{"id":6743,"date":"2024-08-06T14:22:06","date_gmt":"2024-08-06T14:22:06","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6743"},"modified":"2024-08-06T14:22:06","modified_gmt":"2024-08-06T14:22:06","slug":"chisandra-chinensis-goji-berry","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/chisandra-chinensis-goji-berry\/","title":{"rendered":"Schisandra chinensis Goji berry'nin radyasyon kaynakl\u0131 karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma mekanizmas\u0131n\u0131 ke\u015ffetmek i\u00e7in a\u011f farmakolojisi ile birlikte GEO \u00e7ip analizi"},"content":{"rendered":"

Schisandra chinensis Goji berry'nin radyasyon kaynakl\u0131 karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma mekanizmas\u0131n\u0131 ke\u015ffetmek i\u00e7in a\u011f farmakolojisi ile birlikte GEO \u00e7ip analizi
\nRadyasyona ba\u011fl\u0131 karaci\u011fer hasar\u0131 (RILI), radyasyon tedavisi veya n\u00fckleer s\u0131z\u0131nt\u0131n\u0131n neden oldu\u011fu, belirli bir miktarda radyasyona maruz kald\u0131ktan sonra karaci\u011fer fonksiyonlar\u0131nda azalma, karaci\u011fer enzimlerinde art\u0131\u015f ve karaci\u011ferde di\u011fer hasarlarla sonu\u00e7lanan bir t\u00fcr karaci\u011fer hasar\u0131d\u0131r. I\u015f\u0131k mikroskobu alt\u0131nda, karaci\u011fer dokusunun erken patolojik belirtileri esas olarak karaci\u011fer lob\u00fcllerinin merkezi b\u00f6lgesinde t\u0131kan\u0131kl\u0131k, hepatosit \u00f6demi ve enflamatuar reaksiyonlar\u0131 i\u00e7erir. Ge\u00e7 a\u015famada, yava\u015f yava\u015f geri d\u00f6n\u00fc\u015f\u00fc olmayan karaci\u011fer fibrozisi ve siroza d\u00f6n\u00fc\u015f\u00fcr. Ana patogenez mikrovask\u00fcler ve ba\u011f dokusu hasar\u0131n\u0131, a\u015f\u0131r\u0131 serbest radikalleri, a\u015f\u0131r\u0131 otoimm\u00fcn yan\u0131t\u0131 ve sitokin etkisini i\u00e7erir.<\/p>\n

Schisandra Chinensis Fructus (SCF), s\u0131cak bir do\u011faya sahip olan ve iyi karaci\u011fer koruma etkilerine sahip oldu\u011fu tespit edilen Schisandra chinensis'i ifade eder. Etki mekanizmas\u0131 esas olarak antioksidan ve anti-inflamatuar y\u00f6ntemlerle ger\u00e7ekle\u015fir. Lycium barbarum (LF) n\u00f6tr bir yap\u0131ya ve karaci\u011fer ve b\u00f6brekleri besledi\u011fi g\u00f6sterilen farmakolojik etkilere sahiptir. \u0130kisinin kombinasyonu karaci\u011fer hasar\u0131na kar\u015f\u0131 etkili bir \u015fekilde koruma sa\u011flayabilir. Bu makale, RILI'nin korunmas\u0131nda Goji meyveleri ile birlikte Schisandra chinensis'in potansiyel aktif bile\u015fenlerini, hedeflerini ve etki mekanizmalar\u0131n\u0131 tahmin etmek i\u00e7in GEO \u00e7ip analizi, a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknolojisini kullanmakta ve daha derinlemesine ara\u015ft\u0131rma ve klinik uygulamalar i\u00e7in referans sa\u011flamaktad\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Radyasyona ba\u011fl\u0131 karaci\u011fer hasar\u0131, kanser hastalar\u0131nda radyasyon tedavisi veya n\u00fckleer s\u0131z\u0131nt\u0131 s\u00fcrecinde karaci\u011ferin belirli bir dozda radyasyona maruz kalmas\u0131 anlam\u0131na gelir. Erken belirtiler