{"id":6452,"date":"2024-08-06T12:11:32","date_gmt":"2024-08-06T12:11:32","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6452"},"modified":"2024-08-06T12:11:32","modified_gmt":"2024-08-06T12:11:32","slug":"acacetin-j8","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/acacetin-j8\/","title":{"rendered":"Asasetin J8'in endotel h\u00fccre proliferasyon hedefleri ve apoptoz ile ilgili h\u00fccre sinyal yolaklar\u0131 \u00fczerindeki inhibit\u00f6r etkisi \u00fczerine molek\u00fcler yerle\u015ftirme tabanl\u0131 \u00e7al\u0131\u015fma"},"content":{"rendered":"

Asasetin J8'in endotel h\u00fccre proliferasyon hedefleri ve apoptoz ile ilgili h\u00fccre sinyal yolaklar\u0131 \u00fczerindeki inhibit\u00f6r etkisi \u00fczerine molek\u00fcler yerle\u015ftirme tabanl\u0131 \u00e7al\u0131\u015fma
\nAkasya kabu\u011fu, Albizia julibrissin Durazz baklagilinin kurutulmu\u015f kabu\u011fudur. Tatl\u0131 ve hafif bir tad\u0131 vard\u0131r ve farmakopede depresyonu hafifletme, zihni sakinle\u015ftirme, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve \u015fi\u015fli\u011fi azaltma etkilerine sahip oldu\u011fu kaydedilmi\u015ftir. Esas olarak huzursuzluk, depresyon, uykusuzluk, akci\u011fer apsesi, yaralar ve d\u00fc\u015fmelerden kaynaklanan a\u011fr\u0131 gibi semptomlar\u0131n tedavisinde kullan\u0131l\u0131r. Modern farmakolojik \u00e7al\u0131\u015fmalar, Akasya kabu\u011funun ham \u00f6zlerinin ve toplam saponinlerinin in vivo ve in vitro t\u00fcm\u00f6r h\u00fccresi \u00e7o\u011falmas\u0131n\u0131 inhibe etme aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Zhu Liangchun gibi \u00fcnl\u00fc doktorlar akasya kabu\u011fu gibi ila\u00e7larla akci\u011fer kanseri tedavisinde iyi klinik sonu\u00e7lar elde etmi\u015flerdir. Anti-t\u00fcm\u00f6r anjiyogenez aktivitesinin rehberli\u011finde, bu projenin \u00f6n \u00e7al\u0131\u015fmas\u0131, Akasya kabu\u011fundan t\u00fcm\u00f6r anjiyogenezini inhibe eden etkili bile\u015fenleri ve aktif bile\u015fenleri izole edip safla\u015ft\u0131rd\u0131 ve aktif bile\u015fenlerini julioside J8 (J8) olarak tan\u0131mlad\u0131. Ara\u015ft\u0131rma sonu\u00e7lar\u0131, J8'in endotel h\u00fccre proliferasyonu \u00fczerinde \u00f6nemli inhibit\u00f6r aktiviteye sahip oldu\u011funu g\u00f6stermi\u015ftir. Ve h\u00fccre apoptozuna neden olabilir. Bununla birlikte, etkilerini g\u00f6stermek i\u00e7in h\u00fccre d\u0131\u015f\u0131ndan ve h\u00fccre zar\u0131ndan, sitoplazmadan \u00e7ekirde\u011fe sinyal iletimini nas\u0131l d\u00fczenledi\u011fi hala belirsizdir ve yurti\u00e7inde ve yurtd\u0131\u015f\u0131nda ara\u015ft\u0131rma raporlar\u0131 yoktur. Bu \u00e7al\u0131\u015fmada, J8'in endotel h\u00fccre proliferasyonu \u00fczerindeki inhibit\u00f6r etkisinin hedeflerini ve apoptoz ile ilgili h\u00fccre sinyal yolaklar\u0131n\u0131 analiz etmek i\u00e7in in vitro h\u00fccre deneyleri ile birlikte