{"id":6615,"date":"2024-08-06T12:45:17","date_gmt":"2024-08-06T12:45:17","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6615"},"modified":"2026-09-10T03:15:38","modified_gmt":"2026-09-10T03:15:38","slug":"using-response-surface-methodology","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/using-response-surface-methodology\/","title":{"rendered":"Yan\u0131t Y\u00fczey Metodolojisi Kullan\u0131larak Paraherquamide A Fermantasyon S\u00fcrecinin Optimizasyonu"},"content":{"rendered":"

Yan\u0131t Y\u00fczey Metodolojisi Kullan\u0131larak Paraherquamide A Fermantasyon S\u00fcrecinin Optimizasyonu
\nParasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have emerged in many areas. In the late 1980s, China introduced and widely used this type of drug, and now domestic sheep gastrointestinal nematodes have developed varying degrees of resistance to avermectin drugs. Startect \u00ae is a new type of sheep oral short acting deworming drug developed by Zoetis, the world’s largest animal health drug and vaccine company, which can effectively prevent and solve livestock and poultry parasitic diseases and their drug resistance problems. The UK Veterinary Medicines Directorate record for Startect<\/a> identifies derquantel and abamectin as its active substances. The previous sentence confused a substance name and included an inappropriate administration calculation; that instruction has been removed. This fermentation article is not a veterinary dosing guide. Use the current authorized product information and veterinary guidance for the actual product.<\/span> According to the statistics of the Food and Agriculture Organization of the United Nations (FAO), the world’s sheep inventory has reached 1.2 billion. Therefore, the potential demand for Dequnt is in the hundreds of tons or even higher, and the market demand is huge.<\/p>\n

Dextrant, esas olarak PA'n\u0131n amid karbonil indirgenmesi ve deoksijenasyonu yoluyla elde edilen fungal metabolit Paraherquamide A'n\u0131n (PA) kimyasal bir t\u00fcrevidir (bkz. \u015eekil 1). Bu nedenle, Dequnte'nin end\u00fcstriyel hammadde tedariki esas olarak PA \u00fcretiminden etkilenmektedir. Bununla birlikte, Paraherquamide gibi do\u011fal \u00fcr\u00fcnlerin kimyasal yap\u0131s\u0131 karma\u015f\u0131kt\u0131r. \u0130zopren veya izopren epoksitler gibi end\u00fcstriyel hammaddelerden kimyasal olarak sentezlenebilmelerine ra\u011fmen, kimyasal reaksiyon ad\u0131mlar\u0131 46 ad\u0131ma kadar ula\u015fabilir, bu da y\u00fcksek maliyetlere ve son derece d\u00fc\u015f\u00fck verime (2.5%) neden olarak end\u00fcstriyel \u00f6l\u00e7ekte \u00fcretilmesini zorla\u015ft\u0131r\u0131r. Mikrobiyal fermantasyon yoluyla PA \u00fcretimi \u015fu anda bu bile\u015fi\u011fi b\u00fcy\u00fck \u00f6l\u00e7ekte elde etmenin etkili bir yoludur. PA ilk olarak Penicillium cinsine ait bir mantar olan Penicillium paraherquei t\u00fcr\u00fcn\u00fcn fermantasyon \u00fcr\u00fcn\u00fcnden izole edilmi\u015ftir. Bununla birlikte, vah\u015fi tip Penicillium taraf\u0131ndan \u00fcretilen PA'n\u0131n g\u00fcc\u00fc y\u00fcksek de\u011fildi, bu da daha fazla deneysel ara\u015ft\u0131rma ve end\u00fcstriyel uygulamay\u0131 engelledi. Fungal metabolitlerin uygulama ara\u015ft\u0131rmalar\u0131nda, hedef metabolitin etki seviyesi sadece su\u015fun kendi performans\u0131na de\u011fil, daha da \u00f6nemlisi, \u00fcretim kapasitesini tam olarak kullanmak i\u00e7in fermantasyon ve yeti\u015ftirme ko\u015fullar\u0131n\u0131n optimize edilmesine ba\u011fl\u0131d\u0131r. Yan\u0131t y\u00fczeyi metodolojisi \u015fu anda mikrobiyal fermantasyon k\u00fclt\u00fcr\u00fcn\u00fc optimize etmek i\u00e7in yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bu y\u00f6ntem deneysel tasar\u0131m ve matematiksel modellemeyi birle\u015ftirir ve daha az deney, daha k\u0131sa d\u00f6ng\u00fcler, regresyon denklemlerinin elde edilmesinde daha y\u00fcksek do\u011fruluk, daha iyi tahmin performans\u0131 ve \u00e7e\u015fitli fakt\u00f6rler aras\u0131ndaki etkile\u015fimin incelenmesi gibi avantajlara sahiptir.<\/p>\n

