{"id":5799,"date":"2024-08-04T21:13:30","date_gmt":"2024-08-04T21:13:30","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5799"},"modified":"2024-08-04T21:13:30","modified_gmt":"2024-08-04T21:13:30","slug":"dactylosopogia-elegans","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/dactylosopogia-elegans\/","title":{"rendered":"G\u00fcney \u00c7in Denizi'nden bir s\u00fcnger olan Dactylosopogia elegans'\u0131n diterpenoid kimyasal bile\u015fimi ve anti-enflamatuar aktivitesi \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"<p>G\u00fcney \u00c7in Denizi'nden bir s\u00fcnger olan Dactylosopogia elegans'\u0131n diterpenoid kimyasal bile\u015fimi ve anti-enflamatuar aktivitesi \u00fczerine \u00e7al\u0131\u015fma<br \/>\nOkyanusun y\u00fcksek bas\u0131n\u00e7, y\u00fcksek tuzluluk, hipoksi ve d\u00fc\u015f\u00fck \u0131\u015f\u0131k gibi \u00f6zel ekolojik ortam\u0131, deniz organizmalar\u0131n\u0131n benzersiz metabolik mekanizmalara sahip olmas\u0131n\u0131 ve b\u00f6ylece yap\u0131sal olarak yeni ikincil metabolitler \u00fcretmesini sa\u011flar. S\u00fcngerler ikinci en b\u00fcy\u00fck deniz organizmalar\u0131d\u0131r ve okyanusta en bol bulunan do\u011fal \u00fcr\u00fcn kayna\u011f\u0131 olarak kabul edilirler. Dactylosongia cinsi s\u00fcnger bol miktarda biyoaktif ikincil metabolitlere sahiptir. Bu cins s\u00fcngerin literat\u00fcrde bildirilen kimyasal bile\u015fimi temel olarak seskiterpen kinonlar\/hidrokinonlar, seskiterpen asitler, diterpenler, steroidler, seskiterpenler ve \u00e7o\u011fu seskiterpen kinon\/hidrokinon olan di\u011fer bile\u015fik t\u00fcrlerini i\u00e7erir. Bu metabolitler anti-t\u00fcm\u00f6r, anti anjiyogenez, antibakteriyel, anti-enflamatuar, anti tripanozomal, anti s\u0131tma ve antioksidan aktiviteler gibi bir dizi biyolojik aktivite sergilemektedir. \u015eu anda, D elegans s\u00fcngerinden izole edilen nispeten az say\u0131da diterpenoid bile\u015fik vard\u0131r ve Yu ve di\u011ferleri gibi sadece az miktarda literat\u00fcr bunlar\u0131 rapor etmi\u015ftir. D elegans s\u00fcngerinden be\u015f yeni seskiterpen izole edilmi\u015ftir.<\/p>\n<p>Bu makale, yap\u0131sal olarak yeni ve biyolojik olarak aktif bile\u015fikleri ke\u015ffetmek, deniz kaynaklar\u0131ndan do\u011fal \u00fcr\u00fcnleri zenginle\u015ftirmek ve potansiyel t\u0131bbi de\u011feri olan \u00f6nc\u00fc bile\u015fikleri ke\u015ffetmek amac\u0131yla zerafetin kimyasal bile\u015fimi \u00fczerine bir dizi \u00e7al\u0131\u015fma y\u00fcr\u00fct\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5800\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-10.jpg\" alt=\"\" width=\"639\" height=\"355\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5801\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-162.png\" alt=\"\" width=\"366\" height=\"252\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5802\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-152.png\" alt=\"\" width=\"367\" height=\"148\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5803\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-136.png\" alt=\"\" width=\"360\" height=\"254\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5804\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-10.jpg\" alt=\"\" width=\"489\" height=\"352\" \/>Bu makale G\u00fcney \u00c7in Denizi'ndeki Yongxing Adas\u0131'ndan D. elegans s\u00fcngerini ele almaktad\u0131r. elegans'\u0131n kimyasal bile\u015fimi incelenmi\u015f ve bu s\u00fcnger cinsine ait 8 nadir seskiterpen izole edilmi\u015ftir. Bile\u015fik 1 yeni bir bile\u015fiktir ve bile\u015fik 2-8 ilk kez bu s\u00fcngerden izole edilmi\u015ftir. Bile\u015fik 2-8, literat\u00fcrde \u00e7o\u011funlukla Hyatella sp., Phyllospongia sp., Dysidia sp. ve Lendenfeldia sp. gibi s\u00fcngerlerden izole edildi\u011fi bildirilen Scalarane tipi seskiterpenlerdir. \u0130lk kez D El egans s\u00fcngerlerinden izole edilen Scalarane tipi seskiterpenler, bu s\u00fcngerlerin besin zinciri veya simbiyotik mikroorganizmalar\u0131yla ili\u015fkili olabilir. Farelerde lipopolisakkarit (LPS) taraf\u0131ndan ind\u00fcklenen RAW 264.7 makrofajlar\u0131ndan NO sal\u0131n\u0131m\u0131 \u00fczerinde 8 bile\u015fi\u011fin inhibisyon oranlar\u0131 belirlenmi\u015ftir. Anti-enflamatuar de\u011ferlendirme s\u0131ras\u0131nda test edilen bile\u015fiklerin RAW 264.7 h\u00fccreleri \u00fczerindeki sitotoksisitesinden ka\u00e7\u0131nmak i\u00e7in CCK-8 tespiti de yap\u0131ld\u0131. Sonu\u00e7lar, bile\u015fik 1, 3 ve 4'\u00fcn s\u0131ras\u0131yla 65,5%, 48,5% ve 46,0% inhibisyon oranlar\u0131yla 10 \u03bc mol\/L'de iyi NO inhibisyon etkilerine sahip oldu\u011funu ve RAW 264.7 h\u00fccreleri \u00fczerinde sitotoksisiteye sahip olmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bu bile\u015fikler anti-enflamatuar tedavide potansiyel de\u011fere sahip olabilir, ancak anti-enflamatuar etkilere dahil olan spesifik mekanizmalar daha fazla ara\u015ft\u0131rma gerektirir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea The special ecological environment of the ocean, such as high pressure, high salinity, hypoxia, and low light, enables marine organisms to have unique metabolic mechanisms, thereby producing structurally novel secondary metabolites. Sponges are the second largest [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/dactylosopogia-elegans\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the diterpenoid chemical composition and anti-inflammatory activity of Dactylosopogia elegans, a sponge from the South China Sea The special ecological environment of the ocean, such as high pressure, high salinity, hypoxia, and low light, enables marine organisms to have unique metabolic mechanisms, thereby producing structurally novel secondary metabolites. 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