{"id":5806,"date":"2024-08-04T21:25:24","date_gmt":"2024-08-04T21:25:24","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5806"},"modified":"2024-08-04T21:25:24","modified_gmt":"2024-08-04T21:25:24","slug":"streptomyces-using-non-directed-activation-silencing-gene-clusters","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/streptomyces-using-non-directed-activation-silencing-gene-clusters\/","title":{"rendered":"Y\u00f6nlendirilmemi\u015f aktivasyon susturma gen k\u00fcmeleri kullan\u0131larak Streptomyces'in aktif ikincil metabolitlerinin madencili\u011fi \u00fczerine ara\u015ft\u0131rma ilerlemesi"},"content":{"rendered":"<p>Y\u00f6nlendirilmemi\u015f aktivasyon susturma gen k\u00fcmeleri kullan\u0131larak Streptomyces'in aktif ikincil metabolitlerinin madencili\u011fi \u00fczerine ara\u015ft\u0131rma ilerlemesi<br \/>\nMikrobiyal ikincil metabolitler, ila\u00e7 ara\u015ft\u0131rma ve geli\u015ftirmede \u00f6nemli bir rol oynayan yap\u0131sal olarak \u00e7e\u015fitli, i\u015flevsel olarak karma\u015f\u0131k ve biyolojik olarak aktif maddelerden olu\u015fan bir s\u0131n\u0131ft\u0131r. \u015eu an itibariyle, mikroorganizmalardan yakla\u015f\u0131k 300000 bile\u015fik tan\u0131mlanm\u0131\u015ft\u0131r ve antibiyotiklerin 60%'den fazlas\u0131 Streptomyces kaynakl\u0131d\u0131r. Bununla birlikte, \u00e7ok say\u0131da ikincil metabolitin izole edilmesiyle, Streptomyces'ten \u00f6nemli biyolojik aktiviteye ve yeni yap\u0131lara sahip antibiyotiklerin ke\u015ffedilme olas\u0131l\u0131\u011f\u0131 azalmaktad\u0131r. Son y\u0131llarda, mikrobiyal dizilemede genom dizileme teknolojisinin yayg\u0131n olarak uygulanmas\u0131yla, b\u00fcy\u00fck miktarda Streptomyces genom bilgisi halka a\u00e7\u0131k hale getirilmi\u015ftir. Streptomyces genom verilerinin biyoinformatik analizi yoluyla, genlerin b\u00fcy\u00fck bir k\u0131sm\u0131n\u0131n hala sessiz durumda oldu\u011fu bulunmu\u015ftur, bu da hala ke\u015ffedilmemi\u015f \u00e7ok say\u0131da potansiyel ikincil metabolit oldu\u011funu g\u00f6stermektedir. Geleneksel yeti\u015ftirme ko\u015fullar\u0131 nedeniyle, Streptomyces'in biyosentetik gen k\u00fcmeleri etkili bir \u015fekilde aktive edilmemi\u015f, bu da benzersiz metabolik yollar\u0131n\u0131n genellikle daha az ifade edilmesine veya hi\u00e7 ifade edilmemesine neden olmu\u015ftur. Bu nedenle, Streptomyces'in sessiz gen k\u00fcmesini aktive ederek yeni aktif ikincil metabolitleri ke\u015ffetmek b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<br \/>\nStreptomyces'te susturucu genlerin ifadesini etkinle\u015ftirmek ve daha aktif ikincil metabolitler ke\u015ffetmek i\u00e7in, bug\u00fcne kadar susturucu gen k\u00fcmelerini etkinle\u015ftirmek i\u00e7in \u00e7e\u015fitli y\u00f6ntemler geli\u015ftirilmi\u015f ve uygulanm\u0131\u015ft\u0131r. Yayg\u0131n olarak kullan\u0131lan stratejiler iki kategoriye ayr\u0131labilir: Birincisi, k\u00fclt\u00fcr ortam\u0131n\u0131n bile\u015fimini (karbon kayna\u011f\u0131, nitrojen kayna\u011f\u0131, eser elementler, kimyasal aktivat\u00f6rler), su\u015fun b\u00fcy\u00fcme ortam\u0131n\u0131 (s\u0131cakl\u0131k, pH, havaland\u0131rma, kap tipi) veya mikrobiyal ortak k\u00fclt\u00fcr\u00fc de\u011fi\u015ftirerek Streptomyces'i farkl\u0131 metabolitler \u00fcretmeye te\u015fvik eden y\u00f6nlendirilmemi\u015f aktivasyon stratejisidir; Di\u011fer bir t\u00fcr ise gen d\u00fczenleme teknolojisi (CRISPR-Cas9), belirli gen k\u00fcmelerinin hedefli aktivasyonu (promot\u00f6r m\u00fchendisli\u011fi, yola \u00f6zg\u00fc d\u00fczenleyici fakt\u00f6r aktivasyonu, heterolog ekspresyon) ve Streptomyces'te susturulmu\u015f genlerin ekspresyonunu sa\u011flamak i\u00e7in di\u011fer ara\u00e7lar\u0131 kullanan hedefli aktivasyon stratejisidir. Hedefli aktivasyon stratejileriyle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, hedefli olmayan aktivasyon stratejileri hedef su\u015f i\u00e7in bir genetik manip\u00fclasyon sisteminin kurulmas\u0131n\u0131 gerektirmez, bu nedenle basit kullan\u0131m ve birden fazla biyosentetik gen k\u00fcmesini (belirli bir biyosentetik gen k\u00fcmesi yerine) ayn\u0131 anda aktive etme avantajlar\u0131na sahiptir ve bu da onlar\u0131 daha yayg\u0131n olarak uygulanabilir hale getirir. Bu makale, Streptomyces'te genlerin susturulmas\u0131 i\u00e7in