molek\u00fcler yerle\u015ftirme kullan\u0131lm\u0131\u015ft\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"J8, Akasya kabu\u011fundan izole edilen bir saponindir. \u00d6nceki \u00e7al\u0131\u015fmalar, hem in vitro hem de in vivo t\u00fcm\u00f6r anjiyogenezi \u00fczerinde inhibe edici etkileri oldu\u011funu ve endotelyal h\u00fccre apoptozunu ind\u00fckleyebilece\u011fini \u00f6ne s\u00fcrm\u00fc\u015ft\u00fcr. Bununla birlikte, h\u00fccre apoptozunu ind\u00fckledi\u011fi yol \u00e7ok a\u00e7\u0131k de\u011fildir. J8'in endotel h\u00fccre apoptozunu ind\u00fckleme mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in, literat\u00fcrde bildirilen ekstraksiyon, izolasyon ve tan\u0131mlama y\u00f6ntemleri kullan\u0131larak yeni bir numune grubu haz\u0131rland\u0131 ve aktiviteleri tespit edildi. J8'in h\u00fccreler \u00fczerindeki etki mekanizmas\u0131n\u0131, J8'in h\u00fccrelerin i\u00e7ine girip girmedi\u011fini veya h\u00fccre zar\u0131ndaki y\u00fczey proteinleriyle etkile\u015fime girip girmedi\u011fini ara\u015ft\u0131rmak i\u00e7in, h\u00fccre i\u00e7indeki ve d\u0131\u015f\u0131ndaki J8 konsantrasyonunu tespit etmek i\u00e7in HPLC kullan\u0131ld\u0131. Sonu\u00e7lar J8'in endotel h\u00fccrelerinin i\u00e7ine girmedi\u011fini ve sadece h\u00fccre zar\u0131ndaki y\u00fczey proteinleriyle etkile\u015fime girdi\u011fini g\u00f6stermi\u015ftir. Belirli proteinlerle etkile\u015fimini daha fazla ara\u015ft\u0131rmak i\u00e7in, deney ilk olarak apoptoz DR3\u3001DR4\u3001DR5\u3001TFR-1\uff0c ile ili\u015fkili membran proteinleri FAS, FAS ve FAS'\u0131 yerle\u015ftirmek i\u00e7in molek\u00fcler yerle\u015ftirme kulland\u0131 ve J8'in sadece h\u00fccre \u00e7o\u011falmas\u0131yla ilgili proteinler olan FAS ve VEGF'ye iyi ba\u011fland\u0131\u011f\u0131 bulundu.
\nVask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc VEGF, endotelyal h\u00fccre proliferasyonunu, g\u00f6\u00e7\u00fcn\u00fc, artm\u0131\u015f vask\u00fcler ge\u00e7irgenli\u011fi ve anjiyogenezi te\u015fvik edebilen olduk\u00e7a spesifik bir pro endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fcd\u00fcr. VEGF aktivitesinin inhibe edilmesi, t\u00fcm\u00f6r kan damarlar\u0131n\u0131n olu\u015fumunu \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilir ve b\u00f6ylece anti-t\u00fcm\u00f6r tedavisinin terap\u00f6tik hedefine ula\u015fabilir. Literat\u00fcr, Akasya kabu\u011fundan elde edilen toplam saponinlerin t\u00fcm\u00f6r kan damarlar\u0131n\u0131n olu\u015fumunu \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebildi\u011fini ve VEGF aktivitesini bask\u0131layabildi\u011fini bildirmektedir. J8 saponinlerden biridir ve molek\u00fcler yerle\u015ftirme ve in vitro molek\u00fcler tespit, J8'in VEGF'ye ba\u011flanabildi\u011fini ve b\u00f6ylece endotelyal h\u00fccrelerin \u00e7o\u011falmas\u0131n\u0131 engelledi\u011fini g\u00f6stermi\u015ftir.
