{"id":6324,"date":"2024-08-06T11:40:48","date_gmt":"2024-08-06T11:40:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=6324"},"modified":"2024-08-06T11:40:48","modified_gmt":"2024-08-06T11:40:48","slug":"emodin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/emodin\/","title":{"rendered":"Veri madencili\u011fi ve deneysel do\u011frulamaya dayal\u0131 olarak sepsisle ili\u015fkili akut b\u00f6brek hasar\u0131n\u0131n tedavisinde emodinin etki mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Veri madencili\u011fi ve deneysel do\u011frulamaya dayal\u0131 olarak sepsisle ili\u015fkili akut b\u00f6brek hasar\u0131n\u0131n tedavisinde emodinin etki mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131
\nSepsis, kona\u011f\u0131n enfeksiyona verdi\u011fi yan\u0131ttaki dengesizli\u011fin neden oldu\u011fu, ya\u015fam\u0131 tehdit eden bir organ fonksiyon bozuklu\u011fudur. B\u00f6brekler, sepsiste en s\u0131k etkilenen organlardan biridir ve sepsisle ili\u015fkili akut b\u00f6brek hasar\u0131 (SA-AKI), sepsis hastalar\u0131nda genellikle do\u011frudan \u00f6l\u00fcm nedeni haline gelir ve y\u00fcksek \u00f6l\u00fcm oran\u0131 ile klinik doktorlar i\u00e7in benzeri g\u00f6r\u00fclmemi\u015f zorluklar ortaya \u00e7\u0131kar\u0131r. AKI devam eder ve potansiyel kronik b\u00f6brek hastal\u0131\u011f\u0131 (KBH) riskini art\u0131r\u0131r. Hayatta kalan hastalar genellikle ka\u00e7\u0131n\u0131lmaz olarak son d\u00f6nem b\u00f6brek hastal\u0131\u011f\u0131na (SDBH) ilerleyerek ya\u015fam kaliteleri ve g\u00fcvenlikleri i\u00e7in ciddi bir tehdit olu\u015fturmaktad\u0131r.
\nNe yaz\u0131k ki, SA-AKI'yi \u00f6nleme ve tedavi etme konusundaki mevcut yetenekler \u00e7ok s\u0131n\u0131rl\u0131d\u0131r. Aktif s\u0131v\u0131 bazl\u0131 tedavi g\u00fcvenilir kan\u0131ta dayal\u0131 t\u0131bba sahip olmayabilir ve hatta zararl\u0131 olabilir. Kan bas\u0131nc\u0131n\u0131 korumak i\u00e7in vazoaktif ila\u00e7lar\u0131n kullan\u0131m\u0131, b\u00fcy\u00fck dola\u015f\u0131m ve mikrosirk\u00fclasyon aras\u0131nda bir denge gerektirir ve AKI olu\u015fumunu \u00f6nlemeye yard\u0131mc\u0131 olmak i\u00e7in ne kadar kan bas\u0131nc\u0131 hedefinin korunmas\u0131 gerekti\u011fi konusunda bir fikir birli\u011fi yoktur. Renal \u00f6nleme ba\u015far\u0131s\u0131z olursa, tedavi i\u00e7in renal replasman tedavisi (RRT) kullan\u0131lmal\u0131d\u0131r, ancak RRT m\u00fcdahalesinin optimal zamanlamas\u0131 ve y\u00f6ntemi net de\u011fildir. SA-AKI hastalar\u0131 hayatta kal\u0131rsa, \u00e7o\u011fu hastan\u0131n b\u00f6brek fonksiyonu iyile\u015fecek olsa da, b\u00f6brek onar\u0131m mekanizmalar\u0131 veya b\u00f6brek fonksiyon onar\u0131m\u0131n\u0131n ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 hakk\u0131nda \u00e7ok az \u015fey bilinmektedir ve ya\u015fam boyu KBH ve SDBY'ye ilerleme riski daha y\u00fcksektir. \u015eu ana kadar AKI tedavisi i\u00e7in kesin ve g\u00fcvenilir bir ila\u00e7 bulunmamaktad\u0131r. Geleneksel klinik tedavi \u00f6nlemleri temel olarak b\u00f6brek replasman\u0131 ve semptomatik kapsaml\u0131 tedavidir. B\u00f6brek fonksiyonunun onar\u0131m\u0131, b\u00f6bre\u011fin kendisinin bir b\u00fct\u00fcn olarak v\u00fccutta g\u00fcvenilir bir \u015fekilde desteklenmesine ba\u011fl\u0131d\u0131r. Bu nedenle, SA-AKI'yi erken ve zaman\u0131nda etkili bir \u015fekilde \u00f6nleyebilecek veya tedavi edebilecek, kronik b\u00f6brek hastal\u0131\u011f\u0131n\u0131n ortaya \u00e7\u0131kmas\u0131n\u0131 \u00f6nleyebilecek veya b\u00f6brek onar\u0131m\u0131n\u0131 te\u015fvik edebilecek ila\u00e7lar\u0131n veya \u00f6nlemlerin ara\u015ft\u0131r\u0131lmas\u0131, sepsis hastalar\u0131n\u0131n \u00f6l\u00fcm oran\u0131n\u0131 azaltmak ve hayatta kalan hastalar\u0131n ya\u015fam kalitesini iyile\u015ftirmek i\u00e7in \u00f6nemli klinik de\u011fere sahiptir.