k\u00fclt\u00fcr ortam\u0131n\u0131n veya k\u00fclt\u00fcr ko\u015fullar\u0131n\u0131n bile\u015fiminin de\u011fi\u015ftirilmesi, ortak k\u00fclt\u00fcr stratejileri, kimyasal aktivat\u00f6rlerin eklenmesi ve k\u00fcresel d\u00fczenleme (bkz. \u015eekil 1) gibi y\u00f6nlendirilmemi\u015f aktivasyon stratejilerine k\u0131sa bir genel bak\u0131\u015f sa\u011flamakta ve bu alanda kar\u015f\u0131la\u015f\u0131lan sorunlar\u0131 ve gelecekteki geli\u015fme beklentilerini a\u00e7\u0131klamaktad\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5807\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-177.png\" alt=\"\" width=\"800\" height=\"315\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-177.png 800w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-177-768x302.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5808\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-163.png\" alt=\"\" width=\"806\" height=\"424\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-163.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-163-768x404.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5809\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-153.png\" alt=\"\" width=\"806\" height=\"382\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-153.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-153-768x364.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5810\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-137.png\" alt=\"\" width=\"806\" height=\"692\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-137.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-137-768x659.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5811\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-124.png\" alt=\"\" width=\"806\" height=\"734\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-124.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-124-768x699.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-124-791x720.png 791w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5812\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-114.png\" alt=\"\" width=\"806\" height=\"352\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-114.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-114-768x335.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5813\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-104.png\" alt=\"\" width=\"806\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-104.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-104-768x297.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5814\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-95.png\" alt=\"\" width=\"806\" height=\"498\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-95.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-95-768x475.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5815\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-89.png\" alt=\"\" width=\"806\" height=\"561\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-89.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-89-768x535.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5816\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-71.png\" alt=\"\" width=\"806\" height=\"646\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-71.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-71-768x616.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5817\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-65.png\" alt=\"\" width=\"806\" height=\"285\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-65.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-65-768x272.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><br \/>\nAntibiyotiklerin ke\u015ffi, t\u0131bbi geli\u015fim tarihinde \u00f6nemli bir d\u00f6n\u00fcm noktas\u0131d\u0131r ve bakteriyel enfeksiyonlar\u0131n g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131n\u0131 ve \u00f6l\u00fcm oran\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde azaltm\u0131\u015ft\u0131r. \u015eu anda, ke\u015ffedilen antibiyotiklerin yakla\u015f\u0131k 60%'si Streptomyces taraf\u0131ndan \u00fcretilmektedir. Bununla birlikte, antibiyotiklerin yayg\u0131n kullan\u0131m\u0131yla birlikte, diren\u00e7 ve superbug sorunlar\u0131 giderek daha