{"id":6862,"date":"2024-08-06T14:54:24","date_gmt":"2024-08-06T14:54:24","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6862"},"modified":"2024-08-06T14:54:24","modified_gmt":"2024-08-06T14:54:24","slug":"ge-hua-jie-cheng-tang","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/ge-hua-jie-cheng-tang\/","title":{"rendered":"Ge Hua Jie Cheng Tang'\u0131n dalak eksikli\u011fi nemli \u0131s\u0131 \u00fclseratif kolitinin \"inflamasyon kanser d\u00f6n\u00fc\u015f\u00fcm\u00fcnde\" ilgili t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin ekspresyonu \u00fczerindeki etkisi"},"content":{"rendered":"

Ge Hua Jie Cheng Tang'\u0131n dalak eksikli\u011fi nemli \u0131s\u0131 \u00fclseratif kolitinin \"inflamasyon kanser d\u00f6n\u00fc\u015f\u00fcm\u00fcnde\" ilgili t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin ekspresyonu \u00fczerindeki etkisi
\n\u00dclseratif kolit (\u00dcK), kolonda meydana gelen, esas olarak kolon mukozas\u0131na zarar veren ve proksimal u\u00e7tan itibaren kademeli olarak t\u00fcm kolonu etkileyen inflamatuar bir hastal\u0131kt\u0131r. Enflamasyon uyar\u0131lmaya devam ederse, kolayca kolitle ili\u015fkili kanserlerin ortaya \u00e7\u0131kmas\u0131na neden olabilir. \u00dclseratif kolitle ili\u015fkili karsinogenez (UCAC), \u00fclseratif kolitin ciddi komplikasyonlar\u0131ndan biridir ve \"inflamasyon atipik hiperplazi kanseri\" \u015feklinde evrimsel bir s\u00fcre\u00e7 ge\u00e7irir. T\u00fcm\u00f6r geli\u015fimine yol a\u00e7an iltihaplanma s\u00fcreci, karma\u015f\u0131k biyolojik s\u00fcre\u00e7leri i\u00e7eren ad\u0131m ad\u0131m ilerleyen bir s\u00fcre\u00e7tir. \u0130nflamasyonun kansere d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fcn patogenezi i\u00e7in, baz\u0131 \u00e7al\u0131\u015fmalar onkogenlerin a\u015f\u0131r\u0131 aktivasyonu ve t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin inaktivasyonu ile ili\u015fkili oldu\u011funu \u00f6ne s\u00fcrmektedir. Onkogenlerin ve t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin ekspresyonundaki dengesizlik, t\u00fcm\u00f6r geli\u015fiminin temel nedenidir.
\nGeleneksel \u00c7in T\u0131bb\u0131, \u00dcK ile ili\u015fkili kanseri \"kronik diyare\" tan\u0131s\u0131 olarak kategorize eder. \u0130nflamatuar kolorektal kanserin ana patogenezi dalak eksikli\u011fi ve nemli \u0131s\u0131d\u0131r. Ge Hua Jie Cheng Tang, su infiltrasyonunu te\u015fvik etme, \u015faraptaki nemi ve \u0131s\u0131y\u0131 da\u011f\u0131tma, qi'yi d\u00fczenleme ve dala\u011f\u0131 uyand\u0131rma ve dalak ve qi'yi g\u00fc\u00e7lendirme ilkelerini birle\u015ftiren bir form\u00fcld\u00fcr. Bu nedenle, bu \u00e7al\u0131\u015fmada bir dalak eksikli\u011fi nemli \u0131s\u0131 UC-UCAC fare modeli olu\u015fturulmu\u015f ve tedavi i\u00e7in Ge Hua Jie Cheng Tang ile m\u00fcdahale edilmi\u015ftir. Fare kolon mukozas\u0131n\u0131n ultrastr\u00fckt\u00fcr\u00fcndeki de\u011fi\u015fiklikler ve Ge Hua Jie Cheng Tang'\u0131n dalak eksikli\u011fi nemli \u0131s\u0131 UC-UCAC farelerinin kolon dokusundaki