aras\u0131nda karaci\u011ferin merkezi lob\u00fcllerinde karaci\u011fer h\u00fccrelerinin \u00f6demi, periferik enflamatuar reaksiyonlar ve karaci\u011fer fonksiyonunun etkilenmesi yer al\u0131r. Daha sonra, karaci\u011fer fibrozisi veya sirozuna d\u00f6n\u00fc\u015fme e\u011filimi g\u00f6sterir. Son y\u0131llarda, geleneksel \u00c7in t\u0131bb\u0131n\u0131n karaci\u011fer hasar\u0131na kar\u015f\u0131 radyasyon korumas\u0131 \u00fczerine giderek artan miktarda ara\u015ft\u0131rma yap\u0131lmaktad\u0131r. Geleneksel \u00c7in t\u0131bb\u0131, g\u00fcvenli\u011fi, oral uygulama i\u00e7in uygunlu\u011fu, h\u0131zl\u0131 emilimi ve d\u00fc\u015f\u00fck maliyeti nedeniyle b\u00fcy\u00fck bir potansiyele sahiptir.
\nSchisandra chinensis m\u00fckemmel hepatoprotektif etkilere sahiptir. Ara\u015ft\u0131rmalar, Schisandra'n\u0131n esas olarak u\u00e7ucu terpenler, lignanlar, organik asitler ve anti-enflamatuar, antioksidan, ba\u011f\u0131\u015f\u0131kl\u0131k artt\u0131r\u0131c\u0131 ve madde metabolizmas\u0131n\u0131 d\u00fczenleyici \u00f6zelliklere sahip polisakkaritler dahil olmak \u00fczere 200'den fazla kimyasal bile\u015fen i\u00e7erdi\u011fini bulmu\u015ftur. Wang'\u0131n ara\u015ft\u0131rmas\u0131, ham Schisandra chinensis'in enflamatuar fakt\u00f6rleri azaltarak, ya\u011f birikimini azaltarak, CYP2E1 ekspresyonunu d\u00fc\u015f\u00fcrerek ve karaci\u011fer hasar\u0131na kar\u015f\u0131 korumak i\u00e7in Nrf2\/ARE sinyal yollar\u0131n\u0131 geli\u015ftirerek akut alkolik ya\u011fl\u0131 karaci\u011ferin tedavisini ve \u00f6nlenmesini geli\u015ftirdi\u011fini buldu. Zhu'nun in vitro ara\u015ft\u0131rmas\u0131, Schisandra polisakkaritlerinin hidroksil radikallerini, 1,1-difenil-2-trinitrofenilhidrazini ve s\u00fcperoksit iyonlar\u0131n\u0131 etkili bir \u015fekilde temizleyebildi\u011fini; in vivo deneyler ise Schisandra polisakkaritlerinin CCL4 kaynakl\u0131 hepatosit vezik\u00fcler dejenerasyon ve enflamatuar yan\u0131t\u0131n neden oldu\u011fu karaci\u011fer hasar\u0131n\u0131 hafifletebildi\u011fini bulmu\u015ftur. Yang'\u0131n ara\u015ft\u0131rmas\u0131, Schisandra lignanlar\u0131n\u0131n, esas olarak ERBB sinyal yolundaki EGFR ve LPCAT1 ile ilgili proteinlerin ekspresyonunu d\u00fczenleyerek, anti-enflamatuar ve antioksidan etkiler uygulayarak, asetaminofenin neden oldu\u011fu karaci\u011fer hasar\u0131na kar\u015f\u0131 koruyucu bir etkiye sahip oldu\u011funu bulmu\u015ftur. Chen ve arkada\u015flar\u0131, Schisandra chinensis lignanlar\u0131n\u0131n serumdaki AST ve ALT aktivitesini azaltabildi\u011fini, IL-6 ve IL1 \u03b2 gibi enflamatuar fakt\u00f6rleri azaltabildi\u011fini ve g\u00fc\u00e7l\u00fc anti-enflamatuar etkiler sergiledi\u011fini, b\u00f6ylece karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma sa\u011flad\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Chen ve arkada\u015flar\u0131 Schisandra chinensis'ten elde edilen polisakkaritlerin Bcl-2\/Bax oran\u0131n\u0131 azaltabildi\u011fini ve CASP3 aktivasyonunu azaltabildi\u011fini, b\u00f6ylece karaci\u011fer h\u00fccresi apoptozunu azaltt\u0131\u011f\u0131n\u0131 bulmu\u015flard\u0131r.