\nEmodin, ravent ve Polygonum cuspidatum gibi \u00c7in bitkilerinden elde edilen, anti-enflamatuar, antiviral ve anti-t\u00fcm\u00f6r gibi \u00e7e\u015fitli farmakolojik etkileri olan do\u011fal bir bile\u015fiktir. \u00d6nceki \u00e7al\u0131\u015fmalar emodinin sepsis hastalar\u0131 \u00fczerinde koruyucu bir etkiye sahip oldu\u011funu do\u011frulam\u0131\u015f; son \u00e7al\u0131\u015fmalar ise emodinin oksidatif stres, inflamasyon ve h\u00fccre apoptozunun neden oldu\u011fu hasara kar\u015f\u0131 koruyucu bir etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. Bununla birlikte, emodinin SA-AKI hastalar\u0131n\u0131n prognozunu iyile\u015ftirip iyile\u015ftiremeyece\u011fi hala belirsizdir. Bu \u00e7al\u0131\u015fma, ya\u015fam bilimleri ile ilgili veri tabanlar\u0131 arac\u0131l\u0131\u011f\u0131yla SA-AKI patogenezinde yer alan anahtar genleri ara\u015ft\u0131racak ve bu anahtar genlerde yer alan enflamatuar sinyal yollar\u0131n\u0131 analiz edecektir; Ayr\u0131ca, emodinin SA-AKI'nin enflamatuar yolunu ve SA-AKI s\u0131\u00e7anlar\u0131 \u00fczerindeki koruyucu etkisini ve mekanizmas\u0131n\u0131 etkileyip etkilemedi\u011fini ara\u015ft\u0131rmak i\u00e7in hayvan deneyleri yap\u0131lm\u0131\u015f, \u00f6nlenmesi ve tedavisi i\u00e7in yeni fikirler sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nAra\u015ft\u0131rmalar SA-AKI patogenezinin \u00e7ok fakt\u00f6rl\u00fc ve karma\u015f\u0131k oldu\u011funu, inflamasyon, mikro dola\u015f\u0131m disfonksiyonu ve metabolik yeniden programlama aras\u0131ndaki etkile\u015fimi i\u00e7erdi\u011fini g\u00f6stermi\u015ftir. Patofizyolojisi, birden fazla h\u00fccre tipinin hasar g\u00f6rmesini ve i\u015flev bozuklu\u011funu i\u00e7erir. Sepsis s\u00fcrecinde bakteriler endotoksin veya endotoksin benzeri maddeler salarak v\u00fccuttaki n\u00f6trofiller, monositler ve endotel h\u00fccreleri gibi enflamatuar h\u00fccreleri aktive eder ve kan dola\u015f\u0131m\u0131na b\u00fcy\u00fck miktarda endojen enflamatuar mediat\u00f6r salg\u0131lar. Bu durum bir yandan b\u00f6brekler de dahil olmak \u00fczere bir\u00e7ok organda hasara yol a\u00e7arken, di\u011fer yandan da daha fazla iltihap h\u00fccresinin hastal\u0131\u011fa kat\u0131lmas\u0131n\u0131 sa\u011flayarak k\u00f6t\u00fc huylu bir ba\u011f\u0131\u015f\u0131kl\u0131k a\u011f\u0131 yan\u0131t\u0131 olu\u015fturur. Lipopolisakkarit (LPS) ile ind\u00fcklenen SA-AKI'nin SD s\u0131\u00e7an modelinde nerolidol, NF - \u03ba B ve Toll benzeri resept\u00f6r 4 (TLR4) sinyal yolaklar\u0131n\u0131 inhibe ederek SA-AKI'yi hafifletir. TLR4\/NF - \u03ba B yola\u011f\u0131n\u0131n renal enflamasyon yan\u0131t\u0131 s\u00fcrecine dahil oldu\u011fu do\u011frulanm\u0131\u015ft\u0131r ve TLR4\/NF - \u03ba B arac\u0131l\u0131 enflamatuar yan\u0131t\u0131n inhibe edilmesi LPS kaynakl\u0131 AKI \u00fczerinde koruyucu bir etkiye sahiptir. \u0130nflamatuar yan\u0131t\u0131n SA-AKI patogenezinde \u00f6nemli bir mekanizma oldu\u011fu ve inflamatuar yan\u0131t yolunun inhibe edilmesinin sepsis i\u00e7in \u00f6nemli bir tedavi se\u00e7ene\u011fi oldu\u011fu ve SA-AKI hastalar\u0131n\u0131n klinik tedavisi i\u00e7in yeni fikirler sa\u011flad\u0131\u011f\u0131 g\u00f6r\u00fclebilir.