\nModern molek\u00fcler ve h\u00fccresel farmakoloji ara\u015ft\u0131rmalar\u0131, h\u00fccre apoptozunun sinyal iletiminin iki yola ayr\u0131labilece\u011fini \u00f6ne s\u00fcrmektedir: eksojen ve endojen (mitokondriyal) yollar. Ekzojen apoptotik yola\u011fa TNF-a, TRAIL, FAS-L gibi apoptoz resept\u00f6rleri arac\u0131l\u0131k eder. Fas-L, h\u00fccre apoptozunu ba\u015flatmak i\u00e7in FADD'yi i\u015fe alarak ve ba\u011flayarak FAS'a ba\u011flan\u0131r. Mitokondri, farkl\u0131 sinyal yollar\u0131na dayal\u0131 olarak Kaspaz ba\u011f\u0131ml\u0131 ve Kaspaz ba\u011f\u0131ml\u0131 olmayan apoptotik sinyal yollar\u0131na ayr\u0131labilen endojen h\u00fccre apoptozunun d\u00fczenleyici merkezidir. FADD'nin Kaspaz-8'e ba\u011flanmas\u0131 Kaspaz-8 dimerizasyonuna, yani aktivasyonuna yol a\u00e7abilir. Aktive olan Kaspaz-8, Kaspaz-3\/9'u yeniden aktive ederek h\u00fccre apoptozunu ind\u00fckler. Kaspaz ba\u011f\u0131ml\u0131 olmayan apoptotik sinyal yolu esas olarak AIF ve EnDOG'un sal\u0131nmas\u0131 yoluyla sa\u011flan\u0131r, bunlar\u0131n her ikisi de b\u00fcy\u00fck miktarlarda DNA par\u00e7alanmas\u0131na neden olabilir ve h\u00fccre apoptozunu ind\u00fckleyebilir. Deneysel do\u011frulama yoluyla, HUVEC h\u00fccrelerine J8 (2,5 \u03bcg\/mL) eklendikten sonra VEGF, JNK ve di\u011fer proteinlerin ifadesinin \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 reg\u00fcle edildi\u011fi, apoptozla ilgili proteinler p-JNK, Bax ve EnDOG'un ifadesinin ise \u00f6nemli \u00f6l\u00e7\u00fcde yukar\u0131 reg\u00fcle edildi\u011fi bulunmu\u015ftur. J8'in Kaspaz-3, Kaspaz-8 ve Kaspaz-9 ekspresyon seviyeleri \u00fczerinde \u00f6nemli bir etkisi yoktu ve stresle aktive olan bir protein kinaz olan JNK'n\u0131n fosforilasyonunu te\u015fvik edebilirdi. Aktive edilen JNK yolu apoptozla ilgili hedef genlerin ekspresyonunu d\u00fczenleyebilir ve b\u00f6ylece h\u00fccre apoptozunu ind\u00fckleyebilir. Bax ve EnDOG, JNK yolunun a\u015fa\u011f\u0131 ak\u0131\u015f hedef genleridir. J8 ile muamele edildikten sonra, ifade seviyeleri de artar, bu da J8'in VEGF\/JNK yolunun aktivitesini zay\u0131flatarak h\u00fccre \u00f6l\u00fcm\u00fcne neden olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcr\u00fcr. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, J8'in JNK sinyal yolunu d\u00fczenleyerek vask\u00fcler endotelyal h\u00fccrelerin apoptozunu te\u015fvik edebilece\u011fini, di\u011fer bilim adamlar\u0131 taraf\u0131ndan gelecekteki ara\u015ft\u0131rmalar i\u00e7in fikirler sa\u011flayabilece\u011fini ve t\u00fcm\u00f6r anjiyogenez tedavisini inhibe etmek i\u00e7in yeni ara\u015ft\u0131rma ila\u00e7lar\u0131 sunabilece\u011fini g\u00f6stermektedir. Bununla birlikte, bu \u00e7al\u0131\u015fman\u0131n da baz\u0131 eksiklikleri vard\u0131r ve gelecekteki ara\u015ft\u0131rmalarda JNK sinyal yolunun yukar\u0131 ve a\u015fa\u011f\u0131 y\u00f6n\u00fcndeki proteinlerin kapsaml\u0131 bir \u015fekilde tespit edilmesi gerekmektedir. In vitro h\u00fccre deneylerinde baz\u0131 sapmalar olabilir ve deneysel sonu\u00e7lar\u0131n klinik ve hayvan deneylerinde do\u011frulanmas\u0131 gerekir.
\n\u00d6zetle, J8 VEGF \u00fczerinde etkili olarak h\u00fccre proliferasyonunu inhibe edebilirken, JNK sinyal yolunu d\u00fczenleyerek vask\u00fcler endotelyal h\u00fccrelerin apoptozunu te\u015fvik eder ve apoptoz oran\u0131 artan konsantrasyonla \u00f6nemli \u00f6l\u00e7\u00fcde artar.<\/p>","protected":false},"excerpt":{"rendered":"

Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways Acacia bark is the dried bark of the legume Albizia julibrissin Durazz. It has a sweet and mild taste, and is recorded in pharmacopoeia as having the effects of relieving depression, calming the […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMolecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/acacetin-j8\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Molecular docking based study on the inhibitory effect of acacetin J8 on endothelial cell proliferation targets and apoptosis related cell signaling pathways Acacia bark is the dried bark of the legume Albizia julibrissin Durazz. 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