{"id":6532,"date":"2024-08-06T12:27:57","date_gmt":"2024-08-06T12:27:57","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6532"},"modified":"2024-08-06T12:27:57","modified_gmt":"2024-08-06T12:27:57","slug":"huangbai","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/huangbai\/","title":{"rendered":"Huangbai'nin gut tedavisindeki mekanizmas\u0131n\u0131n a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Huangbai'nin gut tedavisindeki mekanizmas\u0131n\u0131n a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131
\nGut, kemik ve eklemlerde monosodyum \u00fcrat (MSU) birikiminin neden oldu\u011fu, p\u00fcrin metabolizmas\u0131 bozukluklar\u0131 ve\/veya azalm\u0131\u015f \u00fcrik asit at\u0131l\u0131m\u0131n\u0131n neden oldu\u011fu hiper\u00fcrisemi (HUA) ile do\u011frudan ili\u015fkili akut ve kronik bir artrittir; ana belirtisi hiper\u00fcrisemidir, buna akut artrit ataklar\u0131, gut tophi olu\u015fumu, eklem deformiteleri, b\u00f6brek ve di\u011fer organ hasarlar\u0131 e\u015flik eder. Hastal\u0131\u011f\u0131n ilerleyen a\u015famalar\u0131nda hipertansiyon, hiperlipidemi, metabolik sendrom ve di\u011fer hastal\u0131klar da ortaya \u00e7\u0131kabilir. Asya, Avrupa ve Kuzey Amerika'da yeti\u015fkinlerde gut prevalans\u0131 0,68% ile 3,90% aras\u0131nda de\u011fi\u015firken, \u00c7in'de 0,86% ile 2,20% aras\u0131nda de\u011fi\u015fmekte ve y\u0131ldan y\u0131la artan bir e\u011filim g\u00f6stererek daha gen\u00e7 ya\u015f gruplar\u0131na do\u011fru y\u00f6nelmektedir. Ara\u015ft\u0131rmalar, interl\u00f6kin-1 \u03b2 (IL-1 \u03b2) aktivitesini serbest b\u0131rakan makrofaj NOD benzeri resept\u00f6r \u0131s\u0131 protein alan\u0131 ili\u015fkili protein 3 (NLRP3) inflamazom sinyal yolunun MSU kristal aktivasyonunun gut artritinin temel patojenik mekanizmas\u0131 oldu\u011funu g\u00f6stermektedir; Gut hastal\u0131\u011f\u0131n\u0131 \u00f6nlemek ve tedavi etmek i\u00e7in klinik uygulamada yayg\u0131n olarak kullan\u0131lan ila\u00e7lar aras\u0131nda nonsteroidal anti-enflamatuar ila\u00e7lar, kol\u015fisin, glukokortikoidler vb. yer almaktad\u0131r. Ancak bunlar\u0131n kullan\u0131m\u0131 \u00e7e\u015fitli advers reaksiyonlar ve klinik kontrendikasyonlar ile s\u0131n\u0131rl\u0131d\u0131r. Bu nedenle, yeni anti-enflamatuar ila\u00e7lar\u0131n ve anti-gut ila\u00e7lar\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<\/p>\n

Phellodendron Chinensis Cortex (PCC), Rutaceae familyas\u0131ndan bir bitki olan Phellodendron chinense Schneid'in kurutulmu\u015f kabu\u011fudur. Genellikle \"Chuan Huangbai\" olarak bilinir ve \u0131s\u0131 ve nemi temizleme, ate\u015fi ve buhar\u0131 giderme, detoksifiye etme ve yaralar\u0131 tedavi etme etkilerine sahiptir. Modern farmakolojik \u00e7al\u0131\u015fmalar, Phellodendron Chinensis ve bitkisel form\u00fcl\u00fcn\u00fcn anti-enflamatuar, analjezik, \u00fcrik asit d\u00fc\u015f\u00fcr\u00fcc\u00fc ve anti-gut etkilerine sahip oldu\u011funu g\u00f6stermi\u015ftir, ancak anti-gut madde temeli ve spesifik mekanizmas\u0131 hala belirsizdir. Bu \u00e7al\u0131\u015fmada, Huangbai'nin gut hastal\u0131\u011f\u0131na kar\u015f\u0131 aktif bile\u015fenlerini ve temel hedeflerini tahmin etmek i\u00e7in a\u011f farmakolojisi y\u00f6ntemleri kullan\u0131lm\u0131\u015f ve ard\u0131ndan Huangbai'nin farmakolojik mekanizmas\u0131n\u0131 analiz etmek i\u00e7in biyoinformatik y\u00f6ntemler kullan\u0131larak protein-protein etkile\u015fim