\nBu \u00e7al\u0131\u015fmada SA-AKI patogenezinde yer alan 2801 anahtar hedefi analiz etmek i\u00e7in biyolojik bir veri taban\u0131 kullan\u0131lm\u0131\u015ft\u0131r. Bu hedeflerin KEGG analizi, TNF sinyal yolu ve IL-17 sinyal yolunun \u00fcst s\u0131ralarda yer ald\u0131\u011f\u0131 ve NF - \u03ba B sinyal yolunun her iki yolun da SA-AKI patogenezine kat\u0131lmas\u0131 i\u00e7in bir merkez g\u00f6revi g\u00f6rd\u00fc\u011f\u00fc toplam 5 temel enflamatuar yan\u0131t sinyal yolunu ortaya \u00e7\u0131karm\u0131\u015ft\u0131r. TNF sinyal yolunda, TNF - \u03b1 sadece NF - \u03ba B sinyalinin anahtar yukar\u0131 y\u00f6nl\u00fc aktivat\u00f6r\u00fc de\u011fil, ayn\u0131 zamanda NF - \u03ba B sinyal yolunun a\u015fa\u011f\u0131 y\u00f6nl\u00fc yan\u0131t veren bir molek\u00fcl\u00fc olarak hizmet eder, bu da NF - \u03ba B sinyal yolunu pozitif geri besleme yoluyla destekledi\u011fini ve ikisinin birbirini tamamlad\u0131\u011f\u0131n\u0131 g\u00f6sterir. IL-17 sinyal yolunda, IL-17A, IL-17 ailesindeki ana ba\u015flat\u0131c\u0131 fakt\u00f6rd\u00fcr ve Th17 h\u00fccreleri ana salg\u0131layan h\u00fccrelerdir. CLP ile ind\u00fcklenen modelde, IL-17A'n\u0131n kar\u0131n bo\u015flu\u011funda y\u00fcksek oranda eksprese edildi\u011fi ve \u015fiddetli sepsis sonras\u0131 inflamatuar yan\u0131tta kilit rol oynad\u0131\u011f\u0131 bulunmu\u015ftur. Kar\u0131n bo\u015flu\u011funda IL-17A'n\u0131n n\u00f6tralize edilmesi, pro-enflamatuar sitokinlerin \u00fcretimini azaltabilir. Bu arada, \u00e7al\u0131\u015fmalar dendritik h\u00fccrelerdeki (DC'ler) Toll benzeri resept\u00f6r 9'un (TLR9) gama delta T h\u00fccreleri taraf\u0131ndan IL-17A \u00fcretimine arac\u0131l\u0131k ederek SA-AKI geli\u015fiminde kilit bir rol oynayabilece\u011fini g\u00f6stermi\u015ftir; Di\u011fer \u00e7al\u0131\u015fmalar IL-17A'n\u0131n devre d\u0131\u015f\u0131 b\u0131rak\u0131lmas\u0131n\u0131n SA-AKI'yi \u00f6nleyebilece\u011fini g\u00f6stermi\u015ftir. Yukar\u0131dakiler, TNF - \u03b1 ve IL-17A'n\u0131n sepsiste pro-enflamatuar fakt\u00f6rler oldu\u011funu ve TNF sinyal yola\u011f\u0131 ile IL-17 sinyal yola\u011f\u0131n\u0131n sepsisin olu\u015fumu ve geli\u015fiminde yayg\u0131n olarak yer ald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir ki bu da veri analizi sonu\u00e7lar\u0131yla tutarl\u0131d\u0131r.<\/p>\n

Sepsisin emodin ile tedavisi \u00fczerine, \u00f6zellikle beyin, kan, kalp, ba\u011f\u0131rsak ve akci\u011fer dokular\u0131na odaklanan bir\u00e7ok \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015ft\u0131r. Sepsis ili\u015fkili ensefalopatide (SAE), emodin bili\u015fsel bozuklu\u011fu ve patolojik hasar\u0131 iyile\u015ftirebilir ve BDNF \/ TrkB sinyalini yukar\u0131 do\u011fru d\u00fczenleyerek farelerde CLP kaynakl\u0131 