\nGoji berry, \u00f6z\u00fc besleyici, g\u00f6r\u00fc\u015f\u00fc iyile\u015ftirici, karaci\u011fer ve b\u00f6brekleri besleyici vb. etkilere sahiptir. Polisakkaritler, u\u00e7ucu ya\u011flar, alkaloidler, flavonoidler ve di\u011fer bile\u015fenler bak\u0131m\u0131ndan zengindir. Modern farmakolojik ara\u015ft\u0131rmalar, ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131, antioksidan\u0131, karaci\u011fer korumas\u0131n\u0131 iyile\u015ftirebilece\u011fini ve retinay\u0131 koruyabilece\u011fini g\u00f6stermi\u015ftir. Tian'\u0131n ara\u015ft\u0131rmas\u0131, Lycium barbarum polisakkaritlerinin protein tiyollerinin azalmas\u0131n\u0131 ve SOD'un inaktivasyonunu \u00f6nleyebilece\u011fini ve gama radyasyonu taraf\u0131ndan \u00fcretilen serbest radikallerin neden oldu\u011fu fare karaci\u011fer mitokondriyal h\u00fccrelerinin membran hasar\u0131 \u00fczerinde iyi antioksidan etkilere sahip oldu\u011funu buldu. Goji meyveleri ve schisandra kombinasyonu karaci\u011fer korumas\u0131n\u0131n etkinli\u011fini art\u0131r\u0131r. Zhang'\u0131n ara\u015ft\u0131rmas\u0131, Lycium barbarum polisakkaritlerinin radyasyon kaynakl\u0131 ince ba\u011f\u0131rsak hasar\u0131 \u00fczerinde koruyucu bir etkiye sahip oldu\u011funu, oksidatif reaksiyonlarda bir azalma ve h\u00fccre apoptozunu inhibe etmek i\u00e7in Bcl-2 \/ Bax oran\u0131nda bir art\u0131\u015f sa\u011flad\u0131\u011f\u0131n\u0131 buldu. Gao ve arkada\u015flar\u0131, karaci\u011fer hasar\u0131 olan s\u0131\u00e7anlara goji berry polifenollerinin uygulanmas\u0131n\u0131n oksidatif fonksiyonlar\u0131n\u0131 art\u0131rabilece\u011fini ve mekanizman\u0131n Nrf2 ve a\u015fa\u011f\u0131 ak\u0131\u015f proteinlerinin ekspresyonunu art\u0131rarak karaci\u011fer hasar\u0131n\u0131 azaltmada rol oynayabilece\u011fini bulmu\u015flard\u0131r.
