r.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Normoksik ko\u015fullar alt\u0131nda, HIF-1 \u03b1 ve VEGF'nin ifadesi d\u00fc\u015f\u00fckt\u00fcr, ancak magnolol uygulamas\u0131 HIF-1 \u03b1 ve VEGF proteinlerinin ifadesini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131r\u0131r; Hipoksik ko\u015fullar alt\u0131nda, HIF-1 \u03b1 ve VEGF y\u00fcksek oranda ifade edilir ve honokiol uygulamas\u0131 HIF-1 \u03b1 ve VEGF'nin ifadesini \u00f6nemli \u00f6l\u00e7\u00fcde engeller. Houpo fenol, farkl\u0131 durumlarda HIF-1 \u03b1 ve VEGF \u00fczerinde farkl\u0131 d\u00fczenleyici etkiler sergilemektedir ve bu da farmakolojik mekanizmas\u0131n\u0131n incelenmesi ve kullan\u0131m\u0131n\u0131n geli\u015ftirilmesi i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Honokiol\u00fcn HIF-1 \u03b1'n\u0131n olu\u015fumunu ve bozunmas\u0131n\u0131 nas\u0131l etkiledi\u011fine ili\u015fkin olarak, bu \u00e7al\u0131\u015fman\u0131n molek\u00fcler yerle\u015ftirme sonu\u00e7lar\u0131 honokiol\u00fcn iki bozunma enzimi olan PHDs ve VHL ile iyi bir ba\u011flanma aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Bununla birlikte, spesifik degradasyon enziminin aktive mi edildi\u011fi yoksa inhibe mi edildi\u011fini hala netle\u015ftiremiyoruz, bu da gelecekte \u00e7al\u0131\u015f\u0131lmas\u0131 gereken bir y\u00f6nd\u00fcr.<\/p>\n

A\u011f farmakolojisi, ila\u00e7 hedeflerinin belirlenmesini kolayla\u015ft\u0131rabilen sistem biyolojisi y\u00f6ntemleriyle y\u00fcr\u00fct\u00fclen bir \u00e7al\u0131\u015fmad\u0131r ve geleneksel \u00c7in t\u0131bb\u0131nda etken maddelerin ve etki mekanizmalar\u0131n\u0131n tahmin edilmesinde yayg\u0131n olarak uygulanmaktad\u0131r. \u00d6rne\u011fin, ara\u015ft\u0131rmalar antidepresan tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n a\u011f d\u00fczenleme mekanizmas\u0131n\u0131 \u00f6zetlemi\u015ftir ve sonu\u00e7lar geleneksel \u00c7in t\u0131bb\u0131n\u0131n \"\u00e7ok hedefli \u00e7oklu yol\", \"n\u00f6roendokrin ba\u011f\u0131\u015f\u0131kl\u0131k a\u011f\u0131\" ve PI3K Akt sinyal yolunun d\u00fczenlenmesi yoluyla antidepresan etkiler g\u00f6sterdi\u011fini ortaya koymu\u015ftur. Geleneksel \u00c7in t\u0131bb\u0131 anti-t\u00fcm\u00f6r a\u011f farmakolojisi ara\u015ft\u0131rmalar\u0131nda, geleneksel \u00c7in t\u0131bb\u0131n\u0131n anti-enflamatuar, anti-ba\u011f\u0131\u015f\u0131kl\u0131k sistemi, anti anjiyogenez, enerji metabolizmas\u0131 ve di\u011fer mekanizmalar yoluyla anti-t\u00fcm\u00f6r etkiler g\u00f6sterdi\u011fi bildirilmi\u015ftir. Buna ek olarak, baz\u0131 ara\u015ft\u0131rmac\u0131lar geleneksel \u00c7in t\u0131bb\u0131n\u0131n PI3K Akt yolu, HIF-1 yolu ve TNF yolunu d\u00fczenleyerek sinir h\u00fccrelerinin b\u00fcy\u00fcmesini ve \u00e7o\u011falmas\u0131n\u0131 te\u015fvik etti\u011fini ve h\u00fccre apoptozunu inhibe etti\u011fini, b\u00f6ylece hipokside belirli bir d\u00fczenleyici