inflamasyonu inhibe edebilir. Kan sisteminde, emodin P-selektini a\u015fa\u011f\u0131 reg\u00fcle eder, sepsisin ge\u00e7 evresinde trombosit say\u0131s\u0131n\u0131 ve agregasyon yetene\u011fini art\u0131r\u0131r ve endojen p\u0131ht\u0131la\u015fma fakt\u00f6r\u00fc aktivitesini ve fibrinojen fonksiyonunu art\u0131rarak anti-enflamatuar etkiler g\u00f6sterir. Septik kardiyomiyopatide, emodinin septik s\u0131\u00e7anlarda kardiyak disfonksiyonu tersine \u00e7evirebildi\u011fi ve miyokardiyal durumu iyile\u015ftirebildi\u011fi bulunmu\u015ftur, bu da inflamazom aktivasyonunu inhibe etmesiyle ilgili olabilir. Sepsisin neden oldu\u011fu ba\u011f\u0131rsak hasar\u0131nda emodin, enflamatuar fakt\u00f6rlerin ve oksidatif stres belirte\u00e7lerinin seviyelerini azaltarak ba\u011f\u0131rsak mukozal hasar\u0131n\u0131 iyile\u015ftirebilir ve etki mekanizmas\u0131 VDR\/Nrf2\/HO-1 yola\u011f\u0131 ile ili\u015fkili olabilir; Ve s\u0131k\u0131 ba\u011flant\u0131 (TJ) proteininin ekspresyon seviyesini art\u0131rarak ba\u011f\u0131rsak bariyerinin b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc korur ve ba\u011f\u0131rsak bariyeri ge\u00e7irgenli\u011fini inhibe eder. Emodin, ba\u011f\u0131rsa\u011f\u0131n enflamatuar tepkisini ve bariyer i\u015flevini iyile\u015ftirmenin yan\u0131 s\u0131ra, Escherichia coli'nin yer de\u011fi\u015ftirmesini \u00f6nleyebilir, bakterilerin yay\u0131lmas\u0131n\u0131 ve transferini \u00f6nleyebilir ve bakterilerin neden oldu\u011fu ikincil zarar\u0131 azaltabilir. Sepsise ba\u011fl\u0131 akut akci\u011fer hasar\u0131nda, emodin NF - \u03ba B ve y\u00fcksek hareketlilik grubu kutusu 1 (HMGB1) yolaklar\u0131n\u0131 inhibe edebilir, b\u00f6ylece pulmoner oksidatif stresi ve enflamatuar yan\u0131t\u0131 azaltabilir. Akci\u011ferler \u00fczerinde yap\u0131lan bir ba\u015fka \u00e7al\u0131\u015fma da otofaji yola\u011f\u0131na dayanmaktad\u0131r ve emodin m\u00fcdahalesi akut akci\u011fer hasar\u0131n\u0131n ilerlemesini etkili bir \u015fekilde \u00f6nleyebilir. Ayr\u0131ca, di\u011fer \u00e7al\u0131\u015fmalar emodinin sepsis kaynakl\u0131 akut akci\u011fer hasar\u0131nda akuaporin (AQP), TJ, enflamatuar fakt\u00f6rler ve akci\u011fer h\u00fccresi apoptozunu d\u00fczenleyerek pulmoner doku \u00f6demini etkili bir \u015fekilde hafifletebilece\u011fini g\u00f6stermi\u015ftir. Emodinin SA-AKI \u00fczerindeki \u00e7al\u0131\u015fmas\u0131 hen\u00fcz rapor edilmemi\u015ftir. Bu \u00e7al\u0131\u015fma sayesinde, emodin ile tedavi edilen CLP modeli s\u0131\u00e7anlar\u0131n ELISA sonu\u00e7lar\u0131nda TNF - \u03b1, IL-17 ve IFN - \u03b3 ekspresyonunda azalma g\u00f6sterdi\u011fi bulunmu\u015ftur ki bu da emodinin sepsis inflamasyonu \u00fczerindeki inhibit\u00f6r etkisiyle tutarl\u0131d\u0131r.