ilgili onkogenlerin ve t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin ekspresyonu \u00fczerindeki etkileri g\u00f6zlemlenerek, UC-UCAC olu\u015fumunu \u00f6nlemek i\u00e7in teorik bir temel olu\u015fturmak amac\u0131yla dalak eksikli\u011fi nemli \u0131s\u0131 UC-UCAC d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fc geciktirmenin olas\u0131 mekanizmas\u0131 ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"UCAC, UC'nin s\u00fcrekli ve tekrarlanan uyar\u0131m\u0131 alt\u0131nda kademeli olarak olu\u015fur. Enflamasyonun t\u00fcm\u00f6rlere ilerleme s\u00fcreci karma\u015f\u0131k biyolojik s\u00fcre\u00e7leri i\u00e7erir ve ara\u015ft\u0131rmac\u0131lar v\u00fccuttaki onkogenlerin a\u015f\u0131r\u0131 aktivasyonu ve t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin inaktivasyonunun t\u00fcm\u00f6r olu\u015fumunun temel nedenleri oldu\u011funa inanmaktad\u0131r. Karsinogenez s\u00fcreci, h\u00fccresel onkogenler ve t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerdeki de\u011fi\u015fiklikleri i\u00e7erir. Proto onkogenler, hayvan genomlar\u0131nda bulunan ve h\u00fccre \u00e7o\u011falmas\u0131 ile yak\u0131ndan ili\u015fkili olan h\u00fccresel onkogenlerdir. Proto onkogenler a\u015f\u0131r\u0131 eksprese edilirse, h\u00fccreler a\u015f\u0131r\u0131 \u00e7o\u011falmaya ba\u011fl\u0131 olarak t\u00fcm\u00f6rler olu\u015fturabilir; anti-kanser genleri olarak da bilinen t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genler, h\u00fccre \u00e7o\u011falmas\u0131n\u0131n biyolojik s\u00fcrecinde negatif d\u00fczenleyici fakt\u00f6rlerdir. \u00c7al\u0131\u015fmalar, kolorektal kanserle ili\u015fkili onkogenlerin tipik temsilcilerinin c-jun, c-fos ve c-myc oldu\u011funu, kolorektal kanserle ili\u015fkili t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin tipik temsilcilerinin ise p53 ve Rb genlerini i\u00e7erdi\u011fini g\u00f6stermi\u015ftir. C-jun, c-fos ve myc, h\u00fccre \u00e7o\u011falmas\u0131n\u0131 te\u015fvik edebilen ve t\u00fcm\u00f6r olu\u015fumunda \u00f6nemli bir rol oynayan myc gen ailesine aittir. Hem c-fos hem de c-jun erken kurulan genlerdir ve aktive edilmi\u015f c-fos ve c-jun, c-jun\/c-fos dimer veya c-jun homodimer \u015feklinde AP-1 olu\u015fturur. AP-1, ilgili onkogenlerin ifadesini ind\u00fckler ve h\u00fccrelerin malign d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fc destekler. p53 geni, h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fc negatif y\u00f6nde d\u00fczenleyerek h\u00fccre \u00e7o\u011falmas\u0131n\u0131 ve farkl\u0131la\u015fmas\u0131n\u0131 d\u00fczenleyen bir t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 gendir. Silindi\u011finde veya mutasyona u\u011frad\u0131\u011f\u0131nda, s\u0131n\u0131rs\u0131z h\u00fccre b\u00fcy\u00fcmesini te\u015fvik ederek t\u00fcm\u00f6rlerin geli\u015fmesine yol a\u00e7abilir. \u00c7al\u0131\u015fmalar, p53 genindeki mutasyonlar\u0131n UC karsinogenezinde en kritik fakt\u00f6r oldu\u011funu g\u00f6stermi\u015ftir. Retinoblastoma geni 1 (RB1) insanlardan izole edilen ilk klonlanm\u0131\u015f t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 gendir. \u00d6nceki \u00e7al\u0131\u015fmalar, RB1 geninin h\u00fccre d\u00f6ng\u00fcs\u00fc d\u00fczenlemesi ve apoptoz gibi biyolojik s\u00fcre\u00e7lerde yer ald\u0131\u011f\u0131n\u0131 ve pRB kaynakl\u0131 apoptozun t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 gen p53'\u00fcn aktivasyonu yoluyla sa\u011fland\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. H\u00fccre apoptozu s\u00fcrecinde, pRB \u00e7ift y\u00f6nl\u00fc bir d\u00fczenleyici etkiye sahiptir. Bir yandan, h\u00fccreler karsinogenez ge\u00e7irirse, pRB p53 yolu arac\u0131l\u0131\u011f\u0131yla apoptotik program\u0131 ba\u015flatarak malign h\u00fccrelerin apoptoza girmesine neden olur; \u00d6te yandan, belirli fakt\u00f6rler a\u015f\u0131r\u0131 eksprese edilirse veya pro apoptotik proteinler ifade edilirse, pRB normal h\u00fccre \u00e7o\u011falmas\u0131n\u0131 te\u015fvik etmek i\u00e7in bu proteinlerle etkile\u015fime girer.<\/p>\n

Kolit kanseri d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fcn t\u00fcm s\u00fcrecinde, patogenezi dalak eksikli\u011fine ve ba\u011f\u0131rsaklarda sa\u011fl\u0131ks\u0131z, nemli \u0131s\u0131 birikimine ba\u011flanabilir. Bir\u00e7ok ara\u015ft\u0131rmac\u0131, kolit kanseri d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fcn patogenezinin esas olarak dalak eksikli\u011fi ve nemli \u0131s\u0131 oldu\u011funa inanmaktad\u0131r. Li ve arkada\u015flar\u0131, dalak eksikli\u011fi ve nemli \u0131s\u0131n\u0131n inflamatuar kolorektal kanserin ana patogenezi oldu\u011funa inanmaktad\u0131r. Fan ve arkada\u015flar\u0131, dalak ve mide zay\u0131fl\u0131\u011f\u0131n\u0131n kolon kanserinde prekanser\u00f6z lezyonlar\u0131n temel nedeni oldu\u011funa inanmaktad\u0131r. Yan ve arkada\u015flar\u0131, ba\u011f\u0131rsaklar\u0131 bloke eden nemli \u0131s\u0131n\u0131n patogenezin ay\u0131rt edici \u00f6zelli\u011fi oldu\u011funa inanmaktad\u0131r. Wang ve arkada\u015flar\u0131, nemli \u0131s\u0131 birikimi sendromunun kolorektal kanserin ana sendrom tipi oldu\u011funa inanmaktad\u0131r. \"Ge Hua Jie Jiu Tang\" veya \"Jie Cheng Tang\" olarak da bilinen Ge Hua Jie Cheng Tang, Jin ve Yuan hanedanl\u0131klar\u0131 d\u00f6neminde Li Dongyuan'\u0131n \"Dalak ve Mide \u00dczerine\" adl\u0131 eserinden gelmektedir ve \"a\u015f\u0131r\u0131 i\u00e7me ve yaralanma\" i\u00e7in bilinir. Ge Hua Jie Cheng Tang'\u0131n bile\u015fimi, dozaj\u0131 ve endikasyonlar\u0131 \"Dalak ve Mide Teorisi\" kitab\u0131nda a\u00e7\u0131klanm\u0131\u015ft\u0131r. S\u00f6ylendi\u011fi gibi, \"Ye\u015fil deri \u00fc\u00e7 par\u00e7a, odun kokusu be\u015f par\u00e7a, portakal kabu\u011fu, ginseng, Poria cocos ve Poria cocos'un her biri bir bu\u00e7uk sent, Shenqu k\u0131zarm\u0131\u015f sar\u0131, Alisma, kurutulmu\u015f zencefil ve Atractylodes macrocephala'n\u0131n her biri iki sent ve beyaz fasulye lor \u00e7ekirdekleri, Ge Hua ve Sha Ren'in her biri be\u015f senttir... Ama biraz terlerseniz, alkol hastal\u0131\u011f\u0131ndan kurtulursunuz.