rol oynad\u0131\u011f\u0131n\u0131 bulmu\u015flard\u0131r. GO zenginle\u015ftirme analizi sonu\u00e7lar\u0131 hipoksiye verilen yan\u0131tlar\u0131, vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc stim\u00fclasyonuna verilen h\u00fccresel yan\u0131tlar\u0131, enflamatuar yan\u0131tlar\u0131 ve hipoksinin karma\u015f\u0131k patogeneziyle ilgili olabilecek di\u011fer biyolojik s\u00fcre\u00e7leri i\u00e7erir. Bu da honokiol\u00fcn hastal\u0131klar\u0131n olu\u015fumu ve geli\u015fimine \u00e7oklu seviyelerden ve yollardan m\u00fcdahale edebilece\u011fini g\u00f6stermektedir. KEGG zenginle\u015ftirme analizi sonu\u00e7lar\u0131 HIF-1 yolu, VEGF yolu, PI3K Akt yolu vb. i\u00e7erir. PI3K Akt yolu, fosforilasyon yoluyla ilgili proteinleri d\u00fczenleyebilir, b\u00f6ylece h\u00fccre b\u00fcy\u00fcmesini te\u015fvik edebilir ve apoptozu inhibe edebilir. HIF-1 yolu, v\u00fccudun oksijen sa\u011flama kapasitesini iyile\u015ftirmek ve iskemik ve hipoksik ortamlara uyum sa\u011flamak i\u00e7in kan ak\u0131\u015f\u0131n\u0131 art\u0131rmak \u00fczere gen ifadesini de\u011fi\u015ftirebilir. VEGF, HIF-1 \u03b1'n\u0131n a\u015fa\u011f\u0131 ak\u0131\u015f hedef genidir. Hipoksik ko\u015fullar alt\u0131nda, HIF-1 \u03b1'n\u0131n \u00fcretimini ve stabilizasyonunu uyarabilir ve VEGF'nin transkripsiyonunu ba\u015flatarak VEGF'nin ifadesinin artmas\u0131na neden olabilir. A\u015fa\u011f\u0131da, depresyon, serebral iskemi ve t\u00fcm\u00f6r hastal\u0131klar\u0131n\u0131 tart\u0131\u015fmaya odaklanaca\u011f\u0131z.
\nHIF-1 \u03b1 - VEGF sinyal yolunun etkinle\u015ftirilmesi, sinaptik plastisitenin te\u015fvik edilmesinde ve CUMS'de depresyon benzeri davran\u0131\u015f ve haf\u0131za bozuklu\u011funun etkili bir \u015fekilde tersine \u00e7evrilmesinde \u00f6nemli bir rol oynamaktad\u0131r. Bunlar aras\u0131nda, hipoksi ind\u00fcklenebilir fakt\u00f6r-1 (HIF-1) hipoksiye yan\u0131t veren bir transkripsiyon fakt\u00f6r\u00fcd\u00fcr. H\u00fccresel bir oksijen resept\u00f6r\u00fc olarak, insan h\u00fccrelerinde yayg\u0131n olarak ifade edilen karars\u0131z alfa ve beta alt birimlerinden olu\u015fan bir heterodimerdir. \u00c7al\u0131\u015fmalar hipoksik \u00f6nko\u015fullaman\u0131n (HP) hipokampus, hipotalamusun paraventrik\u00fcler \u00e7ekirde\u011fi ve s\u0131\u00e7anlar\u0131n neokorteksinde HIF-1 \u03b1 ekspresyonunu art\u0131rabildi\u011fini g\u00f6stermi\u015ftir. Aral\u0131kl\u0131 hipoksinin (IH) hipokampal anjiyogenezi ve n\u00f6rojenezi uyarabildi\u011fi ve beyin haf\u0131za bozuklu\u011funu iyile\u015ftirebildi\u011fi bildirilmi\u015ftir. Bu nedenle, HIF-1 \u03b1 sinyal yolu depresyon tedavisi i\u00e7in umut verici bir potansiyel hedeftir. Vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) endotelyal h\u00fccreler i\u00e7in y\u00fcksek \u00f6zg\u00fcll\u00fc\u011fe sahiptir ve merkezi sinir sisteminde n\u00f6rotrofik ve n\u00f6roprotektif etki