{"id":6458,"date":"2024-08-06T12:14:47","date_gmt":"2024-08-06T12:14:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6458"},"modified":"2024-08-06T12:14:47","modified_gmt":"2024-08-06T12:14:47","slug":"volatile-oil-components","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/volatile-oil-components\/","title":{"rendered":"Plantago asiatica'daki U\u00e7ucu Ya\u011f Bile\u015fenlerinin GC-MS Analizine Dayal\u0131 Farkl\u0131l\u0131klar\u0131 ve Benzerlikleri"},"content":{"rendered":"<p>Plantago asiatica'daki U\u00e7ucu Ya\u011f Bile\u015fenlerinin GC-MS Analizine Dayal\u0131 Farkl\u0131l\u0131klar\u0131 ve Benzerlikleri<br \/>\nDuoji orijinal t\u0131bbi malzemeleri, \u00c7in Farmakopesi'nde listelenen \u00c7in t\u0131bbi malzemelerinin \u00f6nemli bir bile\u015fenidir. 'Birden fazla k\u00f6kene sahip tek bitki', iki veya daha fazla t\u00fcr kayna\u011f\u0131na sahip ayn\u0131 \u00c7in t\u0131bbi bitkisini ifade eder. Birden fazla k\u00f6kene sahip tek bir ila\u00e7, geleneksel \u00c7in t\u0131bb\u0131 kayna\u011f\u0131n\u0131n geni\u015fletilmesi ve klinik ila\u00e7 talebinin sa\u011flanmas\u0131 \u00fczerinde olumlu bir etkiye sahiptir, ancak farkl\u0131 k\u00f6kenlerin malzeme temelinde baz\u0131 farkl\u0131l\u0131klar olabilir ve bu da klinik uygulamaya baz\u0131 zorluklar getirir. Bay Xie Zongwan, tek bir bitkinin farkl\u0131 \u00e7e\u015fitlerinin i\u015flev ve endikasyonlar\u0131n\u0131n son derece benzer olmas\u0131 gerekti\u011fine inanmaktad\u0131r. Farkl\u0131 \u00e7e\u015fitlerin i\u015flev ve endikasyonlar\u0131ndaki y\u00fcksek tutarl\u0131l\u0131k derecesi, farmakolojik madde temellerindeki y\u00fcksek benzerli\u011fe atfedilmelidir. Bu nedenle, \u00e7ok bazl\u0131 orijinal t\u0131bbi malzemelerin farkl\u0131 \u00e7e\u015fitlerinin madde temeli \u00fczerinde kar\u015f\u0131la\u015ft\u0131rmal\u0131 ara\u015ft\u0131rmalar yap\u0131lmas\u0131 gerekmektedir.<\/p>\n<p>Plantago asiatica L. veya Plantago depression Willd. olarak da bilinen Plantago asiatica L., Plantago asiatica L. veya Plantago depression Willd.'den elde edilen kurutulmu\u015f b\u00fct\u00fcn bir bitkidir. Plantago asiatica'n\u0131n \u0131s\u0131y\u0131 temizleme, di\u00fcrez, di\u00fcrezi te\u015fvik etme, balgam\u0131 ortadan kald\u0131rma, kan\u0131 so\u011futma ve detoksifiye etme etkileri vard\u0131r. Is\u0131ya ba\u011fl\u0131 a\u011fr\u0131, \u00f6dem, olig\u00fcri, \u0131s\u0131 ve rutubetin neden oldu\u011fu ishal, balgaml\u0131 s\u0131cak \u00f6ks\u00fcr\u00fck, kan kusma ve kanama, apse ve yaralar gibi semptomlar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Modern farmakolojik ara\u015ft\u0131rmalar Plantago asiatica'n\u0131n kan lipitlerini d\u00fc\u015f\u00fcrme, ya\u015flanmay\u0131 geciktirme, antibakteriyel ve anti-inflamatuar, antioksidan ve anti-t\u00fcm\u00f6r gibi farmakolojik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. U\u00e7ucu ya\u011f, Plantago asiatica'n\u0131n \u00f6nemli bir t\u0131bbi maddesidir, ancak \u015fu anda iki farkl\u0131 Plantago asiatica t\u00fcr\u00fcn\u00fcn u\u00e7ucu ya\u011f bile\u015fenlerini kar\u015f\u0131la\u015ft\u0131ran bir rapor bulunmamaktad\u0131r. Bu \u00e7al\u0131\u015fma, kurutulmu\u015f b\u00fct\u00fcn muz ve d\u00fcz yatakl\u0131 muzdaki u\u00e7ucu ya\u011f bile\u015fenlerini kar\u015f\u0131la\u015ft\u0131rmak ve analiz etmek i\u00e7in kimyasal \u00f6r\u00fcnt\u00fc tan\u0131ma ile birlikte gaz kromatografisi-k\u00fctle spektrometresi teknolojisini kullanan ilk \u00e7al\u0131\u015fmad\u0131r ve muzun rasyonel klinik kullan\u0131m\u0131 i\u00e7in bilimsel temel sa\u011flamay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6459\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-231.png\" alt=\"\" width=\"721\" height=\"438\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6460\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-192.png\" alt=\"\" width=\"711\" height=\"305\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6461\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-180.png\" alt=\"\" width=\"605\" height=\"838\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-180.png 