\" Ge Hua Jie Cheng Tang alkol yaralanmalar\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131lan temsili bir form\u00fcld\u00fcr. Baz\u0131 ara\u015ft\u0131rmac\u0131lar, zarar verici \"alkol\" hastal\u0131\u011f\u0131n\u0131n patogenezinin dalak ve mide zay\u0131fl\u0131\u011f\u0131 ve nemli \u0131s\u0131 durgunlu\u011fu olarak \u00f6zetlenebilece\u011fine inanmaktad\u0131r. Form\u00fcldeki tatl\u0131, so\u011fuk ve ho\u015f kokulu Ge \u00e7i\u00e7e\u011fi, sarho\u015flu\u011fu gidermek ve dala\u011f\u0131 canland\u0131rmak i\u00e7in iyi bir \u00fcr\u00fcnd\u00fcr. Ayn\u0131 zamanda berrak ve hafiftir ve \u015farap rutubetinin y\u00fczeyden sal\u0131nmas\u0131n\u0131 te\u015fvik ederek onu \u015fifal\u0131 bir bitki haline getirebilir. Han Hanedanl\u0131\u011f\u0131'n\u0131n \"T\u0131bbi Form\u00fcller ve A\u00e7\u0131klamalar Koleksiyonu \"nda Ge Hua'n\u0131n kayd\u0131 \u015f\u00f6yle der: \"Bu el ve ayak Yangming ilac\u0131 da kullan\u0131l\u0131r. A\u015f\u0131r\u0131 i\u00e7me, mide ve ba\u011f\u0131rsaklarda rutubet ve \u0131s\u0131 toksinlerinin birikmesine yol a\u00e7ar. Ge Hua tek ba\u015f\u0131na Yangming'e girerek kaslardan rutubet ve \u0131s\u0131n\u0131n sal\u0131nmas\u0131na neden olur.\" Shenqu ya\u011f birikimini ortadan kald\u0131r\u0131r; Bai Kou ve Sha Ren kuru ve nemlidir, mideyi etkiler; Poria cocos, Atractylodes macrocephala, Zexie ve Poria cocos dala\u011f\u0131 g\u00fc\u00e7lendirir ve nemi ortadan kald\u0131r\u0131r, nem ve \u0131s\u0131n\u0131n idrar yoluyla ge\u00e7mesine izin verir; Ye\u015fil deri, turuncu k\u0131rm\u0131z\u0131 ve odun kokusu qi ve mide dola\u015f\u0131m\u0131n\u0131 te\u015fvik eder ve alkol ve yiyecek durgunlu\u011funu te\u015fvik eder. Qi akt\u0131\u011f\u0131nda t\u00fck\u00fcr\u00fck dola\u015f\u0131m\u0131n\u0131 te\u015fvik eder ve t\u00fck\u00fcr\u00fck akt\u0131\u011f\u0131nda nem alma ve durgunlu\u011fu giderme amac\u0131na ula\u015fmak i\u00e7in nemlendirir; Kurutulmu\u015f zencefil s\u0131cakt\u0131r ve su ta\u015f\u0131nmas\u0131 i\u00e7in faydal\u0131d\u0131r; Ginseng qi'yi tonland\u0131r\u0131r, toksinleri \u00f6nler ve \u00e7ok fazlas\u0131n\u0131 da\u011f\u0131t\u0131r. K\u0131sacas\u0131, Ge Hua Jie Cheng Tang suyu da\u011f\u0131tma, su ak\u0131\u015f\u0131n\u0131 te\u015fvik etme, dala\u011f\u0131 canland\u0131rmak i\u00e7in ortadaki qi'yi d\u00fczenleme ve sindirimi te\u015fvik etmek i\u00e7in dala\u011f\u0131 g\u00fc\u00e7lendirme i\u015flevlerine sahiptir. Su infiltrasyonunu te\u015fvik etme, \u015faraptaki nemi ve \u0131s\u0131y\u0131 da\u011f\u0131tma, dala\u011f\u0131 canland\u0131rmak i\u00e7in qi'yi d\u00fczenleme ve dalak ve qi'yi g\u00fc\u00e7lendirme y\u00f6ntemlerini birle\u015ftiren bir form\u00fcld\u00fcr. Ge Hua grubu, qi grubunu d\u00fczenleyen, dalak grubunu g\u00fc\u00e7lendiren, su grubunu te\u015fvik eden ve orta grubu \u0131s\u0131tan geleneksel \u00c7in t\u0131bb\u0131n\u0131n titiz kombinasyonu sayesinde, dalak