potansiyeline sahiptir. Ara\u015ft\u0131rmalar VEGF'nin n\u00f6ronlarda sinaptik plastisiteyi etkiledi\u011fini ve aksonal b\u00fcy\u00fcmeyi ve n\u00f6rogenezi te\u015fvik edebilece\u011fini g\u00f6stermi\u015ftir. VEGFR-2 (KDR), VEGF i\u00e7in bir h\u00fccre y\u00fczeyi resept\u00f6r\u00fcd\u00fcr ve resept\u00f6r\u00fc VEGFR-2 arac\u0131l\u0131\u011f\u0131yla uzun s\u00fcreli g\u00fc\u00e7lendirme, plastisite geli\u015fimi ve bili\u015fsel fonksiyon geli\u015fimine arac\u0131l\u0131k ederek \u00f6\u011frenme ve haf\u0131zada rol oynar. \u00d6zetle, HIF-1 \u03b1 - VEGF sinyal yolunun aktive edilmesi, depresif benzeri davran\u0131\u015flar\u0131n iyile\u015ftirilmesi i\u00e7in olduk\u00e7a ara\u015ft\u0131r\u0131lm\u0131\u015f bir stratejidir. Buna ek olarak, sinir h\u00fccrelerinde, PI3K Akt yolu sinir h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 ve farkl\u0131la\u015fmas\u0131n\u0131 d\u00fczenleyebilir ve ayr\u0131ca serebral kan ak\u0131\u015f\u0131n\u0131 d\u00fczenlemeye ve depresyonun olu\u015fumu ve geli\u015fimi ile yak\u0131ndan ili\u015fkili olan n\u00f6ronal sa\u011fkal\u0131m\u0131 te\u015fvik etmeye kat\u0131labilir. Depresyonun patogenezi sinaptik plastisite bozuklu\u011fu ile ili\u015fkilidir. Sinaptik plastisite de\u011fi\u015fiklikleri sinaptik proteinlerin ekspresyonu ile yak\u0131ndan ili\u015fkilidir. PSD95, sinaptik iletimi ve sinaptik i\u015flevi d\u00fczenleyebilen bir t\u00fcr postsinaptik yo\u011fun materyal (PSD) protein ailesidir. SYN1, sinapslar\u0131n say\u0131s\u0131n\u0131, yo\u011funlu\u011funu ve da\u011f\u0131l\u0131m\u0131n\u0131 yans\u0131tabilen sinaptik vezik\u00fcller i\u00e7in spesifik bir marker proteindir. PSD95 ve SYN1, sinyal iletimi ve sinaptik plastisitenin desteklenmesinde \u00f6nemli bir rol oynar ve baz\u0131 antidepresan ila\u00e7lar sinaptik plastisiteyi \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabilir. Bu, honokiol\u00fcn PC12 h\u00fccrelerinde sinaptik plastisiteyi art\u0131rmak i\u00e7in PSD95 ve SYN1 proteinlerinin seviyelerini art\u0131rabildi\u011fi 2.8 ve 2.9'un sonu\u00e7lar\u0131yla tutarl\u0131d\u0131r.<\/p>\n

Fokal serebral iskemili s\u0131\u00e7anlar\u0131n n\u00f6rolojik fonksiyonlar\u0131n\u0131n iyile\u015ftirilmesi, HIF-1 \u03b1 - VEGF sinyal yolunun ekspresyonunun te\u015fvik edilmesi ve serebral iskemi sonras\u0131 sinaptik plastisite olu\u015fumu ile ili\u015fkili olabilir. Ara\u015ft\u0131rmac\u0131lar, beyin koruma mekanizmas\u0131n\u0131n HIF-1 \u03b1 ve onun a\u015fa\u011f\u0131 ak\u0131\u015f hedef genleri VEGF ve EPO'nun artan ekspresyonu ile ili\u015fkili oldu\u011funu bulmu\u015flard\u0131r. Y\u00fcksek irtifa hipoksisinin neden oldu\u011fu serebral iskemiyi iyile\u015ftirme mekanizmas\u0131 da HIF-1 \u03b1 yolunun yukar\u0131 reg\u00fclasyonu ile ilgilidir. PI3K Akt yolunun aktivasyonu da n\u00f6rolojik defisitleri iyile\u015ftirebilir ve serebral