a\u011flar\u0131 (PPI) olu\u015fturulmu\u015ftur. Ayn\u0131 zamanda, aktif bile\u015fenlerin potansiyel hedef proteinlere ba\u011flanmas\u0131n\u0131 do\u011frulamak i\u00e7in molek\u00fcler yerle\u015ftirme teknolojisi kullan\u0131lm\u0131\u015f ve \u00e7ekirdek kimyasal bile\u015fenlerin anti-gut etkisi in vitro deneylere dayanarak do\u011frulanm\u0131\u015f, b\u00f6ylece Huangbai'nin anti-gut etkisinin olas\u0131 maddi temeli ve mekanizmas\u0131 ortaya \u00e7\u0131kar\u0131lm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma, otantik Sichuan \u015fifal\u0131 bitkisi Huangbai'nin farmakolojik ara\u015ft\u0131rmas\u0131n\u0131 zenginle\u015ftirecek ve Huangbai'yi geleneksel \u00c7in t\u0131bb\u0131 form\u00fcllerinin bir bile\u015feni olarak kullanarak gut ve komplikasyonlar\u0131n\u0131n \u00f6nlenmesi ve tedavisi i\u00e7in teorik bir temel sa\u011flayacakt\u0131r. Ayn\u0131 zamanda, Huangbai ve aktif bile\u015fenlerine dayal\u0131 yenilik\u00e7i yeni \u00c7in t\u0131bb\u0131 ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesi i\u00e7in sa\u011flam bir temel olu\u015fturacakt\u0131r.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Bu \u00e7al\u0131\u015fmadaki geleneksel \u00c7in t\u0131bb\u0131 etken maddelerinin anahtar hedeflerinin a\u011f diyagram\u0131, Phellodendron amurense'deki quercetin, rutaecarpine, \u03b2 - sitosterol, stigmasterol ve dehydrotanshinone IIA etken maddelerinin a\u011fda nispeten y\u00fcksek de\u011ferlere sahip oldu\u011funu g\u00f6stermektedir, bu da bunlar\u0131n anti gut etkileri i\u00e7in Phellodendron amurense'nin farmakolojik madde temeli olabilece\u011fini g\u00f6stermektedir. Quercetin, SIRT1 ifadesini yukar\u0131 do\u011fru d\u00fczenleyerek ve NLRP3 inflamazomunun aktivasyonunu bask\u0131layarak enflamatuar hasar\u0131 engelleyebilir. Ayn\u0131 zamanda bir XO inhibit\u00f6r\u00fc olarak kullan\u0131labilir ve gut kar\u015f\u0131t\u0131 etkileri olan yeni bir ila\u00e7 olarak geli\u015ftirilebilir. Wu Zhuyu alkaloidleri, JNK \/ p38MAPK sinyal yolunu bask\u0131layarak inflamasyonu ve oksidatif stresi inhibe edebilir; Kaspaz-12 ve NF - \u03ba B yollar\u0131n\u0131 e\u015fzamanl\u0131 olarak inhibe etmek, septik farelerde peritoneal makrofaj apoptozunu ve inflamatuar yan\u0131t\u0131 iyile\u015ftirir. \u03b2 - sitosterol, LPS taraf\u0131ndan ind\u00fcklenen IL-1 \u03b2 ve t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc - \u03b1 (TNF - \u03b1) gibi enflamatuar arac\u0131lar\u0131n sal\u0131n\u0131m\u0131n\u0131 azaltt\u0131\u011f\u0131 tespit edilen do\u011fal bir bitki sterol\u00fc ve antioksidand\u0131r. Hem sitosterol hem de \u03b2 - sitosterol bitki sterol s\u0131n\u0131f\u0131na aittir ve LPS ile ind\u00fcklenen COX-2 ve iNOS gen ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir, bu da bu bile\u015fiklerin gen ekspresyonunu ve enflamatuar fakt\u00f6rlerin sal\u0131n\u0131m\u0131n\u0131 inhibe ederek anti-enflamatuar etkiler g\u00f6sterebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Tanshinone IIA'n\u0131n aktif metaboliti olan dehydrotanshinone IIA'n\u0131n anti-enflamatuar ve anti-gut etkileri \u015fimdiye kadar rapor edilmemi\u015ftir. Bununla birlikte, Zhou ve arkada\u015flar\u0131n\u0131n ara\u015ft\u0131rmas\u0131na g\u00f6re, tanshinone IIA, LPS kaynakl\u0131 enflamasyonu ve kondrosit apoptozunu inhibe edebilir ve artritin enflamatuar yan\u0131t\u0131n\u0131 azaltmada ve eklem kondrositlerini korumada \u00f6nemli terap\u00f6tik etkilere sahiptir. Ayr\u0131ca LPS taraf\u0131ndan uyar\u0131lan makrofajlarda mitokondriyal reaktif oksijen t\u00fcrlerinin (ROS) \u00fcretimini azaltabilir, NLRP3 inflamazomunun aktivasyonunu inhibe edebilir ve gut iltihab\u0131n\u0131 hafifletebilir.<\/p>\n