\nPPI a\u011f analizi yoluyla tan\u0131mlanan \u00e7ekirdek proteinler aras\u0131nda CASP3, EGFR ve ESR1 bulunmaktad\u0131r. Kaspazlar (CASP) h\u00fccre apoptozunun d\u00fczenlenmesinde \u00f6nemli bir rol oynar ve pro apoptotik sinyallere yan\u0131t olarak kaskad reaksiyonlar\u0131 tetikler. CASP3, CASP'de \u00f6nemli bir y\u00f6netici proteindir ve apoptoz herhangi bir h\u00fccrede meydana gelir. Fiziksel, kimyasal ve di\u011fer molek\u00fcler mekanizmalar yoluyla h\u00fccre b\u00fcy\u00fcmesi ve \u00f6l\u00fcm\u00fcn\u00fcn dinamik dengesini d\u00fczenleyebilir. Cao ve arkada\u015flar\u0131, Schisandrin B'nin Hacat h\u00fccrelerinde radyasyona ba\u011fl\u0131 apoptoz \u00fczerinde inhibe edici bir etkiye sahip oldu\u011funu ve mekanizmas\u0131n\u0131n CASP3, P53 ve P21 gibi apoptotik genlerin ekspresyonunu azaltarak koruyucu bir etki g\u00f6sterdi\u011fini bulmu\u015ftur. Duan'\u0131n ara\u015ft\u0131rmas\u0131, goji berry suyunun \u0131\u015f\u0131nlanm\u0131\u015f fareler \u00fczerinde antioksidan etkilere sahip oldu\u011funu ve CASP3 ve CASP6'n\u0131n ekspresyonunu azaltarak koruyucu bir etki g\u00f6sterdi\u011fini ortaya koymu\u015ftur. CASP3, Schisandra chinensis Goji meyvelerindeki aktif bile\u015fenler arac\u0131l\u0131\u011f\u0131yla CASP3 proteinini d\u00fczenleyerek, b\u00f6ylece h\u00fccre apoptozunu inhibe ederek ve b\u00fcy\u00fcme ile \u00f6l\u00fcm aras\u0131nda dinamik bir denge sa\u011flayarak radyasyona ba\u011fl\u0131 karaci\u011fer hasar\u0131n\u0131n apoptoz s\u00fcrecinde yer almaktad\u0131r. Epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r\u00fc (EGFR), epitel h\u00fccreleri, fibroblastlar ve glial h\u00fccrelerin y\u00fczeyinde yayg\u0131n olarak da\u011f\u0131lan epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r ailesinin bir \u00fcyesidir ve h\u00fccrelerin b\u00fcy\u00fcmesi, \u00e7o\u011falmas\u0131 ve farkl\u0131la\u015fmas\u0131nda \u00f6nemli bir rol oynar. Li ve arkada\u015flar\u0131, Schisandrin A'n\u0131n EGFR'nin gen ekspresyonunu art\u0131rarak ve apoptoz genleri P53 ve P21'in ekspresyonunu azaltarak karaci\u011fer h\u00fccresi apoptozunu inhibe edebilece\u011fini ve karaci\u011fer rezeksiyonu ameliyat\u0131ndan sonra karaci\u011fer h\u00fccresi rejenerasyonunu te\u015fvik edebilece\u011fini bulmu\u015flard\u0131r. Zhang'\u0131n ara\u015ft\u0131rmas\u0131, Lycium barbarum polisakkaritlerinin oksidatif stresin neden oldu\u011fu endotelyal fonksiyon hasar\u0131n\u0131 iyile\u015ftirmek i\u00e7in EGFR ve fosforile protein seviyelerinin ekspresyonunu d\u00fczenleyebilece\u011fini ve etki mekanizmas\u0131n\u0131n PI3K Akt sinyal yolu \u00fczerinden olabilece\u011fini buldu. Schisandra chinensis goji berry'deki aktif bile\u015fenler, EGFR \u00fczerinde etkili