{"id":6386,"date":"2024-08-06T11:52:55","date_gmt":"2024-08-06T11:52:55","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6386"},"modified":"2024-08-06T11:52:55","modified_gmt":"2024-08-06T11:52:55","slug":"volatile-component-quality-markers","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/volatile-component-quality-markers\/","title":{"rendered":"GC-MS parmak izi ve a\u011f farmakolojisine dayal\u0131 olarak Atractylodes macrocephala'da u\u00e7ucu bile\u015fen kalite belirte\u00e7lerinin tahmini ve analizi"},"content":{"rendered":"<p>GC-MS parmak izi ve a\u011f farmakolojisine dayal\u0131 olarak Atractylodes macrocephala'da u\u00e7ucu bile\u015fen kalite belirte\u00e7lerinin tahmini ve analizi<br \/>\nGeleneksel \u00c7in t\u0131bb\u0131 genellikle birden fazla k\u00f6ken ve birden fazla \u00fcretim yeri gibi karma\u015f\u0131k ko\u015fullara sahiptir ve kalite a\u00e7\u0131s\u0131ndan \u00f6nemli farkl\u0131l\u0131klar g\u00f6sterir. Geleneksel \u00c7in t\u0131bb\u0131 i\u00e7in bilimsel ve makul bir kalite g\u00fcvence sisteminin kurulmas\u0131 acildir. \u015eu anda, \u00c7in t\u0131bbi malzemeleri i\u00e7in kalite kontrol g\u00f6stergelerinin \u00e7o\u011fu i\u00e7erdikleri kimyasal bile\u015fenlere g\u00f6re se\u00e7ilmektedir, ancak bunlar\u0131n ila\u00e7 etkinli\u011fi ile korelasyonu yetersizdir. Buna dayanarak Akademisyen Liu Changxiao \"geleneksel \u00c7in t\u0131bb\u0131 kalite belirte\u00e7lerinin\" kullan\u0131lmas\u0131 kavram\u0131n\u0131 \u00f6nermi\u015ftir. \u00c7in t\u0131bb\u0131 kalite belirte\u00e7leri, \u00c7in t\u0131bb\u0131 kalite kontrol\u00fcn\u00fcn geli\u015fim y\u00f6n\u00fcn\u00fc yans\u0131tan, \u00c7in t\u0131bb\u0131n\u0131n i\u015flevsel \u00f6zellikleriyle yak\u0131ndan ili\u015fkili kimyasal maddelerdir. Bu nedenle, geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite belirte\u00e7lerini incelemek, \u00c7in'deki geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite kontrol seviyesini iyile\u015ftirmek ve klinik kullan\u0131m i\u00e7in g\u00fcvenli ve etkili geleneksel \u00c7in t\u0131bb\u0131 \u00fcr\u00fcnleri sa\u011flamak i\u00e7in \u00f6nemli bir ara\u00e7t\u0131r.<\/p>\n<p>Atractylodes macrocephala, dala\u011f\u0131 g\u00fc\u00e7lendirme, nemi kurutma, di\u00fcrezi te\u015fvik etme ve terlemeyi durdurma etkilerine sahip, yayg\u0131n olarak kullan\u0131lan geleneksel bir \u00c7in ilac\u0131d\u0131r. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n klinik uygulamalar\u0131nda yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bununla birlikte, \u015fu anda Atractylodes macrocephala i\u00e7in end\u00fcstride tan\u0131nan bir kalite belirteci yoktur, bu da kalitesinin iyile\u015ftirilmesini ve daha fazla geli\u015ftirilmesini ve kullan\u0131lmas\u0131n\u0131 etkileyecektir. Mevcut ara\u015ft\u0131rmalar, u\u00e7ucu ya\u011flar\u0131n ve polisakkaritlerin Atractylodes macrocephala'n\u0131n ana aktif bile\u015fenleri oldu\u011funu g\u00f6stermektedir. Benzersiz yap\u0131lar\u0131 nedeniyle, polisakkaritlerin kalite belirte\u00e7leri veya kalite kontrol bile\u015fenleri olarak kullan\u0131lmas\u0131 \u015fu anda zordur. Ara\u015ft\u0131rmalar, Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n gastrointestinal sistemi d\u00fczenleme, mide mukozas\u0131n\u0131 onarma, bakterileri inhibe etme ve karaci\u011feri koruma gibi Atractylodes macrocephala'n\u0131nkine benzer farmakolojik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. GC-MS gibi teknikler kullan\u0131larak kalitatif ve kantitatif tespit sa\u011flanabilir. Bu nedenle, Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131ndan kalite belirte\u00e7lerinin taranmas\u0131 uygulanabilir ve etkili bir yakla\u015f\u0131md\u0131r. Ancak, Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131 k\u00f6ken, toprak, iklim ve hasat gibi fakt\u00f6rlerden etkilenerek kimyasal bile\u015fimde \u00f6nemli farkl\u0131l\u0131klara neden olur. Bu nedenle, ortak kimyasal \u00f6zelliklerini tan\u0131mlamak ve aday kalite belirte\u00e7lerini \u00f6nceden belirlemek i\u00e7in Atractylodes macrocephala u\u00e7ucu ya\u011f\u0131n\u0131n GC-MS parmak izini olu\u015fturmak gerekir. Sistematiklik ve b\u00fct\u00fcnsellik \u00f6zelliklerine sahip olan a\u011f farmakolojisi, sistem biyolojisi ve a\u011f biyolojisine dayanan yeni bir ara\u015ft\u0131rma y\u00f6ntemidir. Hastal\u0131klar i\u00e7in tek ila\u00e7 ve bile\u015fik ila\u00e7 tedavilerinin maddi temelinde ve \u00e7ok hedefli mekanizma tahmininde yayg\u0131n olarak uygulanmaktad\u0131r. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite belirte\u00e7lerini aramak i\u00e7in parmak izi spektrumunu a\u011f farmakolojisi ile birle\u015ftirme y\u00f6ntemi, Fructus Aurantii, Forsythia suspensa, Hedyotis diffusa ve Lonicera japonica gibi geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite belirte\u00e7lerini tahmin etmek i\u00e7in ba\u015far\u0131yla uygulanm\u0131\u015ft\u0131r. Bununla birlikte, Atractylodes macrocephala'daki u\u00e7ucu ya\u011f\u0131n kalite belirte\u00e7lerini tahmin etmek ve analiz etmek i\u00e7in GC-MS parmak izi spektrumunu a\u011f farmakolojisi ile birle\u015ftiren bir y\u00f6ntem hala yoktur. Bu nedenle, bu \u00e7al\u0131\u015fmada, Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f bile\u015fenlerini analiz etmek ve bir parmak izi spektrumu olu\u015fturmak i\u00e7in GC-MS kullan\u0131lm\u0131\u015ft\u0131r. A\u011f farmakolojisi y\u00f6ntemleriyle birlikte, Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n bile\u015fenleri, hedefleri ve yollar\u0131 sistematik olarak analiz edilmi\u015f ve Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n potansiyel kalite belirte\u00e7leri tahmin edilmi\u015ftir. Ama\u00e7, Atractylodes macrocephala tabletlerinin kalitesinin kapsaml\u0131 kontrol\u00fc ve de\u011ferlendirilmesi i\u00e7in bilimsel temel ve teorik referans sa\u011flamakt\u0131r.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6387\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-226.png\" alt=\"\" width=\"410\" height=\"283\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6388\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-188.png\" alt=\"\" width=\"410\" height=\"334\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6389\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-174.png\" alt=\"\" width=\"750\" height=\"338\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6390\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-17.jpg\" alt=\"\" width=\"765\" height=\"205\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6391\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-12.jpg\" alt=\"\" width=\"765\" height=\"258\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6392\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-124.png\" alt=\"\" width=\"410\" height=\"225\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6393\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-113.png\" alt=\"\" width=\"740\" height=\"410\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6394\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-102.png\" alt=\"\" width=\"740\" height=\"326\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6395\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-94.png\" alt=\"\" width=\"740\" height=\"470\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6396\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-75.png\" alt=\"\" width=\"761\" height=\"624\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6397\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-69.png\" alt=\"\" width=\"740\" height=\"520\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6398\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-54.png\" alt=\"\" width=\"740\" height=\"523\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6399\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-49.png\" alt=\"\" width=\"741\" height=\"429\" \/><br \/>\nBu \u00e7al\u0131\u015fmada, GC-MS y\u00f6ntemi kullan\u0131larak farkl\u0131 k\u00f6kenlerden gelen 11 parti Atractylodes macrocephala'daki u\u00e7ucu ya\u011f bile\u015fenlerinin parmak izi spektrumlar\u0131 olu\u015fturulmu\u015f ve 10 ortak pik tan\u0131mlanm\u0131\u015ft\u0131r. Ortak bile\u015fenlerin toplam i\u00e7eri\u011fi, toplam u\u00e7ucu ya\u011f i\u00e7eri\u011finin 85%'sinden fazlas\u0131n\u0131 olu\u015fturmu\u015ftur. Ortak bile\u015fenlerin PCA analizinin sonu\u00e7lar\u0131, Zhejiang ve Anhui'de \u00fcretilen Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131 aras\u0131nda \u00f6nemli bir fark oldu\u011funu ve Zhejiang'da \u00fcretilen Atractylodes macrocephala'n\u0131n da\u011f\u0131l\u0131m\u0131n\u0131n daha konsantre oldu\u011funu g\u00f6stermi\u015ftir; K\u00fcme analizi, s\u0131n\u0131fland\u0131rma mesafesi 15 oldu\u011funda, Zhejiang Atractylodes macrocephala'n\u0131n d\u00f6rt partisinin birlikte grupland\u0131r\u0131labilece\u011fini g\u00f6stermektedir; bu da Anhui Atractylodes macrocephala ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, Zhejiang Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f kimyasal bile\u015fiminin daha benzer ve kararl\u0131 oldu\u011funu g\u00f6stermektedir. Ancak, Sichuan, Yunnan ve Jiangxi \u00fcretim b\u00f6lgelerindeki tek parti Atractylodes macrocephala nedeniyle, genel da\u011f\u0131l\u0131m\u0131 ve Zhejiang ve Anhui Atractylodes macrocephala'dan farkl\u0131l\u0131klar\u0131 ge\u00e7ici olarak belirlenemez.