PPI a\u011f analizi ve KEGG yol zenginle\u015ftirme analizi, Huangbai'nin gut tedavisindeki temel hedeflerinin, esas olarak PI3K Akt, MAPK ve di\u011fer sinyal yollar\u0131n\u0131 i\u00e7eren AKT1, TNF, IL-6 vb. i\u00e7erdi\u011fini g\u00f6stermi\u015ftir. Bunlar aras\u0131nda, en zengin sinyal yolu olarak PI3K\/Akt, h\u00fccre \u00e7o\u011falmas\u0131, apoptoz, enflamatuar yan\u0131t ve otofajinin d\u00fczenlenmesinde \u00f6nemli bir rol oynar. Y\u00fcksek \u00fcrik asit seviyeleri AKT-PRAS40 sinyal yolunu aktive edebilir, mTOR'u aktive edebilir, b\u00f6ylece otofajiyi inhibe edebilir, inflamatuar fakt\u00f6r IL-1 \u03b2 ekspresyonunu art\u0131rabilir ve IL-1 resept\u00f6r antagonistini (IL-Ra) bozarak inflamatuar yan\u0131t\u0131 \u015fiddetlendirebilir. Bu nedenle, AKT1 gut tedavisi i\u00e7in \u00f6nemli bir hedef olabilir. Ara\u015ft\u0131rmalar, otofaji inhibisyonunun inflamazom aktivasyonu ve IL-1 \u03b2 transkripsiyonunun yukar\u0131 reg\u00fclasyonu ile yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. MAPK sinyal yolunun zenginle\u015fme d\u00fczeyi, \u00e7e\u015fitli pro-enflamatuar s\u00fcre\u00e7lerle yak\u0131ndan ili\u015fkili olan PI3K\/Akt sinyal yolundan sonra ikinci s\u0131radad\u0131r. \u00c7\u00f6z\u00fcn\u00fcr \u00fcrik asidin p38 MAPK ve h\u00fccre d\u0131\u015f\u0131 sinyalle d\u00fczenlenen kinazlar\u0131 (ERK'ler) aktive edebildi\u011fi, ayr\u0131ca NF - \u03ba B ve AP1 transkripsiyon fakt\u00f6rlerini aktive edebildi\u011fi ve IL-1 \u03b2, IL-6 vb. inflamatuar sitokinlerin transkripsiyonunu yukar\u0131 do\u011fru d\u00fczenleyebildi\u011fi do\u011frulanm\u0131\u015ft\u0131r. Buna ek olarak, TNF'nin a\u015fa\u011f\u0131 ak\u0131\u015f sinyal yollar\u0131 olarak MAPK'lar, enflamatuar kaskad reaksiyonlar\u0131na arac\u0131l\u0131k edebilir ve gut hastal\u0131\u011f\u0131n\u0131 \u015fiddetlendirebilir. \u00d6zetle, Huangbai'nin otofajiyi ba\u015flatmak i\u00e7in PI3K\/Akt yolunu aktive edebilece\u011fini ve gut kar\u015f\u0131t\u0131 etkiler g\u00f6stermek i\u00e7in MAPK'lar gibi \u00e7oklu sinyal yollar\u0131n\u0131 d\u00fczenleyebilece\u011fini tahmin ediyoruz (bkz. \u015eekil 9).<\/p>\n

Bu \u00e7al\u0131\u015fmada, Phellodendron amurense'nin a\u011f farmakolojisi taraf\u0131ndan tahmin edilen aktif bile\u015fenlerinin AKT1, TNF, IL-6, PPARG ve PTGS2 anahtar hedeflerine ba\u011flanma yetene\u011fini do\u011frulamak i\u00e7in molek\u00fcler yerle\u015ftirme teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Aktif bile\u015fenler ile temel hedefler aras\u0131ndaki en d\u00fc\u015f\u00fck ba\u011flanma enerjisinin -9,60 ile -6,10 kcal\/mol aras\u0131nda oldu\u011fu, bunun da temel olarak hidrojen ba\u011f\u0131 etkile\u015fimleri yoluyla ger\u00e7ekle\u015fti\u011fi ve g\u00fc\u00e7l\u00fc ba\u011flanma kabiliyetine i\u015faret etti\u011fi bulunmu\u015ftur. Yukar\u0131daki ara\u015ft\u0131rma sonu\u00e7lar\u0131na dayanarak, bu \u00e7al\u0131\u015fmada MSU ile birlikte LPS taraf\u0131ndan ind\u00fcklenen bir in vitro inflamasyon modeli benimsenmi\u015ftir. Kuersetin, rutaekarpin, \u03b2 - sitosterol gibi temsili aktif bile\u015fenler ve Phellodendron amurense