ve mideyi \u0131s\u0131tma, \u015farap birikimini ortadan kald\u0131rma ve \u0131s\u0131 ve nemi temizleme g\u00fcc\u00fcne sahiptir. K\u0131sacas\u0131, Ge Hua Jie Cheng Tang'\u0131n patogenez teorisi k\u00f6kte eksiklik ve hedefte fazlal\u0131k, kar\u0131\u015f\u0131k so\u011fuk ve s\u0131cak ve qi hareketinde dengesizlik kombinasyonunu i\u00e7erir. Hem sindirimi hem de takviyeyi, \u0131s\u0131tmay\u0131 ve temizlemeyi ve qi'yi beslemeyi ve qi dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmeyi birle\u015ftiren bir form\u00fcld\u00fcr. Bu nedenle, bu \u00e7al\u0131\u015fmada kolit kanseri d\u00f6n\u00fc\u015f\u00fcm\u00fc s\u00fcrecinde Ge Hua Jie Cheng Tang'\u0131n mekanizmas\u0131n\u0131 ke\u015ffetmek amac\u0131yla dalak eksikli\u011fi nemli \u0131s\u0131 tipi UCAC farelerine m\u00fcdahale etmek i\u00e7in Ge Hua Jie Cheng Tang se\u00e7ilmi\u015ftir.<\/p>\n

Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, model grup farelerin kolon dokusundaki c-jun, c-fos ve c-myc proteinlerinin ekspresyon seviyelerinin bo\u015f gruba k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131, p53 ve RB1 proteinlerinin ekspresyon seviyelerinin ise bo\u015f gruba k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131; c-jun, c-fos ve c-myc mRNA ekspresyon seviyelerinin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131, p53 ve RB1 mRNA ekspresyon seviyelerinin ise bo\u015f gruba k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir; \u00c7e\u015fitli ila\u00e7 gruplar\u0131yla tedaviden sonra, fare kolon dokusunda c-jun, c-fos ve c-myc proteinlerinin ekspresyon seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131rken, p53 ve RB1 proteinlerinin ekspresyon seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r; c-jun, c-fos ve c-myc mRNA ekspresyonu \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131rken, p53 ve RB1 mRNA ekspresyonu, \u00f6zellikle Ge Hua Jie Cheng Tang'\u0131n y\u00fcksek ve orta doz gruplar\u0131nda ve mesalazin grubunda \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r. Ge Hua Jie Cheng Tang sadece model farelerin zihinsel durum, diyet, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve aktivite gibi genel ko\u015fullar\u0131n\u0131 iyile\u015ftirmekle kalmaz, ayn\u0131 zamanda farelerin kolon mukozas\u0131n\u0131 da iyile\u015ftirir. Ayr\u0131ca ilgili onkogenlerin ve t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genlerin ekspresyon seviyelerini etkileyebilir, h\u00fccre \u00e7o\u011falmas\u0131n\u0131 ve apoptoz s\u00fcre\u00e7lerini d\u00fczenleyebilir.<\/p>","protected":false},"excerpt":{"rendered":"

The effect of Ge Hua Jie Cheng Tang on the expression of related tumor suppressor genes in the “inflammation cancer transformation” of spleen deficiency damp heat ulcerative colitis Ulcerative colitis (UC) is an inflammatory disease that occurs in the colon, mainly damaging the colonic mucosa and gradually affecting the entire colon from the proximal end. 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