olarak apoptozun neden oldu\u011fu h\u00fccre say\u0131lar\u0131ndaki dengesizli\u011fi d\u00fczenleyebilir ve v\u00fccudu normal fizyolojik seviyeye do\u011fru y\u00f6nlendirebilir. \u00d6strojen resept\u00f6r\u00fc 1 (ER1) h\u00fccrenin \u00e7ekirde\u011finde bulunur ve hormon ba\u011flanmas\u0131, DNA ba\u011flanmas\u0131 ve transkripsiyonel aktivasyon i\u00e7in \u00f6nemli yap\u0131sal alanlardan olu\u015fur. Zeng'in \u00e7al\u0131\u015fmas\u0131, goji meyvelerinin su \u00f6z\u00fct\u00fcn\u00fcn PC12 h\u00fccrelerinde mRNA ifadesini d\u00fczenleyebildi\u011fini, sadece ESR1'i yukar\u0131 do\u011fru d\u00fczenlemekle kalmay\u0131p ayn\u0131 zamanda CASP3 ifadesini a\u015fa\u011f\u0131 do\u011fru d\u00fczenleyerek goji meyvesi hedefleri i\u00e7in belirli bir referans sa\u011flad\u0131\u011f\u0131n\u0131 buldu. Liu ve arkada\u015flar\u0131, ESR1'in NEDD4L\/CD71 sinyal yolu arac\u0131l\u0131\u011f\u0131yla meme kanseri h\u00fccrelerinde iyonla\u015ft\u0131r\u0131c\u0131 radyasyon kaynakl\u0131 demir \u00f6l\u00fcm\u00fcn\u00fc engelleyebilece\u011fini g\u00f6stermi\u015ftir. ESR1 a\u015f\u0131r\u0131 eksprese edildi\u011finde, meme kanseri hastalar\u0131n\u0131n hayatta kalma oran\u0131n\u0131 art\u0131rabilir. ESR1 devre d\u0131\u015f\u0131 b\u0131rak\u0131ld\u0131ktan sonra, iyonla\u015ft\u0131r\u0131c\u0131 radyasyon arac\u0131l\u0131 demir \u00f6l\u00fcm\u00fcn\u00fc art\u0131r\u0131r. ESR1, RILI'yi korumak i\u00e7in potansiyel bir hedef olabilir.
\nBu \u00e7al\u0131\u015fma, Schisandra chinensis Goji berry'nin a\u011f farmakolojisi yoluyla RILI'yi koruma mekanizmas\u0131n\u0131 tahmin etmi\u015f ve ilac\u0131n anahtar protein hedefleri olan aktif bile\u015fenlerin bir a\u011f diyagram\u0131n\u0131 olu\u015fturmu\u015ftur. Sonu\u00e7lar, quercetin, genistein ve deoxypurpurin'in d\u00fc\u011f\u00fcm derecesi de\u011ferlerinin nispeten y\u00fcksek oldu\u011funu ve bu aktif bile\u015fenlerin RILI'nin korunmas\u0131nda \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. GO fonksiyon zenginle\u015ftirmesi ve 66 potansiyel protein hedefinin KEGG yol analizi yoluyla, Schisandra chinensis Wolfberry'nin aktif bile\u015fenlerinin kimyasal karsinogenez resept\u00f6r aktivasyonu, lipid ve arteriyel ateroskleroz, PI3K-Akt, MAPK, apoptoz ve di\u011fer sinyal yollar\u0131n\u0131 d\u00fczenleyerek RILI'nin korunmas\u0131nda rol oynayabilece\u011fi tahmin edilmektedir. Bu makale verileri b\u00fct\u00fcnle\u015ftirmekte ve \u00f6ng\u00f6rmektedir. S\u0131n\u0131rl\u0131 \u00f6rneklem b\u00fcy\u00fckl\u00fc\u011f\u00fc nedeniyle, ara\u015ft\u0131rman\u0131n s\u00fcrekli derinle\u015fmesiyle, \u00f6ng\u00f6r\u00fcc\u00fc analizin daha kapsaml\u0131 ve do\u011fru sonu\u00e7lar getirece\u011fine inan\u0131lmaktad\u0131r.