605w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-180-520x720.png 520w\" sizes=\"(max-width: 605px) 100vw, 605px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6462\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-159.png\" alt=\"\" width=\"613\" height=\"843\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-159.png 613w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-159-524x720.png 524w\" sizes=\"(max-width: 613px) 100vw, 613px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6463\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-143.png\" alt=\"\" width=\"599\" height=\"843\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-143.png 599w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-143-512x720.png 512w\" sizes=\"(max-width: 599px) 100vw, 599px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6464\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-129.png\" alt=\"\" width=\"603\" height=\"840\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-129.png 603w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-129-517x720.png 517w\" sizes=\"(max-width: 603px) 100vw, 603px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6465\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-117.png\" alt=\"\" width=\"721\" height=\"256\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6466\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-106.png\" alt=\"\" width=\"701\" height=\"263\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6467\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-98.png\" alt=\"\" width=\"706\" height=\"319\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6468\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-78.png\" alt=\"\" width=\"711\" height=\"361\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6469\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-72.png\" alt=\"\" width=\"711\" height=\"363\" \/><br \/>\nSon y\u0131llarda, gaz kromatografisi-k\u00fctle spektrometresi (GC-MS) teknolojisi, geleneksel \u00c7in t\u0131bb\u0131ndaki u\u00e7ucu bile\u015fenlerin tan\u0131mlanmas\u0131 i\u00e7in yayg\u0131n olarak kullan\u0131lmakta ve baz\u0131 karma\u015f\u0131k u\u00e7ucu ya\u011f bile\u015fenlerinin ayr\u0131lmas\u0131 ve tespit edilmesinin entegrasyonunu sa\u011flamaktad\u0131r. Bununla birlikte, \u00f6l\u00e7\u00fclen veri setinin b\u00fcy\u00fck boyutu ve y\u00fcksek enlem, y\u00fcksek g\u00fcr\u00fclt\u00fc, de\u011fi\u015fkenler aras\u0131nda y\u00fcksek korelasyon ve y\u00fcksek de\u011fi\u015fkenlik gibi karma\u015f\u0131k \u00f6zellikleri nedeniyle, s\u0131k\u0131c\u0131 veri setinden farkl\u0131 \u00f6rnekler aras\u0131ndaki benzerlikleri ve farkl\u0131l\u0131klar\u0131 ke\u015ffetmek i\u00e7in kimyasal stokiyometriyi birle\u015ftirmek, daha sonraki veri analizi i\u00e7in pop\u00fcler bir ara\u00e7t\u0131r. \u015eu anda, kemometrik y\u00f6ntemlerle birle\u015ftirilmi\u015f GC-MS, geleneksel \u00c7in t\u0131bb\u0131n\u0131n benzer \u00e7e\u015fitlerinin tan\u0131mlanmas\u0131nda yayg\u0131n olarak kullan\u0131lmaktad\u0131r.<\/p>\n<p>Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, d\u00fcz yatakl\u0131 nakliye \u00f6ncesinde 7 parti Plantago asiatica ve 7 parti u\u00e7ucu ya\u011fda, \u00e7o\u011funlukla alkanlar ve asitlerden olu\u015fan toplam 62 kimyasal bile\u015fen tespit edildi\u011fini g\u00f6stermi\u015ftir. Plantago asiatica 10 bile\u015fene sahipken, Platycodon grandiflorus 12 bile\u015fene sahiptir. Bunlar aras\u0131nda, Plantago asiatica ve Platycodon grandiflorus'ta nispeten y\u00fcksek ortalama nispi i\u00e7eri\u011fe sahip kimyasal bile\u015fenler, s\u0131ras\u0131yla 46.4%, 15.38%, 19.11% ve 35.93%, 9.69% ve 15.48%'ye kar\u015f\u0131l\u0131k gelen esas olarak