\u00d6n \u00e7al\u0131\u015fmada, ara\u015ft\u0131rma grubumuz y\u00fcksek PA \u00fcretimine sahip deniz kaynakl\u0131 bir Penicillium mantar\u0131 KWF31 ke\u015ffetti. \u0130lk ke\u015fif, fermantasyon g\u00fcc\u00fcn\u00fcn Chatelier ortam\u0131 alt\u0131nda 55.8 \u00b1 3.7mg\/L oldu\u011funu ve bunun end\u00fcstriyel \u00fcretim gereksinimlerini kar\u015f\u0131lamad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, Plackett Burman tasar\u0131m\u0131, en dik t\u0131rmanma tasar\u0131m\u0131 ve Box Behnken tasar\u0131m\u0131 gibi yan\u0131t y\u00fczeyi y\u00f6ntemlerini kullanarak KWF31 su\u015funun fermantasyon ortam\u0131n\u0131 optimize etmek ve y\u00fcksek verimli ve istikrarl\u0131 bir PA \u00fcretim s\u00fcreci teknolojisi \u015femas\u0131 olu\u015fturmakt\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"PA, benzersiz bir kimyasal yap\u0131ya ve m\u00fckemmel b\u00f6cek direnci aktivitesine sahip bir izopentenil indol alkaloiddir. Ticari b\u00f6cek diren\u00e7li ajan Dextrant'\u0131n sentezi i\u00e7in bir hammaddedir ve y\u00fcksek pazar de\u011ferine ve b\u00fcy\u00fck pazar talebine sahiptir. Bununla birlikte, vah\u015fi tip Penicillium su\u015fu, birden fazla kimyasal sentez a\u015famas\u0131 ve d\u00fc\u015f\u00fck verim ile d\u00fc\u015f\u00fck PA verimine sahiptir ve bu da pazar talebini kar\u015f\u0131lamay\u0131 zorla\u015ft\u0131rmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, sekiz fakt\u00f6rden \u00e7alkalamal\u0131 \u015fi\u015felerde yabani KWF31 su\u015fu taraf\u0131ndan PA'n\u0131n yatay fermantasyon \u00fcretimini \u00f6nemli \u00f6l\u00e7\u00fcde etkileyen \u00fc\u00e7 ortam bile\u015fenini taramak i\u00e7in Plackett Burman tasar\u0131m\u0131 kullan\u0131lm\u0131\u015ft\u0131r: \u00e7\u00f6z\u00fcn\u00fcr ni\u015fasta, glikoz ve maya \u00f6z\u00fct\u00fc; Konsantrasyonlar\u0131, t\u0131rmanma deneyleri ve Box Behnken tasar\u0131m\u0131 kullan\u0131larak kademeli olarak optimize edilmi\u015ftir. Optimize edilmi\u015f optimum konsantrasyonlar \u00e7\u00f6z\u00fcn\u00fcr ni\u015fasta 31.0g\/L, glikoz 1208g\/L ve maya \u00f6z\u00fct\u00fc 14.5g\/L'dir. Bu ortamda, yabani tip KWF31 su\u015fu, sallama \u015fi\u015fesi yatay fermantasyonu s\u0131ras\u0131nda PA \u00fcretimi i\u00e7in 243,7 mg\/L'lik y\u00fcksek bir potens g\u00f6stermi\u015ftir; bu, optimizasyon \u00f6ncesine g\u00f6re (55,8 mg\/L) 3,4 kat daha y\u00fcksektir. Bu \u00e7al\u0131\u015fmada deniz mantar\u0131 KWF31 taraf\u0131ndan PA fermantasyon \u00fcretimi i\u00e7in olu\u015fturulan s\u00fcre\u00e7 iyi bir tekrarlanabilirlik, stabilite ve kontrol edilebilirli\u011fe sahiptir. Bu temelde, sanayile\u015fmi\u015f fermantasyon s\u00fcre\u00e7lerinin daha da geli\u015ftirilmesi, \u00c7in'de hayvanc\u0131l\u0131\u011f\u0131n sa\u011fl\u0131kl\u0131 geli\u015fimini te\u015fvik etmek i\u00e7in \u00f6nemli teorik ve pratik \u00f6neme sahip olan \u00c7in'de yeni anti nematod pestisitlerin geli\u015ftirilmesinin temelini olu\u015fturmaktad\u0131r.<\/p>\n

Correction: 10 September 2026. Corrected the veterinary product identity and removed a dosing sentence that incorrectly named dexmedetomidine. This is a targeted claim correction; other historical statements still require their own supporting evidence.