\nEmodinin Th17\/Treg enflamatuar ekseni \u00fczerindeki ayn\u0131 etkisi de ayd\u0131nlat\u0131lm\u0131\u015ft\u0131r. Akut pankreatit \u00e7al\u0131\u015fmas\u0131nda, emodinin IFN - \u03b3\/IL-17 oran\u0131n\u0131 d\u00fczenleyerek \u015fiddetli akut pankreatitte imm\u00fcn yan\u0131t\u0131 inhibe etti\u011fi ve b\u00f6ylece ba\u011f\u0131rsak bariyeri i\u015flev bozuklu\u011funu hafifletti\u011fi bulunmu\u015ftur. Bu \u00e7al\u0131\u015fmada da SA-AKI'de emodinin IL-17A ekspresyonunu azaltabildi\u011fi ve enflamatuar yan\u0131t\u0131 iyile\u015ftirebildi\u011fi bulunmu\u015ftur.
\n\u00d6zetle, bu \u00e7al\u0131\u015fma veri madencili\u011fi yoluyla emodin patogenezinde yer alan 2801 anahtar gen tan\u0131mlam\u0131\u015ft\u0131r. GO biyolojik s\u00fcre\u00e7 analizi, bu hedeflerin biyolojik i\u015flevlerinin esas olarak membran sinyal iletimi, vask\u00fcler d\u00fczenleme ve yara iyile\u015fmesini i\u00e7erdi\u011fini g\u00f6stermektedir. KEGG yolak zenginle\u015ftirme analizi TNF, IL-17, PI3K Akt, NF - \u03ba B ve MAPK sinyal yolaklar\u0131n\u0131n inflamasyonla ilgili sinyal yolaklar\u0131nda zenginle\u015fti\u011fini g\u00f6stermi\u015ftir. Deneysel do\u011frulama, emodin tedavisinin SA-AKI'de b\u00f6brek fonksiyonunu iyile\u015ftirdi\u011fini ve oksidatif stres (MDA) ve inflamatuar sitokin (TNF - \u03b1, IL-17 ve IFN - \u03b3) seviyelerinin azald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. IL-17A, TNF - \u03b1, TRAF6, NF - \u03ba Bp65'in protein ekspresyonu ve I \u03ba B \u03b1'n\u0131n fosforilasyon seviyesi, veri analizi sonu\u00e7lar\u0131yla tutarl\u0131 olarak CLP grubuna k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r. Emodinin s\u0131\u00e7anlarda SA-AKI'yi iyile\u015ftirebilece\u011fi ve bunun da IL-17\/NF - \u03ba B ve TNF\/NF - \u03ba B sinyal yolaklar\u0131yla ili\u015fkili olabilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification Sepsis is a life-threatening organ dysfunction caused by an imbalance in the host’s response to infection. The kidneys are one of the most commonly affected organs in sepsis, and sepsis associated acute kidney injury […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/emodin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification Sepsis is a life-threatening organ dysfunction caused by an imbalance in the host’s response to infection. The kidneys are one of the most commonly affected organs in sepsis, and sepsis associated acute kidney injury […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/emodin\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-06T11:40:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/emodin\/\",\"url\":\"https:\/\/longchangextracts.com\/emodin\/\",\"name\":\"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/emodin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/emodin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png\",\"datePublished\":\"2024-08-06T11:40:48+00:00\",\"dateModified\":\"2024-08-06T11:40:48+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/emodin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/emodin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/emodin\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/emodin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Veri madencili\u011fi ve deneysel do\u011frulamaya dayal\u0131 olarak sepsise ba\u011fl\u0131 akut b\u00f6brek hasar\u0131n\u0131n tedavisinde emodinin etki mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/emodin\/","og_locale":"tr_TR","og_type":"article","og_title":"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification - China Chemical Manufacturer","og_description":"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification Sepsis is a life-threatening organ dysfunction caused by an imbalance in the host’s response to infection. The kidneys are one of the most commonly affected organs in sepsis, and sepsis associated acute kidney injury […]","og_url":"https:\/\/longchangextracts.com\/tr\/emodin\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-06T11:40:48+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"9 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/emodin\/","url":"https:\/\/longchangextracts.com\/emodin\/","name":"Veri madencili\u011fi ve deneysel do\u011frulamaya dayal\u0131 olarak sepsise ba\u011fl\u0131 akut b\u00f6brek hasar\u0131n\u0131n tedavisinde emodinin etki mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/emodin\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/emodin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png","datePublished":"2024-08-06T11:40:48+00:00","dateModified":"2024-08-06T11:40:48+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/emodin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/emodin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/emodin\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-221.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/emodin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Exploring the mechanism of action of emodin in treating sepsis related acute kidney injury based on data mining and experimental verification"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6324"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=6324"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6324\/revisions"}],"predecessor-version":[{"id":6336,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/6324\/revisions\/6336"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=6324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=6324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=6324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}