belirgin hale gelmektedir. \u0130la\u00e7 direnci ve s\u00fcper b\u00f6cek sorunlar\u0131n\u0131 ele almak i\u00e7in acilen yeni antibiyotikler ke\u015ffetmemiz gerekiyor. Streptomyces genom verilerinin biyoinformatik analizi yoluyla, genlerin \u00f6nemli bir k\u0131sm\u0131n\u0131n sessiz durumda oldu\u011fu bulunmu\u015ftur. Bu nedenle, Streptomyces'teki susturulmu\u015f gen k\u00fcmelerinin aktivasyonu \u015fu anda \u00f6nemli konulardan biridir. Giderek daha fazla say\u0131da bilim insan\u0131 Streptomyces'in yeni bile\u015fikler ke\u015ffetme potansiyelini fark etmi\u015f ve sessiz gen k\u00fcmelerinin aktivasyonunun nas\u0131l te\u015fvik edilece\u011fini ara\u015ft\u0131rmaya ba\u015flam\u0131\u015ft\u0131r.<\/p>\n<p>Aktivasyon i\u00e7in hedef genin net olup olmamas\u0131na ba\u011fl\u0131 olarak, mevcut aktivasyon stratejilerini y\u00f6nlendirilmi\u015f aktivasyon stratejileri ve y\u00f6nlendirilmemi\u015f aktivasyon stratejileri olarak ikiye ay\u0131r\u0131yoruz. Y\u00f6nlendirilmemi\u015f aktivasyon stratejileri, k\u00fclt\u00fcr ortam\u0131n\u0131n bile\u015fimini veya ko\u015fullar\u0131n\u0131 de\u011fi\u015ftiren aktivasyon stratejilerini, ortak k\u00fclt\u00fcr stratejilerini, kimyasal aktivat\u00f6rlerin eklenmesini ve k\u00fcresel d\u00fczenlemeyi i\u00e7erir. Ribozom m\u00fchendisli\u011fi, promot\u00f6r m\u00fchendisli\u011fi, transkripsiyon fakt\u00f6r\u00fc d\u00fczenlemesi gibi baz\u0131 gen tabanl\u0131 y\u00f6ntemlerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, y\u00f6nlendirilmemi\u015f aktivasyon stratejilerinin kendi avantajlar\u0131 ve s\u0131n\u0131rlamalar\u0131 vard\u0131r (bkz. Tablo 4). Son y\u0131llarda, susturulmu\u015f gen k\u00fcmelerinin uyar\u0131lmas\u0131nda b\u00fcy\u00fck rol oynayan mikroak\u0131\u015fkan platformlar, mikro fermantasyon ve genom \u00f6l\u00e7e\u011finde metabolik modellerin kombinasyonu, biyojenik t\u00fcpler ve genomiklerin kombinasyonu, HiTE'ler vb. gibi baz\u0131 yeni ve son teknoloji y\u00f6ntemler geli\u015ftirilmi\u015ftir. Hedeflenmemi\u015f aktivasyon stratejilerinin metabolit parmak izi analizi ile kombinasyonunun, ikincil metabolitlerin madencili\u011finde \u00f6nemli sonu\u00e7lar elde etti\u011fi kan\u0131tlanm\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research progress on mining active secondary metabolites of Streptomyces using non directed activation silencing gene clusters Microbial secondary metabolites are a class of structurally diverse, functionally complex, and biologically active substances that play an important role in drug research and development. As of now, approximately 300000 compounds have been identified from microorganisms, with over 60% [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research progress on mining active secondary metabolites of Streptomyces using non directed activation silencing gene clusters - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/streptomyces-using-non-directed-activation-silencing-gene-clusters\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress on mining active secondary metabolites of Streptomyces using non directed activation silencing gene clusters - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress on mining active secondary metabolites of Streptomyces using non directed activation silencing gene clusters Microbial secondary metabolites are a class of structurally diverse, functionally complex, and biologically active substances that play an important role in drug research and development. 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\u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/streptomyces-using-non-directed-activation-silencing-gene-clusters\/","og_locale":"tr_TR","og_type":"article","og_title":"Research progress on mining active secondary metabolites of Streptomyces using non directed activation silencing gene clusters - China Chemical Manufacturer","og_description":"Research progress on mining active secondary metabolites of Streptomyces using non directed activation silencing gene clusters Microbial secondary metabolites are a class of structurally diverse, functionally complex, and biologically active substances that play an important role in drug research and development. 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