iskemi-reperf\u00fczyon hasar\u0131 olan s\u0131\u00e7anlar \u00fczerinde n\u00f6roprotektif bir etkiye sahip olabilir. Ayr\u0131ca, HIF-1 \u03b1 - VEGF sinyal yolu t\u00fcm\u00f6rlerin, \u00f6zellikle de merkezi sinir sistemi t\u00fcm\u00f6rlerinin olu\u015fumunda ve geli\u015fiminde \u00f6nemli bir rol oynamaktad\u0131r. Ara\u015ft\u0131rmalar, honokiol\u00fcn HIF-1 \u03b1 ve hedef genleri VEGF ve GLUT1'in ekspresyonunu azaltarak glioma h\u00fccrelerinin proliferasyonunu inhibe etti\u011fini bulmu\u015ftur. Hayvan deneylerinde, baz\u0131 ara\u015ft\u0131rmac\u0131lar insan kolon kanseri h\u00fccrelerinin kat\u0131 bir t\u00fcm\u00f6r modelini olu\u015fturmak i\u00e7in \u00e7\u0131plak fareleri kullanm\u0131\u015flard\u0131r. Magnolol\u00fcn oral uygulamas\u0131ndan sonra, t\u00fcm\u00f6r b\u00fcy\u00fcmesini \u00f6nemli \u00f6l\u00e7\u00fcde inhibe eder ve mekanizmas\u0131 HIF-1 \u03b1 - VEGF yolunun ve PI3K Akt yolunun inhibisyonu ile ilgilidir.<\/p>\n

\u00d6zetle, magnolol normal ve hipoksik ortamlarda HIF-1 \u03b1 - VEGF sinyal yolu \u00fczerinde farkl\u0131 d\u00fczenleyici etkilere sahiptir. Houpo fenol, depresyon, serebral iskemi ve t\u00fcm\u00f6r hastal\u0131klar\u0131n\u0131 birden fazla yol ve hedef arac\u0131l\u0131\u011f\u0131yla tedavi edebilir ve bu hastal\u0131klar\u0131n tedavisinde Houpo fenol mekanizmas\u0131 hakk\u0131nda daha fazla ara\u015ft\u0131rma i\u00e7in y\u00f6n sa\u011flar. Ayr\u0131ca, tahmin edilen molek\u00fcler kenetlenme a\u00e7\u0131s\u0131 ve honokiol ile HIF-1 \u03b1 par\u00e7alay\u0131c\u0131 enzim aras\u0131nda iyi kenetlenme g\u00f6zlenmi\u015ftir. Bu \u00e7al\u0131\u015fma, honokiol\u00fcn molek\u00fcler biyoloji ve di\u011fer y\u00f6ntemleri kullanarak HIF-1 \u03b1'y\u0131 nas\u0131l etkiledi\u011fini ara\u015ft\u0131rmaya devam edecektir.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the regulatory effect of honokiol on HIF-1 \u03b1 – VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. The main components of Magnolia […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the regulatory effect of honokiol on HIF-1 \u03b1 - VEGF pathway in PC12 cells based on network pharmacology and cell experiments - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/honokiol-on-hif-1-\u03b1-vegf-pathway-in-pc12-cells\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the regulatory effect of honokiol on HIF-1 \u03b1 - VEGF pathway in PC12 cells based on network pharmacology and cell experiments - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the regulatory effect of honokiol on HIF-1 \u03b1 – VEGF pathway in PC12 cells based on network pharmacology and cell experiments Magnolia officinalis, as a Qi regulating medicine that can dry dampness, eliminate phlegm, and relieve excess Qi, has been widely studied both domestically and internationally in recent years. 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