alkaloidleri ve Berberin gibi Phellodendron amurense'nin karakteristik bile\u015fenleri, g\u00fc\u00e7l\u00fc anti-enflamatuar etkilere sahip aktif bile\u015fenleri ara\u015ft\u0131rmak ve taramak i\u00e7in sonraki h\u00fccre deneyleri i\u00e7in se\u00e7ilmi\u015ftir. ELISA sonu\u00e7lar\u0131, Wu Zhuyu alkaloidinin d\u00fc\u015f\u00fck konsantrasyonlarda MSU taraf\u0131ndan ind\u00fcklenen inflamatuar fakt\u00f6rler IL-1 \u03b2 ve IL-6 sal\u0131n\u0131m\u0131 \u00fczerinde \u00f6nemli bir inhibit\u00f6r etkiye sahip oldu\u011funu ve in vitro anti-gut etkisinin Huangbai kalite belirte\u00e7leri olan berberin ve Huangbai alkaloidinden daha iyi oldu\u011funu g\u00f6stermi\u015ftir. Yukar\u0131daki \u00e7al\u0131\u015fmalar, a\u011f farmakolojisi taraf\u0131ndan tahmin edilen aktif bile\u015fenlerin, gut kar\u015f\u0131t\u0131 geleneksel \u00c7in t\u0131bb\u0131 \u00fczerine daha sonraki ara\u015ft\u0131rmalar i\u00e7in yeni ila\u00e7lar veya ila\u00e7 \u00f6nc\u00fcleri olarak kullan\u0131labilecek potansiyel gut kar\u015f\u0131t\u0131 aktif bile\u015fenler olabilece\u011fini g\u00f6stermektedir.<\/p>\n

\u00d6zetle, bu \u00e7al\u0131\u015fma Huangbai'nin gut tedavisindeki maddi temelini ve mekanizmas\u0131n\u0131 a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme y\u00f6ntemleri ve in vitro deneysel do\u011frulama kullanarak ara\u015ft\u0131rm\u0131\u015ft\u0131r. A\u011f farmakolojisi, disiplinler aras\u0131 uygulamalar ve genel biyolojik a\u011f analizi yoluyla \"\u00e7ok bile\u015fenli, \u00e7ok hedefli ve \u00e7ok yollu\" geleneksel \u00c7in t\u0131bb\u0131n\u0131n (bile\u015fik) etkili bir \u015fekilde tahmin edilmesini sa\u011flam\u0131\u015f olsa da, \u00e7e\u015fitli veri tabanlar\u0131ndaki e\u015fit olmayan bilgiler, bile\u015fen hedef bilgilerine s\u0131n\u0131rl\u0131 eri\u015fim ve birden fazla geleneksel \u00c7in ilac\u0131n\u0131n belirsiz in vivo etkile\u015fim mekanizmalar\u0131 gibi hala \u00e7\u00f6z\u00fclmesi gereken \u00e7e\u015fitli sorunlar vard\u0131r. Takip ara\u015ft\u0131rma ekibi, Huangbai'nin gut hastal\u0131\u011f\u0131n\u0131n \u00f6nlenmesi ve tedavisinde klinik uygulamas\u0131 i\u00e7in teorik temel sa\u011flamak ve Huangbai ve aktif bile\u015fenlerine dayal\u0131 yenilik\u00e7i geleneksel \u00c7in t\u0131bb\u0131 yeni ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesi i\u00e7in sa\u011flam bir temel olu\u015fturmak amac\u0131yla, hedefler, sinyal yollar\u0131 ve aktif bile\u015fenlerin in vivo deneyleri dahil olmak \u00fczere anti-gut aktif maddeleri ve mekanizmalar\u0131 hakk\u0131nda daha fazla ara\u015ft\u0131rma yapacakt\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification Gout is an acute and chronic arthritis caused by the deposition of monosodium urate (MSU) in bones and joints, which is directly related to hyperuricemia (HUA) caused by purine metabolism disorders and\/or reduced uric acid excretion; The main […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/huangbai\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Huangbai in treating gout based on network pharmacology, molecular docking, and experimental verification Gout is an acute and chronic arthritis caused by the deposition of monosodium urate (MSU) in bones and joints, which is directly related to hyperuricemia (HUA) caused by purine metabolism disorders and\/or reduced uric acid excretion; 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