<\/p>\n<p>Buna ek olarak, bu \u00e7al\u0131\u015fma 11 parti Atractylodes macrocephala kaynatma par\u00e7as\u0131ndaki ortak u\u00e7ucu ya\u011f bile\u015fenlerini ba\u015flang\u0131\u00e7 noktas\u0131 olarak almakta ve Atractylodes macrocephala u\u00e7ucu ya\u011f\u0131n\u0131n ana etki yollar\u0131n\u0131 ve hedeflerini tahmin ederek Atractylodes macrocephala u\u00e7ucu ya\u011f\u0131n\u0131n bir \"bile\u015fen hedef yolu\" eylem a\u011f\u0131n\u0131 olu\u015fturmak i\u00e7in a\u011f farmakolojisi analiz y\u00f6ntemlerini birle\u015ftirmektedir. A\u011f farmakolojisinin sonu\u00e7lar\u0131, palmitik asit, \u03b2 - okaliptol, \u03b3 - elemen, elemen ve Atractylodes macrocephala ketonunun Atractylodes macrocephala u\u00e7ucu ya\u011f\u0131 i\u00e7in potansiyel kalite belirte\u00e7leri olabilece\u011fini g\u00f6stermi\u015ftir. Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n gastrointestinal sistemi d\u00fczenlemek, mide mukozas\u0131n\u0131 onarmak, bakterileri inhibe etmek ve karaci\u011feri korumak gibi i\u015flevleri vard\u0131r. Modern ara\u015ft\u0131rmalar, palmitik asit, \u03b2 - okaliptol, \u03b3 - elemene, elemene ve Atractylodes macrocephala gibi bile\u015fenlerin antibakteriyel, yat\u0131\u015ft\u0131r\u0131c\u0131, analjezik, gastrointestinal motiliteyi d\u00fczenleyici, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcr\u00fcc\u00fc, karaci\u011feri koruyucu, anti-enflamatuar, antiviral ve anti enfektif \u00f6zellikler gibi farmakolojik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131na benzerler, bu nedenle bu bile\u015fenler Atractylodes macrocephala u\u00e7ucu ya\u011f\u0131n\u0131n farmakolojik etkileri i\u00e7in ana malzeme temeli olabilir ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n i\u015flevsel \u00f6zellikleriyle yak\u0131ndan ili\u015fkilidir. \"Bile\u015fen hedef yolu\" a\u011f\u0131n\u0131n olu\u015fturulmas\u0131n\u0131n sonu\u00e7lar\u0131, MAPK1, PTGS2, RXRA, CYP19A1, PPARA, NOS3, TNF, CYP2C19 ve metabolik yollar\u0131n, kimyasal karsinogenez resept\u00f6r aktivasyonunun, PPAR sinyal yolunun, serotonerjik sinaps\u0131n ve \u00f6strojen sinyal yolunun Atractylodes macrocephala u\u00e7ucu ya\u011f\u0131n\u0131n etkisi i\u00e7in anahtar hedefler ve sinyal yollar\u0131 olabilece\u011fini g\u00f6stermi\u015ftir.<\/p>\n<p>\u00d6zet olarak, ara\u015ft\u0131rmam\u0131z farkl\u0131 k\u00f6kenlerden gelen Atractylodes macrocephala dilimlerinin u\u00e7ucu ya\u011f bile\u015fenlerinin Atractylodes macrocephala keton, (-) - izopenten, \u03b3 - elemen, \u03b2 - okaliptol, palmitik asit trans-valerenil asetat, filantol ve 4-sikloheksilasetofenon ana bile\u015fikler oldu\u011funu, ancak i\u00e7eriklerinin de\u011fi\u015fti\u011fini bulmu\u015ftur. A\u011f farmakolojisi ile birle\u015ftirilen GC-MS parmak izi, palmitik asit, \u03b2 - okaliptol, \u03b3 - elemene, elemene ve Atractylodes macrocephala'y\u0131 Atractylodes macrocephala'n\u0131n u\u00e7ucu ya\u011f\u0131 i\u00e7in potansiyel kalite belirte\u00e7leri olarak tan\u0131mlam\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma, Atractylodes macrocephala'n\u0131n kalite kontrol sistemini daha da geli\u015ftirmi\u015f, Atractylodes macrocephala'n\u0131n kalite kontrol\u00fc i\u00e7in teorik bir temel sa\u011flam\u0131\u015f ve ayr\u0131ca di\u011fer benzer geleneksel \u00c7in t\u0131bbi malzemelerinin kalite belirte\u00e7lerinin incelenmesi i\u00e7in teorik bir referans sa\u011flam\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Prediction and analysis of volatile component quality markers in Atractylodes macrocephala based on GC-MS fingerprint and network pharmacology Traditional Chinese medicine commonly has complex conditions such as multiple origins and multiple production sites, with significant differences in quality. It is urgent to establish a scientific and reasonable quality assurance system for traditional Chinese medicine. 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