palmitik asit, linoleik asit ve alfa linolenik asittir. Bu sonu\u00e7, Al Mazroa ve arkada\u015flar\u0131n\u0131n Plantago asiatica'n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n ana bile\u015fen palmitik asit i\u00e7erdi\u011fine dair bulgular\u0131yla benzerlik g\u00f6stermektedir. Hui ve arkada\u015flar\u0131, Plantago asiatica'n\u0131n u\u00e7ucu ya\u011f bile\u015fenlerinin en y\u00fcksek 2,6-di-tert-butyl-p-cresol i\u00e7eri\u011fine sahip oldu\u011funu bulmu\u015f ve ara\u015ft\u0131rmadaki farkl\u0131l\u0131klar\u0131n Plantago asiatica'n\u0131n tutars\u0131z ekstraksiyon y\u00f6ntemleriyle ilgili olabilece\u011fini \u00f6ne s\u00fcrm\u00fc\u015ft\u00fcr.<\/p>\n<p>\u00c7ok k\u00f6kenli geleneksel \u00c7in t\u0131bb\u0131n\u0131n e\u015fde\u011ferli\u011fi, \u00c7in t\u0131bb\u0131n\u0131n kalitesini de\u011ferlendirmenin \u00f6nemli bir y\u00f6n\u00fcd\u00fcr. Ara\u015ft\u0131rma grubumuz daha \u00f6nce Yangchun kum \u00e7ekirde\u011fi, ye\u015fil kabuklu kum \u00e7ekirde\u011fi, Sichuan Gaoben ve Liao Gaoben'in u\u00e7ucu bile\u015fenlerini kar\u015f\u0131la\u015ft\u0131rmak ve incelemek i\u00e7in kemometri ile birlikte GC-MS teknolojisini kullanm\u0131\u015ft\u0131r. HCA ve PCA sonu\u00e7lar\u0131na g\u00f6re, Yangchun kum \u00e7ekirde\u011fi ve ye\u015fil kabuklu kum \u00e7ekirde\u011finin yan\u0131 s\u0131ra Chuangaoben ve Liaogaoben tamamen ayr\u0131labilir. Bununla birlikte, bu \u00e7al\u0131\u015fma 7 Plantago asiatica partisi ile 7 Platycodon grandiflorus partisi aras\u0131nda 9 ortak bile\u015fen oldu\u011funu ve g\u00f6receli y\u00fczdelerin 80%'den fazla oldu\u011funu ve i\u00e7eri\u011fin palmitik asit, linoleik asit ve alfa linolenik asitte daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir; Benzerlik analizi sonu\u00e7lar\u0131na g\u00f6re, t\u00fcm partilerin benzerli\u011fi 0'\u0131n \u00fczerindedir.967'nin \u00fczerindedir ve bu da y\u00fcksek bir genel benzerli\u011fe i\u015faret etmektedir; HCA ve 3D PCA s\u0131n\u0131fland\u0131rma sonu\u00e7lar\u0131ndan, Plantago asiatica'n\u0131n 14 partisinin tamam\u0131n\u0131n \u00e7e\u015fitlere g\u00f6re tamamen ay\u0131rt edilemedi\u011fi g\u00f6r\u00fclebilir. VIP de\u011ferleri 1'den b\u00fcy\u00fck olan OPLS-DA modeli kullan\u0131larak, yukar\u0131daki s\u0131n\u0131fland\u0131rmaya \u00f6nemli \u00f6l\u00e7\u00fcde katk\u0131da bulunan bile\u015fenler palmitik asit, linoleik asit ve alfa linolenik asit olarak tan\u0131mlanm\u0131\u015ft\u0131r. \u00d6zetle, araban\u0131n ve d\u00fcz yata\u011f\u0131n \u00f6n\u00fcndeki u\u00e7ucu ya\u011f bile\u015fenleri olduk\u00e7a benzerdir, bu nedenle her ikisinin de ayn\u0131 \u015fifal\u0131 bitki olarak kullan\u0131lmas\u0131 i\u00e7in belirli bir bilimsel temel vard\u0131r. U\u00e7ucu olmayan bile\u015fenlerinin ayn\u0131 \u00f6zelliklere sahip olup olmad\u0131\u011f\u0131 daha fazla incelenmeye de\u011fer.<\/p>\n<p>\u00d6zetle, bu \u00e7al\u0131\u015fma Plantago asiatica ve Plantago asiatica'n\u0131n u\u00e7ucu ya\u011f bile\u015fenlerini kar\u015f\u0131la\u015ft\u0131rmak i\u00e7in kimyasal modellerle birlikte GC-MS teknolojisini kullanan ilk \u00e7al\u0131\u015fmad\u0131r ve ikisinin u\u00e7ucu ya\u011f bile\u015fenlerinin olduk\u00e7a benzer oldu\u011funu bulmu\u015ftur. Bu, \u00c7in \u015fifal\u0131 bitkisi Plantago asiatica'n\u0131n \"tek ila\u00e7, \u00e7oklu kaynak\" bilimsel \u00e7a\u011fr\u0131\u015f\u0131m\u0131n\u0131n ayd\u0131nlat\u0131lmas\u0131 i\u00e7in temel olu\u015fturmaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Differences and Similarities of Volatile Oil Components in Plantago asiatica Based on GC-MS Analysis Duoji original medicinal materials are an important component of Chinese medicinal materials listed in the Chinese Pharmacopoeia. &#8216;One herb with multiple origins&#8217; refers to the same Chinese medicinal herb having two or more species sources. 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