<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nOptimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/yanit-yuzeyi-metodolojisi-kullanarak\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/yanit-yuzeyi-metodolojisi-kullanarak\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-06T12:45:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-10T03:15:38+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"Longchang Chemical\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/\",\"url\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/\",\"name\":\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png\",\"datePublished\":\"2024-08-06T12:45:17+00:00\",\"dateModified\":\"2026-09-10T03:15:38+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"description\":\"Longchang Chemical is the company publisher of chemical, ingredient and technical procurement information on longchangextracts.com. Publication responsibility rests with Shandong Longchang Chemical Co., Ltd. See the Authors & Editorial Responsibility page for the scope of this company byline and correction contacts.\",\"sameAs\":[\"https:\/\/longchangextracts.com\/authors\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Yan\u0131t Y\u00fczey Metodolojisi Kullan\u0131larak Paraherquamide A Fermantasyon S\u00fcrecinin Optimizasyonu - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/yanit-yuzeyi-metodolojisi-kullanarak\/","og_locale":"tr_TR","og_type":"article","og_title":"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology - China Chemical Manufacturer","og_description":"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology Parasitic nematode disease is a parasitic disease of livestock and poultry that seriously affects the development of animal husbandry. At present, avernectins are the most widely used antiparasitic drugs in veterinary clinical practice worldwide. However, due to the abuse of this drug, drug-resistant strains have […]","og_url":"https:\/\/longchangextracts.com\/tr\/yanit-yuzeyi-metodolojisi-kullanarak\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-06T12:45:17+00:00","article_modified_time":"2026-09-10T03:15:38+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"Longchang Chemical","Tahmini okuma s\u00fcresi":"6 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/","url":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/","name":"Yan\u0131t Y\u00fczey Metodolojisi Kullan\u0131larak Paraherquamide A Fermantasyon S\u00fcrecinin Optimizasyonu - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png","datePublished":"2024-08-06T12:45:17+00:00","dateModified":"2026-09-10T03:15:38+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/using-response-surface-methodology\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-243.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/using-response-surface-methodology\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Optimization of Paraherquamide A Fermentation Process Using Response Surface Methodology"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"Longchang Chemical","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"description":"Longchang Chemical, longchangextracts.com adresinde kimyasal, bile\u015fen ve teknik tedarik bilgilerini yay\u0131nlayan \u015firkettir. Yay\u0131n sorumlulu\u011fu Shandong Longchang Chemical Co., Ltd.\u2019ye aittir. Bu \u015firketin imza sat\u0131r\u0131n\u0131n kapsam\u0131 ve d\u00fczeltme i\u00e7in ileti\u015fim bilgileri hakk\u0131nda bilgi almak i\u00e7in \u201cYazarlar ve Yay\u0131n Sorumlulu\u011fu\u201d sayfas\u0131na bak\u0131n\u0131z.","sameAs":["https:\/\/longchangextracts.com\/authors\/"]}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6615"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=6615"}],"version-history":[{"count":2,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6615\/revisions"}],"predecessor-version":[{"id":10930,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6615\/revisions\/10930"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=6615"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=6615"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=6615"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}