\nGEO \u00e7ip analizi, a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknolojisi kullan\u0131larak Schisandra chinensis Goji berry \u00fczerinde kapsaml\u0131 ve \u00e7ok boyutlu bir \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015f ve Schisandra chinensis Goji berry'nin radyasyon kaynakl\u0131 karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma mekanizmas\u0131 \u00f6nceden tahmin edilmi\u015ftir. Aktif bile\u015fen gen hedefi radyasyon karaci\u011fer hasar\u0131 a\u011f\u0131 taraf\u0131ndan \u00f6ng\u00f6r\u00fclen radyasyon karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma i\u00e7in schisandra chinensis wolfberry'nin etkili madde temeli, kimyasal karsinogenez resept\u00f6r aktivasyonunu, lipid ve arteriyel aterosklerozu d\u00fczenleyerek radyasyon karaci\u011fer hasar\u0131n\u0131 korumada rol oynayan quercetin, daidzein ve deoxysshikonin olabilir, PI3K-Akt, MAPK, apoptoz ve di\u011fer sinyal yolaklar\u0131n\u0131n temel hedefleri CASP3, EFGR, ESR1 \u00fczerinde etkili olarak schisandra chinensis wolfberry'nin \"\u00e7ok bile\u015fenli\", \"\u00e7ok hedefli\" ve \"\u00e7ok yolakl\u0131\" radyasyon karaci\u011fer hasar\u0131n\u0131 korumada rol oynad\u0131\u011f\u0131n\u0131 g\u00f6sterir ve bu da daha sonra etki mekanizmas\u0131 ve klinik uygulama \u00fczerine yap\u0131lacak ara\u015ft\u0131rmalar i\u00e7in belirli bir referans temeli sa\u011flayabilir.<\/p>","protected":false},"excerpt":{"rendered":"

GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury Radiation induced liver injury (RILI) is a type of liver damage caused by radiation therapy or nuclear leakage, which results in a decrease in liver function, an increase in liver enzymes, and other […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nGEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/chisandra-chinensis-goji-berry\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury Radiation induced liver injury (RILI) is a type of liver damage caused by radiation therapy or nuclear leakage, which results in a decrease in liver function, an increase in liver enzymes, and other […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/chisandra-chinensis-goji-berry\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-06T14:22:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/\",\"url\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/\",\"name\":\"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png\",\"datePublished\":\"2024-08-06T14:22:06+00:00\",\"dateModified\":\"2024-08-06T14:22:06+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Schisandra chinensis Goji berry'nin radyasyon kaynakl\u0131 karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma mekanizmas\u0131n\u0131 ke\u015ffetmek i\u00e7in a\u011f farmakolojisi ile birlikte GEO \u00e7ip analizi - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/chisandra-chinensis-goji-berry\/","og_locale":"tr_TR","og_type":"article","og_title":"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury - China Chemical Manufacturer","og_description":"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury Radiation induced liver injury (RILI) is a type of liver damage caused by radiation therapy or nuclear leakage, which results in a decrease in liver function, an increase in liver enzymes, and other […]","og_url":"https:\/\/longchangextracts.com\/tr\/chisandra-chinensis-goji-berry\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-06T14:22:06+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"9 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/","url":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/","name":"Schisandra chinensis Goji berry'nin radyasyon kaynakl\u0131 karaci\u011fer hasar\u0131na kar\u015f\u0131 koruma mekanizmas\u0131n\u0131 ke\u015ffetmek i\u00e7in a\u011f farmakolojisi ile birlikte GEO \u00e7ip analizi - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png","datePublished":"2024-08-06T14:22:06+00:00","dateModified":"2024-08-06T14:22:06+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-253.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/chisandra-chinensis-goji-berry\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"GEO chip analysis combined with network pharmacology to explore the mechanism of Schisandra chinensis Goji berry in protecting against radiation-induced liver injury"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6743"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=6743"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6743\/revisions"}],"predecessor-version":[{"id":6756,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6743\/revisions\/6756"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=6743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=6743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=6743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}